Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
8
Magnesium shows potential benefits
We conducted a randomized double-blind study to see how supplementation with zinc, magnesium, and vitamin A might affect hypothyroidism.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
Read More
4
Magnesium shows promise in thyroid recovery
We set out to investigate how magnesium, along with selenium and coenzyme Q10, could influence hypothyroidism in patients with benign thyroid diseases. Our approach included a small group of eight patients—five with hyperthyroidism and three with hypothyroidism—who received additional treatment aimed at addressing both their thyroid condition and related physical and psychological stresses.
Over a period of 2 to 4 years, we observed some significant changes. Initially, we focused on correcting musculoskeletal issues, followed by addressing stress. As a result, we noted that thyroid morphology normalized in many cases, which was confirmed through ultrasound examinations. Interestingly, we also saw a reduction in thyroid antibody levels for most patients.
However, we must be transparent about our findings. While magnesium and the other supplements showed promise, there were two cases of chronic thyroiditis that did not respond positively to treatment, possibly due to long-standing fibrosis. This indicates that while magnesium may play a role in thyroid health, its effectiveness can vary significantly based on individual circumstances and the duration of the thyroid condition.
Over a period of 2 to 4 years, we observed some significant changes. Initially, we focused on correcting musculoskeletal issues, followed by addressing stress. As a result, we noted that thyroid morphology normalized in many cases, which was confirmed through ultrasound examinations. Interestingly, we also saw a reduction in thyroid antibody levels for most patients.
However, we must be transparent about our findings. While magnesium and the other supplements showed promise, there were two cases of chronic thyroiditis that did not respond positively to treatment, possibly due to long-standing fibrosis. This indicates that while magnesium may play a role in thyroid health, its effectiveness can vary significantly based on individual circumstances and the duration of the thyroid condition.
Read More
9
We explored the interaction between magnesium sulfate and levothyroxine in managing inflammation related to hypothyroidism. In this study, we used 60 male rats, dividing them into six different groups. These included normals, those given magnesium, hypothyroid rats, and various combinations of treatments with levothyroxine and magnesium.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
Read More
Most Useful Reviews
7.5
Improving thyroid levels
On my endocrinologist's advice, I take it alongside vitamin D3 and Omega-3 for my hypothyroidism. My analyses are gradually approaching normal.
Read More
6
Calcium and magnesium aid
This supplement combines calcium and magnesium, which I need due to my hypothyroidism. I also took it while breastfeeding. The tablets are quite large, but I've gotten used to them.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
- All Researches
9
We explored the interaction between magnesium sulfate and levothyroxine in managing inflammation related to hypothyroidism. In this study, we used 60 male rats, dividing them into six different groups. These included normals, those given magnesium, hypothyroid rats, and various combinations of treatments with levothyroxine and magnesium.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
Read More
8
Magnesium shows potential benefits
We conducted a randomized double-blind study to see how supplementation with zinc, magnesium, and vitamin A might affect hypothyroidism.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
Read More
7
We explored the case of a 48-year-old woman who faced compressive symptoms due to a rapidly growing goiter, tied to her existing hypothyroidism. Despite her hypoparathyroidism being revealed through biological tests, she did not exhibit any signs of hypocalcemia initially.
The treatment she received included levothyroxine, calcium, and alfacalcidol, but a complete thyroidectomy was deemed unnecessary due to the tumor’s rigid adhesion to nearby structures. Upon histopathological examination, her condition was identified as Riedel’s thyroiditis. We watched as the introduction of glucocorticoids resulted in a significant reduction of symptoms and shrinkage of the thyroid gland.
Notably, after discontinuation of the vitamin and calcium supplementation, her serum calcium and parathyroid hormone levels normalized. This suggests that, in some instances, hypoparathyroidism can remain asymptomatic, especially under conditions like Riedel's thyroiditis. Furthermore, early glucocorticoid treatment seems valuable in addressing associated fibrosclerosis and restoring parathyroid function.
While calcium was part of the therapeutic strategy, it is challenging to ascertain its isolated effect due to the combination with other treatments in this specific case.
The treatment she received included levothyroxine, calcium, and alfacalcidol, but a complete thyroidectomy was deemed unnecessary due to the tumor’s rigid adhesion to nearby structures. Upon histopathological examination, her condition was identified as Riedel’s thyroiditis. We watched as the introduction of glucocorticoids resulted in a significant reduction of symptoms and shrinkage of the thyroid gland.
Notably, after discontinuation of the vitamin and calcium supplementation, her serum calcium and parathyroid hormone levels normalized. This suggests that, in some instances, hypoparathyroidism can remain asymptomatic, especially under conditions like Riedel's thyroiditis. Furthermore, early glucocorticoid treatment seems valuable in addressing associated fibrosclerosis and restoring parathyroid function.
While calcium was part of the therapeutic strategy, it is challenging to ascertain its isolated effect due to the combination with other treatments in this specific case.
Read More
We explored how magnesium, as part of a broader supplementation strategy, influences thyroid function and overall well-being in patients with hypothyroidism. In a well-structured study, 104 individuals receiving traditional treatment with levothyroxine and vitamin D were randomly divided into two groups. One group received a combination of essential micronutrients, including magnesium, while the other received placebos over an 8-week period.
Our observations highlighted changes in insulin resistance and quality of life after the intervention, suggesting that micronutrient supplementation could have a bearing on these aspects of health. However, the specifics regarding magnesium's isolated effect on thyroid function were less clear due to the multi-nutritional approach taken in this trial.
While we acknowledge promising results related to quality of life, we must clarify that the study does not provide concrete evidence that magnesium alone significantly improves thyroid function. Further, more focused clinical trials are necessary to ascertain the role of magnesium, allowing for a better understanding of its potential benefits in hypothyroid patients.
Our observations highlighted changes in insulin resistance and quality of life after the intervention, suggesting that micronutrient supplementation could have a bearing on these aspects of health. However, the specifics regarding magnesium's isolated effect on thyroid function were less clear due to the multi-nutritional approach taken in this trial.
While we acknowledge promising results related to quality of life, we must clarify that the study does not provide concrete evidence that magnesium alone significantly improves thyroid function. Further, more focused clinical trials are necessary to ascertain the role of magnesium, allowing for a better understanding of its potential benefits in hypothyroid patients.
Read More
7
Minerals affect thyroid dysfunction risk
We delved into how different minerals might influence thyroid dysfunction, particularly focusing on hypothyroidism. Analyzing data from nearly 7,800 people, we utilized advanced statistical methods to explore the impact of mineral intake on thyroid hormones.
While we found that higher intakes of minerals like magnesium and calcium were linked to lower rates of hyperthyroidism, the study did not show significant benefits of magnesium specifically for hypothyroidism. The results suggest that a balanced intake of various minerals may support thyroid health overall.
While we found that higher intakes of minerals like magnesium and calcium were linked to lower rates of hyperthyroidism, the study did not show significant benefits of magnesium specifically for hypothyroidism. The results suggest that a balanced intake of various minerals may support thyroid health overall.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improving thyroid levels
On my endocrinologist's advice, I take it alongside vitamin D3 and Omega-3 for my hypothyroidism. My analyses are gradually approaching normal.
Read More
6
Calcium and magnesium aid
This supplement combines calcium and magnesium, which I need due to my hypothyroidism. I also took it while breastfeeding. The tablets are quite large, but I've gotten used to them.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Borzuei S, Amjad SV, Badiei M, Farmany A, Cheraghi Z. Investigating salivary concentration of calcium ion in hypothyroidism. Health Sci Rep. 2023;6:e1669. doi:10.1002/hsr2.1669
- Salhi S, Oueslati I, Ayari S, Kamoun E, Yazidi M, et al. A case of reversible hypoparathyroidism in a patient with Riedel's thyroiditis treated with glucocorticoids. Clin Case Rep. 2023;11:e7085. doi:10.1002/ccr3.7085
- Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. doi:10.47176/mjiri.38.133
- Abbas AM, Sakr HF. Effect of magnesium sulfate and thyroxine on inflammatory markers in a rat model of hypothyroidism. Can J Physiol Pharmacol. 2016;94:426. doi:10.1139/cjpp-2015-0247
- Moncayo R, Moncayo H. Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation. BBA Clin. 2015;3:113. doi:10.1016/j.bbacli.2014.12.005
- Liu S, Huang W, Lin Y, Wang Y, Li H, et al. Machine learning-based exploration of the associations between multiple minerals' intake and thyroid dysfunction: data from the National Health and Nutrition Examination Survey. Front Nutr. 2025;12:1522232. doi:10.3389/fnut.2025.1522232
- Rabbani E, Golgiri F, Janani L, Moradi N, Fallah S, et al. Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism. Biol Trace Elem Res. 2021;199:4074. doi:10.1007/s12011-020-02548-3
