' 
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin K2(as Menaquinone-7) (MK-7 ) (MenaQ7®)
100 mcg
**
Top Medical Research Studies
9
Vitamin K2 aids bone healing
Effects of vitamin K2 administration on guided bone regeneration in diabetic rats.
Strong relevance to diabetes treatment.
We studied how vitamin K2 influences bone regeneration in diabetic rats, especially focusing on its effects on healing critical-size defects in the skull. In our experiment, we included both non-diabetic and diabetic rats to see how this vitamin fares in conditions known to hinder healing.
With a diverse set of control and experimental groups, we treated some rats with vitamin K2 while others received a saline solution. After four weeks, we assessed bone healing through various tests, including looking at new bone formation and specific proteins linked to bone health.
The results were promising! We found that vitamin K2 significantly enhanced bone healing, especially when combined with a bone graft. New bone formation was notably higher in the groups treated with vitamin K2 compared to those that weren’t. Moreover, levels of osteocalcin and osteopontin—two key markers for bone health—were also elevated in these groups.
Overall, our findings suggest that vitamin K2 could be a beneficial addition to treatments aimed at improving bone regeneration in diabetic patients. This avenue offers interesting possibilities for enhancing recovery strategies in individuals with similar conditions.
With a diverse set of control and experimental groups, we treated some rats with vitamin K2 while others received a saline solution. After four weeks, we assessed bone healing through various tests, including looking at new bone formation and specific proteins linked to bone health.
The results were promising! We found that vitamin K2 significantly enhanced bone healing, especially when combined with a bone graft. New bone formation was notably higher in the groups treated with vitamin K2 compared to those that weren’t. Moreover, levels of osteocalcin and osteopontin—two key markers for bone health—were also elevated in these groups.
Overall, our findings suggest that vitamin K2 could be a beneficial addition to treatments aimed at improving bone regeneration in diabetic patients. This avenue offers interesting possibilities for enhancing recovery strategies in individuals with similar conditions.
Read More
9
Vitamin K2 aids diabetes management
Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.
High relevance for diabetes treatment
We explored how vitamin K2, specifically its natural form MK-7, affects type 2 diabetes management through its impact on gut bacteria. To dive deeper into this question, we conducted a six-month randomized controlled trial involving 60 participants with type 2 diabetes. We compared those receiving MK-7 supplementation to a control group and analyzed their health markers, including blood glucose and insulin levels.
After the six months, we observed significant reductions in fasting serum glucose, insulin, and HbA1c levels among participants taking MK-7. This suggests that vitamin K2 might improve glycemic control and insulin sensitivity. Additionally, we investigated its effects further by transplanting gut microbiota from MK-7 supplemented individuals into mice with diet-induced obesity. The results were promising, showcasing improved glucose tolerance in these mice.
Importantly, we noted an increase in beneficial metabolites, like secondary bile acids and short-chain fatty acids, in both human and mouse feces. These metabolites are crucial as they can enhance metabolism and affect gut health. Overall, our findings reveal that vitamin K2 may play a significant role in diabetes management, potentially paving the way for its broader clinical application.
After the six months, we observed significant reductions in fasting serum glucose, insulin, and HbA1c levels among participants taking MK-7. This suggests that vitamin K2 might improve glycemic control and insulin sensitivity. Additionally, we investigated its effects further by transplanting gut microbiota from MK-7 supplemented individuals into mice with diet-induced obesity. The results were promising, showcasing improved glucose tolerance in these mice.
Importantly, we noted an increase in beneficial metabolites, like secondary bile acids and short-chain fatty acids, in both human and mouse feces. These metabolites are crucial as they can enhance metabolism and affect gut health. Overall, our findings reveal that vitamin K2 may play a significant role in diabetes management, potentially paving the way for its broader clinical application.
Read More
8
Vitamin K2 improves diabetes cognitive decline
Vitamin K2 Ameliorates Diabetes-Associated Cognitive Decline by Reducing Oxidative Stress and Neuroinflammation.
Direct focus on Vitamin K2 effects
We investigated how Vitamin K2 might help mitigate cognitive decline associated with diabetes. Our study focused on a group of adult Swiss albino mice, which we induced with diabetes through a high-fat diet and a low dose of streptozotocin, a compound known to cause diabetes. After confirming the onset of diabetes, we administered Vitamin K2 to one group of these diabetic mice for three weeks while monitoring various health indicators and cognitive functions through behavioral tests.
The results were promising. We observed that Vitamin K2 treatment led to reductions in blood glucose levels and improved measures of cognitive performance. Specifically, it seemed to reverse some of the cognitive decline experienced by the diabetic mice. This improvement was linked to a reduction in neuroinflammation and oxidative stress, which are known to damage brain cells over time. Alongside this, we found that Vitamin K2 increased the density of important neurons in the brain regions associated with memory and learning.
Overall, we concluded that Vitamin K2 exhibits potential benefits for cognitive health in diabetic conditions, highlighting its role in enhancing neuronal health while diminishing inflammation and oxidative damage in the brain.
The results were promising. We observed that Vitamin K2 treatment led to reductions in blood glucose levels and improved measures of cognitive performance. Specifically, it seemed to reverse some of the cognitive decline experienced by the diabetic mice. This improvement was linked to a reduction in neuroinflammation and oxidative stress, which are known to damage brain cells over time. Alongside this, we found that Vitamin K2 increased the density of important neurons in the brain regions associated with memory and learning.
Overall, we concluded that Vitamin K2 exhibits potential benefits for cognitive health in diabetic conditions, highlighting its role in enhancing neuronal health while diminishing inflammation and oxidative damage in the brain.
Read More
Most Useful Reviews
8.8
Lowered cholesterol
I have struggled with high cholesterol for years, and despite a healthy lifestyle, my condition worsened. After starting statins, my issues escalated, including muscle pain and elevated A1C levels. Following my sibling's heart attack, I researched and began K-2 supplements. Within four months, my cholesterol returned to normal, allowing me to stop taking statins. I aim to normalise my A1C now. I feel everything in our bodies is interconnected, and I need to care for my blood sugar.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 15 Researches
6.9
9
Vitamin K2 aids bone healing
Effects of vitamin K2 administration on guided bone regeneration in diabetic rats.
Strong relevance to diabetes treatment.
We studied how vitamin K2 influences bone regeneration in diabetic rats, especially focusing on its effects on healing critical-size defects in the skull. In our experiment, we included both non-diabetic and diabetic rats to see how this vitamin fares in conditions known to hinder healing.
With a diverse set of control and experimental groups, we treated some rats with vitamin K2 while others received a saline solution. After four weeks, we assessed bone healing through various tests, including looking at new bone formation and specific proteins linked to bone health.
The results were promising! We found that vitamin K2 significantly enhanced bone healing, especially when combined with a bone graft. New bone formation was notably higher in the groups treated with vitamin K2 compared to those that weren’t. Moreover, levels of osteocalcin and osteopontin—two key markers for bone health—were also elevated in these groups.
Overall, our findings suggest that vitamin K2 could be a beneficial addition to treatments aimed at improving bone regeneration in diabetic patients. This avenue offers interesting possibilities for enhancing recovery strategies in individuals with similar conditions.
With a diverse set of control and experimental groups, we treated some rats with vitamin K2 while others received a saline solution. After four weeks, we assessed bone healing through various tests, including looking at new bone formation and specific proteins linked to bone health.
The results were promising! We found that vitamin K2 significantly enhanced bone healing, especially when combined with a bone graft. New bone formation was notably higher in the groups treated with vitamin K2 compared to those that weren’t. Moreover, levels of osteocalcin and osteopontin—two key markers for bone health—were also elevated in these groups.
Overall, our findings suggest that vitamin K2 could be a beneficial addition to treatments aimed at improving bone regeneration in diabetic patients. This avenue offers interesting possibilities for enhancing recovery strategies in individuals with similar conditions.
Read More
9
Vitamin K2 aids diabetes management
Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.
High relevance for diabetes treatment
We explored how vitamin K2, specifically its natural form MK-7, affects type 2 diabetes management through its impact on gut bacteria. To dive deeper into this question, we conducted a six-month randomized controlled trial involving 60 participants with type 2 diabetes. We compared those receiving MK-7 supplementation to a control group and analyzed their health markers, including blood glucose and insulin levels.
After the six months, we observed significant reductions in fasting serum glucose, insulin, and HbA1c levels among participants taking MK-7. This suggests that vitamin K2 might improve glycemic control and insulin sensitivity. Additionally, we investigated its effects further by transplanting gut microbiota from MK-7 supplemented individuals into mice with diet-induced obesity. The results were promising, showcasing improved glucose tolerance in these mice.
Importantly, we noted an increase in beneficial metabolites, like secondary bile acids and short-chain fatty acids, in both human and mouse feces. These metabolites are crucial as they can enhance metabolism and affect gut health. Overall, our findings reveal that vitamin K2 may play a significant role in diabetes management, potentially paving the way for its broader clinical application.
After the six months, we observed significant reductions in fasting serum glucose, insulin, and HbA1c levels among participants taking MK-7. This suggests that vitamin K2 might improve glycemic control and insulin sensitivity. Additionally, we investigated its effects further by transplanting gut microbiota from MK-7 supplemented individuals into mice with diet-induced obesity. The results were promising, showcasing improved glucose tolerance in these mice.
Importantly, we noted an increase in beneficial metabolites, like secondary bile acids and short-chain fatty acids, in both human and mouse feces. These metabolites are crucial as they can enhance metabolism and affect gut health. Overall, our findings reveal that vitamin K2 may play a significant role in diabetes management, potentially paving the way for its broader clinical application.
Read More
9
VK2 prevents diabetes-related bone loss
A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis.
Directly addresses diabetes impact
We examined the impact of Vitamin K2 (VK2) on the effects of high glucose in the context of type 2 diabetic osteoporosis (T2DOP). Our research was conducted using a mouse model that mimicked diabetes and a high-fat diet, alongside laboratory cultures of bone marrow stem cells in a high-glucose environment.
Through our experiments, we discovered that VK2 not only helped reduce bone loss linked to high glucose levels but also counteracted a specific type of cell death known as ferroptosis. This was evident as VK2 treatments led to lower levels of harmful compounds like reactive oxygen species and lipid peroxidation in the bone cells.
Further analysis revealed that VK2 enhanced bone health by boosting key proteins involved in cell survival and bone formation, such as SIRT1 and GPX4. Additionally, we identified that VK2 activates a crucial signaling pathway, AMPK/SIRT1, which plays a significant role in protecting bone cells from damage caused by high glucose.
Overall, our findings suggest that VK2 could represent a promising approach for mitigating diabetes-related bone health issues by targeting the mechanisms of cell death influenced by nutritional factors.
Through our experiments, we discovered that VK2 not only helped reduce bone loss linked to high glucose levels but also counteracted a specific type of cell death known as ferroptosis. This was evident as VK2 treatments led to lower levels of harmful compounds like reactive oxygen species and lipid peroxidation in the bone cells.
Further analysis revealed that VK2 enhanced bone health by boosting key proteins involved in cell survival and bone formation, such as SIRT1 and GPX4. Additionally, we identified that VK2 activates a crucial signaling pathway, AMPK/SIRT1, which plays a significant role in protecting bone cells from damage caused by high glucose.
Overall, our findings suggest that VK2 could represent a promising approach for mitigating diabetes-related bone health issues by targeting the mechanisms of cell death influenced by nutritional factors.
Read More
8
Vitamin K2 improves diabetes cognitive decline
Vitamin K2 Ameliorates Diabetes-Associated Cognitive Decline by Reducing Oxidative Stress and Neuroinflammation.
Direct focus on Vitamin K2 effects
We investigated how Vitamin K2 might help mitigate cognitive decline associated with diabetes. Our study focused on a group of adult Swiss albino mice, which we induced with diabetes through a high-fat diet and a low dose of streptozotocin, a compound known to cause diabetes. After confirming the onset of diabetes, we administered Vitamin K2 to one group of these diabetic mice for three weeks while monitoring various health indicators and cognitive functions through behavioral tests.
The results were promising. We observed that Vitamin K2 treatment led to reductions in blood glucose levels and improved measures of cognitive performance. Specifically, it seemed to reverse some of the cognitive decline experienced by the diabetic mice. This improvement was linked to a reduction in neuroinflammation and oxidative stress, which are known to damage brain cells over time. Alongside this, we found that Vitamin K2 increased the density of important neurons in the brain regions associated with memory and learning.
Overall, we concluded that Vitamin K2 exhibits potential benefits for cognitive health in diabetic conditions, highlighting its role in enhancing neuronal health while diminishing inflammation and oxidative damage in the brain.
The results were promising. We observed that Vitamin K2 treatment led to reductions in blood glucose levels and improved measures of cognitive performance. Specifically, it seemed to reverse some of the cognitive decline experienced by the diabetic mice. This improvement was linked to a reduction in neuroinflammation and oxidative stress, which are known to damage brain cells over time. Alongside this, we found that Vitamin K2 increased the density of important neurons in the brain regions associated with memory and learning.
Overall, we concluded that Vitamin K2 exhibits potential benefits for cognitive health in diabetic conditions, highlighting its role in enhancing neuronal health while diminishing inflammation and oxidative damage in the brain.
Read More
8
Vitamin K2 may reduce arterial stiffness
Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial.
Findings specifically address diabetes
We conducted a multicenter randomized clinical trial to examine the effectiveness of vitamin K2 (menaquinone-7, or MK-7) supplementation in patients undergoing chronic hemodialysis who also have diabetes. With a total of 96 participants, we divided them into two groups: one receiving daily doses of MK-7 and the other receiving standard care.
Over 24 weeks, we measured changes in arterial stiffness, specifically using carotid-femoral pulse wave velocity (cfPWV) as our main indicator. While we didn't find a significant difference overall in cfPWV reduction between the MK-7 group and the control group, a notable discovery emerged for participants with diabetes. In this subgroup, MK-7 supplementation led to a 10% reduction in cfPWV while the control group showed a slight increase.
Additionally, the MK-7 group experienced a lower rate of arterial stiffness progression compared to those receiving standard care, particularly among diabetic patients. While our findings underscore the promising potential of vitamin K2 in helping to manage arterial stiffness in diabetes patients on dialysis, further research is necessary to explore its broader cardiovascular benefits.
Over 24 weeks, we measured changes in arterial stiffness, specifically using carotid-femoral pulse wave velocity (cfPWV) as our main indicator. While we didn't find a significant difference overall in cfPWV reduction between the MK-7 group and the control group, a notable discovery emerged for participants with diabetes. In this subgroup, MK-7 supplementation led to a 10% reduction in cfPWV while the control group showed a slight increase.
Additionally, the MK-7 group experienced a lower rate of arterial stiffness progression compared to those receiving standard care, particularly among diabetic patients. While our findings underscore the promising potential of vitamin K2 in helping to manage arterial stiffness in diabetes patients on dialysis, further research is necessary to explore its broader cardiovascular benefits.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Lowered cholesterol
I have struggled with high cholesterol for years, and despite a healthy lifestyle, my condition worsened. After starting statins, my issues escalated, including muscle pain and elevated A1C levels. Following my sibling's heart attack, I researched and began K-2 supplements. Within four months, my cholesterol returned to normal, allowing me to stop taking statins. I aim to normalise my A1C now. I feel everything in our bodies is interconnected, and I need to care for my blood sugar.
Read More
