Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
USERS' SCORE
Likely Ineffective
Based on 11 Reviews
4.7
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
We explored the effectiveness of calcium in alleviating heartburn, especially in pregnant women. Our findings highlighted that many expectant mothers experience heartburn due to hormonal changes and the physical pressure of a growing fetus on the stomach.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
Read More
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Read More
Most Useful Reviews
10
Heartburn relief
My husband suffers from calcium deficiency, and after taking this, he no longer experiences heartburn or a feeling of heaviness. I highly recommend it, especially at its reasonable price.
Read More
10
No heartburn
The product offers good value for money, as it doesn’t cause heartburn or tingling after eating.
Read More
10
Easy digestion
This is my second purchase, and I'm very satisfied with the calcium and magnesium. It’s easy to digest and doesn’t cause heartburn!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.8
- All Researches
9
We explored the combined effects of calcium from carbonate antacids and extract from the prickly pear plant, Opuntia ficus-indica, on heartburn symptoms. This was investigated through tests designed to mimic conditions in the esophagus during acid reflux. Our main goal was to understand if these ingredients could effectively help in neutralizing stomach acid and safeguarding esophageal cells from damage caused by both acidic and non-acidic reflux.
In our experiments, we found that the carbonate antacids worked to neutralize the acidity, which in turn helped to protect esophageal cells from harm due to low pH levels. Additionally, the prickly pear extract showed promise in reducing irritation from bile acids, as it decreased inflammation markers typically associated with reflux. This dual action of both components suggests that combining them could be an effective way to manage heartburn.
Overall, this study indicates that while calcium plays a role through antacid effects, the inclusion of prickly pear extract enhances the overall protective benefits against heartburn, making it a potentially valuable treatment option for those experiencing gastrointestinal discomfort.
In our experiments, we found that the carbonate antacids worked to neutralize the acidity, which in turn helped to protect esophageal cells from harm due to low pH levels. Additionally, the prickly pear extract showed promise in reducing irritation from bile acids, as it decreased inflammation markers typically associated with reflux. This dual action of both components suggests that combining them could be an effective way to manage heartburn.
Overall, this study indicates that while calcium plays a role through antacid effects, the inclusion of prickly pear extract enhances the overall protective benefits against heartburn, making it a potentially valuable treatment option for those experiencing gastrointestinal discomfort.
Read More
9
We explored how calcium-containing antacids can help relieve heartburn, especially for pregnant women dealing with gastroesophageal reflux disease (GERD). This common issue affects many expectant mothers, causing discomfort and aggravation throughout their pregnancy.
The recommendation suggests starting with lifestyle changes to manage symptoms. But when heartburn is severe, introducing calcium-based antacids shows significant promise in reducing those pesky acid reflux issues. This approach prioritizes the health and safety of both mother and baby while aiming for effective relief from symptoms.
If symptoms persist, other treatments like Sucralfate or histamine-2 receptor antagonists can be considered. However, adding calcium-based antacids early on is a preferred first step for many women. Overall, we can see a clear benefit in using calcium for heartburn management during pregnancy, providing a healthy option for easing discomfort.
The recommendation suggests starting with lifestyle changes to manage symptoms. But when heartburn is severe, introducing calcium-based antacids shows significant promise in reducing those pesky acid reflux issues. This approach prioritizes the health and safety of both mother and baby while aiming for effective relief from symptoms.
If symptoms persist, other treatments like Sucralfate or histamine-2 receptor antagonists can be considered. However, adding calcium-based antacids early on is a preferred first step for many women. Overall, we can see a clear benefit in using calcium for heartburn management during pregnancy, providing a healthy option for easing discomfort.
Read More
9
This study aimed to assess how effectively GutsyGum™, a chewing gum containing calcium carbonate along with licorice extract, papain, and apple cider vinegar, alleviates heartburn after consuming a refluxogenic meal. We conducted a double-blind, placebo-controlled crossover trial with 24 participants who had a history of gastro-esophageal reflux (GER). They were asked to chew either GutsyGum™ or a placebo after the meal, and their GER symptoms were measured using visual analogue scales over a four-hour period.
The results revealed that GutsyGum™ significantly reduced heartburn and acid reflux symptoms compared to the placebo. Specifically, the adjusted heartburn score was lower in those chewing GutsyGum™. However, when it came to other symptoms like nausea and belching, we didn't find significant differences. Although there was a trend indicating less pain with GutsyGum™, it didn't reach statistical significance.
Importantly, while calcium carbonate is a component of GutsyGum™, the effectiveness we noted comes from the combination of ingredients, making it challenging to pinpoint calcium's isolated role in reducing heartburn.
The results revealed that GutsyGum™ significantly reduced heartburn and acid reflux symptoms compared to the placebo. Specifically, the adjusted heartburn score was lower in those chewing GutsyGum™. However, when it came to other symptoms like nausea and belching, we didn't find significant differences. Although there was a trend indicating less pain with GutsyGum™, it didn't reach statistical significance.
Importantly, while calcium carbonate is a component of GutsyGum™, the effectiveness we noted comes from the combination of ingredients, making it challenging to pinpoint calcium's isolated role in reducing heartburn.
Read More
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
Laportea aestuans aids heartburn relief
We set out to explore how the aerial parts of Laportea aestuans, a plant historically consumed by pregnant women in Ghana for heartburn relief, can work with calcium carbonate (CaCO3) to help neutralize stomach acid.
Using a controlled laboratory method, we mimicked the conditions in the stomach by stirring a mixture of tap water and plant material at 37°C, followed by titrating it with artificial gastric acid. This allowed us to carefully measure how effective both L. aestuans and CaCO3 were in alleviating acidity compared to just plain water.
Our results revealed that both L. aestuans and CaCO3 displayed significant potential to neutralize stomach acid. The combination of L. aestuans at a lower dose of 666 mg with CaCO3 performed similarly to CaCO3 on its own. However, when we increased the plant material to 1332 mg, it took longer for the mixture to reach the desired pH, but it maintained a higher pH for a more extended period, suggesting a complementary antacid effect.
Overall, these findings suggest that L. aestuans combined with calcium carbonate may serve as a promising natural remedy for heartburn.
Using a controlled laboratory method, we mimicked the conditions in the stomach by stirring a mixture of tap water and plant material at 37°C, followed by titrating it with artificial gastric acid. This allowed us to carefully measure how effective both L. aestuans and CaCO3 were in alleviating acidity compared to just plain water.
Our results revealed that both L. aestuans and CaCO3 displayed significant potential to neutralize stomach acid. The combination of L. aestuans at a lower dose of 666 mg with CaCO3 performed similarly to CaCO3 on its own. However, when we increased the plant material to 1332 mg, it took longer for the mixture to reach the desired pH, but it maintained a higher pH for a more extended period, suggesting a complementary antacid effect.
Overall, these findings suggest that L. aestuans combined with calcium carbonate may serve as a promising natural remedy for heartburn.
Read More
User Reviews
USERS' SCORE
Likely Ineffective
Based on 11 Reviews
4.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Heartburn relief
My husband suffers from calcium deficiency, and after taking this, he no longer experiences heartburn or a feeling of heaviness. I highly recommend it, especially at its reasonable price.
Read More
10
No heartburn
The product offers good value for money, as it doesn’t cause heartburn or tingling after eating.
Read More
10
Easy digestion
This is my second purchase, and I'm very satisfied with the calcium and magnesium. It’s easy to digest and doesn’t cause heartburn!
Read More
10
Family use
We continuously order for the whole family and drink it in courses twice a year. My mother says she experiences no heartburn after taking it. My rating is excellent!
Read More
10
No side effects
After starting this course, I found no heartburn or side effects. I await the results eagerly.
Read More
Frequently Asked Questions
10
No side effects
After starting this course, I found no heartburn or side effects. I await the results eagerly.
10
No heartburn
The product offers good value for money, as it doesn’t cause heartburn or tingling after eating.
10
Family use
We continuously order for the whole family and drink it in courses twice a year. My mother says she experiences no heartburn after taking it. My rating is excellent!
0
Negative reaction
242 people found this helpful
For the first time, the calcium did not work for me. I took 3 tablets a day as instructed, but my stomach reacted poorly—terrible heartburn and difficulty digesting food. I’ve used products from other manufacturers without such negative effects, so I’m uncertain if it’s my body’s reaction.
2
Individual intolerance
1 people found this helpful
Following each dose, I developed heartburn, despite never having experienced this issue before. It seems to be my individual intolerance, as a different magnesium form didn’t cause this reaction. Others facing similar issues may wish to explore alternative forms of magnesium.
10
Heartburn relief
My husband suffers from calcium deficiency, and after taking this, he no longer experiences heartburn or a feeling of heaviness. I highly recommend it, especially at its reasonable price.
10
Easy digestion
This is my second purchase, and I'm very satisfied with the calcium and magnesium. It’s easy to digest and doesn’t cause heartburn!
10
Great product
With a sufficient dosage and an optimal jar size, this product lasts a couple of months. The large tablet can be crushed and mixed with water. It has no taste and does not cause heartburn—great product.
9
We explored the combined effects of calcium from carbonate antacids and extract from the prickly pear plant, Opuntia ficus-indica, on heartburn symptoms. This was investigated through tests designed to mimic conditions in the esophagus during acid reflux. Our main goal was to understand if these ingredients could effectively help in neutralizing stomach acid and safeguarding esophageal cells from damage caused by both acidic and non-acidic reflux.
In our experiments, we found that the carbonate antacids worked to neutralize the acidity, which in turn helped to protect esophageal cells from harm due to low pH levels. Additionally, the prickly pear extract showed promise in reducing irritation from bile acids, as it decreased inflammation markers typically associated with reflux. This dual action of both components suggests that combining them could be an effective way to manage heartburn.
Overall, this study indicates that while calcium plays a role through antacid effects, the inclusion of prickly pear extract enhances the overall protective benefits against heartburn, making it a potentially valuable treatment option for those experiencing gastrointestinal discomfort.
In our experiments, we found that the carbonate antacids worked to neutralize the acidity, which in turn helped to protect esophageal cells from harm due to low pH levels. Additionally, the prickly pear extract showed promise in reducing irritation from bile acids, as it decreased inflammation markers typically associated with reflux. This dual action of both components suggests that combining them could be an effective way to manage heartburn.
Overall, this study indicates that while calcium plays a role through antacid effects, the inclusion of prickly pear extract enhances the overall protective benefits against heartburn, making it a potentially valuable treatment option for those experiencing gastrointestinal discomfort.
9
We explored how calcium-containing antacids can help relieve heartburn, especially for pregnant women dealing with gastroesophageal reflux disease (GERD). This common issue affects many expectant mothers, causing discomfort and aggravation throughout their pregnancy.
The recommendation suggests starting with lifestyle changes to manage symptoms. But when heartburn is severe, introducing calcium-based antacids shows significant promise in reducing those pesky acid reflux issues. This approach prioritizes the health and safety of both mother and baby while aiming for effective relief from symptoms.
If symptoms persist, other treatments like Sucralfate or histamine-2 receptor antagonists can be considered. However, adding calcium-based antacids early on is a preferred first step for many women. Overall, we can see a clear benefit in using calcium for heartburn management during pregnancy, providing a healthy option for easing discomfort.
The recommendation suggests starting with lifestyle changes to manage symptoms. But when heartburn is severe, introducing calcium-based antacids shows significant promise in reducing those pesky acid reflux issues. This approach prioritizes the health and safety of both mother and baby while aiming for effective relief from symptoms.
If symptoms persist, other treatments like Sucralfate or histamine-2 receptor antagonists can be considered. However, adding calcium-based antacids early on is a preferred first step for many women. Overall, we can see a clear benefit in using calcium for heartburn management during pregnancy, providing a healthy option for easing discomfort.
9
This study aimed to assess how effectively GutsyGum™, a chewing gum containing calcium carbonate along with licorice extract, papain, and apple cider vinegar, alleviates heartburn after consuming a refluxogenic meal. We conducted a double-blind, placebo-controlled crossover trial with 24 participants who had a history of gastro-esophageal reflux (GER). They were asked to chew either GutsyGum™ or a placebo after the meal, and their GER symptoms were measured using visual analogue scales over a four-hour period.
The results revealed that GutsyGum™ significantly reduced heartburn and acid reflux symptoms compared to the placebo. Specifically, the adjusted heartburn score was lower in those chewing GutsyGum™. However, when it came to other symptoms like nausea and belching, we didn't find significant differences. Although there was a trend indicating less pain with GutsyGum™, it didn't reach statistical significance.
Importantly, while calcium carbonate is a component of GutsyGum™, the effectiveness we noted comes from the combination of ingredients, making it challenging to pinpoint calcium's isolated role in reducing heartburn.
The results revealed that GutsyGum™ significantly reduced heartburn and acid reflux symptoms compared to the placebo. Specifically, the adjusted heartburn score was lower in those chewing GutsyGum™. However, when it came to other symptoms like nausea and belching, we didn't find significant differences. Although there was a trend indicating less pain with GutsyGum™, it didn't reach statistical significance.
Importantly, while calcium carbonate is a component of GutsyGum™, the effectiveness we noted comes from the combination of ingredients, making it challenging to pinpoint calcium's isolated role in reducing heartburn.
References
- Lehner MD, Scheyhing U, Elsässer J. A combination of carbonates and Opuntia ficus-indica extract protects esophageal cells against simulated acidic and non-acidic reflux in vitro. Sci Rep. 2024;14:22355. doi:10.1038/s41598-024-74047-7
- Altuwaijri M. Evidence-based treatment recommendations for gastroesophageal reflux disease during pregnancy: A review. Medicine (Baltimore). 2022;101:e30487. doi:10.1097/MD.0000000000030487
- Christensen CB, Soelberg J, Jäger AK. Antacid activity of Laportea aestuans (L.) Chew. J Ethnopharmacol. 2015;171:1. doi:10.1016/j.jep.2015.05.026
- Brown R, Sam CH, Green T, Wood S. Effect of GutsyGum(tm), A Novel Gum, on Subjective Ratings of Gastro Esophageal Reflux Following A Refluxogenic Meal. J Diet Suppl. 2015;12:138. doi:10.3109/19390211.2014.950783
- Sulz MC, Manz M, Grob P, Meier R, Drewe J, et al. Comparison of two antacid preparations on intragastric acidity--a two-centre open randomised cross-over placebo-controlled trial. Digestion. 2007;75:69.
- Thomas M, Weisman SM. Calcium supplementation during pregnancy and lactation: effects on the mother and the fetus. Am J Obstet Gynecol. 2006;194:937.
- Raj JP, Saxena U, Belhekar MN, Mamde A, Darak H, et al. Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. Complement Med Res. 2025;32:26. doi:10.1159/000543367
- Kim Y, Bae S, Jeon I, Kwon J, Hong SH, et al. Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to the Enteric-Coated Esomeprazole. Clin Ther. 2024;46:870. doi:10.1016/j.clinthera.2024.08.006
- Dragomiretska NV, Babov KD, Gushcha SG, Zabolotna IB, Plakida AL, et al. Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2020;66:225. doi:10.23736/S1121-421X.20.02601-X
- Neiworth-Petshow EM, Baldwin-Sayre C. Naturopathic Treatment of Gastrointestinal Dysfunction in the Setting of Parkinson's Disease. Integr Med (Encinitas). 2018;17:44.
- Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient. J Biol Regul Homeost Agents. 2018;32:983.
- Aragona SE, Mereghetti G, Bianchetti M, Mangiavillano B, Zurlo T, et al. Regenerative medicine in the treatment of gastro-esophageal reflux disease and laryngo-pharyngeal reflux. From research to cure. J Biol Regul Homeost Agents. 2017;31:207.
