Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 9 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
†
Top Medical Research Studies
7
We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.
To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.
Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.
Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
Read More
9
Myo-inositol aids menopause health
We conducted a study to see if myo-inositol, recognized for its insulin-sensitizing properties, could help postmenopausal women dealing with metabolic syndrome. Eighty women participated in a controlled trial, engaging in a modified diet combined with either myo-inositol supplementation or a placebo for six months.
Our findings were promising. Women who took myo-inositol experienced notable improvements in several health markers. Specifically, there was a reduction in both systolic and diastolic blood pressure, along with significant drops in the HOMA index—an important measure of insulin resistance—cholesterol levels, and triglycerides. In fact, those taking myo-inositol saw a remarkable 75% decrease in insulin resistance and a 20% reduction in triglycerides.
The results suggest that myo-inositol could be a valuable option for improving the health of postmenopausal women suffering from metabolic syndrome. This is encouraging news for those looking for effective ways to manage their health during menopause.
Our findings were promising. Women who took myo-inositol experienced notable improvements in several health markers. Specifically, there was a reduction in both systolic and diastolic blood pressure, along with significant drops in the HOMA index—an important measure of insulin resistance—cholesterol levels, and triglycerides. In fact, those taking myo-inositol saw a remarkable 75% decrease in insulin resistance and a 20% reduction in triglycerides.
The results suggest that myo-inositol could be a valuable option for improving the health of postmenopausal women suffering from metabolic syndrome. This is encouraging news for those looking for effective ways to manage their health during menopause.
Read More
9
Myo-inositol improves menopausal symptoms
We undertook a retrospective clinical study examining how myo-inositol, along with cocoa polyphenols and soy isoflavones, influences menopausal symptoms in women with metabolic syndrome. Analyzing data from 200 menopausal women, we focused on the effects of a daily supplement over a period of six months.
Our findings indicated significant improvements in both vasomotor symptoms, like hot flushes, and overall metabolic health. For instance, the number of women experiencing frequent hot flushes reduced dramatically, with more women reporting only a few flushes after supplementation. Additionally, we noted a decrease in moderate depression symptoms among participants.
On the metabolic side, women showed improvements in body mass index and waist circumference, paralleling a reduction in the percentage of those categorized as overweight or obese. We also observed a reduction in the number of participants suffering from non-insulin dependent diabetes, suggesting a positive impact of the supplement on metabolic health.
These encouraging results point to the potential benefits of myo-inositol and its accompanying compounds for managing menopausal symptoms and metabolic issues. However, we recognize the need for further controlled clinical trials to fully understand the effectiveness of these natural supplements.
Our findings indicated significant improvements in both vasomotor symptoms, like hot flushes, and overall metabolic health. For instance, the number of women experiencing frequent hot flushes reduced dramatically, with more women reporting only a few flushes after supplementation. Additionally, we noted a decrease in moderate depression symptoms among participants.
On the metabolic side, women showed improvements in body mass index and waist circumference, paralleling a reduction in the percentage of those categorized as overweight or obese. We also observed a reduction in the number of participants suffering from non-insulin dependent diabetes, suggesting a positive impact of the supplement on metabolic health.
These encouraging results point to the potential benefits of myo-inositol and its accompanying compounds for managing menopausal symptoms and metabolic issues. However, we recognize the need for further controlled clinical trials to fully understand the effectiveness of these natural supplements.
Read More
Most Useful Reviews
9
Irritation reduced
1 people found this helpful
I've repurchased this product as it has improved all symptoms of late-stage menopause for me. I even recommended it to my nephew, who experienced insomnia, and he felt better shortly after taking it. I truly appreciate inositol's effects and gladly recommend it for anyone looking to reduce irritability.
Read More
9
Doctor approved
During menopause, this remedy has been very important and necessary. My doctor has approved its use!
Read More
9
Relieves symptoms
This product boasts excellent quality ingredients. Inositol aids in enhancing insulin sensitivity, essential for preventing diabetes, especially during menopause. It alleviates symptoms like high blood pressure, sudden hot flashes, and mood shifts. The capsule size is medium, tasteless, and odourless, and I take it alongside other supplements.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
- All Researches
9
Myo-inositol improves menopausal symptoms
We undertook a retrospective clinical study examining how myo-inositol, along with cocoa polyphenols and soy isoflavones, influences menopausal symptoms in women with metabolic syndrome. Analyzing data from 200 menopausal women, we focused on the effects of a daily supplement over a period of six months.
Our findings indicated significant improvements in both vasomotor symptoms, like hot flushes, and overall metabolic health. For instance, the number of women experiencing frequent hot flushes reduced dramatically, with more women reporting only a few flushes after supplementation. Additionally, we noted a decrease in moderate depression symptoms among participants.
On the metabolic side, women showed improvements in body mass index and waist circumference, paralleling a reduction in the percentage of those categorized as overweight or obese. We also observed a reduction in the number of participants suffering from non-insulin dependent diabetes, suggesting a positive impact of the supplement on metabolic health.
These encouraging results point to the potential benefits of myo-inositol and its accompanying compounds for managing menopausal symptoms and metabolic issues. However, we recognize the need for further controlled clinical trials to fully understand the effectiveness of these natural supplements.
Our findings indicated significant improvements in both vasomotor symptoms, like hot flushes, and overall metabolic health. For instance, the number of women experiencing frequent hot flushes reduced dramatically, with more women reporting only a few flushes after supplementation. Additionally, we noted a decrease in moderate depression symptoms among participants.
On the metabolic side, women showed improvements in body mass index and waist circumference, paralleling a reduction in the percentage of those categorized as overweight or obese. We also observed a reduction in the number of participants suffering from non-insulin dependent diabetes, suggesting a positive impact of the supplement on metabolic health.
These encouraging results point to the potential benefits of myo-inositol and its accompanying compounds for managing menopausal symptoms and metabolic issues. However, we recognize the need for further controlled clinical trials to fully understand the effectiveness of these natural supplements.
Read More
9
Myo-inositol aids menopause health
We conducted a study to see if myo-inositol, recognized for its insulin-sensitizing properties, could help postmenopausal women dealing with metabolic syndrome. Eighty women participated in a controlled trial, engaging in a modified diet combined with either myo-inositol supplementation or a placebo for six months.
Our findings were promising. Women who took myo-inositol experienced notable improvements in several health markers. Specifically, there was a reduction in both systolic and diastolic blood pressure, along with significant drops in the HOMA index—an important measure of insulin resistance—cholesterol levels, and triglycerides. In fact, those taking myo-inositol saw a remarkable 75% decrease in insulin resistance and a 20% reduction in triglycerides.
The results suggest that myo-inositol could be a valuable option for improving the health of postmenopausal women suffering from metabolic syndrome. This is encouraging news for those looking for effective ways to manage their health during menopause.
Our findings were promising. Women who took myo-inositol experienced notable improvements in several health markers. Specifically, there was a reduction in both systolic and diastolic blood pressure, along with significant drops in the HOMA index—an important measure of insulin resistance—cholesterol levels, and triglycerides. In fact, those taking myo-inositol saw a remarkable 75% decrease in insulin resistance and a 20% reduction in triglycerides.
The results suggest that myo-inositol could be a valuable option for improving the health of postmenopausal women suffering from metabolic syndrome. This is encouraging news for those looking for effective ways to manage their health during menopause.
Read More
8
Myo-inositol shows potential benefits
This study explored how a new supplement, featuring myo-inositol, cocoa polyphenols, and soy isoflavones, affects cardiovascular risk markers in postmenopausal women dealing with metabolic syndrome. We recruited 60 women and divided them into two groups: one received the supplement, while the other got a placebo for six months.
During this period, we looked at various health indicators such as glucose levels, triglycerides, and specific proteins associated with inflammation and bone health. By the six-month mark, we observed meaningful improvements in glucose, triglycerides, visfatin, resistin, and bone-specific alkaline phosphatase (bone-ALP) for those taking the supplement compared to the placebo group.
However, levels of HDL cholesterol and adiponectin did not show any significant differences between the two groups. Overall, while the combination of ingredients in the supplement improved several biomarkers tied to metabolic syndrome, it’s challenging to pinpoint the specific contribution of myo-inositol alone due to the complexity of the formulation.
During this period, we looked at various health indicators such as glucose levels, triglycerides, and specific proteins associated with inflammation and bone health. By the six-month mark, we observed meaningful improvements in glucose, triglycerides, visfatin, resistin, and bone-specific alkaline phosphatase (bone-ALP) for those taking the supplement compared to the placebo group.
However, levels of HDL cholesterol and adiponectin did not show any significant differences between the two groups. Overall, while the combination of ingredients in the supplement improved several biomarkers tied to metabolic syndrome, it’s challenging to pinpoint the specific contribution of myo-inositol alone due to the complexity of the formulation.
Read More
8
We conducted a six-month randomized placebo-controlled trial involving 155 postmenopausal women with metabolic syndrome, specifically those at risk for breast cancer. Our goal was to see how the combination of inositol and alpha lipoic acid impacts insulin resistance and other metabolic features related to menopause.
Participants were assigned to either a treatment group, taking inositol and alpha lipoic acid, or a placebo group. They all followed a low-calorie diet. We focused on primary outcomes such as reducing the HOMA-IR index and lowering triglyceride levels, as well as secondary outcomes like improving HDL cholesterol and reducing body measurements.
The results showed that this combination can significantly improve insulin sensitivity and help with metabolic syndrome symptoms. Given that metabolic syndrome is a modifiable risk factor for breast cancer, this suggests that incorporating inositol and alpha lipoic acid could be beneficial for those looking to improve their health during menopause.
Participants were assigned to either a treatment group, taking inositol and alpha lipoic acid, or a placebo group. They all followed a low-calorie diet. We focused on primary outcomes such as reducing the HOMA-IR index and lowering triglyceride levels, as well as secondary outcomes like improving HDL cholesterol and reducing body measurements.
The results showed that this combination can significantly improve insulin sensitivity and help with metabolic syndrome symptoms. Given that metabolic syndrome is a modifiable risk factor for breast cancer, this suggests that incorporating inositol and alpha lipoic acid could be beneficial for those looking to improve their health during menopause.
Read More
7
We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.
To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.
Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.
Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Irritation reduced
1 people found this helpful
I've repurchased this product as it has improved all symptoms of late-stage menopause for me. I even recommended it to my nephew, who experienced insomnia, and he felt better shortly after taking it. I truly appreciate inositol's effects and gladly recommend it for anyone looking to reduce irritability.
Read More
9
Doctor approved
During menopause, this remedy has been very important and necessary. My doctor has approved its use!
Read More
9
Relieves symptoms
This product boasts excellent quality ingredients. Inositol aids in enhancing insulin sensitivity, essential for preventing diabetes, especially during menopause. It alleviates symptoms like high blood pressure, sudden hot flashes, and mood shifts. The capsule size is medium, tasteless, and odourless, and I take it alongside other supplements.
Read More
7.5
Revitalized feeling achieved
8 people found this helpful
As I age and experience menopause, I often feel fatigued with a heavy head, likely exacerbated by daily alcohol consumption. However, after trying this supplement, I have felt progressively lighter and more refreshed. I take it right after breakfast and intend to continue.
Read More
9
Clearer mind
Since I began taking these, the brain fog from menopause has significantly lifted, leaving my mind much clearer. The benefits are remarkable, so I’ve ordered another two batches to be shipped to New Zealand!
Read More
Frequently Asked Questions
9
Clearer mind
Since I began taking these, the brain fog from menopause has significantly lifted, leaving my mind much clearer. The benefits are remarkable, so I’ve ordered another two batches to be shipped to New Zealand!
7.5
Revitalized feeling achieved
8 people found this helpful
As I age and experience menopause, I often feel fatigued with a heavy head, likely exacerbated by daily alcohol consumption. However, after trying this supplement, I have felt progressively lighter and more refreshed. I take it right after breakfast and intend to continue.
7.5
Reduced anxiety
This is a great-quality product with notable benefits. It’s among my top brands. I've noticed a reduction in pre-menstrual pain and inflammation. Currently in my first stage of menopause, I find it beneficial for the nervous system and hormonal imbalance affecting my emotional state and metabolism. I've felt calmer, less irritable, and maintained my weight during a time when many women gain. The flavour is neutral, and the size is average. Regular intake is essential to reap the full benefits.
9
Irritation reduced
1 people found this helpful
I've repurchased this product as it has improved all symptoms of late-stage menopause for me. I even recommended it to my nephew, who experienced insomnia, and he felt better shortly after taking it. I truly appreciate inositol's effects and gladly recommend it for anyone looking to reduce irritability.
9
Relieves symptoms
This product boasts excellent quality ingredients. Inositol aids in enhancing insulin sensitivity, essential for preventing diabetes, especially during menopause. It alleviates symptoms like high blood pressure, sudden hot flashes, and mood shifts. The capsule size is medium, tasteless, and odourless, and I take it alongside other supplements.
7.5
Symptoms alleviated
19 people found this helpful
Upon turning 40, I began to experience various issues such as anxiety, irritability, and palpitations, possibly linked to pre-menopause or PMS. Although my hormone levels were normal, I preferred focusing on natural remedies. I'm using Chinese medicine, iron, choline, and inositol to support my nervous system. This supplement has significantly soothed my symptoms which were still present before my period, making it a worthwhile addition to my routine.
9
Doctor approved
During menopause, this remedy has been very important and necessary. My doctor has approved its use!
9
Myo-inositol improves menopausal symptoms
We undertook a retrospective clinical study examining how myo-inositol, along with cocoa polyphenols and soy isoflavones, influences menopausal symptoms in women with metabolic syndrome. Analyzing data from 200 menopausal women, we focused on the effects of a daily supplement over a period of six months.
Our findings indicated significant improvements in both vasomotor symptoms, like hot flushes, and overall metabolic health. For instance, the number of women experiencing frequent hot flushes reduced dramatically, with more women reporting only a few flushes after supplementation. Additionally, we noted a decrease in moderate depression symptoms among participants.
On the metabolic side, women showed improvements in body mass index and waist circumference, paralleling a reduction in the percentage of those categorized as overweight or obese. We also observed a reduction in the number of participants suffering from non-insulin dependent diabetes, suggesting a positive impact of the supplement on metabolic health.
These encouraging results point to the potential benefits of myo-inositol and its accompanying compounds for managing menopausal symptoms and metabolic issues. However, we recognize the need for further controlled clinical trials to fully understand the effectiveness of these natural supplements.
Our findings indicated significant improvements in both vasomotor symptoms, like hot flushes, and overall metabolic health. For instance, the number of women experiencing frequent hot flushes reduced dramatically, with more women reporting only a few flushes after supplementation. Additionally, we noted a decrease in moderate depression symptoms among participants.
On the metabolic side, women showed improvements in body mass index and waist circumference, paralleling a reduction in the percentage of those categorized as overweight or obese. We also observed a reduction in the number of participants suffering from non-insulin dependent diabetes, suggesting a positive impact of the supplement on metabolic health.
These encouraging results point to the potential benefits of myo-inositol and its accompanying compounds for managing menopausal symptoms and metabolic issues. However, we recognize the need for further controlled clinical trials to fully understand the effectiveness of these natural supplements.
9
Myo-inositol aids menopause health
We conducted a study to see if myo-inositol, recognized for its insulin-sensitizing properties, could help postmenopausal women dealing with metabolic syndrome. Eighty women participated in a controlled trial, engaging in a modified diet combined with either myo-inositol supplementation or a placebo for six months.
Our findings were promising. Women who took myo-inositol experienced notable improvements in several health markers. Specifically, there was a reduction in both systolic and diastolic blood pressure, along with significant drops in the HOMA index—an important measure of insulin resistance—cholesterol levels, and triglycerides. In fact, those taking myo-inositol saw a remarkable 75% decrease in insulin resistance and a 20% reduction in triglycerides.
The results suggest that myo-inositol could be a valuable option for improving the health of postmenopausal women suffering from metabolic syndrome. This is encouraging news for those looking for effective ways to manage their health during menopause.
Our findings were promising. Women who took myo-inositol experienced notable improvements in several health markers. Specifically, there was a reduction in both systolic and diastolic blood pressure, along with significant drops in the HOMA index—an important measure of insulin resistance—cholesterol levels, and triglycerides. In fact, those taking myo-inositol saw a remarkable 75% decrease in insulin resistance and a 20% reduction in triglycerides.
The results suggest that myo-inositol could be a valuable option for improving the health of postmenopausal women suffering from metabolic syndrome. This is encouraging news for those looking for effective ways to manage their health during menopause.
7
We explored the effects of a dietary supplement, myo-inositol, on women going through menopause. This study involved 40 women aged between 45 and 55 who had not had their period for at least six months. Participants were divided into two groups: one received myo-inositol alone, while the other got a combination of myo-inositol and melatonin.
After six months of treatment, we evaluated various health indicators, including thyroid function and insulin levels. The results indicated that while myo-inositol alone improved thyroid function, the combination with melatonin positively influenced glucose metabolism. We also noted that serum insulin levels decreased in both groups.
Notably, there were no significant differences between the two groups at baseline or after the trial, making it challenging to isolate the specific impact of inositol alone on menopausal symptoms. Our findings suggest that while myo-inositol has potential benefits, more research is needed to discern its effectiveness without the influence of melatonin.
After six months of treatment, we evaluated various health indicators, including thyroid function and insulin levels. The results indicated that while myo-inositol alone improved thyroid function, the combination with melatonin positively influenced glucose metabolism. We also noted that serum insulin levels decreased in both groups.
Notably, there were no significant differences between the two groups at baseline or after the trial, making it challenging to isolate the specific impact of inositol alone on menopausal symptoms. Our findings suggest that while myo-inositol has potential benefits, more research is needed to discern its effectiveness without the influence of melatonin.
7
We conducted a study to explore how myo-inositol interacts with metformin in postmenopausal women who have prediabetes. Our research included two groups of women: one group taking myo-inositol and the other not.
Both groups were treated with metformin for six months to see how these treatments would affect different hormone levels, particularly gonadotropins, which are crucial for reproductive health. We found that the women taking myo-inositol experienced a stronger decrease in certain hormone levels compared to those who didn't.
While the results suggest that myo-inositol may enhance the effects of metformin, it's important to note that our study involved a small group of participants. This limits our ability to draw broader conclusions, especially about how this combination might work in premenopausal women.
Overall, the insights gained could be beneficial for postmenopausal women considering treatment options for hormone regulation associated with menopause.
Both groups were treated with metformin for six months to see how these treatments would affect different hormone levels, particularly gonadotropins, which are crucial for reproductive health. We found that the women taking myo-inositol experienced a stronger decrease in certain hormone levels compared to those who didn't.
While the results suggest that myo-inositol may enhance the effects of metformin, it's important to note that our study involved a small group of participants. This limits our ability to draw broader conclusions, especially about how this combination might work in premenopausal women.
Overall, the insights gained could be beneficial for postmenopausal women considering treatment options for hormone regulation associated with menopause.
7
We enrolled eighty postmenopausal women suffering from metabolic syndrome to explore the effects of myo-inositol on various health parameters over a twelve-month period. All participants followed a low-energy diet and were randomly assigned to receive either 2 grams of myo-inositol twice daily or a placebo. Throughout the study, we monitored several health indicators, including blood glucose, insulin levels, and cholesterol.
After twelve months, we observed significant improvements in nearly all parameters for those taking myo-inositol, with only body mass index and waist circumference not showing notable changes. Encouragingly, 20% of the women in the myo-inositol group no longer met the criteria for metabolic syndrome by the end of the study, compared to just one woman in the placebo group.
While this study focused on metabolic syndrome rather than menopause symptoms, the findings suggest that myo-inositol may help enhance insulin sensitivity in postmenopausal women. However, we did not specifically investigate the direct effects on menopause symptoms, making it challenging to draw conclusions about its overall impact in this area.
After twelve months, we observed significant improvements in nearly all parameters for those taking myo-inositol, with only body mass index and waist circumference not showing notable changes. Encouragingly, 20% of the women in the myo-inositol group no longer met the criteria for metabolic syndrome by the end of the study, compared to just one woman in the placebo group.
While this study focused on metabolic syndrome rather than menopause symptoms, the findings suggest that myo-inositol may help enhance insulin sensitivity in postmenopausal women. However, we did not specifically investigate the direct effects on menopause symptoms, making it challenging to draw conclusions about its overall impact in this area.
8
We conducted a six-month randomized placebo-controlled trial involving 155 postmenopausal women with metabolic syndrome, specifically those at risk for breast cancer. Our goal was to see how the combination of inositol and alpha lipoic acid impacts insulin resistance and other metabolic features related to menopause.
Participants were assigned to either a treatment group, taking inositol and alpha lipoic acid, or a placebo group. They all followed a low-calorie diet. We focused on primary outcomes such as reducing the HOMA-IR index and lowering triglyceride levels, as well as secondary outcomes like improving HDL cholesterol and reducing body measurements.
The results showed that this combination can significantly improve insulin sensitivity and help with metabolic syndrome symptoms. Given that metabolic syndrome is a modifiable risk factor for breast cancer, this suggests that incorporating inositol and alpha lipoic acid could be beneficial for those looking to improve their health during menopause.
Participants were assigned to either a treatment group, taking inositol and alpha lipoic acid, or a placebo group. They all followed a low-calorie diet. We focused on primary outcomes such as reducing the HOMA-IR index and lowering triglyceride levels, as well as secondary outcomes like improving HDL cholesterol and reducing body measurements.
The results showed that this combination can significantly improve insulin sensitivity and help with metabolic syndrome symptoms. Given that metabolic syndrome is a modifiable risk factor for breast cancer, this suggests that incorporating inositol and alpha lipoic acid could be beneficial for those looking to improve their health during menopause.
8
Myo-inositol shows potential benefits
This study explored how a new supplement, featuring myo-inositol, cocoa polyphenols, and soy isoflavones, affects cardiovascular risk markers in postmenopausal women dealing with metabolic syndrome. We recruited 60 women and divided them into two groups: one received the supplement, while the other got a placebo for six months.
During this period, we looked at various health indicators such as glucose levels, triglycerides, and specific proteins associated with inflammation and bone health. By the six-month mark, we observed meaningful improvements in glucose, triglycerides, visfatin, resistin, and bone-specific alkaline phosphatase (bone-ALP) for those taking the supplement compared to the placebo group.
However, levels of HDL cholesterol and adiponectin did not show any significant differences between the two groups. Overall, while the combination of ingredients in the supplement improved several biomarkers tied to metabolic syndrome, it’s challenging to pinpoint the specific contribution of myo-inositol alone due to the complexity of the formulation.
During this period, we looked at various health indicators such as glucose levels, triglycerides, and specific proteins associated with inflammation and bone health. By the six-month mark, we observed meaningful improvements in glucose, triglycerides, visfatin, resistin, and bone-specific alkaline phosphatase (bone-ALP) for those taking the supplement compared to the placebo group.
However, levels of HDL cholesterol and adiponectin did not show any significant differences between the two groups. Overall, while the combination of ingredients in the supplement improved several biomarkers tied to metabolic syndrome, it’s challenging to pinpoint the specific contribution of myo-inositol alone due to the complexity of the formulation.
7
We explored the role of inositol alongside other supplements like resveratrol and vitamins D and K in addressing cardiovascular and osteoporosis risks during menopause. Research highlights the effectiveness of inositol in enhancing metabolic health, particularly in postmenopausal women.
In clinical studies, inositol has shown promise for improving aspects of metabolic syndrome, which includes conditions that can heighten cardiovascular risks. While it works best when combined with other supplements, its specific benefits on menopause and related health outcomes are well noted.
Although the study provided insights into inositol's contribution to metabolic health, it appears more research is needed to fully understand its isolated effects during menopause. Nevertheless, the synergy of these supplements presents an exciting opportunity for women navigating this life phase.
In clinical studies, inositol has shown promise for improving aspects of metabolic syndrome, which includes conditions that can heighten cardiovascular risks. While it works best when combined with other supplements, its specific benefits on menopause and related health outcomes are well noted.
Although the study provided insights into inositol's contribution to metabolic health, it appears more research is needed to fully understand its isolated effects during menopause. Nevertheless, the synergy of these supplements presents an exciting opportunity for women navigating this life phase.
References
- Cho KA, Kim YH, Woo SY, Ryu KH. Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle. Tissue Eng Regen Med. 2025. 10.1007/s13770-025-00709-w
- Mainini G, Ercolano S, De Simone R, Iavarone I, Lizza R, et al. Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study. Medicina (Kaunas). 2024;60. 10.3390/medicina60040598
- Krysiak R, Kowalcze K, Okopień B. Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women. Gynecol Obstet Invest. 2022;87:373. 10.1159/000527365
- D'Anna R, Santamaria A, Giorgianni G, Vaiarelli A, Gullo G, et al. Myo-inositol and melatonin in the menopausal transition. Gynecol Endocrinol. 2017;33:279. 10.1080/09513590.2016.1254613
- D'Anna R, Santamaria A, Cannata ML, Interdonato ML, Giorgianni GM, et al. Effects of a new flavonoid and Myo-inositol supplement on some biomarkers of cardiovascular risk in postmenopausal women: a randomized trial. Int J Endocrinol. 2014;2014:653561. 10.1155/2014/653561
- Parazzini F. Resveratrol, inositol, vitamin D and K in the prevention of cardiovascular and osteoporotic risk: a novel approach in peri- and postmenopause. Minerva Ginecol. 2014;66:513.
- Capasso I, Esposito E, Maurea N, Montella M, Crispo A, et al. Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. Trials. 2013;14:273. 10.1186/1745-6215-14-273
- Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, et al. One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome. Climacteric. 2012;15:490. 10.3109/13697137.2011.631063
- Giordano D, Corrado F, Santamaria A, Quattrone S, Pintaudi B, et al. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. Menopause. 2011;18:102. 10.1097/gme.0b013e3181e8e1b1
