Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
9
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
7
We explored the relationship between magnesium intake and bone health in postmenopausal black South African women over a two-year period. In this study, which included 144 participants, researchers measured bone mineral density (BMD) at several key sites, alongside various biochemical analyses, including bone turnover markers.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
Read More
8
Calcium maltobionate supports bone health
We conducted a study to investigate how calcium maltobionate affects bone density in healthy Japanese women, particularly focusing on those who are pre- and post-menopausal. In a well-structured trial, 48 women aged between 30 and 69 were randomly divided into two groups: one received calcium maltobionate tablets while the other took a placebo designed to mimic the calcium content.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Read More
Most Useful Reviews
9
Reduced mood swings
8 people found this helpful
I feel calmed down! These vitamins, calcium, and magnesium work well together for absorption. I take them alongside a B complex from the same brand. They calmed my nervous system significantly. My mood swings and depression linked to menopause have diminished, and my epilepsy attacks are less frequent. My hair and nails have improved too. The vitamins are of good natural quality, and the price is superb compared to local pharmacies. I recommend it, especially for women over 40.
Read More
7.5
Pain relief observed
6 people found this helpful
I noticed significant joint pain related to menopause, particularly before menstruation. After starting this supplement, the discomfort has drastically decreased. While I’m unsure if it's solely due to this product, I plan to continue taking it.
Read More
9
Osteoporosis prevention
1 people found this helpful
My husband and I have been taking this for two years as a preventive measure against early osteoporosis due to menopause. We also recommend it for our children to avert stress fractures during growth. Although the grains are large, they become easier to swallow over time.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
- All Researches
9
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
Read More
9
Our exploration centered on the effects of magnesium, particularly from nanofiltrated deep ocean water (DOW), in addressing osteoporosis, a common concern during menopause. In our study, we used ovariectomized female Sprague-Dawley rats, a model that simulates menopausal conditions. We administered varying amounts of DOW daily over eight weeks to observe its impact on bone health.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
We found that DOW supplementation significantly increased bone density and reduced bone loss related to menopause. This was particularly notable as the rats that received DOW showed improved bone structure and reduced adiposity in their bones. More specifically, the lowest doses of DOW led to increased expression of a key protein called RUNX2, which plays an essential role in the formation of bone cells known as osteoblasts.
In human osteoblasts, DOW also raised levels of osteocalcin and alkaline phosphatase—both vital for promoting bone health. Overall, our findings demonstrated that magnesium-rich DOW can enhance osteoblast differentiation, contributing positively to bone structure integrity during menopause. This work highlights how incorporating magnesium into our diets or supplements could be beneficial for bone health as we age.
Read More
9
Isoflavones, probiotics boost bone health
We explored the impact of a novel red clover extract rich in isoflavones and probiotics on bone health in postmenopausal osteopenic women. In a year-long double-blind trial with 78 participants, we compared this treatment alongside standard supplements against a placebo. Results showed that the extract substantially reduced bone mineral density loss and improved certain estrogen metabolism markers. However, it did not affect other bone turnover indicators significantly. Overall, combining the extract with calcium and magnesium proved beneficial for bone health in this demographic.
Read More
9
We explored the effects of a nutraceutical blend, including magnesium, on menopause symptoms through a crossover trial involving 43 postmenopausal women.
Participants experienced significant reductions in menopause symptoms, as measured by the Menopause Rating Scale, after using the nutraceuticals.
Additionally, improvements were noted in cardiovascular risk factors, such as lower cholesterol levels and blood pressure.
Overall, this study suggests that magnesium, combined with other nutrients, may provide meaningful relief for postmenopausal symptoms.
Participants experienced significant reductions in menopause symptoms, as measured by the Menopause Rating Scale, after using the nutraceuticals.
Additionally, improvements were noted in cardiovascular risk factors, such as lower cholesterol levels and blood pressure.
Overall, this study suggests that magnesium, combined with other nutrients, may provide meaningful relief for postmenopausal symptoms.
Read More
8
Calcium maltobionate supports bone health
We conducted a study to investigate how calcium maltobionate affects bone density in healthy Japanese women, particularly focusing on those who are pre- and post-menopausal. In a well-structured trial, 48 women aged between 30 and 69 were randomly divided into two groups: one received calcium maltobionate tablets while the other took a placebo designed to mimic the calcium content.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced mood swings
8 people found this helpful
I feel calmed down! These vitamins, calcium, and magnesium work well together for absorption. I take them alongside a B complex from the same brand. They calmed my nervous system significantly. My mood swings and depression linked to menopause have diminished, and my epilepsy attacks are less frequent. My hair and nails have improved too. The vitamins are of good natural quality, and the price is superb compared to local pharmacies. I recommend it, especially for women over 40.
Read More
7.5
Pain relief observed
6 people found this helpful
I noticed significant joint pain related to menopause, particularly before menstruation. After starting this supplement, the discomfort has drastically decreased. While I’m unsure if it's solely due to this product, I plan to continue taking it.
Read More
9
Osteoporosis prevention
1 people found this helpful
My husband and I have been taking this for two years as a preventive measure against early osteoporosis due to menopause. We also recommend it for our children to avert stress fractures during growth. Although the grains are large, they become easier to swallow over time.
Read More
9
Effective calcium supplement
The calcium tablets are rather large, but calcium supplementation is essential during menopause, and I find this product to be effective.
Read More
7.5
Menopause relief experienced
2 people found this helpful
The package arrived well packed, and I was surprised by its size. My mother is taking one large capsule daily and feels great; it has significantly helped her during menopause. After one month, her calcium levels have improved based on lab results.
Read More
Frequently Asked Questions
7.5
Menopause relief experienced
2 people found this helpful
The package arrived well packed, and I was surprised by its size. My mother is taking one large capsule daily and feels great; it has significantly helped her during menopause. After one month, her calcium levels have improved based on lab results.
7.5
Improved back pain
I’ve had persistent low back pain potentially linked to menopause. After using this product for a while, I noticed an improvement and would consider repurchasing.
7.5
Pain relief observed
6 people found this helpful
I noticed significant joint pain related to menopause, particularly before menstruation. After starting this supplement, the discomfort has drastically decreased. While I’m unsure if it's solely due to this product, I plan to continue taking it.
9
Reduced mood swings
8 people found this helpful
I feel calmed down! These vitamins, calcium, and magnesium work well together for absorption. I take them alongside a B complex from the same brand. They calmed my nervous system significantly. My mood swings and depression linked to menopause have diminished, and my epilepsy attacks are less frequent. My hair and nails have improved too. The vitamins are of good natural quality, and the price is superb compared to local pharmacies. I recommend it, especially for women over 40.
7.5
Improved sleep quality
1 people found this helpful
The calcium magnesium assists with insomnia, depression, and menopause symptoms. The natural ingredients relieve stress and enhance sleep quality, ensuring a deeper rest. The medium-sized capsules are easy to manage.
7.5
Bone health support
1 people found this helpful
This calcium from a good producer has improved my mother's wellbeing during menopause. The endocrinologist advised combining it with vitamin D. The packaging is very convenient. I highly recommend this supplement.
9
We explored the connection between magnesium deficiency and various challenges commonly faced by postmenopausal women, such as chronic pain, memory decline, and mood disorders. Our research specifically focused on how magnesium supplementation can help in alleviating these issues in ovariectomized and aged female mice—modeling the postmenopausal state.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
We administered magnesium-L-threonate to these mice to assess its effects on pain sensitivity, memory function, and emotional behavior through behavioral tests. We found that this treatment not only prevented but also reversed many of the disturbances associated with aging and menopause.
Additionally, we noted significant changes at the molecular level, such as increased levels of inflammatory markers in the brain and spinal cord of untreated mice, which were significantly normalized with magnesium treatment. Notably, low magnesium levels in various body fluids were also addressed by this supplementation, suggesting its potential as a therapeutic approach for menopause-related disorders.
In summary, while estrogen loss during menopause leads to neuroinflammation and related health issues, magnesium supplementation presents a promising option to support postmenopausal health.
7
We explored the relationship between magnesium intake and bone health in postmenopausal black South African women over a two-year period. In this study, which included 144 participants, researchers measured bone mineral density (BMD) at several key sites, alongside various biochemical analyses, including bone turnover markers.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
The findings highlighted that higher dietary magnesium intake was linked to lower levels of C-Telopeptide of type I collagen (CTX-1), indicating reduced bone resorption. Moreover, calcium intake showed a positive correlation with BMD at the distal radius both at the start and end of the study.
Interestingly, one dietary pattern—snacking—also related to BMD scores over time, suggesting that what we eat can influence our bone health as we age. The results revealed that magnesium intake alone predicted a notable portion of the changes in bone turnover, emphasizing its potential role in supporting bone health during menopause.
Overall, this study suggests that paying attention to magnesium in our diets could be beneficial for women navigating menopause, especially regarding bone health.
This systematic review aimed to understand how different traditional Chinese exercises, combined with calcium supplementation, can improve bone mineral density (BMD) in postmenopausal women. Researchers examined a variety of approaches—such as Tai Chi and Baduanjin—while comparing these exercises to control groups that either did not participate in exercise or received only calcium supplements.
The results revealed that exercises like Tai Chi were effective in improving BMD across multiple sites in the body, including the lumbar spine and femoral neck. When calcium supplementation was paired with these exercises, particularly with Baduanjin, there were notable increases in bone density. However, it’s important to note that while calcium showed some benefit, it was mostly in conjunction with the exercise interventions, making it hard to fully separate the effects of calcium from those of the exercises.
Ultimately, while both calcium supplementation and traditional Chinese exercises like Tai Chi and Baduanjin can contribute to bone health in menopausal women, the study highlights that the exercises may be the most effective method for preventing bone loss.
The results revealed that exercises like Tai Chi were effective in improving BMD across multiple sites in the body, including the lumbar spine and femoral neck. When calcium supplementation was paired with these exercises, particularly with Baduanjin, there were notable increases in bone density. However, it’s important to note that while calcium showed some benefit, it was mostly in conjunction with the exercise interventions, making it hard to fully separate the effects of calcium from those of the exercises.
Ultimately, while both calcium supplementation and traditional Chinese exercises like Tai Chi and Baduanjin can contribute to bone health in menopausal women, the study highlights that the exercises may be the most effective method for preventing bone loss.
8
Calcium maltobionate supports bone health
We conducted a study to investigate how calcium maltobionate affects bone density in healthy Japanese women, particularly focusing on those who are pre- and post-menopausal. In a well-structured trial, 48 women aged between 30 and 69 were randomly divided into two groups: one received calcium maltobionate tablets while the other took a placebo designed to mimic the calcium content.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
Over 24 weeks, we measured changes in facial and calcaneal bone density along with bone resorption markers. Our results indicated that facial bone mineral density declines more rapidly than that of other areas like the lumbar spine. Importantly, we observed that continuous intake of calcium maltobionate helped to slow down this decline in bone density for women in both menopausal stages, suggesting its potential role in osteoporosis prevention.
Overall, we found that facial bone mineral density may serve as an important indicator of bone health in middle-aged women. While our study highlights the beneficial aspects of calcium maltobionate, it’s essential to note that the individual effects of calcium itself could not be isolated from the compound used in the treatment.
References
- Suehiro D, Ikeda N, Hirooka K, Ihara A, Fukami K, et al. Decrease in Facial Bone Density with Aging and Maintenance Effect of Calcium Maltobionate Ingestion in Japanese Adult Women: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial. Nutrients. 2025;17. doi:10.3390/nu17020262
- Hou J, Mao H, Xie P, Cui Y, Rong M. The effect of different traditional Chinese exercises on bone mineral density in menopausal women: a systematic review and network meta-analysis. Front Public Health. 2024;12:1430608. doi:10.3389/fpubh.2024.1430608
- Atteia HH, Ahmed SF, Askar ME, Sakr AT. Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04476-y
- Zhang J, Mai CL, Xiong Y, Lin ZJ, Jie YT, et al. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice. J Inflamm Res. 2021;14:6633. doi:10.2147/JIR.S330894
- Chen PC, Lee YC, Jao HY, Wang CP, Jacobs A, et al. Supplementation of nanofiltrated deep ocean water ameliorate the progression of osteoporosis in ovariectomized rat via regulating osteoblast differentiation. J Food Biochem. 2020;44:e13236. doi:10.1111/jfbc.13236
- Kolanu BR, Vadakedath S, Boddula V, Kandi V. Activities of Serum Magnesium and Thyroid Hormones in Pre-, Peri-, and Post-menopausal Women. Cureus. 2020;12:e6554. doi:10.7759/cureus.6554
- Wright HH, Kruger MC, Schutte WD, Wentzel-Viljoen E, Kruger IM, et al. Magnesium Intake Predicts Bone Turnover in Postmenopausal Black South African Women. Nutrients. 2019;11. doi:10.3390/nu11102519
- Lambert MNT, Thybo CB, Lykkeboe S, Rasmussen LM, Frette X, et al. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Am J Clin Nutr. 2017;106:909. doi:10.3945/ajcn.117.153353
- McCabe D, Lisy K, Lockwood C, Colbeck M. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. JBI Database System Rev Implement Rep. 2017;15:402. doi:10.11124/JBISRIR-2016-002965
- Trimarco V, Rozza F, Izzo R, De Leo V, Cappelli V, et al. Effects of a new combination of nutraceuticals on postmenopausal symptoms and metabolic profile: a crossover, randomized, double-blind trial. Int J Womens Health. 2016;8:581.
