Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
USERS' SCORE
Good
Based on 70 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin K2(as Menaquinone-7) (MK-7 ) (MenaQ7®)
100 mcg
**

Top Medical Research Studies

9
Vitamin K2 supports BMD in osteoporosis
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.

The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.

While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
8
Vitamin K2 may support bone health
We delved into the effects of vitamin K2 on postmenopausal osteoporosis by reviewing data from 16 randomized controlled trials with over 6,400 participants.

Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.

However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
Read More
9
MK-4 enhances bone health
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.

Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.

Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More

Most Useful Reviews

9
Reduces osteoporosis risk
420 people found this helpful
Vitamin K2 (MK-7) is essential for treating osteoporosis by removing calcium from arteries and directing it to bones. I take it regularly with vitamin D3 to strengthen my bones. In high doses, it lowers cholesterol and prevents vascular calcification. The 100 mcg dosage is optimal, and the packaging is intact. It could be cheaper, though!
Read More
9
Supports osteoporosis management
140 people found this helpful
I recommend 180 mcg of vitamin K2 (MK-7) daily for postmenopausal women and older men, especially those on statins, as it enhances calcium absorption and may reduce coronary heart disease mortality. Vitamin K2 is vital for bone strength and prevents osteoporosis. Coupled with vitamin D, it assists in effective calcium utilisation.
Read More
7.5
Enhances calcium absorption
53 people found this helpful
At 38, I've noticed stronger teeth and improved calcium absorption thanks to vitamin K2 (MK-7). It associates with vitamin D3, preventing calcium build-up in soft tissues and effectively transporting it to bones and teeth. This often-overlooked vitamin has been crucial for my health.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
  • All Researches
9
Vitamin K2 supports BMD in osteoporosis
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.

The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.

While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
9
MK-4 enhances bone health
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.

Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.

Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More
9
Vitamin K2 enhances osteoporosis treatment
We aimed to understand how vitamin K2 influences osteoporosis, especially when combined with another treatment known as recombinant human parathyroid hormone 1-34 (rhPTH (1-34)).

In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.

Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.

Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
Read More
We explored the role of UBIAD1, an enzyme crucial for converting dietary vitamin K into its active form, MK-4, in the context of bone health and osteoporosis. The study involved a special mouse model where UBIAD1 was intentionally disabled from the first week of life. This allowed us to observe the effects of reduced UBIAD1 activity on bone development.

Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.

These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
Read More
9
Vitamin K2 promotes bone health
We aimed to investigate how vitamin K2 (VK2), a small but powerful nutrient, can enhance osteogenic differentiation, which is crucial for bone health and may help counteract osteoporosis. Using C3H10 T1/2 clone 8 cells, we examined the effects of VK2 on various markers associated with bone generation.

Our results showed that VK2 significantly boosted alkaline phosphatase activity and increased levels of key osteogenic indicators such as osteocalcin and RUNX2. We also conducted RNA sequencing to identify how VK2 triggers these changes, uncovering numerous genes that were impacted by its administration.

Notably, we found that VK2 not only elevated signals associated with bone formation but also influenced specific signaling pathways. It seemed to work by reducing the expression of STAT1 through the Bcl-6 and IL-6/JAK signaling pathways. This means that VK2 may enhance bone growth by modulating the intricate network of biological signals involved in bone development.

Overall, our findings suggest that vitamin K2 could play a beneficial role in promoting bone health through its action on crucial biological pathways, hinting at its potential as a supportive treatment for osteoporosis.
Read More

User Reviews

USERS' SCORE
Good
Based on 70 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduces osteoporosis risk
420 people found this helpful
Vitamin K2 (MK-7) is essential for treating osteoporosis by removing calcium from arteries and directing it to bones. I take it regularly with vitamin D3 to strengthen my bones. In high doses, it lowers cholesterol and prevents vascular calcification. The 100 mcg dosage is optimal, and the packaging is intact. It could be cheaper, though!
Read More
9
Supports osteoporosis management
140 people found this helpful
I recommend 180 mcg of vitamin K2 (MK-7) daily for postmenopausal women and older men, especially those on statins, as it enhances calcium absorption and may reduce coronary heart disease mortality. Vitamin K2 is vital for bone strength and prevents osteoporosis. Coupled with vitamin D, it assists in effective calcium utilisation.
Read More
7.5
Enhances calcium absorption
53 people found this helpful
At 38, I've noticed stronger teeth and improved calcium absorption thanks to vitamin K2 (MK-7). It associates with vitamin D3, preventing calcium build-up in soft tissues and effectively transporting it to bones and teeth. This often-overlooked vitamin has been crucial for my health.
Read More
7.5
Improves bone health
36 people found this helpful
I've seen a notable improvement in calcium absorption and stronger teeth at 38, thanks to vitamin K2 (MK-7). It works with vitamin D3 for effective calcium transport to bones and teeth, helping avoid calcium deposits in soft tissues.
Read More
9
Strengthens bones
28 people found this helpful
I take vitamin K2 (MK-7) during menopause to combat osteoporosis. It helps the body absorb calcium while also removing crystallised calcium from blood vessels. After two months, I feel my bones are denser and healthier.
Read More

Frequently Asked Questions

9
Strengthens bones
28 people found this helpful
I take vitamin K2 (MK-7) during menopause to combat osteoporosis. It helps the body absorb calcium while also removing crystallised calcium from blood vessels. After two months, I feel my bones are denser and healthier.
9
Osteoporosis reversed
1 people found this helpful
This is a great product to pair with vitamin D3. After being diagnosed with osteoporosis, I took MK7 and vitamin D3 daily for two years. At my latest checkup, the doctor was surprised to find I no longer had osteoporosis.
9
Osteoporosis prevention
1 people found this helpful
I have been taking K2 for about 20 years as an alternative to Actonel, and I am pleased with the results. K2 helps me keep calcium in my bones, and I believe it has prevented osteoporosis. It’s one of many NOW products I use, with the correct dosage of ingredients.
10
Osteoporosis-free
4 people found this helpful
MK-7 is fantastic with vitamin D3! After two years of daily intake, my doctor was surprised that I am free from osteoporosis, despite not consuming dairy or calcium supplements. This combination truly works.
9
Reduces osteoporosis risk
420 people found this helpful
Vitamin K2 (MK-7) is essential for treating osteoporosis by removing calcium from arteries and directing it to bones. I take it regularly with vitamin D3 to strengthen my bones. In high doses, it lowers cholesterol and prevents vascular calcification. The 100 mcg dosage is optimal, and the packaging is intact. It could be cheaper, though!
7.5
Improves bone health
36 people found this helpful
I've seen a notable improvement in calcium absorption and stronger teeth at 38, thanks to vitamin K2 (MK-7). It works with vitamin D3 for effective calcium transport to bones and teeth, helping avoid calcium deposits in soft tissues.
9
Essential for health
14 people found this helpful
I find vitamin K2 (MK-7) vital for osteoporosis prevention, improving calcium absorption and artery health. Prioritising vitamins for health is essential, so I encourage others to invest in their well-being.
7.5
Boosts bone absorption
9 people found this helpful
I've taken vitamin D with K2 and magnesium for a long time to combat osteoporosis and joint pain. Vitamin K2 plays a vital role in bone health by enhancing calcium absorption and preventing harmful calcium deposits.
9
Prevents vascular calcification
1 people found this helpful
Vitamin K2 (MK-7) stands out because it does not increase blood clotting like other forms of K. It should be taken regularly with vitamin D3, as they together help prevent and reduce vascular calcification and osteoporosis.
9
Supports osteoporosis management
140 people found this helpful
I recommend 180 mcg of vitamin K2 (MK-7) daily for postmenopausal women and older men, especially those on statins, as it enhances calcium absorption and may reduce coronary heart disease mortality. Vitamin K2 is vital for bone strength and prevents osteoporosis. Coupled with vitamin D, it assists in effective calcium utilisation.
8
Vitamin K2 may support bone health
We delved into the effects of vitamin K2 on postmenopausal osteoporosis by reviewing data from 16 randomized controlled trials with over 6,400 participants.

Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.

However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
9
Vitamin K2 enhances osteoporosis treatment
We aimed to understand how vitamin K2 influences osteoporosis, especially when combined with another treatment known as recombinant human parathyroid hormone 1-34 (rhPTH (1-34)).

In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.

Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.

Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
8
VK2 combats diabetic osteoporosis mechanism
We explored how vitamin K2 (VK2) affects osteoporosis in the context of type 2 diabetes. By simulating a diabetic environment in our study, we found that VK2 can help prevent bone loss and cellular death caused by high glucose levels.

Through treatment, VK2 not only preserved bone mass but also boosted the activity of important proteins involved in cell survival. Overall, our findings suggest that VK2 shows promise as a therapeutic option for managing osteoporosis in diabetic patients by targeting specific signaling pathways.
4
Vitamin K shows modest hip geometry effects
We evaluated how vitamin K supplementation could impact fracture risk in post-menopausal women with osteoporosis, particularly when paired with bisphosphonates, calcium, and vitamin D. Although our study involved 105 women and used rigorous methods, we found no significant improvements in bone density or turnover.

Interestingly, vitamin K did show a modest effect on hip geometry, suggesting some potential benefits in this area. However, to truly understand its effectiveness, further studies are necessary to confirm these findings.

References

  1. Ding F, Zhang W, Liu T, Rong X, Cui Y, et al. MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells. Drug Des Devel Ther. 2025;19:2173. doi:10.2147/DDDT.S503930
  2. Wang Q, Yu H, Kong Y. Association of vitamins with bone mineral density and osteoporosis measured by dual-energy x-ray absorptiometry: a cross-sectional study. BMC Musculoskelet Disord. 2024;25:69. doi:10.1186/s12891-024-07173-y
  3. Öz İ, Kochai A, Avan YL, Keskin D, Çınar BM, et al. The effect of pharmacological treatment in combination with vitamin K on healing in an experimental rat model of osteoporosis. Jt Dis Relat Surg. 2023;34:356. doi:10.52312/jdrs.2023.911
  4. Moore AE, Dulnoan D, Voong K, Ayis S, Mangelis A, et al. The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial. Arch Osteoporos. 2023;18:83. doi:10.1007/s11657-023-01288-w
  5. Li C, Liang C, Kong Z, Su Y, Ren W, et al. Determination of Vitamin K1, MK-4, MK-7, and D Levels in Human Serum of Postmenopausal Osteoporosis Women Based on High Stability LC-MS/MS: MK-7 May Be a New Marker of Bone Metabolism. Ann Nutr Metab. 2023;79:334. doi:10.1159/000531065
  6. Giordani C, Matacchione G, Giuliani A, Valli D, Scarpa ES, et al. Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells. Int J Mol Sci. 2023;24. doi:10.3390/ijms24108820
  7. Lee AS, Sung MJ, Son SJ, Han AR, Hong SM, et al. Effect of Menaquinone-4 on Receptor Activator of Nuclear Factor B Ligand-Induced Osteoclast Differentiation and Ovariectomy-Induced Bone Loss. J Med Food. 2023;26:128. doi:10.1089/jmf.2022.K.0078
  8. Jin C, Tan K, Yao Z, Lin BH, Zhang DP, et al. A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. J Agric Food Chem. 2023;71:2745. doi:10.1021/acs.jafc.2c05632
  9. Tao X, Xu T, Liu L, Lin X, Zhang Z, et al. Case report: Clinical characteristics and treatment of secondary osteoporosis induced by X-linked congenital adrenal dysplasia. Front Endocrinol (Lausanne). 2022;13:961322. doi:10.3389/fendo.2022.961322
  10. Ma ML, Ma ZJ, He YL, Sun H, Yang B, et al. Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials. Front Public Health. 2022;10:979649. doi:10.3389/fpubh.2022.979649
  11. Zhou M, Han S, Zhang W, Wu D. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. J Bone Miner Metab. 2022;40:763. doi:10.1007/s00774-022-01342-6
  12. Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. doi:10.1097/BRS.0000000000004309
  13. Mandatori D, Penolazzi L, Pelusi L, Lambertini E, Michelucci F, et al. Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2. Nutrients. 2021;13. doi:10.3390/nu13082823
  14. Wang H, Zhang N, Li L, Yang P, Ma Y. Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling. Nutrients. 2021;13. doi:10.3390/nu13082570
  15. Wang B, Tang J, Weng S, Chen L, Wu Z, et al. Is vitamin K a treatment choice for atypical femoral fractures in patients with secondary osteoporosis?. J Int Med Res. 2021;49:3000605211001643. doi:10.1177/03000605211001643
  16. Solmaz I, Ozdemir MA, Unal E, Abdurrezzak U, Muhtaroglu S, et al. Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study. J Pediatr Endocrinol Metab. 2021;34:441. doi:10.1515/jpem-2020-0637
  17. Zhang Z, Xia K, Gong W, Mai R, Liu P, et al. Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis. Horm Metab Res. 2025;57:33. doi:10.1055/a-2371-1642
  18. Hirashima S, Kiyooka Y, Kaetsu S, Nakagawa K. Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice. Biochem Biophys Res Commun. 2024;702:149635. doi:10.1016/j.bbrc.2024.149635
  19. Kong M, Gao C, Luan X, Fan C, Hao M, et al. Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis. BMC Musculoskelet Disord. 2024;25:109. doi:10.1186/s12891-024-07227-1
  20. Skalny AV, Aschner M, Tsatsakis A, Rocha JBT, Santamaria A, et al. Role of vitamins beyond vitamin D in bone health and osteoporosis (Review). Int J Mol Med. 2024;53. doi:10.3892/ijmm.2023.5333
  21. Cui Y, Zhang W, Yang P, Zhu S, Luo S, et al. Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis. Free Radic Biol Med. 2023;206:33. doi:10.1016/j.freeradbiomed.2023.06.022
  22. Wang H, Li L, Zhang N, Ma Y. Vitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6 and IL-6/JAK in C3H10 T1/2 Clone 8 Cells. Nutrients. 2022;14. doi:10.3390/nu14142934
  23. Jadhav N, Ajgaonkar S, Saha P, Gurav P, Pandey A, et al. Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities. Front Pharmacol. 2022;13:896920. doi:10.3389/fphar.2022.896920
  24. Hu L, Ji J, Li D, Meng J, Yu B. The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:592. doi:10.1186/s13018-021-02728-4
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