' 
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
8.3 mcg (333 IU)
42%
Calcium (elemental) (from 1,270 mg Calcium Citrate)
266 mg
20%
Magnesium (elemental) (from 230 mg Magnesium Oxide)
133 mg
32%
Vitamin K2 (as Menaquinone)
30 mcg
†
Top Medical Research Studies
9
Magnesium aids menopause-related issues
The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice.
Strong relevance to menopause research
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
7
Magnesium impacts menopause bone health
Magnesium Intake Predicts Bone Turnover in Postmenopausal Black South African Women.
Significant findings on bone health
We explored the relationship between magnesium intake and bone health in postmenopausal black South African women over a two-year period. In this study, which included 144 participants, researchers measured bone mineral density (BMD) at several key sites, alongside various biochemical analyses, including bone turnover markers.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
Read More
8
Calcium maltobionate supports bone health
Decrease in Facial Bone Density with Aging and Maintenance Effect of Calcium Maltobionate Ingestion in Japanese Adult Women: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.
Relevant but not definitive impact
We conducted a study to investigate how calcium maltobionate affects bone density in healthy Japanese women, particularly focusing on those who are pre- and post-menopausal. In a well-structured trial, 48 women aged between 30 and 69 were randomly divided into two groups: one received calcium maltobionate tablets while the other took a placebo designed to mimic the calcium content.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Read More
Most Useful Reviews
8.8
Improved health
I ordered this for myself as my test results showed I had nearly no calcium and vitamin D3. I was experiencing soreness in my hands and legs, along with a generally sluggish feeling. Additionally, there was menopause to contend with. The doctor suggested this dietary supplement, as it also includes magnesium and K2. This combination is effective: Vitamin D3 absorbs better with K2, and calcium with Vitamin D3. After using this product, my health improved, and the pain in my arms and legs vanished. I recommend it to everyone.
Read More
8.8
Better sleep
I bought this for my mother, who is going through menopause, and she mentioned that her sleep quality has greatly improved.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
- All Researches
9
Magnesium aids menopause-related issues
The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice.
Strong relevance to menopause research
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
9
Magnesium's impact on bone health
Supplementation of nanofiltrated deep ocean water ameliorate the progression of osteoporosis in ovariectomized rat via regulating osteoblast differentiation.
Study shows mixed magnesium benefits
Our exploration centered on the effects of magnesium, particularly from nanofiltrated deep ocean water (DOW), in addressing osteoporosis, a common concern during menopause. In our study, we used ovariectomized female Sprague-Dawley rats, a model that simulates menopausal conditions. We administered varying amounts of DOW daily over eight weeks to observe its impact on bone health.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
Read More
9
Isoflavones, probiotics boost bone health
Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial.
Evidence-based findings on menopause treatment
We explored the impact of a novel red clover extract rich in isoflavones and probiotics on bone health in postmenopausal osteopenic women. In a year-long double-blind trial with 78 participants, we compared this treatment alongside standard supplements against a placebo. Results showed that the extract substantially reduced bone mineral density loss and improved certain estrogen metabolism markers. However, it did not affect other bone turnover indicators significantly. Overall, combining the extract with calcium and magnesium proved beneficial for bone health in this demographic.
Read More
9
Magnesium reduces menopause symptoms
Effects of a new combination of nutraceuticals on postmenopausal symptoms and metabolic profile: a crossover, randomized, double-blind trial.
High relevance to menopause treatment
We explored the effects of a nutraceutical blend, including magnesium, on menopause symptoms through a crossover trial involving 43 postmenopausal women.
Participants experienced significant reductions in menopause symptoms, as measured by the Menopause Rating Scale, after using the nutraceuticals.
Additionally, improvements were noted in cardiovascular risk factors, such as lower cholesterol levels and blood pressure.
Overall, this study suggests that magnesium, combined with other nutrients, may provide meaningful relief for postmenopausal symptoms.
Participants experienced significant reductions in menopause symptoms, as measured by the Menopause Rating Scale, after using the nutraceuticals.
Additionally, improvements were noted in cardiovascular risk factors, such as lower cholesterol levels and blood pressure.
Overall, this study suggests that magnesium, combined with other nutrients, may provide meaningful relief for postmenopausal symptoms.
Read More
8
Calcium maltobionate supports bone health
Decrease in Facial Bone Density with Aging and Maintenance Effect of Calcium Maltobionate Ingestion in Japanese Adult Women: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial.
Relevant but not definitive impact
We conducted a study to investigate how calcium maltobionate affects bone density in healthy Japanese women, particularly focusing on those who are pre- and post-menopausal. In a well-structured trial, 48 women aged between 30 and 69 were randomly divided into two groups: one received calcium maltobionate tablets while the other took a placebo designed to mimic the calcium content.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved health
I ordered this for myself as my test results showed I had nearly no calcium and vitamin D3. I was experiencing soreness in my hands and legs, along with a generally sluggish feeling. Additionally, there was menopause to contend with. The doctor suggested this dietary supplement, as it also includes magnesium and K2. This combination is effective: Vitamin D3 absorbs better with K2, and calcium with Vitamin D3. After using this product, my health improved, and the pain in my arms and legs vanished. I recommend it to everyone.
Read More
8.8
Better sleep
I bought this for my mother, who is going through menopause, and she mentioned that her sleep quality has greatly improved.
