Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.4
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More
8
We observed that magnesium plays a notable role in migraine prevention and treatment. Specifically, magnesium is recommended for both chronic migraine management and immediate intravenous relief during acute migraine episodes. The use of magnesium appears to be linked with mild gastrointestinal side effects, indicating that it is generally well-tolerated by those who use it.
Although individual responses may vary, magnesium has shown promising results for many people managing migraines. It's essential to consider this approach alongside other treatments, as magnesium supplementation might enhance overall migraine management. For those looking for alternative or complementary options, magnesium could be a viable choice worth exploring further.
Although individual responses may vary, magnesium has shown promising results for many people managing migraines. It's essential to consider this approach alongside other treatments, as magnesium supplementation might enhance overall migraine management. For those looking for alternative or complementary options, magnesium could be a viable choice worth exploring further.
Read More
9
Magnesium significantly alleviates migraines
We explored how magnesium supplementation affects the frequency and intensity of migraine attacks. The study relied on evidence gathered from twenty-two randomized controlled trials, providing a solid foundation for our findings.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Read More
Most Useful Reviews
10
Migraine relief
1 people found this helpful
My migraines have disappeared. I'm taking Two-Per-Day, but since it doesn't contain Cal-Mag, I'm using this as well. The migraines caused by pressure have gone. I'd like to continue taking this.
Read More
9
Fewer migraines
I ordered it for my mother; she has fewer migraines! Although she's only been drinking it for a month, just one tablet per night! Absolutely fantastic!
Read More
7.5
Improved wellbeing
1 people found this helpful
Cospa is good! I learned that people with migraines tend to be deficient in magnesium, so I used to take magnesium alone. However, I discovered it works well with calcium, so I bought this. I feel better, and it has also improved my bowel movements! It's an advantage that it doesn't diminish easily due to the larger dosage.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.6
- All Researches
9.5
We evaluated the impact of a comprehensive treatment program on migraines in 30 patients aged 16-66. This program combined hormone therapy, balancing the sympathetic and parasympathetic systems, and managing calcium and magnesium levels.
Remarkably, everyone responded positively to the treatment, with none reporting migraines after starting the program. Improvements included normalization of various hormone levels and the disappearance of associated health issues like insomnia and depression.
Our findings suggest that restoring neurohormonal and metabolic balance could be crucial in managing migraines effectively.
Remarkably, everyone responded positively to the treatment, with none reporting migraines after starting the program. Improvements included normalization of various hormone levels and the disappearance of associated health issues like insomnia and depression.
Our findings suggest that restoring neurohormonal and metabolic balance could be crucial in managing migraines effectively.
Read More
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More
9
Magnesium significantly alleviates migraines
We explored how magnesium supplementation affects the frequency and intensity of migraine attacks. The study relied on evidence gathered from twenty-two randomized controlled trials, providing a solid foundation for our findings.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Read More
9
We examined how magnesium oxide (MgO), both alone and with riboflavin, helps prevent migraines in pregnant individuals. This retrospective study included 203 patients treated between 2015 and 2020, analyzing outcomes such as migraine frequency, severity, and duration.
We found that both treatment options reduced migraines significantly, with 77% of participants experiencing improvement in associated symptoms. The results indicate that magnesium oxide can be an effective option for managing migraines during pregnancy, making it a potential consideration for expectant mothers suffering from this condition.
We found that both treatment options reduced migraines significantly, with 77% of participants experiencing improvement in associated symptoms. The results indicate that magnesium oxide can be an effective option for managing migraines during pregnancy, making it a potential consideration for expectant mothers suffering from this condition.
Read More
8
We investigated how glutamate affects pain signals involved in migraines, focusing on its interaction with NMDA receptors in the trigeminal system. By using various techniques, we found that glutamate and NMDA receptors indeed play a role in activating neurons linked to migraine pain, especially when magnesium levels are low. However, we didn't observe any changes in the levels of CGRP, a key migraine mediator. These results point to the potential benefit of magnesium supplements for migraine sufferers by improving NMDA channel function.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Migraine relief
1 people found this helpful
My migraines have disappeared. I'm taking Two-Per-Day, but since it doesn't contain Cal-Mag, I'm using this as well. The migraines caused by pressure have gone. I'd like to continue taking this.
Read More
9
Fewer migraines
I ordered it for my mother; she has fewer migraines! Although she's only been drinking it for a month, just one tablet per night! Absolutely fantastic!
Read More
7.5
Improved wellbeing
1 people found this helpful
Cospa is good! I learned that people with migraines tend to be deficient in magnesium, so I used to take magnesium alone. However, I discovered it works well with calcium, so I bought this. I feel better, and it has also improved my bowel movements! It's an advantage that it doesn't diminish easily due to the larger dosage.
Read More
10
Effective dosage
Big jar, enough for a long time. The composition is good; for migraines, taking 6-8 pieces is sufficient for the attack to pass. Luxurious magnesium.
Read More
9
Migraine resolution
People who exercise daily need magnesium. I used to exercise a lot and suffered from migraines, but after taking this, the migraine went away.
Read More
Frequently Asked Questions
9
Fewer migraines
I ordered it for my mother; she has fewer migraines! Although she's only been drinking it for a month, just one tablet per night! Absolutely fantastic!
7.5
Improved migraine management
It normalises sleep (with regular intake of 2 capsules). It improves my migraines markedly. Now, when I take pills and magnesium, migraines dissipate quickly—usually within a couple of hours. The frequency has decreased as well, but I also have medicinal support. If I use magnesium regularly without breaks, both PMS and menstruation become more manageable. Chronic pain is also less severe. Although I can't directly attribute this solely to magnesium as I take other supplements too, its effects are evident. We experienced no allergies or stomach issues. The quality is excellent, and the ingredients are natural.
10
Migraine relief
1 people found this helpful
My migraines have disappeared. I'm taking Two-Per-Day, but since it doesn't contain Cal-Mag, I'm using this as well. The migraines caused by pressure have gone. I'd like to continue taking this.
7.5
Improved wellbeing
1 people found this helpful
Cospa is good! I learned that people with migraines tend to be deficient in magnesium, so I used to take magnesium alone. However, I discovered it works well with calcium, so I bought this. I feel better, and it has also improved my bowel movements! It's an advantage that it doesn't diminish easily due to the larger dosage.
10
Effective dosage
Big jar, enough for a long time. The composition is good; for migraines, taking 6-8 pieces is sufficient for the attack to pass. Luxurious magnesium.
9
Magnesium significantly alleviates migraines
We explored how magnesium supplementation affects the frequency and intensity of migraine attacks. The study relied on evidence gathered from twenty-two randomized controlled trials, providing a solid foundation for our findings.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
Through a detailed analysis, we found that magnesium supplementation significantly reduced migraine attacks, with a marked decrease in severity and the number of days afflicted each month. Specifically, magnesium showed a mean difference of -2.51 in attack frequency and -0.88 in severity compared to those who did not receive the supplement.
This promising outcome suggests that magnesium could be an effective option for individuals seeking migraine relief. As we delved deeper into the study, it became clear that while additional research is needed to establish long-term effects, magnesium’s immediate benefits in reducing migraines are noteworthy.
8
We observed that magnesium plays a notable role in migraine prevention and treatment. Specifically, magnesium is recommended for both chronic migraine management and immediate intravenous relief during acute migraine episodes. The use of magnesium appears to be linked with mild gastrointestinal side effects, indicating that it is generally well-tolerated by those who use it.
Although individual responses may vary, magnesium has shown promising results for many people managing migraines. It's essential to consider this approach alongside other treatments, as magnesium supplementation might enhance overall migraine management. For those looking for alternative or complementary options, magnesium could be a viable choice worth exploring further.
Although individual responses may vary, magnesium has shown promising results for many people managing migraines. It's essential to consider this approach alongside other treatments, as magnesium supplementation might enhance overall migraine management. For those looking for alternative or complementary options, magnesium could be a viable choice worth exploring further.
7
We explored the role of magnesium as a potential treatment for migraines through a review of existing literature. Migraines can be intense and debilitating, impacting many individuals' day-to-day lives. Our focus was on understanding whether supplementing magnesium could help in preventing or managing these attacks.
Some studies suggest that low levels of magnesium may be linked to more frequent or severe migraine episodes. When people suffer from migraines, inflammation and oxidative stress might contribute to their pain, and magnesium appears to play a role in helping regulate these processes. By supporting brain health and energy metabolism, magnesium could potentially mitigate some of the triggers associated with migraines.
Although the evidence does point to benefits from magnesium supplementation, we noted that more extensive, well-controlled studies are necessary to draw firm conclusions. Overall, while magnesium shows promise, it may not be a standalone solution and could work best in combination with other treatments.
Some studies suggest that low levels of magnesium may be linked to more frequent or severe migraine episodes. When people suffer from migraines, inflammation and oxidative stress might contribute to their pain, and magnesium appears to play a role in helping regulate these processes. By supporting brain health and energy metabolism, magnesium could potentially mitigate some of the triggers associated with migraines.
Although the evidence does point to benefits from magnesium supplementation, we noted that more extensive, well-controlled studies are necessary to draw firm conclusions. Overall, while magnesium shows promise, it may not be a standalone solution and could work best in combination with other treatments.
7
We observed that magnesium is often mentioned in discussions about effective treatments for migraines. This mineral plays a vital role in many bodily functions, and its potential to alleviate migraine symptoms is supported by anecdotal evidence.
Our analysis points out that while magnesium is particularly noted for its benefits, the details surrounding its standalone effectiveness in managing migraines remain unclear. It seems to work best when combined with lifestyle changes such as stress management and sleep hygiene, as well as with dietary adjustments that avoid common migraine triggers.
We understand that people looking for relief from migraines may find hope in using magnesium supplements. However, it's essential to highlight that in the broader context of migraine treatments, magnesium alone may not completely resolve the issue for everyone. So, while some individuals report improvements, it's not a one-size-fits-all solution.
Our analysis points out that while magnesium is particularly noted for its benefits, the details surrounding its standalone effectiveness in managing migraines remain unclear. It seems to work best when combined with lifestyle changes such as stress management and sleep hygiene, as well as with dietary adjustments that avoid common migraine triggers.
We understand that people looking for relief from migraines may find hope in using magnesium supplements. However, it's essential to highlight that in the broader context of migraine treatments, magnesium alone may not completely resolve the issue for everyone. So, while some individuals report improvements, it's not a one-size-fits-all solution.
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
References
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- Dzugan SA, Dzugan KS. Is migraine a consequence of a loss of neurohormonal and metabolic integrity? A new hypothesis. Neuro Endocrinol Lett. 2015;36:421.
- Mauskop A, Altura BT, Cracco RQ, Altura BM. Deficiency in serum ionized magnesium but not total magnesium in patients with migraines. Possible role of ICa2+/IMg2+ ratio. Headache. 1993;33:135.
- Ilik F, Ertem DH, Ilik MK. [Management of migraine without aura in adolescents: The experience of flunarizine use in a Turkish cohort]. Ideggyogy Sz. 2025;78:122. doi:10.18071/isz.77.0122
- Ma C, Zhu C, Zhang Y, Yu M, Song Y, et al. Gastrodin alleviates NTG-induced migraine-like pain via inhibiting succinate/HIF-1α/TRPM2 signaling pathway in trigeminal ganglion. Phytomedicine. 2024;125:155266. doi:10.1016/j.phymed.2023.155266
- Carcel C, Haghdoost F, Shen J, Nanda P, Bai Y, et al. The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis. Cephalalgia. 2023;43:3331024231183166. doi:10.1177/03331024231183166
- Dominguez LJ, Veronese N, Sabico S, Al-Daghri NM, Barbagallo M. Magnesium and Migraine. Nutrients. 2025;17. doi:10.3390/nu17040725
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Hajhashemy Z, Golpour-Hamedani S, Eshaghian N, Sadeghi O, Khorvash F, et al. Practical supplements for prevention and management of migraine attacks: a narrative review. Front Nutr. 2024;11:1433390. doi:10.3389/fnut.2024.1433390
- Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials. Neurol Sci. 2025;46:651. doi:10.1007/s10072-024-07794-0
- Gazerani P, Papetti L, Dalkara T, Cook CL, Webster C, et al. The Brain, the Eating Plate, and the Gut Microbiome: Partners in Migraine Pathogenesis. Nutrients. 2024;16. doi:10.3390/nu16142222
- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. doi:10.1111/imj.16314
- Kurhade PI, Kodape SM, Das A, Bansod PG. Synergistic action of sumatriptan delivery and targeting magnesium deficiency using green, pH-responsive MgO nanoparticles synthesized from mahua flower extracts. Environ Sci Pollut Res Int. 2023. doi:10.1007/s11356-023-30648-9
- Umemoto KK, Tawk K, Mazhari N, Abouzari M, Djalilian HR. Management of Migraine-Associated Vestibulocochlear Disorders. Audiol Res. 2023;13:528. doi:10.3390/audiolres13040047
- Gaul C, Zaranek L, Goßrau G. [Complementary and supplementary procedures in the treatment of headache]. Schmerz. 2023;37:448. doi:10.1007/s00482-023-00738-1
- Shenoy NN, Gheewala GK, Kedambadi R, Pai S, Zulfikli KM, et al. Can Serum Magnesium Level and Visual Evoked Potentials (P100) be a Predictive in Migraineurs?: Evidence Based Study. Neurol India. 2023;71:463. doi:10.4103/0028-3886.378668
- Frank M, Abouzari M, Djalilian HR. Meniere's disease is a manifestation of migraine. Curr Opin Otolaryngol Head Neck Surg. 2023;31:313. doi:10.1097/MOO.0000000000000908
- Pawar V, Ashraf H, Dorsala S, Mary P, Hameed N, et al. Motorist's Vestibular Disorientation Syndrome (MVDS)-Proposed Diagnostic Criteria. J Pers Med. 2023;13. doi:10.3390/jpm13050732
- Hoshino MT, Bochio MG, Spagnol Bonache J, Ludwig L, Leandro de Campos M, et al. Plasma and erythrocyte magnesium levels: from validation of the method to analysis in volunteers diagnosed to migraine. Magnes Res. 2022;35:51. doi:10.1684/mrh.2022.0502
- Mahajan R, Anand KS, Mahajan RK, Garg J, Juneja A. Serum Magnesium Levels During the Ictal and Interictal Phase in Patients of Migraine: A Prospective Observational Study. Neurol India. 2022;70:1852. doi:10.4103/0028-3886.359247
- Bhurat R, Premkumar S, Manokaran RK. Serum Magnesium Levels in Children With and Without Migraine: A Cross-Sectional Study. Indian Pediatr. 2022;59:623.
- Mazza GR, Solorio C, Stek AM, Kalayjian LA, Wilson ML, et al. Assessing the efficacy of magnesium oxide and riboflavin as preventative treatment of migraines in pregnancy. Arch Gynecol Obstet. 2023;308:1749. doi:10.1007/s00404-022-06872-y
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. doi:10.1007/s11916-022-01019-9
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. doi:10.1007/s10072-021-05843-6
- Karim MR, Bhattacharjee M, Islam MS, Banerjee S, Hossain S, et al. Relation between Serum Magnesium Level and Migraine. Mymensingh Med J. 2021;30:301.
