5/9/2025
Last update
5/9/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8
Supplement Facts
Serving Size: 1 Level Teaspoon (approx. 4 g)
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
4 g
1%**
Dietary Fiber
4 g
14%*
Organic Inulin (FOS) (from Blue Agave)
3.3 g
†
Top Medical Research Studies
9
Inulin reduces pulmonary hypertension effects
We explored how a high-soluble-fiber diet, specifically one rich in inulin, impacts pulmonary hypertension in a controlled study involving mice. After feeding them diets with either 0% or 16.9% inulin, we exposed the mice to hypoxic conditions for 21 days, aiming to see if inulin could lessen the effects of pulmonary hypertension brought on by low oxygen levels.
Our findings showed that the mice on the high-soluble-fiber diet experienced lower right ventricular systolic pressure and reduced pulmonary vascular resistance compared to those on the low-fiber diet. Notably, this dietary change altered the gut microbiome, promoting bacteria that produce beneficial short-chain fatty acids and decreasing harmful bacteria associated with disease. We also observed a decrease in certain inflammatory immune cells in the lungs, which may contribute to the positive effects on vascular remodeling.
This study presents exciting evidence that a high-soluble-fiber diet, particularly one rich in inulin, may have the potential to mitigate the effects of pulmonary hypertension caused by hypoxia. These results suggest that dietary choices can play a significant role in managing vascular health and highlight the significance of nutrients like inulin in improving overall lung function.
Our findings showed that the mice on the high-soluble-fiber diet experienced lower right ventricular systolic pressure and reduced pulmonary vascular resistance compared to those on the low-fiber diet. Notably, this dietary change altered the gut microbiome, promoting bacteria that produce beneficial short-chain fatty acids and decreasing harmful bacteria associated with disease. We also observed a decrease in certain inflammatory immune cells in the lungs, which may contribute to the positive effects on vascular remodeling.
This study presents exciting evidence that a high-soluble-fiber diet, particularly one rich in inulin, may have the potential to mitigate the effects of pulmonary hypertension caused by hypoxia. These results suggest that dietary choices can play a significant role in managing vascular health and highlight the significance of nutrients like inulin in improving overall lung function.
Read More
We investigated how the prebiotic fiber inulin affects hypertension and overall heart health in rats with metabolic syndrome. Using a model called DahlS.Z-/ (DS/obese) rats, we provided a diet with varying amounts of inulin and monitored several health indicators over a period of weeks.
The results were quite promising. We found that inulin significantly reduced hypertension, improved left ventricular inflammation, and lessened diastolic dysfunction. We also noticed a decrease in inflammation and fibrosis in both cardiac and adipose tissues, alongside lowered levels of interleukin-6, a marker linked to inflammation. Interestingly, while inulin helped with high blood pressure and cardiac issues, it did not have a significant impact on obesity or insulin resistance in these rats.
However, there was a drawback; inulin treatment led to higher triglyceride levels in the blood. This points to a nuanced impact where inulin exerts beneficial effects on heart health, but at the same time, it raises triglycerides, which is concerning. Overall, inulin appears to help manage certain aspects of heart health and reduces inflammation without affecting weight or insulin sensitivity in this model of metabolic syndrome.
The results were quite promising. We found that inulin significantly reduced hypertension, improved left ventricular inflammation, and lessened diastolic dysfunction. We also noticed a decrease in inflammation and fibrosis in both cardiac and adipose tissues, alongside lowered levels of interleukin-6, a marker linked to inflammation. Interestingly, while inulin helped with high blood pressure and cardiac issues, it did not have a significant impact on obesity or insulin resistance in these rats.
However, there was a drawback; inulin treatment led to higher triglyceride levels in the blood. This points to a nuanced impact where inulin exerts beneficial effects on heart health, but at the same time, it raises triglycerides, which is concerning. Overall, inulin appears to help manage certain aspects of heart health and reduces inflammation without affecting weight or insulin sensitivity in this model of metabolic syndrome.
Read More
7
We explored the link between dietary inulin intake and the risk of hypertension (HTN) in a cohort of adults. The study was part of the broader Tehran Lipid and Glucose Study, which tracked participants from 2006 to 2018 to gather data on various health outcomes.
Our findings reveal that individuals who consumed higher amounts of inulin had a lower risk of developing hypertension. Specifically, the analysis indicated a 21% reduction in risk for those with greater inulin intake, suggesting that incorporating more inulin-rich foods could be beneficial for blood pressure management.
However, it's important to note that while there was a significant association with HTN, we did not find a similar relationship between inulin consumption and chronic kidney disease or cardiovascular disease. This highlights that while inulin may help in lowering hypertension risk, its role in other cardiometabolic diseases needs further investigation.
Our findings reveal that individuals who consumed higher amounts of inulin had a lower risk of developing hypertension. Specifically, the analysis indicated a 21% reduction in risk for those with greater inulin intake, suggesting that incorporating more inulin-rich foods could be beneficial for blood pressure management.
However, it's important to note that while there was a significant association with HTN, we did not find a similar relationship between inulin consumption and chronic kidney disease or cardiovascular disease. This highlights that while inulin may help in lowering hypertension risk, its role in other cardiometabolic diseases needs further investigation.
Read More
Most Useful Reviews
7.5
Positive digestive effects
By optimising inulin in my diet, I have found it can help reduce the risk of developing arterial hypertension and other cardiovascular diseases. I also noticed inulin's beneficial effects on the digestive system, promoting the growth of healthy intestinal microflora and enhancing digestion.
Read More
6
Reduced hypertension risk
6 people found this helpful
Fine Inulin, a polysaccharide and complex carbohydrate, serves as a prebiotic. It is naturally found in various plants and root vegetables, such as garlic, Jerusalem artichoke, agave, chicory, and burdock. As a soluble dietary fibre, inulin isn’t absorbed in the gastrointestinal tract. Optimising inulin in your diet may help reduce the risk of developing hypertension and other cardiovascular diseases. Additionally, inulin positively impacts the digestive system by supporting and promoting the growth of healthy intestinal microflora, thereby improving digestion.
Read More
6
Hypertension prevention benefits
Inulin is a polysaccharide and complex carbohydrate, also a prebiotic, found in many plants and root vegetables like garlic, Jerusalem artichoke, agave, chicory, and burdock. As a soluble dietary fibre that isn't absorbed in the gastrointestinal tract, optimising inulin intake may help reduce the risk of hypertension and other cardiovascular diseases. It positively affects the digestive system, supporting the growth of normal intestinal microflora and improving digestion.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
- All Researches
9
Inulin reduces pulmonary hypertension effects
We explored how a high-soluble-fiber diet, specifically one rich in inulin, impacts pulmonary hypertension in a controlled study involving mice. After feeding them diets with either 0% or 16.9% inulin, we exposed the mice to hypoxic conditions for 21 days, aiming to see if inulin could lessen the effects of pulmonary hypertension brought on by low oxygen levels.
Our findings showed that the mice on the high-soluble-fiber diet experienced lower right ventricular systolic pressure and reduced pulmonary vascular resistance compared to those on the low-fiber diet. Notably, this dietary change altered the gut microbiome, promoting bacteria that produce beneficial short-chain fatty acids and decreasing harmful bacteria associated with disease. We also observed a decrease in certain inflammatory immune cells in the lungs, which may contribute to the positive effects on vascular remodeling.
This study presents exciting evidence that a high-soluble-fiber diet, particularly one rich in inulin, may have the potential to mitigate the effects of pulmonary hypertension caused by hypoxia. These results suggest that dietary choices can play a significant role in managing vascular health and highlight the significance of nutrients like inulin in improving overall lung function.
Our findings showed that the mice on the high-soluble-fiber diet experienced lower right ventricular systolic pressure and reduced pulmonary vascular resistance compared to those on the low-fiber diet. Notably, this dietary change altered the gut microbiome, promoting bacteria that produce beneficial short-chain fatty acids and decreasing harmful bacteria associated with disease. We also observed a decrease in certain inflammatory immune cells in the lungs, which may contribute to the positive effects on vascular remodeling.
This study presents exciting evidence that a high-soluble-fiber diet, particularly one rich in inulin, may have the potential to mitigate the effects of pulmonary hypertension caused by hypoxia. These results suggest that dietary choices can play a significant role in managing vascular health and highlight the significance of nutrients like inulin in improving overall lung function.
Read More
We investigated how the prebiotic fiber inulin affects hypertension and overall heart health in rats with metabolic syndrome. Using a model called DahlS.Z-/ (DS/obese) rats, we provided a diet with varying amounts of inulin and monitored several health indicators over a period of weeks.
The results were quite promising. We found that inulin significantly reduced hypertension, improved left ventricular inflammation, and lessened diastolic dysfunction. We also noticed a decrease in inflammation and fibrosis in both cardiac and adipose tissues, alongside lowered levels of interleukin-6, a marker linked to inflammation. Interestingly, while inulin helped with high blood pressure and cardiac issues, it did not have a significant impact on obesity or insulin resistance in these rats.
However, there was a drawback; inulin treatment led to higher triglyceride levels in the blood. This points to a nuanced impact where inulin exerts beneficial effects on heart health, but at the same time, it raises triglycerides, which is concerning. Overall, inulin appears to help manage certain aspects of heart health and reduces inflammation without affecting weight or insulin sensitivity in this model of metabolic syndrome.
The results were quite promising. We found that inulin significantly reduced hypertension, improved left ventricular inflammation, and lessened diastolic dysfunction. We also noticed a decrease in inflammation and fibrosis in both cardiac and adipose tissues, alongside lowered levels of interleukin-6, a marker linked to inflammation. Interestingly, while inulin helped with high blood pressure and cardiac issues, it did not have a significant impact on obesity or insulin resistance in these rats.
However, there was a drawback; inulin treatment led to higher triglyceride levels in the blood. This points to a nuanced impact where inulin exerts beneficial effects on heart health, but at the same time, it raises triglycerides, which is concerning. Overall, inulin appears to help manage certain aspects of heart health and reduces inflammation without affecting weight or insulin sensitivity in this model of metabolic syndrome.
Read More
8
Inulin reduces hypertension effects
We assessed whether inulin, along with other components like short-chain fatty acids, could help manage hypertension in mice suffering from systemic lupus erythematosus (SLE) triggered by TLR7 activation. In our findings, treatment with inulin-rich dietary fibers played a supportive role in preventing hypertension and reducing cardiac hypertrophy.
The results highlighted that inulin, combined with other short-chain fatty acids such as acetate and butyrate, not only helped in lowering blood pressure but also improved the functionality of blood vessels. Remarkably, these treatments led to better aortic relaxation and reduced oxidative stress in the vascular system—two critical factors in maintaining cardiovascular health.
Additionally, we discovered that these interventions also helped in preserving intestinal health, diminishing endotoxemia, and lowering the levels of inflammatory Th17 cells that contribute to a dysfunctional vascular response. This transformation was essential for maintaining a balanced relationship between gut health and immune function, which directly impacts hypertension in SLE models. Thus, our exploration suggests a promising role for inulin in the holistic approach to managing hypertension in conditions influenced by immune response.
The results highlighted that inulin, combined with other short-chain fatty acids such as acetate and butyrate, not only helped in lowering blood pressure but also improved the functionality of blood vessels. Remarkably, these treatments led to better aortic relaxation and reduced oxidative stress in the vascular system—two critical factors in maintaining cardiovascular health.
Additionally, we discovered that these interventions also helped in preserving intestinal health, diminishing endotoxemia, and lowering the levels of inflammatory Th17 cells that contribute to a dysfunctional vascular response. This transformation was essential for maintaining a balanced relationship between gut health and immune function, which directly impacts hypertension in SLE models. Thus, our exploration suggests a promising role for inulin in the holistic approach to managing hypertension in conditions influenced by immune response.
Read More
8
Inulin may mitigate hypertension effects
We aimed to uncover how a diet rich in fructose influences hypertension, and whether inulin could help counteract this effect. Using a rat model, we compared a fructose-based diet to one where fructose was partially swapped out for inulin. After observing the aorta of the rats, it became clear that fructose significantly altered the expression of over 1700 genes related to blood vessel function and metabolism.
However, when inulin was introduced into the mix, we found it modified the expression of more than 1300 genes involved specifically in vascular functions and immune responses. This indicates that inulin may play a protective role against the adverse effects of fructose on blood vessels. We also discovered key transcription factors and microRNAs that might help regulate these gene changes.
These findings suggest that a fructose-heavy diet can have detrimental effects on hypertension, but incorporating inulin could offer a beneficial counterbalance. Our study shines a light on the molecular pathways involved, making a compelling case for considering inulin as a dietary aid against hypertension.
However, when inulin was introduced into the mix, we found it modified the expression of more than 1300 genes involved specifically in vascular functions and immune responses. This indicates that inulin may play a protective role against the adverse effects of fructose on blood vessels. We also discovered key transcription factors and microRNAs that might help regulate these gene changes.
These findings suggest that a fructose-heavy diet can have detrimental effects on hypertension, but incorporating inulin could offer a beneficial counterbalance. Our study shines a light on the molecular pathways involved, making a compelling case for considering inulin as a dietary aid against hypertension.
Read More
7
Fiber's uncertain impact on hypertension
We investigated whether dietary fibers, specifically inulin-type fructans (ITF), could help manage hypertension in a genetic mouse model of systemic lupus erythematosus (SLE). In our experiments, we treated female NZBWF1 SLE mice with ITF and another fiber, resistant starch (RS), to see if these treatments could prevent vascular and renal damage associated with the disease.
Both fiber types showed promising effects, particularly RS, as they prevented the development of high blood pressure and improved heart and kidney function. However, when we looked more closely at the effects of ITF alone, we found that its impact on hypertension was less clear. Notably, although we observed improvements in some areas, the overall disease activity linked to SLE didn’t show any significant changes with either fiber treatment.
Additionally, we looked at how gut microbiota was influenced by fiber consumption. The fiber treatments helped favor beneficial bacteria, which seemed to support better gut and vascular health. However, the specific contributions of inulin were challenging to pinpoint due to its combination with other fibers in our research approach.
In summary, while fiber consumption can rebalance the gut-immune-vascular interactions in SLE, inulin's specific impact on reducing hypertension remains inconclusive based on our study, as it did not significantly alter disease outcomes.
Both fiber types showed promising effects, particularly RS, as they prevented the development of high blood pressure and improved heart and kidney function. However, when we looked more closely at the effects of ITF alone, we found that its impact on hypertension was less clear. Notably, although we observed improvements in some areas, the overall disease activity linked to SLE didn’t show any significant changes with either fiber treatment.
Additionally, we looked at how gut microbiota was influenced by fiber consumption. The fiber treatments helped favor beneficial bacteria, which seemed to support better gut and vascular health. However, the specific contributions of inulin were challenging to pinpoint due to its combination with other fibers in our research approach.
In summary, while fiber consumption can rebalance the gut-immune-vascular interactions in SLE, inulin's specific impact on reducing hypertension remains inconclusive based on our study, as it did not significantly alter disease outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Positive digestive effects
By optimising inulin in my diet, I have found it can help reduce the risk of developing arterial hypertension and other cardiovascular diseases. I also noticed inulin's beneficial effects on the digestive system, promoting the growth of healthy intestinal microflora and enhancing digestion.
Read More
6
Reduced hypertension risk
6 people found this helpful
Fine Inulin, a polysaccharide and complex carbohydrate, serves as a prebiotic. It is naturally found in various plants and root vegetables, such as garlic, Jerusalem artichoke, agave, chicory, and burdock. As a soluble dietary fibre, inulin isn’t absorbed in the gastrointestinal tract. Optimising inulin in your diet may help reduce the risk of developing hypertension and other cardiovascular diseases. Additionally, inulin positively impacts the digestive system by supporting and promoting the growth of healthy intestinal microflora, thereby improving digestion.
Read More
6
Hypertension prevention benefits
Inulin is a polysaccharide and complex carbohydrate, also a prebiotic, found in many plants and root vegetables like garlic, Jerusalem artichoke, agave, chicory, and burdock. As a soluble dietary fibre that isn't absorbed in the gastrointestinal tract, optimising inulin intake may help reduce the risk of hypertension and other cardiovascular diseases. It positively affects the digestive system, supporting the growth of normal intestinal microflora and improving digestion.
Read More
Frequently Asked Questions
7.5
Positive digestive effects
By optimising inulin in my diet, I have found it can help reduce the risk of developing arterial hypertension and other cardiovascular diseases. I also noticed inulin's beneficial effects on the digestive system, promoting the growth of healthy intestinal microflora and enhancing digestion.
6
Reduced hypertension risk
6 people found this helpful
Fine Inulin, a polysaccharide and complex carbohydrate, serves as a prebiotic. It is naturally found in various plants and root vegetables, such as garlic, Jerusalem artichoke, agave, chicory, and burdock. As a soluble dietary fibre, inulin isn’t absorbed in the gastrointestinal tract. Optimising inulin in your diet may help reduce the risk of developing hypertension and other cardiovascular diseases. Additionally, inulin positively impacts the digestive system by supporting and promoting the growth of healthy intestinal microflora, thereby improving digestion.
8
Inulin reduces hypertension effects
We assessed whether inulin, along with other components like short-chain fatty acids, could help manage hypertension in mice suffering from systemic lupus erythematosus (SLE) triggered by TLR7 activation. In our findings, treatment with inulin-rich dietary fibers played a supportive role in preventing hypertension and reducing cardiac hypertrophy.
The results highlighted that inulin, combined with other short-chain fatty acids such as acetate and butyrate, not only helped in lowering blood pressure but also improved the functionality of blood vessels. Remarkably, these treatments led to better aortic relaxation and reduced oxidative stress in the vascular system—two critical factors in maintaining cardiovascular health.
Additionally, we discovered that these interventions also helped in preserving intestinal health, diminishing endotoxemia, and lowering the levels of inflammatory Th17 cells that contribute to a dysfunctional vascular response. This transformation was essential for maintaining a balanced relationship between gut health and immune function, which directly impacts hypertension in SLE models. Thus, our exploration suggests a promising role for inulin in the holistic approach to managing hypertension in conditions influenced by immune response.
The results highlighted that inulin, combined with other short-chain fatty acids such as acetate and butyrate, not only helped in lowering blood pressure but also improved the functionality of blood vessels. Remarkably, these treatments led to better aortic relaxation and reduced oxidative stress in the vascular system—two critical factors in maintaining cardiovascular health.
Additionally, we discovered that these interventions also helped in preserving intestinal health, diminishing endotoxemia, and lowering the levels of inflammatory Th17 cells that contribute to a dysfunctional vascular response. This transformation was essential for maintaining a balanced relationship between gut health and immune function, which directly impacts hypertension in SLE models. Thus, our exploration suggests a promising role for inulin in the holistic approach to managing hypertension in conditions influenced by immune response.
9
Inulin reduces pulmonary hypertension effects
We explored how a high-soluble-fiber diet, specifically one rich in inulin, impacts pulmonary hypertension in a controlled study involving mice. After feeding them diets with either 0% or 16.9% inulin, we exposed the mice to hypoxic conditions for 21 days, aiming to see if inulin could lessen the effects of pulmonary hypertension brought on by low oxygen levels.
Our findings showed that the mice on the high-soluble-fiber diet experienced lower right ventricular systolic pressure and reduced pulmonary vascular resistance compared to those on the low-fiber diet. Notably, this dietary change altered the gut microbiome, promoting bacteria that produce beneficial short-chain fatty acids and decreasing harmful bacteria associated with disease. We also observed a decrease in certain inflammatory immune cells in the lungs, which may contribute to the positive effects on vascular remodeling.
This study presents exciting evidence that a high-soluble-fiber diet, particularly one rich in inulin, may have the potential to mitigate the effects of pulmonary hypertension caused by hypoxia. These results suggest that dietary choices can play a significant role in managing vascular health and highlight the significance of nutrients like inulin in improving overall lung function.
Our findings showed that the mice on the high-soluble-fiber diet experienced lower right ventricular systolic pressure and reduced pulmonary vascular resistance compared to those on the low-fiber diet. Notably, this dietary change altered the gut microbiome, promoting bacteria that produce beneficial short-chain fatty acids and decreasing harmful bacteria associated with disease. We also observed a decrease in certain inflammatory immune cells in the lungs, which may contribute to the positive effects on vascular remodeling.
This study presents exciting evidence that a high-soluble-fiber diet, particularly one rich in inulin, may have the potential to mitigate the effects of pulmonary hypertension caused by hypoxia. These results suggest that dietary choices can play a significant role in managing vascular health and highlight the significance of nutrients like inulin in improving overall lung function.
7
We explored the link between dietary inulin intake and the risk of hypertension (HTN) in a cohort of adults. The study was part of the broader Tehran Lipid and Glucose Study, which tracked participants from 2006 to 2018 to gather data on various health outcomes.
Our findings reveal that individuals who consumed higher amounts of inulin had a lower risk of developing hypertension. Specifically, the analysis indicated a 21% reduction in risk for those with greater inulin intake, suggesting that incorporating more inulin-rich foods could be beneficial for blood pressure management.
However, it's important to note that while there was a significant association with HTN, we did not find a similar relationship between inulin consumption and chronic kidney disease or cardiovascular disease. This highlights that while inulin may help in lowering hypertension risk, its role in other cardiometabolic diseases needs further investigation.
Our findings reveal that individuals who consumed higher amounts of inulin had a lower risk of developing hypertension. Specifically, the analysis indicated a 21% reduction in risk for those with greater inulin intake, suggesting that incorporating more inulin-rich foods could be beneficial for blood pressure management.
However, it's important to note that while there was a significant association with HTN, we did not find a similar relationship between inulin consumption and chronic kidney disease or cardiovascular disease. This highlights that while inulin may help in lowering hypertension risk, its role in other cardiometabolic diseases needs further investigation.
We investigated how the prebiotic fiber inulin affects hypertension and overall heart health in rats with metabolic syndrome. Using a model called DahlS.Z-/ (DS/obese) rats, we provided a diet with varying amounts of inulin and monitored several health indicators over a period of weeks.
The results were quite promising. We found that inulin significantly reduced hypertension, improved left ventricular inflammation, and lessened diastolic dysfunction. We also noticed a decrease in inflammation and fibrosis in both cardiac and adipose tissues, alongside lowered levels of interleukin-6, a marker linked to inflammation. Interestingly, while inulin helped with high blood pressure and cardiac issues, it did not have a significant impact on obesity or insulin resistance in these rats.
However, there was a drawback; inulin treatment led to higher triglyceride levels in the blood. This points to a nuanced impact where inulin exerts beneficial effects on heart health, but at the same time, it raises triglycerides, which is concerning. Overall, inulin appears to help manage certain aspects of heart health and reduces inflammation without affecting weight or insulin sensitivity in this model of metabolic syndrome.
The results were quite promising. We found that inulin significantly reduced hypertension, improved left ventricular inflammation, and lessened diastolic dysfunction. We also noticed a decrease in inflammation and fibrosis in both cardiac and adipose tissues, alongside lowered levels of interleukin-6, a marker linked to inflammation. Interestingly, while inulin helped with high blood pressure and cardiac issues, it did not have a significant impact on obesity or insulin resistance in these rats.
However, there was a drawback; inulin treatment led to higher triglyceride levels in the blood. This points to a nuanced impact where inulin exerts beneficial effects on heart health, but at the same time, it raises triglycerides, which is concerning. Overall, inulin appears to help manage certain aspects of heart health and reduces inflammation without affecting weight or insulin sensitivity in this model of metabolic syndrome.
7
Fiber's uncertain impact on hypertension
We investigated whether dietary fibers, specifically inulin-type fructans (ITF), could help manage hypertension in a genetic mouse model of systemic lupus erythematosus (SLE). In our experiments, we treated female NZBWF1 SLE mice with ITF and another fiber, resistant starch (RS), to see if these treatments could prevent vascular and renal damage associated with the disease.
Both fiber types showed promising effects, particularly RS, as they prevented the development of high blood pressure and improved heart and kidney function. However, when we looked more closely at the effects of ITF alone, we found that its impact on hypertension was less clear. Notably, although we observed improvements in some areas, the overall disease activity linked to SLE didn’t show any significant changes with either fiber treatment.
Additionally, we looked at how gut microbiota was influenced by fiber consumption. The fiber treatments helped favor beneficial bacteria, which seemed to support better gut and vascular health. However, the specific contributions of inulin were challenging to pinpoint due to its combination with other fibers in our research approach.
In summary, while fiber consumption can rebalance the gut-immune-vascular interactions in SLE, inulin's specific impact on reducing hypertension remains inconclusive based on our study, as it did not significantly alter disease outcomes.
Both fiber types showed promising effects, particularly RS, as they prevented the development of high blood pressure and improved heart and kidney function. However, when we looked more closely at the effects of ITF alone, we found that its impact on hypertension was less clear. Notably, although we observed improvements in some areas, the overall disease activity linked to SLE didn’t show any significant changes with either fiber treatment.
Additionally, we looked at how gut microbiota was influenced by fiber consumption. The fiber treatments helped favor beneficial bacteria, which seemed to support better gut and vascular health. However, the specific contributions of inulin were challenging to pinpoint due to its combination with other fibers in our research approach.
In summary, while fiber consumption can rebalance the gut-immune-vascular interactions in SLE, inulin's specific impact on reducing hypertension remains inconclusive based on our study, as it did not significantly alter disease outcomes.
References
- Moleón J, González-Correa C, Miñano S, Robles-Vera I, de la Visitación N, et al. Protective effect of microbiota-derived short chain fatty acids on vascular dysfunction in mice with systemic lupus erythematosus induced by toll like receptor 7 activation. Pharmacol Res. 2023;198:106997. 10.1016/j.phrs.2023.106997
- Pakhomov NV, Kostyunina DS, Macori G, Dillon E, Brady T, et al. High-Soluble-Fiber Diet Attenuates Hypoxia-Induced Vascular Remodeling and the Development of Hypoxic Pulmonary Hypertension. Hypertension. 2023;80:2372. 10.1161/HYPERTENSIONAHA.123.20914
- Moleón J, González-Correa C, Robles-Vera I, Miñano S, de la Visitación N, et al. Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study. Gut Microbes. 2023;15:2247053. 10.1080/19490976.2023.2247053
- Ruskovska T, Konic-Ristic A, Mazur A, Milenkovic D. Molecular mechanisms underlying hypertensive effect of fructose and the preventive properties of inulin - Global transcriptomic analysis in rat aorta. Nutr Metab Cardiovasc Dis. 2023;33:441. 10.1016/j.numecd.2022.11.009
- Golzarand M, Bahadoran Z, Mirmiran P, Azizi F. Inulin intake and the incidence of cardiometabolic diseases: a prospective cohort study. Food Funct. 2022;13:10516. 10.1039/d2fo00063f
- Komatsu Y, Aoyama K, Yoneda M, Ashikawa S, Nakano S, et al. The prebiotic fiber inulin ameliorates cardiac, adipose tissue, and hepatic pathology, but exacerbates hypertriglyceridemia in rats with metabolic syndrome. Am J Physiol Heart Circ Physiol. 2021;320:H281. 10.1152/ajpheart.00657.2020
