Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.9
USERS' SCORE
Moderately Good
Based on 42 Reviews
7.9
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
9
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
Nanopowder eggshells improve bone health
We examined how nanopowder eggshells (NPES) could influence bone health in both healthy and ovariectomy-induced osteoporosis rats.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
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Most Useful Reviews
9
Reduced cravings
55 people found this helpful
I take this as prescribed by my orthopaedic surgeon for osteoporosis management before and after pelvic surgery. It's a great remedy for the cramps common during pregnancy. After consuming other types of calcium without relief, I finally found this one. My calcium levels have improved, and the urge to eat chalk has disappeared entirely.
Read More
9
Prevents osteoporosis
4 people found this helpful
I chose this supplement for my mother, as the combination of calcium and magnesium enhances absorption. I also take vitamin D.
Read More
9
Joint improvement
3 people found this helpful
Occasionally, I order this for my 71-year-old mother. Her hands no longer go numb at night, and her sleep has improved. Diagnosed with osteoporosis, we've alternated between glucosamine/chondroitin and calcium/magnesium. Her health has improved significantly, and she even began cycling again—what a positive change!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.9
- All Researches
9
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
Read More
9
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
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9
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
Read More
9
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Read More
9
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 42 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced cravings
55 people found this helpful
I take this as prescribed by my orthopaedic surgeon for osteoporosis management before and after pelvic surgery. It's a great remedy for the cramps common during pregnancy. After consuming other types of calcium without relief, I finally found this one. My calcium levels have improved, and the urge to eat chalk has disappeared entirely.
Read More
9
Prevents osteoporosis
4 people found this helpful
I chose this supplement for my mother, as the combination of calcium and magnesium enhances absorption. I also take vitamin D.
Read More
9
Joint improvement
3 people found this helpful
Occasionally, I order this for my 71-year-old mother. Her hands no longer go numb at night, and her sleep has improved. Diagnosed with osteoporosis, we've alternated between glucosamine/chondroitin and calcium/magnesium. Her health has improved significantly, and she even began cycling again—what a positive change!
Read More
9
Positive family effects
1 people found this helpful
This calcium supplement has worked well for my entire family. After starting it, my husband and son, who were prone to convulsions, no longer experience them. It's helped me keep my hair and improve my teeth after childbirth, while my grandmother has felt better with her osteoporosis.
Read More
9
Supports bone health
1 people found this helpful
The combination of calcium and magnesium in this product enhances absorption and supports overall health. It is particularly suitable for those over 40, helping maintain bone strength. Users report improved well-being and resistance to physical activity.
Read More
Frequently Asked Questions
7.5
Supports osteoporosis treatment
1 people found this helpful
At 50, I take this supplement to prevent osteoporosis. It's effective in combating calcium loss from coffee consumption. The large package lasts a while, and my bones have improved in strength after one month, especially with the addition of Vitamin D3.
8
Bone strength
12 people found this helpful
Calcium and magnesium are crucial minerals for our bodies, essential for maintaining bone strength and preventing osteoporosis. Additionally, they support cardiovascular health and help regulate blood pressure. I've been using this supplement for two years and have seen satisfactory results. Don't overlook their importance!
9
Reduced cravings
55 people found this helpful
I take this as prescribed by my orthopaedic surgeon for osteoporosis management before and after pelvic surgery. It's a great remedy for the cramps common during pregnancy. After consuming other types of calcium without relief, I finally found this one. My calcium levels have improved, and the urge to eat chalk has disappeared entirely.
7.5
Cramps reduced
I started taking this supplement due to night cramps in my legs. Since then, the cramps have disappeared, and I continue to take it to prevent osteoporosis.
9
Joint improvement
3 people found this helpful
Occasionally, I order this for my 71-year-old mother. Her hands no longer go numb at night, and her sleep has improved. Diagnosed with osteoporosis, we've alternated between glucosamine/chondroitin and calcium/magnesium. Her health has improved significantly, and she even began cycling again—what a positive change!
7.5
Improved health
73 people found this helpful
Absolutely perfect! After consuming alcohol for a while, I developed osteoporosis, confirmed by an X-ray showing a hip fracture. My doctor advised that I either stop drinking or start calcium supplementation. Promptly, I began searching for this product on iHerb, and I was pleased with its high quality and acceptable dosage. Each can contains 250 capsules, and it combines both calcium and magnesium. I also remember the doctor stating that I should take vitamin D and K with calcium for better absorption. Here's to good health!
7.5
Affordability
6 people found this helpful
After measuring my body fat, I discovered I had low bone mass, raising concerns about developing osteoporosis. To address this, I purchased this product alongside vitamin D to enhance calcium absorption. The 250-tablet package is affordable and should last four months. The pills are of a suitable size for swallowing.
9
Improved bone density
1 people found this helpful
It's fine. I take one daily. My mother has osteoporosis, prompting me to start taking it as a preventative measure two years ago. I measured my bone density last year, and it had improved to above average. I plan to keep taking it.
9
Supports bone health
1 people found this helpful
The combination of calcium and magnesium in this product enhances absorption and supports overall health. It is particularly suitable for those over 40, helping maintain bone strength. Users report improved well-being and resistance to physical activity.
4
We conducted a thorough review of various treatments for osteoporosis in people living with HIV, particularly focusing on the role of calcium. Our analysis included randomized controlled trials that compared different treatment strategies, such as calcium combined with medications like zoledronate or alendronate.
While zoledronate showed promising results in improving bone mineral density, calcium was often used alongside these treatments. Unfortunately, this combination makes it difficult to isolate the specific effects of calcium on osteoporosis. We found that alendronate, although it helped reduce certain bone turnover markers, did not significantly improve bone density.
Overall, the study indicates that while calcium plays a role in treatment combinations, its isolated impact on osteoporosis remains unclear. We emphasized the need for more focused research to determine calcium's true effectiveness in enhancing bone health for those affected by HIV.
While zoledronate showed promising results in improving bone mineral density, calcium was often used alongside these treatments. Unfortunately, this combination makes it difficult to isolate the specific effects of calcium on osteoporosis. We found that alendronate, although it helped reduce certain bone turnover markers, did not significantly improve bone density.
Overall, the study indicates that while calcium plays a role in treatment combinations, its isolated impact on osteoporosis remains unclear. We emphasized the need for more focused research to determine calcium's true effectiveness in enhancing bone health for those affected by HIV.
5
Calcium's risks for kidney stones
We explored the effects of calcium and vitamin D supplementation on osteoporosis, particularly focusing on the risk of kidney stones. In our study, 204 older adults in southwest China took daily doses of calcium and vitamin D for at least a year. We used various statistical analyses to understand the relationship between these supplements and kidney stone formation.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
Our findings reveal that there is a potential link between the use of calcium supplements for osteoporosis and an increased risk of developing kidney stones. It seems that a history of kidney stones can elevate the likelihood of experiencing them again while undergoing such supplementation, likely due to higher urinary calcium levels.
While calcium is essential for bone health, our results suggest that patients need to be cautious. This research highlights the importance of monitoring kidney health while receiving calcium and vitamin D treatment to prevent complications like kidney stones.
9
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
7
We investigated the relationship between the calcium-to-magnesium intake ratio and osteoporosis among Puerto Rican adults.
Using data from 955 participants aged 47-79, we found that balance in calcium and magnesium is crucial for bone health.
Interestingly, those within a specific calcium-to-magnesium ratio range of 2.2-3.2 showed more favorable bone mineral density, while those at the extremes had higher odds of osteoporosis.
This indicates that the interplay between these nutrients could be significant in dietary recommendations for preventing osteoporosis.
Using data from 955 participants aged 47-79, we found that balance in calcium and magnesium is crucial for bone health.
Interestingly, those within a specific calcium-to-magnesium ratio range of 2.2-3.2 showed more favorable bone mineral density, while those at the extremes had higher odds of osteoporosis.
This indicates that the interplay between these nutrients could be significant in dietary recommendations for preventing osteoporosis.
References
- Wang JC, Chung SM, Wu PT, Tu YK, Lai PC, et al. Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials. EClinicalMedicine. 2025;81:103103. doi:10.1016/j.eclinm.2025.103103
- Chen L, Lin S, He X, Ye J, Huang Y, et al. A calcium-loaded complex based on Antarctic krill protein and supplemented with pectin promotes calcium absorption and bone health. Int J Biol Macromol. 2025. doi:10.1016/j.ijbiomac.2025.141634
- Ma R, Romano E, Ashworth M, Vancampfort D, Solmi M, et al. Is there a disparity in osteoporosis referral and treatment among people with affective disorders? A ten-year data linkage study. Gen Hosp Psychiatry. 2025;94:56. doi:10.1016/j.genhosppsych.2025.02.009
- Chen J, Wang J, Jia W, Zhang Y, Li H, et al. Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats. Eur J Med Res. 2025;30:115. doi:10.1186/s40001-025-02384-y
- Shi L, Bao Y, Deng X, Xu X, Hu J. Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study. BMJ Open. 2025;15:e092901. doi:10.1136/bmjopen-2024-092901
- Joris V, Balmayor ER, van Griensven M. miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells. Mol Ther Nucleic Acids. 2025;36:102446. doi:10.1016/j.omtn.2024.102446
- Hu W, Feng X, Wen C. Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: Findings from NHANES. Medicine (Baltimore). 2024;103:e40768. doi:10.1097/MD.0000000000040768
- Li D, Dai D, Wang J, Zhang C. Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy. Small. 2024;20:e2403907. doi:10.1002/smll.202403907
- Zhou H, He Z, Cao Y, Chu L, Liang B, et al. An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation. Theranostics. 2024;14:3739. doi:10.7150/thno.97412
- Liu L, Luo P, Wen P, Xu P. The role of magnesium in the pathogenesis of osteoporosis. Front Endocrinol (Lausanne). 2024;15:1406248. doi:10.3389/fendo.2024.1406248
- Huang L, Cai P, Bian M, Yu J, Xiao L, et al. Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects. Mater Today Bio. 2024;26:101092. doi:10.1016/j.mtbio.2024.101092
- Weng Z, Ye J, Cai C, Liu Z, Liu Y, et al. Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy. J Nanobiotechnology. 2024;22:314. doi:10.1186/s12951-024-02581-7
- Dai Q, Wang Z, Liu C, Chen X, Cao X. High performance injectable Mg doped bioactive glass bone cement for the regulation of osteogenic immune microenvironment. Biomater Adv. 2024;160:213864. doi:10.1016/j.bioadv.2024.213864
- Li J, Chen Y, Zha D, Wu C, Li X, et al. Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. Lipids Health Dis. 2024;23:88. doi:10.1186/s12944-024-02083-3
- Qin L, Liu Q, Zhang T, Tang X, Mo X, et al. Association Between Combined Polymetallic Exposure and Osteoporosis. Biol Trace Elem Res. 2024;202:3945. doi:10.1007/s12011-023-04002-6
- Ma T, Guan Y, Feng J, Yang Y, Chen J, et al. Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate. Biomater Res. 2023;27:128. doi:10.1186/s40824-023-00474-8
- Zhang C, Du B, Deng G, Zhang S, Yu T, et al. Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice. Chin Med J (Engl). 2024;137:1762. doi:10.1097/CM9.0000000000002877
- Zhao Y, Liu J, Hu L, Yao X, Tu R, et al. Novel "hot spring"-mimetic scaffolds for sequential neurovascular network reconstruction and osteoporosis reversion. Biomaterials. 2025;320:123191. doi:10.1016/j.biomaterials.2025.123191
- Al-Garawi ZS, Al-Qaisi AHI, Al-Shamari KA, Öztürkkan FE, Necefoğlu H. The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study. Bioprocess Biosyst Eng. 2024;47:753. doi:10.1007/s00449-024-03012-5
- Düğer H, Uçan B, Çalışkan M, Bostan H, Demirci T, et al. Hypomagnesemia may be associated with symptomatic disease in patients with primary hyperparathyroidism. Endocrine. 2024;83:466. doi:10.1007/s12020-023-03577-3
- Han H, Chen S, Wang X, Jin J, Li X, et al. Association of the composite dietary antioxidant index with bone mineral density in the United States general population: data from NHANES 2005-2010. J Bone Miner Metab. 2023;41:631. doi:10.1007/s00774-023-01438-7
- Zhu Y, Jia G, Yang Y, Weng J, Liu S, et al. Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway. ACS Biomater Sci Eng. 2023;9:3435. doi:10.1021/acsbiomaterials.2c01097
- Fouhy LE, Mangano KM, Zhang X, Hughes BD, Tucker KL, et al. Association between a Calcium-to-Magnesium Ratio and Osteoporosis among Puerto Rican Adults. J Nutr. 2023;153:2642. doi:10.1016/j.tjnut.2023.05.009
- Xie Y, Bao Z, Wang Z, Du D, Chen G, et al. Magnesium Ascorbyl Phosphate Promotes Bone Formation Via CaMKII Signaling. J Bone Miner Res. 2023;38:1015. doi:10.1002/jbmr.4820
- Salama RHM, Ali SS, Salama THM, Almged MA, Alsanory TA, et al. Dietary Effects of Nanopowder Eggshells on Mineral Contents, Bone Turnover Biomarkers, and Regulators of Bone Resorption in Healthy Rats and Ovariectomy-Induced Osteoporosis Rat Model. Appl Biochem Biotechnol. 2023;195:5034. doi:10.1007/s12010-022-04038-9
