NOW Supplements Calcium &amp; Magnesium 2:1 Ratio

Magnesium treats anxiety in MS

Based on 13 Researches

USERS' SCORE

Excellent

Based on 16 Reviews

Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.

Most Relevant Research

We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.

We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.

Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.

In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.

Life-changing impact

Most Useful Review

These literally saved my life. For years, I struggled with severe anxiety and panic attacks that made it difficult to leave the house. I feared I would end up on disability. After taking these for three months, my anxiety and panic attacks have practically disappeared. I discovered I was calcium deficient, which made a world of difference in conjunction with my magnesium intake. My blood pressure has also improved significantly during stressful doctor visits. It took time, but looking back, I can see a considerable positive shift.

Pelvic Pain details

I accept this as directed by my orthopaedic traumatologist to treat and prevent osteoporosis before and after pelvic surgery. Cramps are common during pregnancy, so calcium plus magnesium is effective. Although I consumed various calcium supplements and craved chalk, this medication restored my body's calcium levels and eliminated my desire for chalk.

Acne details

Mesoporous magnesium carbonate fights acne

Investigation of the Antibacterial Effect of Mesoporous Magnesium Carbonate.

Most Relevant Research

This study looks into how mesoporous magnesium carbonate (MMC) can help with acne by reducing bacteria that thrive on our skin. We used a specific Gram-positive bacterium considered a common culprit in acne lesions. To ensure our results were reliable, we measured bacterial activity using a metabolic assay.

Our findings revealed that MMC exhibits a strong antibacterial effect against this acne-related bacterium. A significant factor contributing to its effectiveness is the material's alkalinity. This suggests that MMC could be developed further as a skincare ingredient aimed at inhibiting bacterial growth, providing an alternative to traditional antibiotic treatments.

Overall, we see promising potential for MMC in topical applications, especially for those looking for non-antibiotic solutions to manage acne and maintain skin health.

Clearer complexion

Most Useful Review

The composition of calcium and magnesium is superb, with a good dosage that is easy to use. I highly recommend purchasing this product. After a week, the results on my nails and hair were evident; my face became clean without any redness, irritation, or acne.

Chest Pain details

Magnesium supplementation aids chest pain

Based on 9 Researches

The prevalence of hypomagnesaemia in pediatric patients with mitral valve prolapse syndrome and the effect of mg therapy.

Most Relevant Research

We explored the effects of magnesium treatment on chest pain in pediatric patients suffering from mitral valve prolapse syndrome. In our study involving 230 young participants, we defined hypomagnesaemia as having a serum magnesium level below 1.5 mg/dl.

After identifying 19 patients with insufficient magnesium levels—representing about 8.2% of the group—we treated them with an oral magnesium chloride supplement for five weeks. We were eager to see whether this would help alleviate symptoms, particularly chest pain.

After the treatment period, we observed that magnesium therapy provided statistically significant relief of chest pain for these patients. However, we did not find substantial improvements in other symptoms like palpitations, fatigue, and dyspnea. This finding is vital, as it indicates that while magnesium may play a role in easing chest pain, its overall benefit to other symptoms remains uncertain.

Overall, our study highlights the relatively low prevalence of magnesium deficiency in pediatric patients with mitral valve prolapse compared to adults. Nevertheless, we concluded that magnesium supplementation could be a beneficial approach to address specific symptoms like chest pain in this population.

9.5

Incredible pain relief

Most Useful Review

Very effective calcium! After trying various pharmaceutical products, this calcium surprised me. After using it for a while, I experienced incredible relief from knee and hip joint pain, which had troubled me for five years. I used to limp but can now run slowly each day. I’m delighted to have forgotten about my arthritis.

Common Cold details

It helps a lot during a common cold.

Diabetes details

Magnesium deficiency affects diabetes control

Based on 7 Researches

Hypomagnesemia in adults with type 2 diabetes mellitus in Riyadh, Saudi Arabia: A cross-sectional study.

Most Relevant Research

We looked into how magnesium levels relate to diabetes, specifically focusing on adults with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia. Conducted as a cross-sectional study, we analyzed data from 294 individuals, including T2DM patients, prediabetics, and nondiabetic controls. Our goal was to uncover the prevalence of magnesium deficiency and its potential effects on various metabolic factors.

The findings revealed a striking difference in magnesium levels across the groups. T2DM patients exhibited notably lower magnesium than those with prediabetes and nondiabetic controls. This deficiency was linked to worse metabolic outcomes, including higher fasting glucose and glycated hemoglobin (HbA1c) levels, as well as increased insulin resistance.

We noted a strong negative correlation between magnesium levels and both glucose and HbA1c, suggesting that as magnesium levels decrease, diabetes control worsens. Interestingly, our analysis indicated that magnesium levels could effectively predict higher HbA1c values, highlighting the need for regular monitoring of magnesium in diabetes management.

While our study emphasizes the significant impact of magnesium deficiency on the metabolic health of T2DM patients, it also opens the door for further exploration regarding the benefits of magnesium supplementation in diabetes care. Overall, these insights push us to consider the broader implications of maintaining proper magnesium levels for better diabetes management.

9.5

Reduced muscle pain

Most Useful Review

Great product! I began taking it due to muscle pain from very low vitamin D. After a week, my muscle discomfort has nearly vanished. I feel energetic in the mornings. I also take selenium, vitamin E, D, zinc, and vitamins B and C. Magnesium is essential for diabetics; my 16-year-old daughter with type 1 diabetes takes one tablet before bed.

Toothache details

Calcium treatment shows comparable results

Based on 5 Researches

Eighteen-month clinical and radiographic evaluation of two root canal-filling materials in primary teeth with pulp necrosis secondary to trauma.

Most Relevant Research

We compared two root canal-filling materials used in treating primary teeth with pulp necrosis caused by trauma. Our main focus was on the effectiveness of a calcium hydroxide-based paste versus traditional zinc oxide and eugenol cement, specifically looking at clinical and radiographic outcomes after 18 months.

In our study involving 26 children, we found that both materials demonstrated similar success rates. Clinical success included factors like the absence of pain and tooth mobility, while radiographic success was determined by the healing of tooth roots. Our results indicated that both calcium treatment and zinc oxide function well for the root canal filling in children suffering from pulp necrosis, making them suitable options.

Overall, our findings suggest that whether we use calcium hydroxide or zinc oxide, parents and dentists can expect effective outcomes when treating dental trauma in young children. Thus, both materials are viable choices for addressing toothache related to pulp issues in primary teeth.

9.5

Instant toothache relief

Most Useful Review

Excellent! I thoroughly enjoyed it. It provided effective relief from my toothache.

Arteriosclerosis details

This supplement delivers great doses of calcium and magnesium, which are essential for our daily intake. Most supplements cannot meet the required amounts due to their size, so taking just one of these pills is advisable even if I use another multivitamin. For optimal bone health, combining calcium with a K2 vitamin supplement, like MenaQ7, is ideal. This vitamin activates osteocalcin, which binds calcium to bones, while preventing calcium from binding to arterial walls, thereby addressing arteriosclerosis. I prefer chelated minerals for better absorption but manage just fine with this supplement, taking one pill every night.

Arthritis details

Magnesium protects against bone erosion

Based on 17 Researches

Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study.

Most Relevant Research

We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.

Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.

Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.

9.5

Significant pain relief

Most Useful Review

Very effective calcium! I've previously tried pharmaceutical calcium products, but this one truly surprised me. I took it with vitamin D3 for my knee and hip joint issues stemming from a meniscus operation. After consuming half a jar, I experienced incredible relief. I used to hobble, but now I can run slowly every day. The frequent pain has vanished, and I’m delighted. Despite scepticism towards reviews like this, I’m now sharing my own. I’ve forgotten about my arthritis and took this for myself as well.

Back Pain details

Magnesium reduces postoperative back pain

Based on 7 Researches

Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting.

Most Relevant Research

We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.

Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.

Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.

8.8

Joint pain relief

Most Useful Review

I took this to strengthen my bones for my mother. Joint pain has diminished, and I recommend it.

Bruise details

Magnesium reduces bruising post-surgery

The Efficacy of Magnesium Sulfate (MgSO4) Wet Dressing in Reducing Eyelid Swelling and Bruising after Blepharoplasty: A Randomized, Controlled, and Observer-Blinded Assessment Study.

Most Relevant Research

We explored the impact of magnesium sulfate (MgSO4) wet dressings on bruising and swelling following blepharoplasty, a common eyelid surgery. In our study, fifty-eight patients were evenly split between two treatments: one side received a magnesium sulfate solution, while the other was cooled with ice packs. This setup allowed us to compare the effectiveness of these two methods objectively.

Over the recovery period, we observed that the eyelid swelling was similar in both groups initially but notably reduced over time. However, by the fifth day after surgery, we found that those treated with the magnesium solution experienced significantly less swelling compared to the cooling method. Additionally, bruising—measured by both area and incidence—was also lower in the magnesium group, highlighting its effectiveness.

Interestingly, a significant majority of patients preferred the magnesium treatment over ice cooling, with many appreciating the convenience and results of the wet dressing. This suggests that magnesium sulfate is not only effective in reducing bruising and swelling but is also a patient-favored option for recovery after eyelid surgery.

8.8

Quick bruise recovery

Most Useful Review

As a nursing mother, I lack calcium, which first affects my teeth, causing sensitivity. Since taking these vitamins, this issue has been resolved; my teeth remain intact without needing any healing. Last winter, I suffered a severe bruise that damaged my ligaments and joints but thankfully not a fracture. I believe my recovery was quite fast, and that's thanks to these vitamins.

Cancer details

Magnesium alloy inhibits cancer growth

Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer.

Most Relevant Research

We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.

In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.

Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.

With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.

8.8

Normal health indicators

Most Useful Review

For a friend, 60+ After cancer, a woman constantly takes some medications, the side effect of which is a decrease in bone density. The doctor recommended taking calcium in addition, along with magnesium and vitamin D3+K2 for better absorption. On control examinations, all her indicators are normal, as well as her well-being. ❤️

Gout details

Magnesium may protect against bone erosion

Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study.

Most Relevant Research

We examined the relationship between magnesium levels and the occurrence of bone erosion in patients with gouty arthritis. In our analysis, we observed that 769 gout patients were studied, allowing us to classify them into groups based on their serum ionized magnesium levels.

The results were striking: those with lower magnesium levels had a significantly higher rate of bone erosion. Specifically, patients in the lowest magnesium group showed a bone erosion prevalence rate of over 60%, compared to less than 45% in those with higher magnesium levels.

Our findings suggest that maintaining adequate levels of magnesium might offer a protective effect against bone deterioration in gout arthritis. This points to the possibility that magnesium supplementation could be beneficial for preventing or slowing down bone erosion in these patients.

Gout healing achieved

Most Useful Review

The gout has healed. I used to suffer from gout attacks thrice a year, but since I started taking this supplement, I no longer have seizures without the need for medications to lower uric acid levels. I also introduced it to three friends who were suffering from gout, and they too experienced healing. It's truly remarkable.

High Cholesterol details

Embelin influences cholesterol metabolism

Embelin Elevates Endoplasmic Reticulum Calcium Levels and Blocks the Sterol Regulatory Element-Binding Protein 2 Mediated Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Improves the Low-Density Lipoprotein Receptor Mediated Lipid Clearance on Hepatocytes.

Most Relevant Research

We examined the effects of embelin, a compound derived from the dried berries of Embelia ribes, on cholesterol levels by focusing on its relationship with calcium in liver cells. Our analysis showed that embelin treatment aids in regulating cholesterol metabolism by influencing key proteins associated with cholesterol clearance.

The study highlighted how embelin can elevate calcium levels within the endoplasmic reticulum (ER), which is essential for proper cellular function. By increasing calcium, we observed a decrease in the activity of a protein known as PCSK9, which typically hinders the liver's ability to remove low-density lipoprotein (LDL) cholesterol from circulation.

By regulating the levels of SREBP2, another protein linked to cholesterol control, embelin ultimately enhances the liver's capacity to clear LDL from the bloodstream. This mechanism reveals that calcium plays an important role, particularly in how embelin mediates cholesterol levels through its effects on proteins involved in cholesterol metabolism.

Overall, the findings suggest that embelin may offer a natural avenue for improving cholesterol management, particularly in the context of cardiovascular health.

9.5

Convenient combination

Most Useful Review

Excellent! When taking calcium, it's not absorbed effectively unless magnesium is included, making this combination very convenient. I highly recommend it for women.

Hypertension details

Magnesium effectively lowers blood pressure

Based on 10 Researches

Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length.

Most Relevant Research

We explored how magnesium supplementation can affect systolic blood pressure (SBP) in the general population. Through careful analysis of placebo-controlled, randomized clinical trials, we focused on understanding the optimal dosages and treatment durations necessary to achieve significant reductions in SBP. Past findings revealed that magnesium could reduce SBP by an average of 2.79 mm Hg, and our goal was to dive deeper into these results.

Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.

While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.

9.5

Reduced headaches

Most Useful Review

I am very satisfied with this product, and I've even ordered it for my mum as a supplement for her hypertension! Since she started, her headaches have noticeably decreased!

Hyperthyroidism details

Due to my hyperthyroidism, I am more susceptible to osteoporosis and dislike sunbathing. My bone density was -3.5 in May and improved to -1.9 in September, which made me very pleased.

Menopause details

Magnesium aids menopause-related issues

Based on 7 Researches

The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice.

Most Relevant Research

We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.

We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.

Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.

In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.

9.5

Reduced mood swings

Most Useful Review

I feel calmed down! These vitamins, calcium, and magnesium work well together for absorption. I take them alongside a B complex from the same brand. They calmed my nervous system significantly. My mood swings and depression linked to menopause have diminished, and my epilepsy attacks are less frequent. My hair and nails have improved too. The vitamins are of good natural quality, and the price is superb compared to local pharmacies. I recommend it, especially for women over 40.

Osteoporosis details

Magnesium's role in osteoporosis therapy

Based on 17 Researches

Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.

Most Relevant Research

We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.

Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.

In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.

Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.

9.5

Reduced cravings

Most Useful Review

I take this as prescribed by my orthopaedic surgeon for osteoporosis management before and after pelvic surgery. It's a great remedy for the cramps common during pregnancy. After consuming other types of calcium without relief, I finally found this one. My calcium levels have improved, and the urge to eat chalk has disappeared entirely.

Reflux details

Calcium's role in reflux protection

A combination of carbonates and Opuntia ficus-indica extract protects esophageal cells against simulated acidic and non-acidic reflux in vitro.

Most Relevant Research

We examined a combination product of carbonate antacids—specifically calcium carbonate and magnesium carbonate—with an extract from Opuntia ficus-indica, commonly known as prickly pear. This study looked at how this product could potentially protect esophageal cells from damage caused by both acidic and non-acidic reflux.

Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.

Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.

9.5

Significant reflux relief

Most Useful Review

The cooling vitamins arrived extremely quickly, even faster than expected. The quality is fantastic and the packaging perfect! The taste is almost non-existent. However, the tablet contains two doses; if you need to take two per day, remember to break the pill in half. I found that after taking calcium and vitamin D, my digestion improved significantly. Endless heartburn began to fade and the frequency of reflux attacks was greatly reduced. My pancreas feels much better, and of course, my bones and immunity are in order!

Tinnitus details

Magnesium's role in tinnitus explored

Based on 6 Researches

Relationship between serum magnesium level and subjective tinnitus.

Most Relevant Research

We explored the connection between serum magnesium levels and the occurrence of severe bilateral subjective tinnitus. This study involved 76 patients suffering from this distressing condition and compared them to 86 healthy participants.

By measuring and analyzing the magnesium levels in both groups, we observed that those with tinnitus had significantly lower magnesium concentrations—1.8 mg/dL compared to 2.3 mg/dL in the control group. This difference suggests that magnesium may play a role in the body’s response to tinnitus.

Our findings indicate that magnesium could be an important factor in understanding the pathophysiology of subjective tinnitus. While this doesn’t confirm that magnesium treatment will alleviate tinnitus symptoms, it certainly opens up avenues for further research in this area.

Tinnitus improvement observed

Most Useful Review

My tinnitus improved after taking magnesium, which I purchased for this purpose. Since I've been consistently taking it, my tinnitus has disappeared.

Blood Clot details

Calcium type affects clot risk

Thrombotic Complications Associated With Right Atrial Lines in Neonates and Infants Undergoing Cardiac Surgery. Is Calcium Chloride a Culprit?

Most Relevant Research

We explored the impact of different calcium infusions on clotting risks in neonates undergoing cardiac surgery. Our study involved analyzing data from 135 babies who received either calcium chloride or calcium gluconate during their treatment.

The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.

With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.

9.5

Blood pressure stabilised

Most Useful Review

A great mix! My wife had severe blood pressure issues until I realised our previous magnesium-calcium supplement had changed, removing calcium. After switching to Now supplements, her blood pressure returned to normal. We found iHerb offered this at a better price, so we’ll continue buying from them.

Brain Tumor details

Calcium affects brain tumor growth

Based on 3 Researches

Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth.

Most Relevant Research

We developed two unique animal models to explore how calcium influences tumor expansion, particularly in craniopharyngioma, a type of brain tumor notoriously known for invading the hypothalamus. This research aimed to understand whether the activity of neuroendocrine neurons impacts tumor growth.

During our study, we conducted a thorough high-throughput drug screening process and identified 74 compounds with significant antitumor properties. Among these, we found that the drug amlodipine besylate was particularly effective. Its administration led to tumor regression, possibly by influencing calcium transients and the chemical interactions between neurons and tumor cells.

Interestingly, we observed that manipulating neuroendocrine neuronal activity could either promote or slow down tumor growth, indicating that craniopharyngioma tumors can exploit these neurons to aid in their progression. Overall, these findings provide deeper insight into tumor biology and suggest potential pathways for developing effective treatments.

8.8

Overall wellbeing

Most Useful Review

The benefits of calcium and magnesium for health are immense! They ensure proper brain function, strengthen bones, improve sleep quality, lower blood pressure, and support the nervous system among others. I've noticed improvements in my teeth and nails, as well as a decrease in impulsive behaviour, leading to greater calmness in various situations. This dietary supplement truly works! In comparison with others, it offers an excellent price-to-quality ratio and suitable dosages. I wish everyone good health and longevity!

Eczema details

Calcium's complex impact on eczema

Based on 3 Researches

Correlation between dietary calcium intake and eczema in American adult population.

Most Relevant Research

We explored the connection between dietary calcium intake and the occurrence of eczema in adults using data from the National Health and Nutrition Examination Survey conducted in 2005-2006. Our aim was to see if there’s a relationship between how much calcium adults consume and the likelihood of developing eczema, a common skin condition.

In this observational study, we analyzed responses from 4,086 adults, of whom 266 reported having eczema. Our statistical analysis revealed an interesting pattern: we found that individuals in the third quartile of calcium intake had a significantly higher risk of eczema compared to those in the first quartile. Essentially, our results suggested that as dietary calcium intake increased, so did the prevalence of eczema—up to a certain point.

We identified an inverted U-shaped relationship between calcium intake and eczema prevalence. Specifically, an increase in calcium intake was associated with a higher occurrence of eczema until calcium levels reached a logarithmic value of 7.089. Thus, moderating calcium intake may help reduce the incidence of eczema.

These findings indicate that while calcium is essential for health, excessive consumption may not always be beneficial, particularly in relation to skin conditions like eczema. Further research is necessary to explore this relationship more deeply and determine the best levels of calcium intake for preventing eczema.

9.5

Eczema improved dramatically

Most Useful Review

The price-quality-dosage ratio is excellent: it lasts a long time and has a reasonable dosage, combining two vitamins in one. My husband and I have been taking them for three months. For optimal absorption, we take chlorophyll in the morning, multivitamins, omega, vitamin D3, and calcium with magnesium in the evening since magnesium and iron don't mix. After the autumn, when eczema appeared post-pregnancy and covered my body, the dermatologist noted that only vitamin D was deficient. Once I started taking the vitamins, the body atopy vanished, and my eczema became localized between my fingers. My general condition improved. I feel magnesium aids my emotional well-being, while calcium helps with my teeth and hair loss.

Heart Attack details

Magnesium implantation improves heart recovery

Based on 15 Researches

Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.

Most Relevant Research

We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.

Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.

Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.

9.5

Reduced heart issues

Most Useful Review

I found this magnesium very effective. I had a severe deficiency, which led to cramps and spasms, including my heart, causing it to beat irregularly. After the first pill, I noticed immediate peace, and my heartbeat improved significantly. Within three to four days, all deficiency symptoms vanished. The only downside is the large tablets, which can be difficult to take.

Hypothyroidism details

Magnesium shows promise in thyroid recovery

Based on 5 Researches

Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation.

Most Relevant Research

We set out to investigate how magnesium, along with selenium and coenzyme Q10, could influence hypothyroidism in patients with benign thyroid diseases. Our approach included a small group of eight patients—five with hyperthyroidism and three with hypothyroidism—who received additional treatment aimed at addressing both their thyroid condition and related physical and psychological stresses.

Over a period of 2 to 4 years, we observed some significant changes. Initially, we focused on correcting musculoskeletal issues, followed by addressing stress. As a result, we noted that thyroid morphology normalized in many cases, which was confirmed through ultrasound examinations. Interestingly, we also saw a reduction in thyroid antibody levels for most patients.

However, we must be transparent about our findings. While magnesium and the other supplements showed promise, there were two cases of chronic thyroiditis that did not respond positively to treatment, possibly due to long-standing fibrosis. This indicates that while magnesium may play a role in thyroid health, its effectiveness can vary significantly based on individual circumstances and the duration of the thyroid condition.

8.8

Improving thyroid levels

Most Useful Review

On my endocrinologist's advice, I take it alongside vitamin D3 and Omega-3 for my hypothyroidism. My analyses are gradually approaching normal.

Migraine details

Magnesium reduces migraine symptoms

Based on 16 Researches

Magnesium and Migraine.

Most Relevant Research

We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.

Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.

We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.

Migraine relief

Most Useful Review

My migraines have disappeared. I'm taking Two-Per-Day, but since it doesn't contain Cal-Mag, I'm using this as well. The migraines caused by pressure have gone. I'd like to continue taking this.

Sleep Apnea details

Magnesium's role in sleep apnea

Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study.

Most Relevant Research

We aimed to uncover the relationship between magnesium levels and sleep quality, particularly focusing on sleep apnea. Our study analyzed data from a large group of adults aged 20 and older, using a well-structured method to assess magnesium levels and the prevalence of sleep issues.

We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.

Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.

While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.

8.8

Improved sleep quality

Most Useful Review

Great help! After a week, I noticed improvements. I began falling asleep faster, and the quality of my sleep improved. My leg muscles stopped hurting. I highly recommend it for the good value; the can is very large!

Stroke details

Calcium Modulation for Stroke Recovery

Based on 19 Researches

Optogenetic calcium modulation in astrocytes enhances post-stroke recovery in chronic capsular infarct.

Most Relevant Research

We investigated the role of calcium in astrocytes to enhance recovery after a stroke. Focusing on a specific optogenetic tool called OptoSTIM1, we were able to selectively activate calcium channels in astrocytes. This approach allowed us to significantly elevate calcium levels in these supporting brain cells, particularly in the sensory-parietal cortex following a stroke.

Our findings revealed that this sustained calcium increase, lasting over 10 minutes, led to noticeable improvements in post-stroke recovery. By manipulating intracellular calcium levels in astrocytes, we observed a remarkable reduction in impairment caused by chronic stroke conditions.

This study highlights the potential of targeting astrocytic calcium signals as a promising strategy for enhancing stroke recovery, paving the way for new therapeutic approaches. Overall, our research suggests that calcium's role in astrocytes could be a game changer in the efforts to improve outcomes for stroke patients.

8.8

Reduces heart attack risk

Most Useful Review

This choice has eliminated stress while addressing magnesium deficit in my body. Magnesium mitigates blood clotting, alleviates stomach cramps, and helps with acidity levels. It’s crucial for hearing acuity, involved in brain function, and necessary for the absorption of B vitamins. Additionally, it has an anti-sclerotic effect and lowers elevated blood pressure, thereby reducing the risk of heart attack and stroke by relaxing blood vessels.

Anemia details

Hemoglobin increase linked to hypercalcemia

Effect of persistent hypercalcemia on hemoglobin levels after kidney transplantation.

Most Relevant Research

We investigated how persistent hypercalcemia—elevated calcium levels—affects hemoglobin levels in kidney transplant recipients (KTRs). Through a retrospective study including 385 patients, we analyzed the trajectories of hemoglobin in those with and without hypercalcemia.

Our findings revealed a surprising link: KTRs with persistent hypercalcemia exhibited higher hemoglobin levels over time—an increase of about 0.76 g/dL per year. This was especially pronounced in men, who showed an increase of 0.80 g/dL per year, compared to a more modest rise of 0.36 g/dL per year in women.

Additionally, our data indicated that these patients had a greater risk of developing post-transplant erythrocytosis, a condition characterized by an elevated red blood cell count. This relationship invites further consideration about the role of calcium levels in blood health, suggesting that rather than causing anemia as might be expected, hypercalcemia may drive erythrocytosis in this unique patient population.

Overall, this study emphasizes the complexity of calcium’s role in post-transplant health and highlights the importance of monitoring hemoglobin levels in KTRs, especially those with persistent hypercalcemia.

Condition improved

Most Useful Review

I took it when symptoms of anemia appeared and completed the course; my condition improved. I love this brand and would recommend it.

Hypomagnesemia because of nedaplatin for cervical cancer: A case report.

Most Relevant Research

We observed a striking case involving a 76-year-old woman diagnosed with cervical cancer, who was treated with nedaplatin, a platinum-based chemotherapy drug. Shortly after starting her treatment, she experienced troubling symptoms, including numbness, dizziness, and a noticeable loss of appetite.

Upon investigation, we discovered low levels of calcium and magnesium in her blood, which were likely contributing to her symptoms. Thankfully, after administering intravenous calcium and magnesium, we saw a prompt improvement in both her mineral levels and her symptoms.

The case underscores the importance of monitoring electrolyte levels during chemotherapy treatments, such as nedaplatin. By focusing on these disturbances, healthcare providers can unveil potential diagnoses even when patients present with vague symptoms. Regular follow-ups during anticancer therapies could be crucial in effectively managing side effects such as dizziness.

Improved dizziness

Most Useful Review

I believe it's beneficial for the nervous system. My husband, who has nerve dysfunction and often feels dizzy, has shown great improvement after several months of taking it. Buying in larger quantities is more cost-effective.

Cardiovascular Disease details

Magnesium's impact on heart health

Based on 9 Researches

The Role of Dietary Magnesium in Cardiovascular Disease.

Most Relevant Research

We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.

Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.

Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.

8.8

Improved bone strength

Most Useful Review

Wonderful! Everyone knows about the benefits of calcium for teeth and bones, yet many still experience insufficient bone strength. This often occurs because calcium is not taken with magnesium. I took these vitamins during pregnancy, and they helped with cramps and maintaining healthy nails and hair. If my review is useful, please support me. I drink these vitamins regularly and recommend them to all.

Frozen Shoulder details

Calcium treatment shows promise

Treatment for frozen shoulder combined with calcific tendinitis of the supraspinatus.

Most Relevant Research

We explored the effects of calcium deposition in the rotator cuff tendons on frozen shoulder, particularly in cases where calcific tendinitis was present. The study involved 32 patients who underwent a specialized procedure combining arthroscopic brisement of the shoulder joint with multiple punctures at the calcific site. This innovative approach aimed to alleviate the pain and restore mobility linked to frozen shoulder.

After following up with the patients for two years, we observed that 30 out of 32 patients reported satisfactory outcomes. While five individuals still showed some postoperative calcium deposits, many experienced significant improvements in their range of motion and relief from pain. This suggests that combining treatment methods can enhance recovery, although we recognize that the isolated effect of calcium treatment alone remains unclear.

Overall, this study contributes valuable insight into managing frozen shoulder, especially when associated with calcific tendinitis, even if it doesn't fully isolate the impact of calcium treatment.

9.5

Joint pain relief

Most Useful Review

Salvation for joints! This medication, prescribed by my rehabilitologist after I injured my knees on a long hike, has worked wonders. After two months, not only did my knees stop hurting, but my frozen shoulder improved as well. I plan to have courses every six months.

Insomnia details

Magnesium improves elderly insomnia

Based on 11 Researches

The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.

Most Relevant Research

We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.

Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.

The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.

Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.

9.5

Improved sleep quality

Most Useful Review

Wonderful calcium! I began taking this regularly due to my physician's recommendation. It has no side effects and is well absorbed, which I can tell by the improvement in my nails. After years of dealing with insomnia, I've begun to sleep better and feel calmer, possibly thanks to the magnesium. My husband and son now use it too. I've learnt calcium should be taken daily, making this a regular purchase for our health.

Knee Pain details

Calcium injection aids knee function

Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee.

Most Relevant Research

We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.

Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.

Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.

8.8

Reduced knee pain

Most Useful Review

Very cool! Calcium and magnesium work well together. I discovered that taking these in the evening allows for better absorption. The jar is large, and the tablets are sizeable. I've noticed significant relief; my knee pain has decreased, and osteochondrosis is less concerning. I prefer to take them in a course.

Autoimmune Disorder details

Calcium's role in RA treatment

Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.

Most Relevant Research

We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.

Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.

We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.

9.5

Strong nails improvement

Most Useful Review

Very high-quality calcium combined with magnesium. I’ve been using NowFoods products for a while, and this calcium to magnesium blend did not disappoint. My nails, which weren't strong naturally, became noticeably stronger and shinier. I also had issues with tooth enamel, but now I don’t feel sensitivity to acids or temperature. Magnesium has helped me manage stress, making me calmer. I confidently recommend this supplement for strengthening nails, teeth, and supporting bone health and the nervous system.

Heart Disease details

Calcium's role in stenting assessed

Based on 3 Researches

A Revised Optical Coherence Tomography-Derived Calcium Score to Predict Stent Underexpansion in Severely Calcified Lesions.

Most Relevant Research

We explored how severe calcium buildup in arteries may affect the success of heart stenting procedures, specifically focusing on identifying which calcified lesions might risk underexpansion of stents. In a study of 250 cases where optical coherence tomography (OCT) helped guide stenting, only those not treated with specific preparation methods were included.

The key findings showed that a significant portion—about 20%—of the lesions displayed stent underexpansion. We also discovered that certain features of the calcium, such as an angle over 270 degrees and a substantial thickness, were connected to reduced stent expansion.

Although the study emphasized calcium's role in predicting stent outcomes, we noted that it didn’t isolate how calcium management impacts heart disease directly. Thus, while the revised calcium scoring system can be useful in assessing stent expansion risk, the benefits of calcium treatment on heart disease remain less clear.

9.5

Heart symptoms vanish

Most Useful Review

This magnesium supplement significantly improved my heart health; after just one to two weeks of use, symptoms of heart disease disappeared. It is well-tolerated without side effects when taken as instructed. Though the tablets are slightly large, I ordered more since women especially benefit from magnesium. I highly recommend it!

Allergies details

Mum is taking it, and it seems her allergies have improved.

Breast Cancer details

Magnesium nanoparticles inhibit cancer growth

Based on 10 Researches

Magnesium whitlockite nanoparticles: Hydrothermal synthesis, anti-inflammatory and anti-cancer potential.

Most Relevant Research

We investigated the effects of magnesium whitlockite nanoparticles, or WH NPs, and their potential role in combating breast cancer. By synthesizing these nanoparticles and exploring their various properties, we aimed to understand how they could influence inflammation and cancer cell growth.

Our detailed analyses revealed that WH NPs are derived from brushite with magnesium ions introduced during a hydrothermal process. In the context of breast cancer, we observed that these nanoparticles exhibited notable anti-cancer activity by effectively inhibiting the proliferation of MDA-MB-231 breast cancer cells.

Additionally, WH NPs demonstrated anti-inflammatory effects, significantly lowering the production of important markers associated with inflammation. This dual action of reducing inflammation and targeting cancerous cells suggests a promising avenue for innovative treatments in the fight against breast cancer.

3.5

Not effective for everyone

Most Useful Review

After a month of use, my mother experienced painful breasts, so she discontinued this supplement and everything returned to normal.

Irritable Bowel Syndrome details

Magnesium boosts colonic activity

Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome.

Most Relevant Research

We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.

Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.

Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.

9.5

Reduced irritability

Most Useful Review

The magnesium helped alleviate my anxiety and irritability, making me more productive and enabling quicker sleep. I took it alongside vitamin D and omega-3, which improved my overall well-being. The dosages are individual, but I felt a notable difference once I incorporated it into my routine.

Indigestion details

Burned chest experience

Most Useful Review

Unfortunately, this supplement burned my chest after taking it, causing heartburn and indigestion. I think the calcium dosage was too high, though the magnesium was calming. It might work for others, but it didn't suit me.

Constipation details

Effectiveness of magnesium on constipation

Based on 13 Researches

Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.

Most Relevant Research

We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.

Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.

Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.

9.5

Reduced swelling

Most Useful Review

I have taken two tablets daily for three months, and the swelling has reduced significantly. People comment on my improved body shape; I’ve even gone down two ring sizes! My constipation has also improved, and leg cramps have disappeared. I am committed to continuing this regimen.

Bloating details

Magnesium alleviates menstrual bloating

Magnesium supplementation alleviates premenstrual symptoms of fluid retention.

Most Relevant Research

We explored the impact of magnesium supplementation on bloating as part of a larger study examining premenstrual symptoms. In our randomized, double-blind, placebo-controlled design, we administered a daily dose of 200 mg of magnesium (as MgO) to participants over the course of two menstrual cycles. Each volunteer kept track of their symptoms using a detailed diary with twenty-two items.

Initially, we found no difference in premenstrual symptoms between the magnesium and placebo groups during the first month. However, during the second month, participants taking magnesium experienced a notable decrease in bloating and hydration-related symptoms such as weight gain and breast tenderness. This reduction in symptoms was statistically significant, indicating that magnesium can indeed alleviate certain premenstrual symptoms like bloating.

Our findings suggest that magnesium supplementation, particularly in the context of fluid retention and bloating, could be beneficial for women experiencing these discomforts during their menstrual cycle. Overall, this study opens the door to considering magnesium as an effective remedy for mild premenstrual bloating.

8.8

Negative impact noted

Most Useful Review

Contains three forms of magnesium, primarily magnesium oxide, which is deemed the least effective. The best type is magnesium citrate, though its quantity here is unknown. Uncontrolled calcium intake may lead to kidney stones, constipation, bloating, and various digestive issues. Additionally, excess calcium can hinder the absorption of vital minerals such as magnesium, zinc, and iron, leading to potential deficiencies and associated problems.

Headache details

Magnesium aids migraine management

Magnesium and Migraine.

Most Relevant Research

We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.

A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.

This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.

8.8

Reduced headaches

Most Useful Review

The doctor identified my lack of calcium and magnesium. After two weeks of taking these supplements, I noticed that the pain in my joints due to the weather and my headaches had lessened significantly. It’s important to use them purposefully, as overdosing can lead to poor reviews. One capsule a day lasts a long time with the sizeable container!

Depression details

Calcium's role in depression explored

Assessment of the Correlation Between Unipolar and Bipolar Depression, Calcium Levels, Thyroid Function, and Inflammatory Markers: A Pilot Cross-Sectional Study.

Most Relevant Research

We aimed to investigate the connection between calcium levels and depression, specifically comparing unipolar and bipolar disorders. In the course of our pilot study, we enrolled 36 patients admitted to the University of Insubria Psychiatric Unit, who completed various psychological assessments to gauge their mental health.

Our findings revealed a noteworthy association between calcium levels and bipolar depression. We observed significant correlations not only between calcium and depressive symptoms, but also with inflammation markers like CRP (C-reactive protein). This indicates a possible relationship where lower calcium levels may relate to more severe symptoms in individuals with bipolar disorder.

While these associations are intriguing, it's important to note that we did not isolate the effects of calcium treatment itself on depressive symptoms. Therefore, while our results push the conversation forward regarding the role of calcium in mental health, they do not establish that calcium treatment is definitively beneficial for those struggling with depression.

Further research is essential to deepen our understanding of how inflammatory markers like calcium may contribute to different forms of depression. Our study highlights a pathway for future exploration into targeted therapeutic strategies that could help in treating these complex mood disorders more effectively.

9.5

Calmness achieved

Most Useful Review

Calm improved! I began to feel much calmer, with no signs of depression. My husband is surprised by my reduced yelling. I highly recommend it.

Nausea details

Magnesium effectively reduces PONV

Based on 4 Researches

Effects of intra-operative magnesium sulfate infusion on orthognathic surgery: A prospective and randomized controlled trial.

Most Relevant Research

We conducted a study to discover how magnesium sulfate affects nausea during orthognathic surgery. In this research, we divided 75 adult patients into two groups: one group received magnesium sulfate, while the other received a placebo saline solution.

We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.

Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.

This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.

9.5

No nausea felt

Most Useful Review

Calcium & Magnesium is not an overly expensive dietary supplement. Its affordability is justified: one of the components sufficiently compensates for all existing deficiencies. Despite their large size, I find the pills easy to swallow. After taking each pill, I attentively listened to my stomach for nausea, but fortunately, I never felt sick during the entire month.

Bone Pain details

Calcium's role in bone pain unclear

In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.

Most Relevant Research

We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.

After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.

Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.

9.5

Strengthened nails

Most Useful Review

NowFoods provides excellent quality calcium and magnesium. This supplement noticeably improved my nails, making them stronger and shinier. I also experienced less tooth sensitivity thanks to magnesium's calming effects. Overall, I highly recommend this supplement for strengthening nails, teeth, and providing nervous system stability.

Kidney Stones details