SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.4
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
†
Top Medical Research Studies
9
Choline aids offspring in hypothyroidism
The effects of choline supplementation in mothers with hypothyroidism on the alteration of cognitive-behavioral, long-term potentiation, morphology, and apoptosis in the hippocampus of pre-pubertal offspring rats.
Direct effects on cognitive function
We explored the impact of choline supplementation on the cognitive development of offspring from mothers with hypothyroidism. The study involved inducing hypothyroidism in mother rats during pregnancy and early postnatal life by adding a substance to their drinking water. To assess the potential benefits of choline, the mothers received this supplement via gavage from the start of pregnancy until their pups were 21 days old.
After administering the treatments, we tested the offspring’s cognitive abilities using methods like the Morris water maze, which measures spatial learning and memory. We also looked at long-term potentiation (LTP)—a key process related to learning—along with examining brain structures for any morphological changes or signs of cell death.
Our findings revealed that the hypothyroid condition negatively impacted both learning and memory, alongside reducing LTP. However, choline treatment appeared to reverse some of these deficits, enhancing the cognitive functions in the offspring.
While they showed improvements, it’s important to note that choline did not significantly reduce apoptosis in the hypothyroid group. Overall, our results suggest that choline can be beneficial in mitigating some cognitive impairments caused by maternal hypothyroidism, yet it does not address all the cellular challenges faced by the offspring.
After administering the treatments, we tested the offspring’s cognitive abilities using methods like the Morris water maze, which measures spatial learning and memory. We also looked at long-term potentiation (LTP)—a key process related to learning—along with examining brain structures for any morphological changes or signs of cell death.
Our findings revealed that the hypothyroid condition negatively impacted both learning and memory, alongside reducing LTP. However, choline treatment appeared to reverse some of these deficits, enhancing the cognitive functions in the offspring.
While they showed improvements, it’s important to note that choline did not significantly reduce apoptosis in the hypothyroid group. Overall, our results suggest that choline can be beneficial in mitigating some cognitive impairments caused by maternal hypothyroidism, yet it does not address all the cellular challenges faced by the offspring.
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8
Choline aids brain development in offspring
Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats.
Relevant study on hypothyroidism effects
This study explored how choline supplementation in pregnant rats with hypothyroidism affects the brain development of their offspring. We induced hypothyroidism in mothers using a substance called 6-propyl-2-thiouracil, which affected their thyroid hormone levels during pregnancy and up until their pups were weaned.
To assess the benefits of choline, we administered it to the mothers from the first day of gestation throughout the early stages of their pups' lives. After analyzing the hippocampal tissue of the pups, we found that both male and female offspring exhibited lower levels of brain-derived neurotrophic factor (BDNF) gene expression due to their mothers' hypothyroid state.
However, we observed that choline significantly increased BDNF gene expression in those same pups, suggesting it may help counteract the negative effects of maternal hypothyroidism. The improvements were particularly notable in male offspring. Overall, our findings indicate that choline supplementation during critical developmental windows can enhance brain development and cognitive function in offspring that were exposed to maternal hypothyroidism.
To assess the benefits of choline, we administered it to the mothers from the first day of gestation throughout the early stages of their pups' lives. After analyzing the hippocampal tissue of the pups, we found that both male and female offspring exhibited lower levels of brain-derived neurotrophic factor (BDNF) gene expression due to their mothers' hypothyroid state.
However, we observed that choline significantly increased BDNF gene expression in those same pups, suggesting it may help counteract the negative effects of maternal hypothyroidism. The improvements were particularly notable in male offspring. Overall, our findings indicate that choline supplementation during critical developmental windows can enhance brain development and cognitive function in offspring that were exposed to maternal hypothyroidism.
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9
Myo-inositol reduces thyroid nodule size
Evaluation of thyroid nodule characteristics in subclinical hypothyroid patients under a myo-inositol plus selenium treatment.
Moderate relevance due to combined treatment
We conducted an observational study to explore how myo-inositol (MI) combined with selenium (Se) impacts patients with subclinical hypothyroidism (SCH) and associated thyroid nodules (TNs).
Our research involved 642 patients suspected of having hypothyroidism, focusing on a subset with SCH. We divided them into two groups: one that received the MI plus Se treatment for six months and a control group that did not receive any treatment.
Among the received results, we found that the treatment group showed a significant reduction in the size and number of mixed TNs, alongside an improved elasticity score. Remarkably, TSH levels also dropped significantly after treatment, indicating a positive response. In contrast, the control group experienced an increase in TSH levels, highlighting the potential benefits of MI plus Se for managing symptoms of hypothyroidism.
These findings suggest promising avenues for further research, particularly regarding the role of inositol in thyroid health. While we observed substantial benefits in the treated group, we also emphasize the need for more extensive studies to confirm these effects and their mechanisms.
Our research involved 642 patients suspected of having hypothyroidism, focusing on a subset with SCH. We divided them into two groups: one that received the MI plus Se treatment for six months and a control group that did not receive any treatment.
Among the received results, we found that the treatment group showed a significant reduction in the size and number of mixed TNs, alongside an improved elasticity score. Remarkably, TSH levels also dropped significantly after treatment, indicating a positive response. In contrast, the control group experienced an increase in TSH levels, highlighting the potential benefits of MI plus Se for managing symptoms of hypothyroidism.
These findings suggest promising avenues for further research, particularly regarding the role of inositol in thyroid health. While we observed substantial benefits in the treated group, we also emphasize the need for more extensive studies to confirm these effects and their mechanisms.
Read More
Most Useful Reviews
9.5
Stopped hair loss
Stops with my hypothyroidism-related hair loss. With hypothyroidism, I often faced hair falling out. After six months on choline, inositol, and biotin, my hair has stopped falling out and is growing thickly again.
Read More
9.5
Cholesterol reduction
I have hypothyroidism and a high cholesterol level. After taking this medication for three months, my total cholesterol dropped significantly from 7.8 to 6.4. It’s effective!
Read More
4.5
Awaiting results
Taken to assist with Hashimoto hypothyroidism; I will see in the future if it has made a difference.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.4
- All Researches
9.5
Myo-Inositol and Selenium Effective
Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Patients with Autoimmune Thyroiditis.
Specific effects of inositol unclear
We explored the potential benefits of combining myo-inositol and selenium in patients with autoimmune thyroiditis, particularly those dealing with subclinical hypothyroidism. Our study included 86 patients who had elevated thyroid-stimulating hormone (TSH) levels but normal thyroid hormone levels, indicating early signs of thyroid dysfunction.
After six months of treatment with myo-inositol and selenium, we observed significant changes: TSH levels decreased, while important thyroid hormone markers, TPOAb and TgAb, also showed reduction. Interestingly, we noted an improvement in the overall quality of life for the patients involved in the study.
A special case of one hyperthyroid patient stood out; their TSH levels showed a positive shift from 0.14 U/ml to 1.02 U/ml, bringing them back into a normal range. This suggests that combined treatment with myo-inositol and selenium not only aids in reducing thyroid-related antibodies but also promotes a healthier thyroid overall.
In summary, our findings indicate that integrating myo-inositol with selenium can effectively support thyroid health for those affected by autoimmune thyroiditis.
After six months of treatment with myo-inositol and selenium, we observed significant changes: TSH levels decreased, while important thyroid hormone markers, TPOAb and TgAb, also showed reduction. Interestingly, we noted an improvement in the overall quality of life for the patients involved in the study.
A special case of one hyperthyroid patient stood out; their TSH levels showed a positive shift from 0.14 U/ml to 1.02 U/ml, bringing them back into a normal range. This suggests that combined treatment with myo-inositol and selenium not only aids in reducing thyroid-related antibodies but also promotes a healthier thyroid overall.
In summary, our findings indicate that integrating myo-inositol with selenium can effectively support thyroid health for those affected by autoimmune thyroiditis.
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9
Myo-inositol and selenium aid hypothyroidism
Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism.
Effects of combined treatment
In our recent study, we explored the effects of myo-inositol combined with selenium on women diagnosed with subclinical hypothyroidism. We included 148 participants from eight centers across Slovakia, all women of reproductive age. These women displayed thyroid-stimulating hormone (TSH) levels indicating subclinical hypothyroidism and some exhibited autoimmune markers.
The treatment involved a daily supplementation of 600 mg of myo-inositol and 83 mcg of selenium over a period of six months. We carefully monitored changes in TSH levels, symptoms associated with hypothyroidism, and overall thyroid function throughout this time.
Our findings revealed a significant improvement in TSH levels among the participants after the supplement regimen. Additionally, there was a notable reduction in autoimmune antibody levels for a subset of patients. Many women reported improvements in their menstrual cycles and a decrease in cholesterol levels, which often aligns with thyroid health.
This combination of myo-inositol and selenium not only appeared to stabilize thyroid function but also alleviated the symptoms linked to subclinical hypothyroidism. Overall, our research indicates the potential benefits of these supplements in managing this condition.
The treatment involved a daily supplementation of 600 mg of myo-inositol and 83 mcg of selenium over a period of six months. We carefully monitored changes in TSH levels, symptoms associated with hypothyroidism, and overall thyroid function throughout this time.
Our findings revealed a significant improvement in TSH levels among the participants after the supplement regimen. Additionally, there was a notable reduction in autoimmune antibody levels for a subset of patients. Many women reported improvements in their menstrual cycles and a decrease in cholesterol levels, which often aligns with thyroid health.
This combination of myo-inositol and selenium not only appeared to stabilize thyroid function but also alleviated the symptoms linked to subclinical hypothyroidism. Overall, our research indicates the potential benefits of these supplements in managing this condition.
Read More
9
Myo-Inositol aids hypothyroidism treatment
Myo-inositol in autoimmune thyroiditis, and hypothyroidism.
Study evaluates Myo-Ins effectiveness
We explored the effects of myo-inositol (Myo-Ins) on individuals with hypothyroidism, particularly those diagnosed with autoimmune thyroiditis. In recent studies, patients were treated with a combination of Myo-Ins and seleniomethionine, which led to significant declines in thyroid-stimulating hormone (TSH) levels. This suggests that Myo-Ins may play a role in managing subclinical hypothyroidism.
Importantly, the treatment also resulted in a decrease in antithyroid autoantibodies and serum CXCL10 levels, indicating an immune-modulatory effect of Myo-Ins. However, it’s crucial to note that because Myo-Ins was evaluated alongside seleniomethionine, it's difficult to determine the specific benefits attributed solely to inositol.
Overall, while the combined treatment shows promise, further research with larger populations is necessary to fully understand Myo-Ins’ impact on quality of life and its mechanisms, especially regarding chemokines.
Importantly, the treatment also resulted in a decrease in antithyroid autoantibodies and serum CXCL10 levels, indicating an immune-modulatory effect of Myo-Ins. However, it’s crucial to note that because Myo-Ins was evaluated alongside seleniomethionine, it's difficult to determine the specific benefits attributed solely to inositol.
Overall, while the combined treatment shows promise, further research with larger populations is necessary to fully understand Myo-Ins’ impact on quality of life and its mechanisms, especially regarding chemokines.
Read More
9
Myo-inositol reduces thyroid nodule size
Evaluation of thyroid nodule characteristics in subclinical hypothyroid patients under a myo-inositol plus selenium treatment.
Moderate relevance due to combined treatment
We conducted an observational study to explore how myo-inositol (MI) combined with selenium (Se) impacts patients with subclinical hypothyroidism (SCH) and associated thyroid nodules (TNs).
Our research involved 642 patients suspected of having hypothyroidism, focusing on a subset with SCH. We divided them into two groups: one that received the MI plus Se treatment for six months and a control group that did not receive any treatment.
Among the received results, we found that the treatment group showed a significant reduction in the size and number of mixed TNs, alongside an improved elasticity score. Remarkably, TSH levels also dropped significantly after treatment, indicating a positive response. In contrast, the control group experienced an increase in TSH levels, highlighting the potential benefits of MI plus Se for managing symptoms of hypothyroidism.
These findings suggest promising avenues for further research, particularly regarding the role of inositol in thyroid health. While we observed substantial benefits in the treated group, we also emphasize the need for more extensive studies to confirm these effects and their mechanisms.
Our research involved 642 patients suspected of having hypothyroidism, focusing on a subset with SCH. We divided them into two groups: one that received the MI plus Se treatment for six months and a control group that did not receive any treatment.
Among the received results, we found that the treatment group showed a significant reduction in the size and number of mixed TNs, alongside an improved elasticity score. Remarkably, TSH levels also dropped significantly after treatment, indicating a positive response. In contrast, the control group experienced an increase in TSH levels, highlighting the potential benefits of MI plus Se for managing symptoms of hypothyroidism.
These findings suggest promising avenues for further research, particularly regarding the role of inositol in thyroid health. While we observed substantial benefits in the treated group, we also emphasize the need for more extensive studies to confirm these effects and their mechanisms.
Read More
9
Supplementation improves thyroid function
Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism.
Study highlights MI-Se effectiveness
We explored the effectiveness of myo-inositol (MI) and selenium (Se) supplements in treating Hashimoto's thyroiditis, specifically for patients dealing with subclinical hypothyroidism (SH). In this study, 168 participants with elevated Thyroid Stimulating Hormone (TSH) levels were split into two groups: one received both MI and Se, while the other group was given Se alone.
After six months of treatment, we observed significant improvements in the group taking MI-Se. Notably, TSH levels, along with anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) antibodies, saw a marked decrease. Moreover, there was a notable rise in free serum T4 levels for those on the combined treatment, which also contributed positively to their overall quality of life.
In conclusion, our findings suggest that the combination of MI and Se is an effective strategy for reinstating normal thyroid function in patients with autoimmune thyroiditis, thus restoring their wellbeing.
After six months of treatment, we observed significant improvements in the group taking MI-Se. Notably, TSH levels, along with anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) antibodies, saw a marked decrease. Moreover, there was a notable rise in free serum T4 levels for those on the combined treatment, which also contributed positively to their overall quality of life.
In conclusion, our findings suggest that the combination of MI and Se is an effective strategy for reinstating normal thyroid function in patients with autoimmune thyroiditis, thus restoring their wellbeing.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Stopped hair loss
Stops with my hypothyroidism-related hair loss. With hypothyroidism, I often faced hair falling out. After six months on choline, inositol, and biotin, my hair has stopped falling out and is growing thickly again.
9.5
Cholesterol reduction
I have hypothyroidism and a high cholesterol level. After taking this medication for three months, my total cholesterol dropped significantly from 7.8 to 6.4. It’s effective!
4.5
Awaiting results
Taken to assist with Hashimoto hypothyroidism; I will see in the future if it has made a difference.
8
Improved sleep quality
I've been sleeping better! I used to consume more ingredients than this, yet I noticed an improvement in my sleep quality. Realising this, I decided to reduce the number of ingredients and switch to this one. The effect has remained consistent. I've heard that inositol is beneficial for hypothyroidism, which is a chronic condition, so I intend to continue this way.
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