Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
9
We investigated the role of calcium in astrocytes to enhance recovery after a stroke. Focusing on a specific optogenetic tool called OptoSTIM1, we were able to selectively activate calcium channels in astrocytes. This approach allowed us to significantly elevate calcium levels in these supporting brain cells, particularly in the sensory-parietal cortex following a stroke.
Our findings revealed that this sustained calcium increase, lasting over 10 minutes, led to noticeable improvements in post-stroke recovery. By manipulating intracellular calcium levels in astrocytes, we observed a remarkable reduction in impairment caused by chronic stroke conditions.
This study highlights the potential of targeting astrocytic calcium signals as a promising strategy for enhancing stroke recovery, paving the way for new therapeutic approaches. Overall, our research suggests that calcium's role in astrocytes could be a game changer in the efforts to improve outcomes for stroke patients.
Our findings revealed that this sustained calcium increase, lasting over 10 minutes, led to noticeable improvements in post-stroke recovery. By manipulating intracellular calcium levels in astrocytes, we observed a remarkable reduction in impairment caused by chronic stroke conditions.
This study highlights the potential of targeting astrocytic calcium signals as a promising strategy for enhancing stroke recovery, paving the way for new therapeutic approaches. Overall, our research suggests that calcium's role in astrocytes could be a game changer in the efforts to improve outcomes for stroke patients.
9
We embarked on an intriguing exploration of how magnesium might help during cerebral ischemia, particularly after an acute stroke. The study set out to determine the potential benefits of a biodegradable neuroprotective stent that releases magnesium into the bloodstream, targeting areas impacted by reperfusion injury.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
8
We explored how magnesium intake might influence the risk of stroke through a robust research design known as two-sample Mendelian randomization. This approach allows us to estimate the causal effects of nutrients on health outcomes, eliminating many confounding factors present in traditional observational studies.
Our findings suggest that higher levels of magnesium are linked to a significantly lower risk of cardioembolic stroke, a type of stroke caused by blood clots that travel to the brain. Specifically, our results showed a striking reduction in risk, indicating that magnesium could play a protective role in stroke prevention.
This study also identified other beneficial nutrients, such as vitamin C and vitamin B9, further emphasizing the importance of diet in stroke management. However, we should exercise caution regarding vitamin B6, which showed a potential association with an increased risk of large-artery stroke, as this finding requires additional investigation.
Overall, this research highlights the importance of magnesium and certain vitamins in stroke prevention. These insights can help shape public health strategies aimed at reducing stroke risk through dietary recommendations.
Our findings suggest that higher levels of magnesium are linked to a significantly lower risk of cardioembolic stroke, a type of stroke caused by blood clots that travel to the brain. Specifically, our results showed a striking reduction in risk, indicating that magnesium could play a protective role in stroke prevention.
This study also identified other beneficial nutrients, such as vitamin C and vitamin B9, further emphasizing the importance of diet in stroke management. However, we should exercise caution regarding vitamin B6, which showed a potential association with an increased risk of large-artery stroke, as this finding requires additional investigation.
Overall, this research highlights the importance of magnesium and certain vitamins in stroke prevention. These insights can help shape public health strategies aimed at reducing stroke risk through dietary recommendations.
Most Useful Reviews
8.8
Reduces heart attack risk
This choice has eliminated stress while addressing magnesium deficit in my body. Magnesium mitigates blood clotting, alleviates stomach cramps, and helps with acidity levels. It’s crucial for hearing acuity, involved in brain function, and necessary for the absorption of B vitamins. Additionally, it has an anti-sclerotic effect and lowers elevated blood pressure, thereby reducing the risk of heart attack and stroke by relaxing blood vessels.
8
Prevents muscle hardening
I wanted to take a course of calcium and discovered that combining it with magnesium is better, specifically in a ratio of 2 to 1. A surplus of calcium alongside inadequate magnesium means calcium may deposit in inappropriate places, like the muscles, which can lead to hardening (risk of stroke!) and make bones fragile. Thus, I found a preparation with the ideal calcium and magnesium ratio!
8.8
Supports stress resistance
Are you often annoyed, distracted, or struggling to sleep? This may stem from insufficient magnesium and calcium. These minerals bolster the nervous system and help the body manage stress. Low magnesium can worsen emotional and physical stress, resulting in serious consequences like seizures, high blood pressure, and heightened risks of strokes and heart attacks. I opted for these vitamins to prevent such issues, and now I feel good; irritability has faded and my joint pain has ceased!
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.8
- All Researches
9
The investigation into how calcium affects stroke led us to explore the role of a compound called Genistein (Gen). Using a rat model of cerebral ischemia/reperfusion, we set out to determine whether this treatment could alleviate the injuries typically observed during stroke events.
Our focus concentrated on the Wnt/Ca signaling pathway, which is known to be involved in processes like calcium overload and cellular stress during such injuries. Excitingly, we noticed that treatment with Genistein resulted in smaller areas of damage in the brain and improved neurological outcomes. This indicates a potential protective effect against the harmful consequences of strokes.
However, while we saw encouraging results, the study primarily highlighted Genistein's ability to regulate calcium through the Wnt/Ca signaling pathway rather than isolating calcium treatment as an independent factor in stroke recovery. This nuanced view underscores the complexities of addressing calcium’s role in the healing process post-stroke.
In summary, although Genistein showed promise in reducing stroke-related damage, the specific contribution of calcium alone remains unclear, emphasizing the need for further research into this vital area.
Our focus concentrated on the Wnt/Ca signaling pathway, which is known to be involved in processes like calcium overload and cellular stress during such injuries. Excitingly, we noticed that treatment with Genistein resulted in smaller areas of damage in the brain and improved neurological outcomes. This indicates a potential protective effect against the harmful consequences of strokes.
However, while we saw encouraging results, the study primarily highlighted Genistein's ability to regulate calcium through the Wnt/Ca signaling pathway rather than isolating calcium treatment as an independent factor in stroke recovery. This nuanced view underscores the complexities of addressing calcium’s role in the healing process post-stroke.
In summary, although Genistein showed promise in reducing stroke-related damage, the specific contribution of calcium alone remains unclear, emphasizing the need for further research into this vital area.
9
We explored the potential of magnesium sulfate (MgSO) as a promising treatment for ischemic stroke recovery, particularly for its role in calcium regulation. By conducting experiments on rats that had undergone a middle cerebral artery occlusion, we aimed to understand how MgSO could act, especially in combination with hypothermia.
Our findings showed that the combination of MgSO and hypothermia worked better than either treatment alone. It significantly improved neurological function and reduced brain damage, suggesting that MgSO might help protect nerve cells during the harmful effects of a stroke. Specifically, we observed that optimizing calcium levels in nerve cells was key to this protective effect.
This study highlights MgSO as a potentially effective solution that could enhance recovery for patients suffering from ischemic strokes. While the results are promising, they also indicate the importance of further research to confirm these effects in actual clinical settings.
Our findings showed that the combination of MgSO and hypothermia worked better than either treatment alone. It significantly improved neurological function and reduced brain damage, suggesting that MgSO might help protect nerve cells during the harmful effects of a stroke. Specifically, we observed that optimizing calcium levels in nerve cells was key to this protective effect.
This study highlights MgSO as a potentially effective solution that could enhance recovery for patients suffering from ischemic strokes. While the results are promising, they also indicate the importance of further research to confirm these effects in actual clinical settings.
9
We investigated the role of calcium in astrocytes to enhance recovery after a stroke. Focusing on a specific optogenetic tool called OptoSTIM1, we were able to selectively activate calcium channels in astrocytes. This approach allowed us to significantly elevate calcium levels in these supporting brain cells, particularly in the sensory-parietal cortex following a stroke.
Our findings revealed that this sustained calcium increase, lasting over 10 minutes, led to noticeable improvements in post-stroke recovery. By manipulating intracellular calcium levels in astrocytes, we observed a remarkable reduction in impairment caused by chronic stroke conditions.
This study highlights the potential of targeting astrocytic calcium signals as a promising strategy for enhancing stroke recovery, paving the way for new therapeutic approaches. Overall, our research suggests that calcium's role in astrocytes could be a game changer in the efforts to improve outcomes for stroke patients.
Our findings revealed that this sustained calcium increase, lasting over 10 minutes, led to noticeable improvements in post-stroke recovery. By manipulating intracellular calcium levels in astrocytes, we observed a remarkable reduction in impairment caused by chronic stroke conditions.
This study highlights the potential of targeting astrocytic calcium signals as a promising strategy for enhancing stroke recovery, paving the way for new therapeutic approaches. Overall, our research suggests that calcium's role in astrocytes could be a game changer in the efforts to improve outcomes for stroke patients.
9
We explored the potential benefits of magnesium sulfate (MgSO) as a novel hypothermia infusion solution to aid recovery in patients experiencing acute ischemic stroke (AIS). In our investigation, we utilized rats that underwent a procedure mimicking stroke by occluding the middle cerebral artery. We compared the effectiveness of MgSO combined with hypothermia to traditional treatment methods.
The results of our study indicated that the combination of MgSO and hypothermia far outperformed either treatment alone. This exciting discovery showed significant improvements in neurological abilities and reduced brain damage, as well as better maintenance of cerebral blood flow. We found that this protective effect was largely due to MgSO's ability to regulate calcium levels in various neurovascular unit (NVU) cells, which are crucial for brain health.
Our findings suggest that magnesium may offer a promising way to enhance recovery in stroke patients when used alongside hypothermia, potentially leading to better outcomes in their rehabilitation journey.
The results of our study indicated that the combination of MgSO and hypothermia far outperformed either treatment alone. This exciting discovery showed significant improvements in neurological abilities and reduced brain damage, as well as better maintenance of cerebral blood flow. We found that this protective effect was largely due to MgSO's ability to regulate calcium levels in various neurovascular unit (NVU) cells, which are crucial for brain health.
Our findings suggest that magnesium may offer a promising way to enhance recovery in stroke patients when used alongside hypothermia, potentially leading to better outcomes in their rehabilitation journey.
9
We explored the effects of combining magnesium salts of salvianolic acid B and ginsenoside Rg1 as a potential treatment for ischemic stroke. The study used a well-structured approach, evaluating the impacts on infarct volume and neurological function in a model of middle cerebral artery occlusion.
Our findings revealed that the combination therapy was more effective than either treatment alone, significantly reducing the injured area of the brain and improving behavior in treated subjects. Specifically, the combined treatment not only resulted in a marked decrease in infarct volume but also supported better structural integrity of the brain tissue and an increase in neuron numbers.
We verified the synergistic benefits of this combination through thorough statistical analysis, showing that this approach could potentially enhance therapeutic outcomes for stroke patients. Notably, the mechanisms behind these improvements hinted towards mitigating cerebral metabolic disorders as a factor.
Overall, while the effect of magnesium alone is less clear, our results highlight the effectiveness of using it in combination with ginsenoside Rg1, paving the way for improved treatment strategies for those affected by stroke.
Our findings revealed that the combination therapy was more effective than either treatment alone, significantly reducing the injured area of the brain and improving behavior in treated subjects. Specifically, the combined treatment not only resulted in a marked decrease in infarct volume but also supported better structural integrity of the brain tissue and an increase in neuron numbers.
We verified the synergistic benefits of this combination through thorough statistical analysis, showing that this approach could potentially enhance therapeutic outcomes for stroke patients. Notably, the mechanisms behind these improvements hinted towards mitigating cerebral metabolic disorders as a factor.
Overall, while the effect of magnesium alone is less clear, our results highlight the effectiveness of using it in combination with ginsenoside Rg1, paving the way for improved treatment strategies for those affected by stroke.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Reduces heart attack risk
This choice has eliminated stress while addressing magnesium deficit in my body. Magnesium mitigates blood clotting, alleviates stomach cramps, and helps with acidity levels. It’s crucial for hearing acuity, involved in brain function, and necessary for the absorption of B vitamins. Additionally, it has an anti-sclerotic effect and lowers elevated blood pressure, thereby reducing the risk of heart attack and stroke by relaxing blood vessels.
8
Prevents muscle hardening
I wanted to take a course of calcium and discovered that combining it with magnesium is better, specifically in a ratio of 2 to 1. A surplus of calcium alongside inadequate magnesium means calcium may deposit in inappropriate places, like the muscles, which can lead to hardening (risk of stroke!) and make bones fragile. Thus, I found a preparation with the ideal calcium and magnesium ratio!
8.8
Supports stress resistance
Are you often annoyed, distracted, or struggling to sleep? This may stem from insufficient magnesium and calcium. These minerals bolster the nervous system and help the body manage stress. Low magnesium can worsen emotional and physical stress, resulting in serious consequences like seizures, high blood pressure, and heightened risks of strokes and heart attacks. I opted for these vitamins to prevent such issues, and now I feel good; irritability has faded and my joint pain has ceased!
Frequently Asked Questions
8.8
Supports stress resistance
Are you often annoyed, distracted, or struggling to sleep? This may stem from insufficient magnesium and calcium. These minerals bolster the nervous system and help the body manage stress. Low magnesium can worsen emotional and physical stress, resulting in serious consequences like seizures, high blood pressure, and heightened risks of strokes and heart attacks. I opted for these vitamins to prevent such issues, and now I feel good; irritability has faded and my joint pain has ceased!
8.8
Reduces heart attack risk
This choice has eliminated stress while addressing magnesium deficit in my body. Magnesium mitigates blood clotting, alleviates stomach cramps, and helps with acidity levels. It’s crucial for hearing acuity, involved in brain function, and necessary for the absorption of B vitamins. Additionally, it has an anti-sclerotic effect and lowers elevated blood pressure, thereby reducing the risk of heart attack and stroke by relaxing blood vessels.
8
Prevents muscle hardening
I wanted to take a course of calcium and discovered that combining it with magnesium is better, specifically in a ratio of 2 to 1. A surplus of calcium alongside inadequate magnesium means calcium may deposit in inappropriate places, like the muscles, which can lead to hardening (risk of stroke!) and make bones fragile. Thus, I found a preparation with the ideal calcium and magnesium ratio!
We explored the connection between serum magnesium levels and the risk of stroke among non-dialysis patients with chronic kidney disease (CKD) stages 4 and 5. By analyzing data from a cohort of 1,271 patients over a ten-year period, we focused on how varying levels of magnesium could influence mortality rates related to fatal heart failure, coronary heart disease, and stroke.
Our findings revealed that higher serum magnesium concentrations were associated with a significantly reduced risk of death from stroke and other cardiovascular events. This suggests that maintaining adequate magnesium levels could play a crucial role in improving outcomes for CKD patients who are at a higher risk for these serious conditions.
While the study did have its limitations, such as potential confounding factors, the association between higher magnesium levels and lower mortality rates is an important consideration in managing the health of CKD patients. As such, ensuring that these patients maintain optimal magnesium levels may be a beneficial strategy in reducing their risk of fatal stroke and enhancing overall health.
Our findings revealed that higher serum magnesium concentrations were associated with a significantly reduced risk of death from stroke and other cardiovascular events. This suggests that maintaining adequate magnesium levels could play a crucial role in improving outcomes for CKD patients who are at a higher risk for these serious conditions.
While the study did have its limitations, such as potential confounding factors, the association between higher magnesium levels and lower mortality rates is an important consideration in managing the health of CKD patients. As such, ensuring that these patients maintain optimal magnesium levels may be a beneficial strategy in reducing their risk of fatal stroke and enhancing overall health.
9
We explored the potential benefits of magnesium sulfate (MgSO) as a novel hypothermia infusion solution to aid recovery in patients experiencing acute ischemic stroke (AIS). In our investigation, we utilized rats that underwent a procedure mimicking stroke by occluding the middle cerebral artery. We compared the effectiveness of MgSO combined with hypothermia to traditional treatment methods.
The results of our study indicated that the combination of MgSO and hypothermia far outperformed either treatment alone. This exciting discovery showed significant improvements in neurological abilities and reduced brain damage, as well as better maintenance of cerebral blood flow. We found that this protective effect was largely due to MgSO's ability to regulate calcium levels in various neurovascular unit (NVU) cells, which are crucial for brain health.
Our findings suggest that magnesium may offer a promising way to enhance recovery in stroke patients when used alongside hypothermia, potentially leading to better outcomes in their rehabilitation journey.
The results of our study indicated that the combination of MgSO and hypothermia far outperformed either treatment alone. This exciting discovery showed significant improvements in neurological abilities and reduced brain damage, as well as better maintenance of cerebral blood flow. We found that this protective effect was largely due to MgSO's ability to regulate calcium levels in various neurovascular unit (NVU) cells, which are crucial for brain health.
Our findings suggest that magnesium may offer a promising way to enhance recovery in stroke patients when used alongside hypothermia, potentially leading to better outcomes in their rehabilitation journey.
9
We investigated the role of calcium in astrocytes to enhance recovery after a stroke. Focusing on a specific optogenetic tool called OptoSTIM1, we were able to selectively activate calcium channels in astrocytes. This approach allowed us to significantly elevate calcium levels in these supporting brain cells, particularly in the sensory-parietal cortex following a stroke.
Our findings revealed that this sustained calcium increase, lasting over 10 minutes, led to noticeable improvements in post-stroke recovery. By manipulating intracellular calcium levels in astrocytes, we observed a remarkable reduction in impairment caused by chronic stroke conditions.
This study highlights the potential of targeting astrocytic calcium signals as a promising strategy for enhancing stroke recovery, paving the way for new therapeutic approaches. Overall, our research suggests that calcium's role in astrocytes could be a game changer in the efforts to improve outcomes for stroke patients.
Our findings revealed that this sustained calcium increase, lasting over 10 minutes, led to noticeable improvements in post-stroke recovery. By manipulating intracellular calcium levels in astrocytes, we observed a remarkable reduction in impairment caused by chronic stroke conditions.
This study highlights the potential of targeting astrocytic calcium signals as a promising strategy for enhancing stroke recovery, paving the way for new therapeutic approaches. Overall, our research suggests that calcium's role in astrocytes could be a game changer in the efforts to improve outcomes for stroke patients.
9
We embarked on an intriguing exploration of how magnesium might help during cerebral ischemia, particularly after an acute stroke. The study set out to determine the potential benefits of a biodegradable neuroprotective stent that releases magnesium into the bloodstream, targeting areas impacted by reperfusion injury.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
References
