We conducted an open-label clinical study to explore how a peel-off facial mask containing myoinositol and trehalose-loaded liposomes could improve adult female acne (AFA). By applying the mask every other day for 60 days, we examined its effects on acne lesions, sebum production, and overall skin health.
During the study, we measured changes in the number of acne lesions and collected skin biopsy samples to analyze hormone levels and markers of autophagy—a process that helps the skin repair and rejuvenate itself. Our findings showed a significant reduction in various types of acne lesions, as well as a decrease in sebum production.
Notably, we observed a decrease in androgen levels in the skin, which is crucial since higher androgens can exacerbate acne. Additionally, levels of beclin-1, a marker associated with skin autophagy, increased, suggesting that the mask not only improved the appearance of acne but also encouraged healthier skin processes.
Overall, the peel-off mask with myoinositol effectively addresses some underlying factors contributing to acne in women, providing a promising option for those struggling with adult acne.