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SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 16 Reviews
8.3
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
8
Magnesium's impact on heart health
The Role of Dietary Magnesium in Cardiovascular Disease.
Direct relationship to heart disease
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
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9
Magnesium may help arterial health
Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium.
Highly relevant to cardiovascular disease.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
8
Magnesium linked to cardiovascular health
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
Highly relevant cardiovascular study
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
Read More
Most Useful Reviews
8.8
Improved bone strength
Wonderful! Everyone knows about the benefits of calcium for teeth and bones, yet many still experience insufficient bone strength. This often occurs because calcium is not taken with magnesium. I took these vitamins during pregnancy, and they helped with cramps and maintaining healthy nails and hair. If my review is useful, please support me. I drink these vitamins regularly and recommend them to all.
Read More
8.8
Prevented osteoporosis
Calcium and magnesium are vital minerals involved in various physiological processes. They play a key role in strengthening bone tissue and preventing osteoporosis while also supporting cardiovascular health and regulating blood pressure. I've been taking these for two years and am satisfied with the results. Don't forget!
Read More
9.5
Calmed nervous system
Excellent vitamins! Calcium and magnesium work in tandem, aiding each other's absorption. I take them with B vitamins, which calmed my nervous system, reduced mood swings, and decreased the frequency of epilepsy attacks. My hair and nails have improved. I highly recommend this product, especially for women over 40!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
9
Magnesium may help arterial health
Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium.
Highly relevant to cardiovascular disease.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
8
Magnesium linked to cardiovascular health
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
Highly relevant cardiovascular study
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
Read More
8
Magnesium linked to heart health
Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes.
Direct link to cardiovascular mortality
We explored the connection between dietary magnesium intake and cardiovascular disease, particularly in people living with diabetes. This study analyzed data from a large group of over 5,000 individuals who participated in the National Health and Nutrition Examination Survey over nearly two decades.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
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8
Magnesium impacts blood sugar control
Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease.
High relevance to cardiovascular health
We explored the connections between magnesium (Mg), calcium (Ca), and abnormal levels of HbA1c—a key marker for blood sugar management—in adults with coronary artery disease (CAD). Our research involved a substantial group of 11,934 patients, allowing us to gain valuable insights into how these minerals impact cardiovascular health.
Our findings reveal a noteworthy association: higher serum magnesium levels appear to be linked to lower HbA1c concentrations. Specifically, patients with higher magnesium levels showed a significant decrease in the likelihood of having abnormal HbA1c readings. In contrast, calcium levels did not demonstrate a similar beneficial effect; they were not associated with abnormal HbA1c levels at all.
Interestingly, we also noted that while magnesium correlates with better fasting blood glucose outcomes, higher calcium levels were actually associated with worse results. Additionally, our analysis indicated that inflammation, as gauged by a specific blood marker, didn't mediate the relationship between magnesium and HbA1c. This suggests that magnesium might play a direct role in blood sugar regulation, separate from inflammation's influence.
Overall, our study highlights magnesium's potential importance in managing blood sugar levels among individuals with heart disease, pointing to a promising area for future research and potential dietary considerations.
Our findings reveal a noteworthy association: higher serum magnesium levels appear to be linked to lower HbA1c concentrations. Specifically, patients with higher magnesium levels showed a significant decrease in the likelihood of having abnormal HbA1c readings. In contrast, calcium levels did not demonstrate a similar beneficial effect; they were not associated with abnormal HbA1c levels at all.
Interestingly, we also noted that while magnesium correlates with better fasting blood glucose outcomes, higher calcium levels were actually associated with worse results. Additionally, our analysis indicated that inflammation, as gauged by a specific blood marker, didn't mediate the relationship between magnesium and HbA1c. This suggests that magnesium might play a direct role in blood sugar regulation, separate from inflammation's influence.
Overall, our study highlights magnesium's potential importance in managing blood sugar levels among individuals with heart disease, pointing to a promising area for future research and potential dietary considerations.
Read More
8
Magnesium's impact on HFpEF mortality
Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.
Strong study on magnesium supplementation
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.3
9.5
Calmed nervous system
Excellent vitamins! Calcium and magnesium work in tandem, aiding each other's absorption. I take them with B vitamins, which calmed my nervous system, reduced mood swings, and decreased the frequency of epilepsy attacks. My hair and nails have improved. I highly recommend this product, especially for women over 40!
Read More
8.8
Improved bone strength
Wonderful! Everyone knows about the benefits of calcium for teeth and bones, yet many still experience insufficient bone strength. This often occurs because calcium is not taken with magnesium. I took these vitamins during pregnancy, and they helped with cramps and maintaining healthy nails and hair. If my review is useful, please support me. I drink these vitamins regularly and recommend them to all.
Read More
8.8
Prevented osteoporosis
Calcium and magnesium are vital minerals involved in various physiological processes. They play a key role in strengthening bone tissue and preventing osteoporosis while also supporting cardiovascular health and regulating blood pressure. I've been taking these for two years and am satisfied with the results. Don't forget!
Read More
8.8
Supports bone density
Good-quality calcium from a reliable producer! I bought it for my mother, as she has experienced bone deterioration. She feels better as a result. It's essential to take it with vitamin D. The combination of calcium and magnesium is highly recommended by our endocrinologist.
8.8
Convenient usage
This supplement is excellent, especially for those with cardiovascular disease. It's ideal for individuals leading an active lifestyle or facing stress. The only downside is that the tablets are quite large, but they are easy to use—two capsules once a day with meals before bedtime.
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