' 
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Curcumin Phytosome(Turmeric Rhizome Extract (curcuma longa)/Phosphatidyl Choline Complex) (Meriva® Turmeric Phytosome)(Standardized to min. 18% Curcuminoids - 90 mg)
500 mg
**
Top Medical Research Studies
9
Curcumin aids cognitive function
The effects of curcumin in learning and memory impairment associated with hypothyroidism in juvenile rats: the role of nitric oxide, oxidative stress, and brain-derived neurotrophic factor.
High relevance to hypothyroidism
We aimed to explore how curcumin, a natural compound found in turmeric, might influence cognitive challenges related to hypothyroidism in young rats. In this study, juvenile rats were split into several groups, with one group receiving hypothyroidism-inducing treatment while others were supplemented with varying doses of curcumin over six weeks.
The findings revealed some intriguing outcomes. In the hypothyroid group, rats struggled significantly in learning tasks compared to their healthy counterparts. They took longer to find hidden platforms in a water maze and spent less time in the desired areas during memory tests, indicating noticeable cognitive impairment. However, after curcumin treatment, the performance of these hypothyroid rats improved in both maze and avoidance tests.
Moreover, curcumin appeared to reduce markers of oxidative stress and increased the levels of important antioxidants in the brain. It also boosted the production of brain-derived neurotrophic factor (BDNF), which is crucial for learning and memory. This suggests that curcumin may help protect against some cognitive decline associated with hypothyroidism by tackling oxidative damage and enhancing essential neurotrophic support.
The findings revealed some intriguing outcomes. In the hypothyroid group, rats struggled significantly in learning tasks compared to their healthy counterparts. They took longer to find hidden platforms in a water maze and spent less time in the desired areas during memory tests, indicating noticeable cognitive impairment. However, after curcumin treatment, the performance of these hypothyroid rats improved in both maze and avoidance tests.
Moreover, curcumin appeared to reduce markers of oxidative stress and increased the levels of important antioxidants in the brain. It also boosted the production of brain-derived neurotrophic factor (BDNF), which is crucial for learning and memory. This suggests that curcumin may help protect against some cognitive decline associated with hypothyroidism by tackling oxidative damage and enhancing essential neurotrophic support.
Read More
7
Curcumin alleviates hypothyroid oxidative stress
Induction of oxidative stress and inhibition of superoxide dismutase expression in rat cerebral cortex and cerebellum by PTU-induced hypothyroidism and its reversal by curcumin.
Highlights curcumin's differential effects
We investigated how curcumin, a compound found in turmeric, impacts oxidative stress associated with hypothyroidism in rats. Specifically, we aimed to understand whether curcumin could enhance the levels of superoxide dismutase (SOD), an important antioxidant enzyme, in the brains of hypothyroid rats induced by a substance called PTU.
Our findings revealed that hypothyroidism led to increased lipid peroxidation—a sign of oxidative stress—in the cerebellum of the rats, although the cerebral cortex did not exhibit this change. When we treated these hypothyroid rats with curcumin, we noticed a significant decrease in lipid peroxidation levels in both brain areas.
Interestingly, while curcumin treatment improved levels of SOD1 and SOD2 proteins in different brain regions, it had varying effects. In the cerebellum, curcumin treatment seemed to reduce the activity of SOD, even though it did improve the translated products. This suggests that curcumin can alter the expression of antioxidant mechanisms differently in the brain's cortex and cerebellum during hypothyroidism.
Overall, our exploration indicates that curcumin might provide a beneficial effect on oxidative stress linked to hypothyroidism, emphasizing the complexity of its impact on brain health.
Our findings revealed that hypothyroidism led to increased lipid peroxidation—a sign of oxidative stress—in the cerebellum of the rats, although the cerebral cortex did not exhibit this change. When we treated these hypothyroid rats with curcumin, we noticed a significant decrease in lipid peroxidation levels in both brain areas.
Interestingly, while curcumin treatment improved levels of SOD1 and SOD2 proteins in different brain regions, it had varying effects. In the cerebellum, curcumin treatment seemed to reduce the activity of SOD, even though it did improve the translated products. This suggests that curcumin can alter the expression of antioxidant mechanisms differently in the brain's cortex and cerebellum during hypothyroidism.
Overall, our exploration indicates that curcumin might provide a beneficial effect on oxidative stress linked to hypothyroidism, emphasizing the complexity of its impact on brain health.
Read More
9
Curcumin may aid hypothyroidism
Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats.
Moderately relevant study findings
We explored the impact of curcumin, a natural compound found in turmeric, on thyroid function in rats suffering from hypothyroidism induced by propylthiouracil (PTU). Over a period of 30 days, rats were treated with varioPUs combinations of curcumin and PTU. Some received only curcumin, some only PTU, while a control group was treated with a vehicle.
Our findings revealed that the rats receiving PTU alone showed significant changes in their thyroid glands, such as increased follicle size and decreased hormone levels. However, when curcumin was administered alongside PTU, we observed a remarkable reversal of these negative effects. The combined treatment appeared to reduce the thyroid gland's hyperactivity and restored hormone levels toward normal.
Importantly, the results suggest that curcumin can protect the thyroid from the damaging effects of hypothyroidism. This research adds valuable insights into how a simple natural remedy might positively influence thyroid health, indicating that curcumin could be a potential supportive treatment for hypothyroidism.
Our findings revealed that the rats receiving PTU alone showed significant changes in their thyroid glands, such as increased follicle size and decreased hormone levels. However, when curcumin was administered alongside PTU, we observed a remarkable reversal of these negative effects. The combined treatment appeared to reduce the thyroid gland's hyperactivity and restored hormone levels toward normal.
Importantly, the results suggest that curcumin can protect the thyroid from the damaging effects of hypothyroidism. This research adds valuable insights into how a simple natural remedy might positively influence thyroid health, indicating that curcumin could be a potential supportive treatment for hypothyroidism.
Read More
Most Useful Reviews
8.3
Control inflammation
Using this to chelate ferritin and lower inflammation from Hashimoto's. As I have Hashimoto's thyroiditis, this specific curcumin offers benefits due to its lack of bioprene. Hashimoto's is an autoimmune condition that inflames and attacks the thyroid, leading to hypothyroidism. If you have high ferritin, it could suggest an underlying infection needing attention. I have found this curcumin helpful in managing ferritin levels and controlling my inflammation while on a balanced diet. The AIP diet significantly improved my symptoms, and I recommend joining support groups for further guidance.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
- All Researches
9
Curcumin supports neural development
In Vitro and In Vivo Supplementation with Curcumin Promotes Hippocampal Neuronal Synapses Development in Rats by Inhibiting GSK-3β and Activating β-catenin.
Curcumin's effects assessed alongside treatments
We explored how curcumin, a compound derived from turmeric, can influence brain development in the context of hypothyroidism. To do this, we set up an experiment using both cell models with oxidative damage and young rats with hypothyroidism. The rats and model cells received treatments with triiodothyronine (T3), tetraiodothyronine (T4), and curcumin.
Our findings revealed that treatment with curcumin, along with T3 and T4, led to an increase in the number of synapses in the brain. This suggests a positive effect on the development of neural connections critical for healthy brain function. We also noticed that curcumin appeared to protect brain cells by inhibiting a protein called GSK-3β, which in turn activated another protein known as β-catenin.
Importantly, when we inhibited β-catenin, the protective effects of curcumin diminished, indicating that β-catenin plays a significant role in curcumin's ability to support neurodevelopment. Overall, our study suggests that curcumin could be a beneficial supplement for addressing some neural impairments associated with hypothyroidism, although the precise impact when isolated from other treatments like T3 and T4 remains an area for further investigation.
Our findings revealed that treatment with curcumin, along with T3 and T4, led to an increase in the number of synapses in the brain. This suggests a positive effect on the development of neural connections critical for healthy brain function. We also noticed that curcumin appeared to protect brain cells by inhibiting a protein called GSK-3β, which in turn activated another protein known as β-catenin.
Importantly, when we inhibited β-catenin, the protective effects of curcumin diminished, indicating that β-catenin plays a significant role in curcumin's ability to support neurodevelopment. Overall, our study suggests that curcumin could be a beneficial supplement for addressing some neural impairments associated with hypothyroidism, although the precise impact when isolated from other treatments like T3 and T4 remains an area for further investigation.
Read More
9
Curcumin may aid hypothyroidism
Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats.
Moderately relevant study findings
We explored the impact of curcumin, a natural compound found in turmeric, on thyroid function in rats suffering from hypothyroidism induced by propylthiouracil (PTU). Over a period of 30 days, rats were treated with varioPUs combinations of curcumin and PTU. Some received only curcumin, some only PTU, while a control group was treated with a vehicle.
Our findings revealed that the rats receiving PTU alone showed significant changes in their thyroid glands, such as increased follicle size and decreased hormone levels. However, when curcumin was administered alongside PTU, we observed a remarkable reversal of these negative effects. The combined treatment appeared to reduce the thyroid gland's hyperactivity and restored hormone levels toward normal.
Importantly, the results suggest that curcumin can protect the thyroid from the damaging effects of hypothyroidism. This research adds valuable insights into how a simple natural remedy might positively influence thyroid health, indicating that curcumin could be a potential supportive treatment for hypothyroidism.
Our findings revealed that the rats receiving PTU alone showed significant changes in their thyroid glands, such as increased follicle size and decreased hormone levels. However, when curcumin was administered alongside PTU, we observed a remarkable reversal of these negative effects. The combined treatment appeared to reduce the thyroid gland's hyperactivity and restored hormone levels toward normal.
Importantly, the results suggest that curcumin can protect the thyroid from the damaging effects of hypothyroidism. This research adds valuable insights into how a simple natural remedy might positively influence thyroid health, indicating that curcumin could be a potential supportive treatment for hypothyroidism.
Read More
9
Curcumin aids cognitive function
The effects of curcumin in learning and memory impairment associated with hypothyroidism in juvenile rats: the role of nitric oxide, oxidative stress, and brain-derived neurotrophic factor.
High relevance to hypothyroidism
We aimed to explore how curcumin, a natural compound found in turmeric, might influence cognitive challenges related to hypothyroidism in young rats. In this study, juvenile rats were split into several groups, with one group receiving hypothyroidism-inducing treatment while others were supplemented with varying doses of curcumin over six weeks.
The findings revealed some intriguing outcomes. In the hypothyroid group, rats struggled significantly in learning tasks compared to their healthy counterparts. They took longer to find hidden platforms in a water maze and spent less time in the desired areas during memory tests, indicating noticeable cognitive impairment. However, after curcumin treatment, the performance of these hypothyroid rats improved in both maze and avoidance tests.
Moreover, curcumin appeared to reduce markers of oxidative stress and increased the levels of important antioxidants in the brain. It also boosted the production of brain-derived neurotrophic factor (BDNF), which is crucial for learning and memory. This suggests that curcumin may help protect against some cognitive decline associated with hypothyroidism by tackling oxidative damage and enhancing essential neurotrophic support.
The findings revealed some intriguing outcomes. In the hypothyroid group, rats struggled significantly in learning tasks compared to their healthy counterparts. They took longer to find hidden platforms in a water maze and spent less time in the desired areas during memory tests, indicating noticeable cognitive impairment. However, after curcumin treatment, the performance of these hypothyroid rats improved in both maze and avoidance tests.
Moreover, curcumin appeared to reduce markers of oxidative stress and increased the levels of important antioxidants in the brain. It also boosted the production of brain-derived neurotrophic factor (BDNF), which is crucial for learning and memory. This suggests that curcumin may help protect against some cognitive decline associated with hypothyroidism by tackling oxidative damage and enhancing essential neurotrophic support.
Read More
7
Curcumin improves liver health
Curcumin restores hepatic epigenetic changes in propylthiouracil(PTU)Induced hypothyroid male rats: A study on DNMTs, MBDs, GADD45a, C/EBP-β and PCNA.
Curcumin's mixed impact noted
We examined how curcumin, an extract from the turmeric plant, affects changes in the liver caused by the hypothyroid drug 6-n-propyl-2-thiouracil (PTU). This drug, while effective for treating certain thyroid conditions, can lead to liver damage and oxidative stress. Our research showed that when rats were given PTU, there were notable epigenetic changes in the liver, including increased levels of specific proteins linked to cell stress and decreased levels of others that are crucial for cell growth and repair.
Surprisingly, when we paired curcumin with PTU treatment, we observed significant improvements. Curcumin appeared to help lower oxidative stress and mitigate the damaging epigenetic changes brought on by PTU, except for one specific factor. Additionally, we noted that the liver's overall cell population and structure were better preserved with the addition of curcumin.
This suggests that curcumin’s powerful antioxidant properties may provide a protective effect against the liver damage associated with certain hypothyroid treatments. However, it’s important to emphasize that our study didn’t isolate the effects of curcumin alone. This means while it showed promise in conjunction with PTU, further research is needed to understand its effects independently.
Surprisingly, when we paired curcumin with PTU treatment, we observed significant improvements. Curcumin appeared to help lower oxidative stress and mitigate the damaging epigenetic changes brought on by PTU, except for one specific factor. Additionally, we noted that the liver's overall cell population and structure were better preserved with the addition of curcumin.
This suggests that curcumin’s powerful antioxidant properties may provide a protective effect against the liver damage associated with certain hypothyroid treatments. However, it’s important to emphasize that our study didn’t isolate the effects of curcumin alone. This means while it showed promise in conjunction with PTU, further research is needed to understand its effects independently.
Read More
7
Curcumin's unclear benefit for hypothyroidism
Curcumin and vitamin E modulate hepatic antioxidant gene expression in PTU-induced hypothyroid rats.
Mixed effects of treatments observed
In our exploration of how curcumin affects hypothyroidism, we examined the impact of both curcumin and vitamin E on antioxidant gene expression in hypothyroid rats. The study involved male rats made hypothyroid through a treatment with 6-propyl-thiouracil and then supplemented with either vitamin E or curcumin for a month.
We observed that the levels of certain antioxidant genes like catalase and glutathione peroxidase were elevated in the hypothyroid rats, but supplementation with either curcumin or vitamin E helped to alleviate these increased levels. Notably, while the activities of some antioxidant enzymes were normalized with curcumin and vitamin E, the overall influence of curcumin alone on hypothyroidism remains unclear, as vitamin E was present in the treatment regimen.
Our findings suggest that curcumin does contribute to antioxidant activity in hypothyroid conditions. However, it’s important to highlight that it may not exert benefits on its own, especially given that vitamin E seemed to play a significant role in the observed effects. Therefore, more research is needed to dissect the specific contributions of curcumin alone in managing hypothyroidism.
We observed that the levels of certain antioxidant genes like catalase and glutathione peroxidase were elevated in the hypothyroid rats, but supplementation with either curcumin or vitamin E helped to alleviate these increased levels. Notably, while the activities of some antioxidant enzymes were normalized with curcumin and vitamin E, the overall influence of curcumin alone on hypothyroidism remains unclear, as vitamin E was present in the treatment regimen.
Our findings suggest that curcumin does contribute to antioxidant activity in hypothyroid conditions. However, it’s important to highlight that it may not exert benefits on its own, especially given that vitamin E seemed to play a significant role in the observed effects. Therefore, more research is needed to dissect the specific contributions of curcumin alone in managing hypothyroidism.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Control inflammation
Using this to chelate ferritin and lower inflammation from Hashimoto's. As I have Hashimoto's thyroiditis, this specific curcumin offers benefits due to its lack of bioprene. Hashimoto's is an autoimmune condition that inflames and attacks the thyroid, leading to hypothyroidism. If you have high ferritin, it could suggest an underlying infection needing attention. I have found this curcumin helpful in managing ferritin levels and controlling my inflammation while on a balanced diet. The AIP diet significantly improved my symptoms, and I recommend joining support groups for further guidance.
Read More
