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NOW Supplements Choline & Inositol
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 10 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg

Top Medical Research Studies

8
Myo-inositol: Depression treatment potential
Cyclitols: From Basic Understanding to Their Association with Neurodegeneration.
Relates to depression treatment exploration
We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.

While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.

However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
Read More
8
Myo-Inositol and Depression Relief
Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study.
Moderate relevance to inositol effects
We conducted a detailed analysis of the effects of myo-inositol, alongside cocoa polyphenols and soy isoflavones, on managing symptoms of depression in menopausal women with metabolic syndrome.

In this study, 200 participants were observed over a six-month period while taking a daily supplement. At the beginning, many reported moderate depression symptoms. After six months, we noted a significant reduction, with only 56% of women reporting similar symptoms compared to 87% at the start.

This improvement in mood is quite promising and suggests that myo-inositol can play a key role in alleviating depressive symptoms during menopause. While the study focused on a specific group of women, the results indicate a potential for using natural compounds to ease their struggles.
Read More
8
Inositol's role in depression unclear
Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis.
Inositol's isolated effect obscured
We explored the role of inositol in alleviating depression among children and adolescents. This systematic review gathered data from nine studies involving 561 participants, focusing on the effectiveness of omega-3 fatty acids alongside inositol in combating depressive symptoms.

Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.

However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.

These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
Read More

Most Useful Reviews

9
Healthy metabolism
B vitamins support brain health and fatty acid metabolism, reducing cholesterol levels. I've noticed a reduction in hair loss since taking this supplement, which has also proven effective for depression.
Read More
8.3
Relieved anxiety
Taking choline seems to have alleviated my depression. I no longer feel anxious without it.
Read More
8.8
Improved emotional control
To change my mindset, I tried it as I read that it helps with depression and panic tendencies. I feel my emotions shift from stress and pessimism to a swifter recovery. Even with negative feelings, if I start a simple task, I can focus and forget the worst. Though it's hard to determine if it's the effect of this alone, I believe the combined effect is beneficial.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
  • All Researches
8
Inositol's role in depression unclear
Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis.
Inositol's isolated effect obscured
We explored the role of inositol in alleviating depression among children and adolescents. This systematic review gathered data from nine studies involving 561 participants, focusing on the effectiveness of omega-3 fatty acids alongside inositol in combating depressive symptoms.

Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.

However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.

These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
Read More
8
Myo-Inositol and Depression Relief
Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study.
Moderate relevance to inositol effects
We conducted a detailed analysis of the effects of myo-inositol, alongside cocoa polyphenols and soy isoflavones, on managing symptoms of depression in menopausal women with metabolic syndrome.

In this study, 200 participants were observed over a six-month period while taking a daily supplement. At the beginning, many reported moderate depression symptoms. After six months, we noted a significant reduction, with only 56% of women reporting similar symptoms compared to 87% at the start.

This improvement in mood is quite promising and suggests that myo-inositol can play a key role in alleviating depressive symptoms during menopause. While the study focused on a specific group of women, the results indicate a potential for using natural compounds to ease their struggles.
Read More
8
Myo-inositol: Depression treatment potential
Cyclitols: From Basic Understanding to Their Association with Neurodegeneration.
Relates to depression treatment exploration
We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.

While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.

However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
Read More
4
No significant effect on depression
Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: Findings from the NiPPeR RCT.
Combined supplements studied
We explored the impact of a specific blend of myo-inositol, probiotics, and micronutrients on mental health for women planning for conception and during pregnancy. In a double-blind randomized controlled trial involving over 600 participants, we assessed mental wellbeing through recognized scales both during pregnancy and after childbirth. Our aim was to find out if this supplement could improve mood and reduce anxiety levels.

While we monitored changes in mood and anxiety symptoms using standardized questionnaires, the results showed no significant differences between the group taking the supplement and the control group receiving standard micronutrients. This indicates that, at least in this study, the combined supplement did not appear to have a notable effect on lowering depression or anxiety during pregnancy.

However, we did find a small improvement in overall mental health functioning, as measured by the Short-Form Health Survey, from preconception to six months post-delivery for those in the intervention group. This suggests that while myo-inositol and its companions may not directly impact mood and anxiety, there could be some beneficial effects on broader mental health after delivery.
Read More

User Reviews

USERS' SCORE
Good
Based on 10 Reviews
8.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Healthy metabolism
B vitamins support brain health and fatty acid metabolism, reducing cholesterol levels. I've noticed a reduction in hair loss since taking this supplement, which has also proven effective for depression.
8.3
Relieved anxiety
Taking choline seems to have alleviated my depression. I no longer feel anxious without it.
8.8
Improved emotional control
To change my mindset, I tried it as I read that it helps with depression and panic tendencies. I feel my emotions shift from stress and pessimism to a swifter recovery. Even with negative feelings, if I start a simple task, I can focus and forget the worst. Though it's hard to determine if it's the effect of this alone, I believe the combined effect is beneficial.
Read More
8.8
Weather depression improved
After about a month of taking Inositol, I noticed an improvement in my weather-related depression. When I searched for reasons, the only change I encountered was this supplement. Initially, I aimed for liver health, but I'm delighted with this unexpected benefit. In Japan, you can only buy two at a time, but this improvement in mood was completely unforeseen.
Read More
9.5
Calm and peaceful effects
As someone with major anxiety and low energy levels, I adore this product recommended by a friend dealing with severe depression. It helps keep me calm throughout the day when I take two pills each morning. I notice my mood swings are harsher without it. I highly recommend it to everyone.
Read More
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