Overview
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin K2(as Menaquinone-7) (MK-7 ) (MenaQ7®)
100 mcg
**
Top Medical Research Studies
9
We studied how vitamin K2 influences bone regeneration in diabetic rats, especially focusing on its effects on healing critical-size defects in the skull. In our experiment, we included both non-diabetic and diabetic rats to see how this vitamin fares in conditions known to hinder healing.
With a diverse set of control and experimental groups, we treated some rats with vitamin K2 while others received a saline solution. After four weeks, we assessed bone healing through various tests, including looking at new bone formation and specific proteins linked to bone health.
The results were promising! We found that vitamin K2 significantly enhanced bone healing, especially when combined with a bone graft. New bone formation was notably higher in the groups treated with vitamin K2 compared to those that weren’t. Moreover, levels of osteocalcin and osteopontin—two key markers for bone health—were also elevated in these groups.
Overall, our findings suggest that vitamin K2 could be a beneficial addition to treatments aimed at improving bone regeneration in diabetic patients. This avenue offers interesting possibilities for enhancing recovery strategies in individuals with similar conditions.
With a diverse set of control and experimental groups, we treated some rats with vitamin K2 while others received a saline solution. After four weeks, we assessed bone healing through various tests, including looking at new bone formation and specific proteins linked to bone health.
The results were promising! We found that vitamin K2 significantly enhanced bone healing, especially when combined with a bone graft. New bone formation was notably higher in the groups treated with vitamin K2 compared to those that weren’t. Moreover, levels of osteocalcin and osteopontin—two key markers for bone health—were also elevated in these groups.
Overall, our findings suggest that vitamin K2 could be a beneficial addition to treatments aimed at improving bone regeneration in diabetic patients. This avenue offers interesting possibilities for enhancing recovery strategies in individuals with similar conditions.
Read More
9
We explored how vitamin K2, specifically its natural form MK-7, affects type 2 diabetes management through its impact on gut bacteria. To dive deeper into this question, we conducted a six-month randomized controlled trial involving 60 participants with type 2 diabetes. We compared those receiving MK-7 supplementation to a control group and analyzed their health markers, including blood glucose and insulin levels.
After the six months, we observed significant reductions in fasting serum glucose, insulin, and HbA1c levels among participants taking MK-7. This suggests that vitamin K2 might improve glycemic control and insulin sensitivity. Additionally, we investigated its effects further by transplanting gut microbiota from MK-7 supplemented individuals into mice with diet-induced obesity. The results were promising, showcasing improved glucose tolerance in these mice.
Importantly, we noted an increase in beneficial metabolites, like secondary bile acids and short-chain fatty acids, in both human and mouse feces. These metabolites are crucial as they can enhance metabolism and affect gut health. Overall, our findings reveal that vitamin K2 may play a significant role in diabetes management, potentially paving the way for its broader clinical application.
After the six months, we observed significant reductions in fasting serum glucose, insulin, and HbA1c levels among participants taking MK-7. This suggests that vitamin K2 might improve glycemic control and insulin sensitivity. Additionally, we investigated its effects further by transplanting gut microbiota from MK-7 supplemented individuals into mice with diet-induced obesity. The results were promising, showcasing improved glucose tolerance in these mice.
Importantly, we noted an increase in beneficial metabolites, like secondary bile acids and short-chain fatty acids, in both human and mouse feces. These metabolites are crucial as they can enhance metabolism and affect gut health. Overall, our findings reveal that vitamin K2 may play a significant role in diabetes management, potentially paving the way for its broader clinical application.
Read More
8
We investigated how Vitamin K2 might help mitigate cognitive decline associated with diabetes. Our study focused on a group of adult Swiss albino mice, which we induced with diabetes through a high-fat diet and a low dose of streptozotocin, a compound known to cause diabetes. After confirming the onset of diabetes, we administered Vitamin K2 to one group of these diabetic mice for three weeks while monitoring various health indicators and cognitive functions through behavioral tests.
The results were promising. We observed that Vitamin K2 treatment led to reductions in blood glucose levels and improved measures of cognitive performance. Specifically, it seemed to reverse some of the cognitive decline experienced by the diabetic mice. This improvement was linked to a reduction in neuroinflammation and oxidative stress, which are known to damage brain cells over time. Alongside this, we found that Vitamin K2 increased the density of important neurons in the brain regions associated with memory and learning.
Overall, we concluded that Vitamin K2 exhibits potential benefits for cognitive health in diabetic conditions, highlighting its role in enhancing neuronal health while diminishing inflammation and oxidative damage in the brain.
The results were promising. We observed that Vitamin K2 treatment led to reductions in blood glucose levels and improved measures of cognitive performance. Specifically, it seemed to reverse some of the cognitive decline experienced by the diabetic mice. This improvement was linked to a reduction in neuroinflammation and oxidative stress, which are known to damage brain cells over time. Alongside this, we found that Vitamin K2 increased the density of important neurons in the brain regions associated with memory and learning.
Overall, we concluded that Vitamin K2 exhibits potential benefits for cognitive health in diabetic conditions, highlighting its role in enhancing neuronal health while diminishing inflammation and oxidative damage in the brain.
Read More
Most Useful Reviews
7.5
Effective for diabetes
1 people found this helpful
Pretty good. I would recommend this product for individuals with diabetes. I noticed a change after 4 weeks.
Read More
9
Promotes bone health
MK-7 Vitamin K-2 is a form of vitamin K with beneficial effects in osteoporosis, cardiovascular disease, inflammation, cancer, Alzheimer’s disease, and diabetes. It supports healthy bones and halts arterial thickening. A high intake of K2 helped reduce body weight and abdominal fat in postmenopausal women. This product is high quality, soy-free, and derived from natto, remaining active in the body longer. The capsule size is perfect.
Read More
9
Recommended for diabetes
Great for type 2 diabetes. We take one potassium capsule as prescribed by a doctor on a continual basis, combined with D3 and omega 3.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
- All Researches
9
We studied how vitamin K2 influences bone regeneration in diabetic rats, especially focusing on its effects on healing critical-size defects in the skull. In our experiment, we included both non-diabetic and diabetic rats to see how this vitamin fares in conditions known to hinder healing.
With a diverse set of control and experimental groups, we treated some rats with vitamin K2 while others received a saline solution. After four weeks, we assessed bone healing through various tests, including looking at new bone formation and specific proteins linked to bone health.
The results were promising! We found that vitamin K2 significantly enhanced bone healing, especially when combined with a bone graft. New bone formation was notably higher in the groups treated with vitamin K2 compared to those that weren’t. Moreover, levels of osteocalcin and osteopontin—two key markers for bone health—were also elevated in these groups.
Overall, our findings suggest that vitamin K2 could be a beneficial addition to treatments aimed at improving bone regeneration in diabetic patients. This avenue offers interesting possibilities for enhancing recovery strategies in individuals with similar conditions.
With a diverse set of control and experimental groups, we treated some rats with vitamin K2 while others received a saline solution. After four weeks, we assessed bone healing through various tests, including looking at new bone formation and specific proteins linked to bone health.
The results were promising! We found that vitamin K2 significantly enhanced bone healing, especially when combined with a bone graft. New bone formation was notably higher in the groups treated with vitamin K2 compared to those that weren’t. Moreover, levels of osteocalcin and osteopontin—two key markers for bone health—were also elevated in these groups.
Overall, our findings suggest that vitamin K2 could be a beneficial addition to treatments aimed at improving bone regeneration in diabetic patients. This avenue offers interesting possibilities for enhancing recovery strategies in individuals with similar conditions.
Read More
9
We explored how vitamin K2, specifically its natural form MK-7, affects type 2 diabetes management through its impact on gut bacteria. To dive deeper into this question, we conducted a six-month randomized controlled trial involving 60 participants with type 2 diabetes. We compared those receiving MK-7 supplementation to a control group and analyzed their health markers, including blood glucose and insulin levels.
After the six months, we observed significant reductions in fasting serum glucose, insulin, and HbA1c levels among participants taking MK-7. This suggests that vitamin K2 might improve glycemic control and insulin sensitivity. Additionally, we investigated its effects further by transplanting gut microbiota from MK-7 supplemented individuals into mice with diet-induced obesity. The results were promising, showcasing improved glucose tolerance in these mice.
Importantly, we noted an increase in beneficial metabolites, like secondary bile acids and short-chain fatty acids, in both human and mouse feces. These metabolites are crucial as they can enhance metabolism and affect gut health. Overall, our findings reveal that vitamin K2 may play a significant role in diabetes management, potentially paving the way for its broader clinical application.
After the six months, we observed significant reductions in fasting serum glucose, insulin, and HbA1c levels among participants taking MK-7. This suggests that vitamin K2 might improve glycemic control and insulin sensitivity. Additionally, we investigated its effects further by transplanting gut microbiota from MK-7 supplemented individuals into mice with diet-induced obesity. The results were promising, showcasing improved glucose tolerance in these mice.
Importantly, we noted an increase in beneficial metabolites, like secondary bile acids and short-chain fatty acids, in both human and mouse feces. These metabolites are crucial as they can enhance metabolism and affect gut health. Overall, our findings reveal that vitamin K2 may play a significant role in diabetes management, potentially paving the way for its broader clinical application.
Read More
9
We examined the impact of Vitamin K2 (VK2) on the effects of high glucose in the context of type 2 diabetic osteoporosis (T2DOP). Our research was conducted using a mouse model that mimicked diabetes and a high-fat diet, alongside laboratory cultures of bone marrow stem cells in a high-glucose environment.
Through our experiments, we discovered that VK2 not only helped reduce bone loss linked to high glucose levels but also counteracted a specific type of cell death known as ferroptosis. This was evident as VK2 treatments led to lower levels of harmful compounds like reactive oxygen species and lipid peroxidation in the bone cells.
Further analysis revealed that VK2 enhanced bone health by boosting key proteins involved in cell survival and bone formation, such as SIRT1 and GPX4. Additionally, we identified that VK2 activates a crucial signaling pathway, AMPK/SIRT1, which plays a significant role in protecting bone cells from damage caused by high glucose.
Overall, our findings suggest that VK2 could represent a promising approach for mitigating diabetes-related bone health issues by targeting the mechanisms of cell death influenced by nutritional factors.
Through our experiments, we discovered that VK2 not only helped reduce bone loss linked to high glucose levels but also counteracted a specific type of cell death known as ferroptosis. This was evident as VK2 treatments led to lower levels of harmful compounds like reactive oxygen species and lipid peroxidation in the bone cells.
Further analysis revealed that VK2 enhanced bone health by boosting key proteins involved in cell survival and bone formation, such as SIRT1 and GPX4. Additionally, we identified that VK2 activates a crucial signaling pathway, AMPK/SIRT1, which plays a significant role in protecting bone cells from damage caused by high glucose.
Overall, our findings suggest that VK2 could represent a promising approach for mitigating diabetes-related bone health issues by targeting the mechanisms of cell death influenced by nutritional factors.
Read More
8
We investigated how Vitamin K2 might help mitigate cognitive decline associated with diabetes. Our study focused on a group of adult Swiss albino mice, which we induced with diabetes through a high-fat diet and a low dose of streptozotocin, a compound known to cause diabetes. After confirming the onset of diabetes, we administered Vitamin K2 to one group of these diabetic mice for three weeks while monitoring various health indicators and cognitive functions through behavioral tests.
The results were promising. We observed that Vitamin K2 treatment led to reductions in blood glucose levels and improved measures of cognitive performance. Specifically, it seemed to reverse some of the cognitive decline experienced by the diabetic mice. This improvement was linked to a reduction in neuroinflammation and oxidative stress, which are known to damage brain cells over time. Alongside this, we found that Vitamin K2 increased the density of important neurons in the brain regions associated with memory and learning.
Overall, we concluded that Vitamin K2 exhibits potential benefits for cognitive health in diabetic conditions, highlighting its role in enhancing neuronal health while diminishing inflammation and oxidative damage in the brain.
The results were promising. We observed that Vitamin K2 treatment led to reductions in blood glucose levels and improved measures of cognitive performance. Specifically, it seemed to reverse some of the cognitive decline experienced by the diabetic mice. This improvement was linked to a reduction in neuroinflammation and oxidative stress, which are known to damage brain cells over time. Alongside this, we found that Vitamin K2 increased the density of important neurons in the brain regions associated with memory and learning.
Overall, we concluded that Vitamin K2 exhibits potential benefits for cognitive health in diabetic conditions, highlighting its role in enhancing neuronal health while diminishing inflammation and oxidative damage in the brain.
Read More
8
Vitamin K2 may reduce arterial stiffness
We conducted a multicenter randomized clinical trial to examine the effectiveness of vitamin K2 (menaquinone-7, or MK-7) supplementation in patients undergoing chronic hemodialysis who also have diabetes. With a total of 96 participants, we divided them into two groups: one receiving daily doses of MK-7 and the other receiving standard care.
Over 24 weeks, we measured changes in arterial stiffness, specifically using carotid-femoral pulse wave velocity (cfPWV) as our main indicator. While we didn't find a significant difference overall in cfPWV reduction between the MK-7 group and the control group, a notable discovery emerged for participants with diabetes. In this subgroup, MK-7 supplementation led to a 10% reduction in cfPWV while the control group showed a slight increase.
Additionally, the MK-7 group experienced a lower rate of arterial stiffness progression compared to those receiving standard care, particularly among diabetic patients. While our findings underscore the promising potential of vitamin K2 in helping to manage arterial stiffness in diabetes patients on dialysis, further research is necessary to explore its broader cardiovascular benefits.
Over 24 weeks, we measured changes in arterial stiffness, specifically using carotid-femoral pulse wave velocity (cfPWV) as our main indicator. While we didn't find a significant difference overall in cfPWV reduction between the MK-7 group and the control group, a notable discovery emerged for participants with diabetes. In this subgroup, MK-7 supplementation led to a 10% reduction in cfPWV while the control group showed a slight increase.
Additionally, the MK-7 group experienced a lower rate of arterial stiffness progression compared to those receiving standard care, particularly among diabetic patients. While our findings underscore the promising potential of vitamin K2 in helping to manage arterial stiffness in diabetes patients on dialysis, further research is necessary to explore its broader cardiovascular benefits.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective for diabetes
1 people found this helpful
Pretty good. I would recommend this product for individuals with diabetes. I noticed a change after 4 weeks.
Read More
9
Promotes bone health
MK-7 Vitamin K-2 is a form of vitamin K with beneficial effects in osteoporosis, cardiovascular disease, inflammation, cancer, Alzheimer’s disease, and diabetes. It supports healthy bones and halts arterial thickening. A high intake of K2 helped reduce body weight and abdominal fat in postmenopausal women. This product is high quality, soy-free, and derived from natto, remaining active in the body longer. The capsule size is perfect.
Read More
9
Recommended for diabetes
Great for type 2 diabetes. We take one potassium capsule as prescribed by a doctor on a continual basis, combined with D3 and omega 3.
Read More
7.5
Improves insulin production
For diabetes, this product offers a good dosage. It increases insulin production and is beneficial in the complex treatment of diabetes, as recommended by my endocrinologist. There is definitely a benefit.
Read More
7.5
Lowered cholesterol
311 people found this helpful
I have struggled with high cholesterol for years, and despite a healthy lifestyle, my condition worsened. After starting statins, my issues escalated, including muscle pain and elevated A1C levels. Following my sibling's heart attack, I researched and began K-2 supplements. Within four months, my cholesterol returned to normal, allowing me to stop taking statins. I aim to normalise my A1C now. I feel everything in our bodies is interconnected, and I need to care for my blood sugar.
Read More
Frequently Asked Questions
7.5
Effective for diabetes
1 people found this helpful
Pretty good. I would recommend this product for individuals with diabetes. I noticed a change after 4 weeks.
7.5
Improves insulin production
For diabetes, this product offers a good dosage. It increases insulin production and is beneficial in the complex treatment of diabetes, as recommended by my endocrinologist. There is definitely a benefit.
9
Promotes bone health
MK-7 Vitamin K-2 is a form of vitamin K with beneficial effects in osteoporosis, cardiovascular disease, inflammation, cancer, Alzheimer’s disease, and diabetes. It supports healthy bones and halts arterial thickening. A high intake of K2 helped reduce body weight and abdominal fat in postmenopausal women. This product is high quality, soy-free, and derived from natto, remaining active in the body longer. The capsule size is perfect.
9
Recommended for diabetes
Great for type 2 diabetes. We take one potassium capsule as prescribed by a doctor on a continual basis, combined with D3 and omega 3.
7.5
Mitigates calcium deposition
I take it with vitamin D3, as vitamin K2 prevents calcium from depositing on blood vessel walls. The capsule is small, with a daily dose of 100 μg, and has a neutral taste. It’s convenient to take in the morning, and the quality is excellent with a GMP certificate. One jar contains 60 capsules, lasting for two months. I take it for type 2 diabetes and cardiovascular disease. Highly recommend!
8
We dove into an intriguing study that explored how vitamin K2, specifically in the form of menaquinone-7 (MK-7), impacts individuals with type 2 diabetes (T2DM). This research was carefully designed as a double-blinded, placebo-controlled trial, providing reliable insights into its potential benefits.
Over a 12-week period, 68 people living with insulin-independent diabetes were either given 180 µg of MK-7 twice daily or a placebo. We closely tracked changes in fasting plasma glucose (FPG), insulin levels, and glycated hemoglobin (HbA1c), among other measurements.
By the end of the trial, we observed that those taking vitamin K2 experienced a notable decrease in both FPG and HbA1c levels, indicating an improvement in glycemic control. Remarkably, a greater number of participants in this group achieved target levels for these key indicators compared to those on the placebo. However, while insulin concentrations decreased somewhat, there were no significant differences compared to the placebo group after the trial ended. Additionally, MK-7 showed no impact on lipid profiles.
Overall, this study suggests that incorporating 360 µg of vitamin K2 daily may offer promising benefits for managing blood sugar levels in T2DM patients without influencing cholesterol or triglycerides.
Over a 12-week period, 68 people living with insulin-independent diabetes were either given 180 µg of MK-7 twice daily or a placebo. We closely tracked changes in fasting plasma glucose (FPG), insulin levels, and glycated hemoglobin (HbA1c), among other measurements.
By the end of the trial, we observed that those taking vitamin K2 experienced a notable decrease in both FPG and HbA1c levels, indicating an improvement in glycemic control. Remarkably, a greater number of participants in this group achieved target levels for these key indicators compared to those on the placebo. However, while insulin concentrations decreased somewhat, there were no significant differences compared to the placebo group after the trial ended. Additionally, MK-7 showed no impact on lipid profiles.
Overall, this study suggests that incorporating 360 µg of vitamin K2 daily may offer promising benefits for managing blood sugar levels in T2DM patients without influencing cholesterol or triglycerides.
4
No insulin sensitivity improvement observed
We conducted a study to investigate how vitamin K2, specifically in the form of menaquinone-7 (MK-7), affects insulin sensitivity in postmenopausal women. By enrolling 148 participants, we divided them into two groups: one received a daily dose of 375 µg of MK-7, while the other was given a placebo. Both groups were also supplemented with calcium and vitamin D for 12 months.
Throughout the study, we measured key indicators, including undercarboxylated osteocalcin (ucOC), insulin sensitivity through HOMA-IR assessments, and levels of plasma adiponectin and leptin. Our findings revealed that while MK-7 treatment significantly decreased ucOC levels and increased adiponectin, there was no notable change in insulin sensitivity between the groups.
This indicates that, despite the positive changes seen in related biomarkers, MK-7 did not lead to improvements in insulin sensitivity for these healthy postmenopausal women. As such, the notion that ucOC plays a direct role in enhancing insulin responsiveness may not hold true in our findings.
Throughout the study, we measured key indicators, including undercarboxylated osteocalcin (ucOC), insulin sensitivity through HOMA-IR assessments, and levels of plasma adiponectin and leptin. Our findings revealed that while MK-7 treatment significantly decreased ucOC levels and increased adiponectin, there was no notable change in insulin sensitivity between the groups.
This indicates that, despite the positive changes seen in related biomarkers, MK-7 did not lead to improvements in insulin sensitivity for these healthy postmenopausal women. As such, the notion that ucOC plays a direct role in enhancing insulin responsiveness may not hold true in our findings.
8
Vitamin K2 may reduce arterial stiffness
We conducted a multicenter randomized clinical trial to examine the effectiveness of vitamin K2 (menaquinone-7, or MK-7) supplementation in patients undergoing chronic hemodialysis who also have diabetes. With a total of 96 participants, we divided them into two groups: one receiving daily doses of MK-7 and the other receiving standard care.
Over 24 weeks, we measured changes in arterial stiffness, specifically using carotid-femoral pulse wave velocity (cfPWV) as our main indicator. While we didn't find a significant difference overall in cfPWV reduction between the MK-7 group and the control group, a notable discovery emerged for participants with diabetes. In this subgroup, MK-7 supplementation led to a 10% reduction in cfPWV while the control group showed a slight increase.
Additionally, the MK-7 group experienced a lower rate of arterial stiffness progression compared to those receiving standard care, particularly among diabetic patients. While our findings underscore the promising potential of vitamin K2 in helping to manage arterial stiffness in diabetes patients on dialysis, further research is necessary to explore its broader cardiovascular benefits.
Over 24 weeks, we measured changes in arterial stiffness, specifically using carotid-femoral pulse wave velocity (cfPWV) as our main indicator. While we didn't find a significant difference overall in cfPWV reduction between the MK-7 group and the control group, a notable discovery emerged for participants with diabetes. In this subgroup, MK-7 supplementation led to a 10% reduction in cfPWV while the control group showed a slight increase.
Additionally, the MK-7 group experienced a lower rate of arterial stiffness progression compared to those receiving standard care, particularly among diabetic patients. While our findings underscore the promising potential of vitamin K2 in helping to manage arterial stiffness in diabetes patients on dialysis, further research is necessary to explore its broader cardiovascular benefits.
8
We explored the intriguing relationship between vitamin K2 and type 2 diabetes, looking closely at various studies conducted on this topic. Our findings come from a systemic review that analyzed research articles up to November 2018, focusing on how vitamin K2 may influence diabetes and related health markers in individuals.
Among the studies reviewed, six observational studies were particularly telling. They showed that higher intake of dietary vitamin K and increased plasma levels of vitamin K were linked to a lower risk of developing type 2 diabetes. In addition, six clinical intervention studies suggested that supplementing with vitamin K1 or K2 might positively impact insulin metabolism, which is vital for managing blood sugar levels.
Interestingly, one Mendelian randomization study proposed that higher circulation levels of vitamin K could potentially reduce the risk of type 2 diabetes significantly. These compelling findings indicate that vitamin K plays a prominent role in the prevention and control of this prevalent condition, especially as it pertains to improving insulin metabolism and regulating blood glucose levels.
While the studies suggest some positive effects of vitamin K2 for diabetes management, it’s important to note that they do not isolate the effects of vitamin K2 alone. This makes it somewhat challenging to determine the precise impact of vitamin K2 without additional research focused exclusively on this factor. Nevertheless, the overall evidence leans toward a beneficial role of vitamin K in diabetes management.
Among the studies reviewed, six observational studies were particularly telling. They showed that higher intake of dietary vitamin K and increased plasma levels of vitamin K were linked to a lower risk of developing type 2 diabetes. In addition, six clinical intervention studies suggested that supplementing with vitamin K1 or K2 might positively impact insulin metabolism, which is vital for managing blood sugar levels.
Interestingly, one Mendelian randomization study proposed that higher circulation levels of vitamin K could potentially reduce the risk of type 2 diabetes significantly. These compelling findings indicate that vitamin K plays a prominent role in the prevention and control of this prevalent condition, especially as it pertains to improving insulin metabolism and regulating blood glucose levels.
While the studies suggest some positive effects of vitamin K2 for diabetes management, it’s important to note that they do not isolate the effects of vitamin K2 alone. This makes it somewhat challenging to determine the precise impact of vitamin K2 without additional research focused exclusively on this factor. Nevertheless, the overall evidence leans toward a beneficial role of vitamin K in diabetes management.
References
- Mrosewski I, Mantel V, Urbank M, Schulze-Tanzil G, Werner C, et al. Menaquinone-7 and its therapeutic potential in type 2 diabetes mellitus based on a Zucker diabetic fatty rat model. Heliyon. 2024;10:e40826. doi:10.1016/j.heliyon.2024.e40826
- Chatterjee K, Pal A, Padhy DS, Saha R, Chatterjee A, et al. Vitamin K2 Ameliorates Diabetes-Associated Cognitive Decline by Reducing Oxidative Stress and Neuroinflammation. J Neuroimmune Pharmacol. 2024;19:56. doi:10.1007/s11481-024-10156-4
- Duman I, Tanrıverdi G, Öztürk Özener H. Effects of vitamin K2 administration on guided bone regeneration in diabetic rats. J Periodontal Res. 2024;59:993. doi:10.1111/jre.13287
- Farahbod K, Slouha E, Gerts A, Rezazadah A, Clunes LA, et al. The Effects of Diet Intervention on the Gut Microbiota in Type 2 Diabetes Mellitus: A Systematic Review. Cureus. 2024;16:e56737. doi:10.7759/cureus.56737
- Mahmoud M, Kokozidou M, Gögele C, Werner C, Auffarth A, et al. Does Vitamin K2 Influence the Interplay between Diabetes Mellitus and Intervertebral Disc Degeneration in a Rat Model?. Nutrients. 2023;15. doi:10.3390/nu15132872
- Naiyarakseree N, Phannajit J, Naiyarakseree W, Mahatanan N, Asavapujanamanee P, et al. Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15112422
- Zhang Y, Liu L, Wei C, Wang X, Li R, et al. Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites. BMC Med. 2023;21:174. doi:10.1186/s12916-023-02880-0
- Jin C, Tan K, Yao Z, Lin BH, Zhang DP, et al. A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. J Agric Food Chem. 2023;71:2745. doi:10.1021/acs.jafc.2c05632
- Karamzad N, Faraji E, Adeli S, Sullman MJM, Pourghassem Gargari B. The effect of menaquinone-7 supplementation on dp-ucMGP, PIVKAII, inflammatory markers, and body composition in type 2 diabetes patients: a randomized clinical trial. Nutr Diabetes. 2022;12:15. doi:10.1038/s41387-022-00192-5
- Kołakowski A, Kurzyna PF, Bzdęga W, Żywno H, Harasim-Symbor E, et al. Influence of vitamin K2 on lipid precursors of inflammation and fatty acids pathway activities in HepG2 cells. Eur J Cell Biol. 2021;100:151188. doi:10.1016/j.ejcb.2021.151188
- Rønn SH, Harsløf T, Pedersen SB, Langdahl BL. Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial. Eur J Clin Nutr. 2021;75:1661. doi:10.1038/s41430-021-00884-8
- Rahimi Sakak F, Moslehi N, Niroomand M, Mirmiran P. Glycemic control improvement in individuals with type 2 diabetes with vitamin K supplementation: a randomized controlled trial. Eur J Nutr. 2021;60:2495. doi:10.1007/s00394-020-02419-6
- Aguayo-Ruiz JI, García-Cobián TA, Pascoe-González S, Sánchez-Enríquez S, Llamas-Covarrubias IM, et al. Effect of supplementation with vitamins D3 and K2 on undercarboxylated osteocalcin and insulin serum levels in patients with type 2 diabetes mellitus: a randomized, double-blind, clinical trial. Diabetol Metab Syndr. 2020;12:73. doi:10.1186/s13098-020-00580-w
- Cao AL, Lai YW, Chen HG, Sheng LT, Pan A. [Research progress of relationship between vitamin K and type 2 diabetes]. Zhonghua Yu Fang Yi Xue Za Zhi. 2020;54:555. doi:10.3760/cma.j.cn112150-20190520-00407
- Takx RAP, van Asperen R, Bartstra JW, Zwakenberg SR, Wolterink JM, et al. Determinants of F-NaF uptake in femoral arteries in patients with type 2 diabetes mellitus. J Nucl Cardiol. 2021;28:2700. doi:10.1007/s12350-020-02099-z
