Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Level Teaspoon (approx. 4 g)
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
4 g
1%**
Dietary Fiber
4 g
14%*
Organic Inulin (FOS) (from Blue Agave)
3.3 g
†
Top Medical Research Studies
9
Inulin reduces depression in migraines
We conducted a randomized double-blind placebo-controlled trial to understand how inulin supplementation influences depression in women prone to migraines. A total of 80 participants, aged between 20 to 50 years, were given either 10 grams of inulin or a placebo daily for 12 weeks.
Throughout the study, we monitored changes in depression, anxiety, stress, and the overall quality of life. Remarkably, we observed significant improvements in mental health for those taking inulin, particularly notable reductions in depression scores. Specifically, participants in the inulin group experienced a drop of about 4.47 points in their depression scores, which was statistically significant.
While the focus of the study was primarily on migraine symptoms, these mental health improvements suggest that inulin could play a supportive role in enhancing emotional well-being for those suffering from migraines. However, it's important to note that we did not see any substantial changes in quality of life scores between the two groups. Overall, our findings advocate for the potential benefits of inulin supplementation on mental health in women facing chronic migraines.
Throughout the study, we monitored changes in depression, anxiety, stress, and the overall quality of life. Remarkably, we observed significant improvements in mental health for those taking inulin, particularly notable reductions in depression scores. Specifically, participants in the inulin group experienced a drop of about 4.47 points in their depression scores, which was statistically significant.
While the focus of the study was primarily on migraine symptoms, these mental health improvements suggest that inulin could play a supportive role in enhancing emotional well-being for those suffering from migraines. However, it's important to note that we did not see any substantial changes in quality of life scores between the two groups. Overall, our findings advocate for the potential benefits of inulin supplementation on mental health in women facing chronic migraines.
Read More
9
We investigated how inulin, a type of dietary fiber, may help alleviate symptoms of post-stroke depression (PSD). Our study was centered on understanding inulin's neuroprotective effects through changes in gut microbiota and its influence on signaling pathways related to depression.
By analyzing gene expression in the hippocampus after inulin intake, we found significant upregulation of the mitogen-activated protein kinase (MAPK) signaling pathway, which is crucial for neuron health. Additionally, we noted that inulin positively altered gut bacteria, increasing beneficial strains like Lactobacillus while reducing potentially harmful ones.
Notably, inulin consumption led to higher levels of insulin-like growth factor 1 (IGF-1) in the blood, which correlated with the abundance of Lactobacillus. This suggests a potential link between gut health and mood improvement, as rats on an inulin-enriched diet showed increased activity levels and a preference for sweet water while losing body weight.
Overall, our findings suggest that inulin could be a promising therapeutic avenue for managing depression, particularly in individuals recovering from strokes, by emphasizing the importance of maintaining a healthy gut microbiota.
By analyzing gene expression in the hippocampus after inulin intake, we found significant upregulation of the mitogen-activated protein kinase (MAPK) signaling pathway, which is crucial for neuron health. Additionally, we noted that inulin positively altered gut bacteria, increasing beneficial strains like Lactobacillus while reducing potentially harmful ones.
Notably, inulin consumption led to higher levels of insulin-like growth factor 1 (IGF-1) in the blood, which correlated with the abundance of Lactobacillus. This suggests a potential link between gut health and mood improvement, as rats on an inulin-enriched diet showed increased activity levels and a preference for sweet water while losing body weight.
Overall, our findings suggest that inulin could be a promising therapeutic avenue for managing depression, particularly in individuals recovering from strokes, by emphasizing the importance of maintaining a healthy gut microbiota.
Read More
9
Inulin positively affects depression
We investigated how inulin, a type of dietary fiber, can impact depression, particularly in the context of chronic stress. Our study followed mice experiencing chronic unpredictable mild stress (CUMS) over nine weeks, during which they were treated with inulin at a specific dosage.
The findings were quite promising. Inulin not only exhibited antidepressant and anxiolytic effects but also boosted both neurogenesis and synaptic plasticity, which are important for brain health. It was observed that these benefits were linked to enhanced CREB/BDNF signaling pathways, key players in mood regulation.
An essential part of our research was the evident improvement in blood-brain barrier (BBB) integrity. Inulin helped to reduce the permeability often exacerbated by chronic stress, preventing harmful substances from penetrating the brain more deeply. We also noted that inulin influenced the inflammatory pathways in the body, specifically targeting the TLR4/MyD88/NF-κB signaling, which can trigger neuroinflammation.
Additionally, we found that inulin protected the gut barrier and increased the production of beneficial short-chain fatty acids (SCFAs). Notably, there was a strong correlation between the formation of these SCFAs and improvements in behavior, BBB integrity, and reduced neuroinflammation.
Overall, our study suggests that incorporating inulin into one’s diet could represent a promising nutritional strategy to combat the effects of chronic stress and improve mental health.
The findings were quite promising. Inulin not only exhibited antidepressant and anxiolytic effects but also boosted both neurogenesis and synaptic plasticity, which are important for brain health. It was observed that these benefits were linked to enhanced CREB/BDNF signaling pathways, key players in mood regulation.
An essential part of our research was the evident improvement in blood-brain barrier (BBB) integrity. Inulin helped to reduce the permeability often exacerbated by chronic stress, preventing harmful substances from penetrating the brain more deeply. We also noted that inulin influenced the inflammatory pathways in the body, specifically targeting the TLR4/MyD88/NF-κB signaling, which can trigger neuroinflammation.
Additionally, we found that inulin protected the gut barrier and increased the production of beneficial short-chain fatty acids (SCFAs). Notably, there was a strong correlation between the formation of these SCFAs and improvements in behavior, BBB integrity, and reduced neuroinflammation.
Overall, our study suggests that incorporating inulin into one’s diet could represent a promising nutritional strategy to combat the effects of chronic stress and improve mental health.
Read More
Most Useful Reviews
7.5
Improved emotional balance
1 people found this helpful
We read an article discussing the benefits of inulin, highlighting the connection between the brain and intestines. A balanced gut, with the right ratio of probiotics and prebiotics, is directly linked to emotional wellbeing, including stress, depression, and overall immunity. We administered inulin to a child alongside probiotics, and it genuinely works. The flavour is pleasant, and the product is long-lasting. Inulin also aids in reducing fat in the liver and muscles, lowers bad cholesterol, and diminishes overall body fat, making it a popular choice for healthy weight loss. A splendid product!
Read More
9
Reduced mood swings
I experience light depression, and since taking it, I feel happier with fewer mood swings. I started with a quarter of a spoon and have now increased to two spoons daily. Some people mentioned that it may cause bloating, but thankfully, I have not experienced any discomfort.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9
Inulin reduces depression in migraines
We conducted a randomized double-blind placebo-controlled trial to understand how inulin supplementation influences depression in women prone to migraines. A total of 80 participants, aged between 20 to 50 years, were given either 10 grams of inulin or a placebo daily for 12 weeks.
Throughout the study, we monitored changes in depression, anxiety, stress, and the overall quality of life. Remarkably, we observed significant improvements in mental health for those taking inulin, particularly notable reductions in depression scores. Specifically, participants in the inulin group experienced a drop of about 4.47 points in their depression scores, which was statistically significant.
While the focus of the study was primarily on migraine symptoms, these mental health improvements suggest that inulin could play a supportive role in enhancing emotional well-being for those suffering from migraines. However, it's important to note that we did not see any substantial changes in quality of life scores between the two groups. Overall, our findings advocate for the potential benefits of inulin supplementation on mental health in women facing chronic migraines.
Throughout the study, we monitored changes in depression, anxiety, stress, and the overall quality of life. Remarkably, we observed significant improvements in mental health for those taking inulin, particularly notable reductions in depression scores. Specifically, participants in the inulin group experienced a drop of about 4.47 points in their depression scores, which was statistically significant.
While the focus of the study was primarily on migraine symptoms, these mental health improvements suggest that inulin could play a supportive role in enhancing emotional well-being for those suffering from migraines. However, it's important to note that we did not see any substantial changes in quality of life scores between the two groups. Overall, our findings advocate for the potential benefits of inulin supplementation on mental health in women facing chronic migraines.
Read More
9
We investigated how inulin, a type of dietary fiber, may help alleviate symptoms of post-stroke depression (PSD). Our study was centered on understanding inulin's neuroprotective effects through changes in gut microbiota and its influence on signaling pathways related to depression.
By analyzing gene expression in the hippocampus after inulin intake, we found significant upregulation of the mitogen-activated protein kinase (MAPK) signaling pathway, which is crucial for neuron health. Additionally, we noted that inulin positively altered gut bacteria, increasing beneficial strains like Lactobacillus while reducing potentially harmful ones.
Notably, inulin consumption led to higher levels of insulin-like growth factor 1 (IGF-1) in the blood, which correlated with the abundance of Lactobacillus. This suggests a potential link between gut health and mood improvement, as rats on an inulin-enriched diet showed increased activity levels and a preference for sweet water while losing body weight.
Overall, our findings suggest that inulin could be a promising therapeutic avenue for managing depression, particularly in individuals recovering from strokes, by emphasizing the importance of maintaining a healthy gut microbiota.
By analyzing gene expression in the hippocampus after inulin intake, we found significant upregulation of the mitogen-activated protein kinase (MAPK) signaling pathway, which is crucial for neuron health. Additionally, we noted that inulin positively altered gut bacteria, increasing beneficial strains like Lactobacillus while reducing potentially harmful ones.
Notably, inulin consumption led to higher levels of insulin-like growth factor 1 (IGF-1) in the blood, which correlated with the abundance of Lactobacillus. This suggests a potential link between gut health and mood improvement, as rats on an inulin-enriched diet showed increased activity levels and a preference for sweet water while losing body weight.
Overall, our findings suggest that inulin could be a promising therapeutic avenue for managing depression, particularly in individuals recovering from strokes, by emphasizing the importance of maintaining a healthy gut microbiota.
Read More
9
Inulin positively affects depression
We investigated how inulin, a type of dietary fiber, can impact depression, particularly in the context of chronic stress. Our study followed mice experiencing chronic unpredictable mild stress (CUMS) over nine weeks, during which they were treated with inulin at a specific dosage.
The findings were quite promising. Inulin not only exhibited antidepressant and anxiolytic effects but also boosted both neurogenesis and synaptic plasticity, which are important for brain health. It was observed that these benefits were linked to enhanced CREB/BDNF signaling pathways, key players in mood regulation.
An essential part of our research was the evident improvement in blood-brain barrier (BBB) integrity. Inulin helped to reduce the permeability often exacerbated by chronic stress, preventing harmful substances from penetrating the brain more deeply. We also noted that inulin influenced the inflammatory pathways in the body, specifically targeting the TLR4/MyD88/NF-κB signaling, which can trigger neuroinflammation.
Additionally, we found that inulin protected the gut barrier and increased the production of beneficial short-chain fatty acids (SCFAs). Notably, there was a strong correlation between the formation of these SCFAs and improvements in behavior, BBB integrity, and reduced neuroinflammation.
Overall, our study suggests that incorporating inulin into one’s diet could represent a promising nutritional strategy to combat the effects of chronic stress and improve mental health.
The findings were quite promising. Inulin not only exhibited antidepressant and anxiolytic effects but also boosted both neurogenesis and synaptic plasticity, which are important for brain health. It was observed that these benefits were linked to enhanced CREB/BDNF signaling pathways, key players in mood regulation.
An essential part of our research was the evident improvement in blood-brain barrier (BBB) integrity. Inulin helped to reduce the permeability often exacerbated by chronic stress, preventing harmful substances from penetrating the brain more deeply. We also noted that inulin influenced the inflammatory pathways in the body, specifically targeting the TLR4/MyD88/NF-κB signaling, which can trigger neuroinflammation.
Additionally, we found that inulin protected the gut barrier and increased the production of beneficial short-chain fatty acids (SCFAs). Notably, there was a strong correlation between the formation of these SCFAs and improvements in behavior, BBB integrity, and reduced neuroinflammation.
Overall, our study suggests that incorporating inulin into one’s diet could represent a promising nutritional strategy to combat the effects of chronic stress and improve mental health.
Read More
9
We explored how inulin-type oligosaccharides from Morinda officinalis can impact depression by addressing inflammation in the brain. To do this, we used chronic restraint stress and lipopolysaccharide treatments to induce depression-like behaviors in mice.
Through various tests, including the sucrose preference test and tail suspension test, we observed that these stressors significantly triggered depressive symptoms in the mice alongside increased inflammation markers. The inflammation was notably evident in the hippocampus, a key area of the brain associated with mood regulation.
However, we found that when treated with IOMO—administered for either 28 days or 9 days—these depression-like behaviors were significantly reversed. Importantly, IOMO treatment also reduced the activation of microglial cells and interrupted the inflammatory process associated with depression.
Our findings suggest that inulin-type oligosaccharides may offer a promising approach to treating depression by targeting the NLRP3 inflammasome in microglial cells. This opens up avenues for developing new antidepressants aimed at alleviating the inflammation linked to depression.
Through various tests, including the sucrose preference test and tail suspension test, we observed that these stressors significantly triggered depressive symptoms in the mice alongside increased inflammation markers. The inflammation was notably evident in the hippocampus, a key area of the brain associated with mood regulation.
However, we found that when treated with IOMO—administered for either 28 days or 9 days—these depression-like behaviors were significantly reversed. Importantly, IOMO treatment also reduced the activation of microglial cells and interrupted the inflammatory process associated with depression.
Our findings suggest that inulin-type oligosaccharides may offer a promising approach to treating depression by targeting the NLRP3 inflammasome in microglial cells. This opens up avenues for developing new antidepressants aimed at alleviating the inflammation linked to depression.
Read More
9
High-fiber diet aids depression
We explored the impact of a high-dietary fiber intake, specifically through inulin, on depression, particularly in mothers who faced antenatal obesity. In our study, female C57BL6/J mice were fed a high-fat diet to simulate antenatal obesity. We found that supplementing their diet with inulin significantly improved cognitive function and reduced depressive-like behaviors after their offspring were weaned.
The high dietary fiber not only assisted in uplifting mood but also enhanced the levels of important neurotransmitters in the brain, specifically 5-hydroxytryptamine (5-HT) and norepinephrine (NE). Moreover, our findings indicated that this dietary change helped to reshape the gut microbiota, resulting in greater production of short-chain fatty acids (SCFAs), which are beneficial for brain health.
Correlation analysis suggested a strong link between the increase in specific gut microbes and levels of SCFAs with the observed improvements in maternal behavior. Overall, we believe that incorporating high-dietary fiber into the diet presents a promising strategy to combat antenatal obesity's negative impacts on mental health, supporting the connection between gut health and emotional well-being.
The high dietary fiber not only assisted in uplifting mood but also enhanced the levels of important neurotransmitters in the brain, specifically 5-hydroxytryptamine (5-HT) and norepinephrine (NE). Moreover, our findings indicated that this dietary change helped to reshape the gut microbiota, resulting in greater production of short-chain fatty acids (SCFAs), which are beneficial for brain health.
Correlation analysis suggested a strong link between the increase in specific gut microbes and levels of SCFAs with the observed improvements in maternal behavior. Overall, we believe that incorporating high-dietary fiber into the diet presents a promising strategy to combat antenatal obesity's negative impacts on mental health, supporting the connection between gut health and emotional well-being.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved emotional balance
1 people found this helpful
We read an article discussing the benefits of inulin, highlighting the connection between the brain and intestines. A balanced gut, with the right ratio of probiotics and prebiotics, is directly linked to emotional wellbeing, including stress, depression, and overall immunity. We administered inulin to a child alongside probiotics, and it genuinely works. The flavour is pleasant, and the product is long-lasting. Inulin also aids in reducing fat in the liver and muscles, lowers bad cholesterol, and diminishes overall body fat, making it a popular choice for healthy weight loss. A splendid product!
Read More
9
Reduced mood swings
I experience light depression, and since taking it, I feel happier with fewer mood swings. I started with a quarter of a spoon and have now increased to two spoons daily. Some people mentioned that it may cause bloating, but thankfully, I have not experienced any discomfort.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Chen P, Chen F, Hou T, Hu X, Xia C, et al. Administration time modify the anxiolytic and antidepressant effects of inulin via gut-brain axis. Int J Biol Macromol. 2025;288:138698. doi:10.1016/j.ijbiomac.2024.138698
- Li K, Wei W, Xu C, Lian X, Bao J, et al. Prebiotic inulin alleviates anxiety and depression-like behavior in alcohol withdrawal mice by modulating the gut microbiota and 5-HT metabolism. Phytomedicine. 2024;135:156181. doi:10.1016/j.phymed.2024.156181
- Khademi F, Tutunchi H, Vaghef-Mehrabani E, Ebrahimi-Mameghani M. The effect of prebiotic supplementation on serum levels of tryptophan and kynurenine in obese women with major depressive disorder: a double-blinded placebo-controlled randomized clinical trial. BMC Res Notes. 2024;17:316. doi:10.1186/s13104-024-06963-w
- Vajdi M, Khorvash F, Askari G. A randomized, double-blind, placebo-controlled parallel trial to test the effect of inulin supplementation on migraine headache characteristics, quality of life and mental health symptoms in women with migraine. Food Funct. 2024;15:10088. doi:10.1039/d4fo02796e
- Shao R, Tan X, Pan M, Huang J, Huang L, et al. Inulin alters gut microbiota to alleviate post-stroke depressive-like behavior associated with the IGF-1-mediated MAPK signaling pathway. Brain Behav. 2024;14:e3387. doi:10.1002/brb3.3387
- Zou H, Gao H, Liu Y, Zhang Z, Zhao J, et al. Dietary inulin alleviated constipation induced depression and anxiety-like behaviors: Involvement of gut microbiota and microbial metabolite short-chain fatty acid. Int J Biol Macromol. 2024;259:129420. doi:10.1016/j.ijbiomac.2024.129420
- Jackson PP, Wijeyesekera A, Williams CM, Theis S, van Harsselaar J, et al. Inulin-type fructans and 2'fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial. Am J Clin Nutr. 2023;118:938. doi:10.1016/j.ajcnut.2023.08.016
- Wang L, Wang Z, Lan Y, Tuo Y, Ma S, et al. Inulin Attenuates Blood-Brain Barrier Permeability and Alleviates Behavioral Disorders by Modulating the TLR4/MyD88/NF-κB Pathway in Mice with Chronic Stress. J Agric Food Chem. 2023;71:13325. doi:10.1021/acs.jafc.3c03568
- Szala-Rycaj J, Szewczyk A, Zagaja M, Kaczmarczyk-Ziemba A, Maj M, et al. The Influence of Topinambur and Inulin Preventive Supplementation on Microbiota, Anxious Behavior, Cognitive Functions and Neurogenesis in Mice Exposed to the Chronic Unpredictable Mild Stress. Nutrients. 2023;15. doi:10.3390/nu15092041
- Aslan Çİn NN, Açik M, Tertemİz OF, Aktan Ç, Akçali DT, et al. Effect of prebiotic and probiotic supplementation on reduced pain in patients with fibromyalgia syndrome: a double-blind, placebo-controlled randomized clinical trial. Psychol Health Med. 2024;29:528. doi:10.1080/13548506.2023.2216464
- Lai ZK, Yin YY, Yan JZ, Wei QQ, Wang B, et al. Inulin-type oligosaccharides of Morinda officinalis exerted antidepressant effects by reducing hippocampal inflammation. Metab Brain Dis. 2023;38:2065. doi:10.1007/s11011-023-01223-5
- Amadieu C, Coste V, Neyrinck AM, Thijssen V, Leyrolle Q, et al. Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients. Gut Microbes. 2022;14:2007042. doi:10.1080/19490976.2021.2007042
- Moludi J, Khedmatgozar H, Nachvak SM, Abdollahzad H, Moradinazar M, et al. The effects of co-administration of probiotics and prebiotics on chronic inflammation, and depression symptoms in patients with coronary artery diseases: a randomized clinical trial. Nutr Neurosci. 2022;25:1659. doi:10.1080/1028415X.2021.1889451
- Guo L, Xiao P, Zhang X, Yang Y, Yang M, et al. Inulin ameliorates schizophrenia modulation of the gut microbiota and anti-inflammation in mice. Food Funct. 2021;12:1156. doi:10.1039/d0fo02778b
- Liu Z, Li L, Ma S, Ye J, Zhang H, et al. High-Dietary Fiber Intake Alleviates Antenatal Obesity-Induced Postpartum Depression: Roles of Gut Microbiota and Microbial Metabolite Short-chain Fatty Acid Involved. J Agric Food Chem. 2020;68:13697. doi:10.1021/acs.jafc.0c04290
- Chi L, Khan I, Lin Z, Zhang J, Lee MYS, et al. Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model. Phytomedicine. 2020;67:153157. doi:10.1016/j.phymed.2019.153157
