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Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 37 Researches
7.8
USERS' SCORE
Good
Based on 24 Reviews
8
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
8
We discovered that a diet enriched with omega-3 fatty acids can effectively reduce symptoms of allergic conjunctivitis (AC) in mice. This reduction occurred without influencing the typical immune responses usually associated with allergies. Instead, omega-3s worked by changing the lipid molecules linked to inflammation.
Notably, these fatty acids completely suppressed itching near the eyes and significantly decreased the presence of eosinophils, cells commonly involved in allergic reactions. However, total serum IgE levels and T2 cytokine expression remained unchanged, suggesting that omega-3s tackle AC symptoms in a unique way.
Notably, these fatty acids completely suppressed itching near the eyes and significantly decreased the presence of eosinophils, cells commonly involved in allergic reactions. However, total serum IgE levels and T2 cytokine expression remained unchanged, suggesting that omega-3s tackle AC symptoms in a unique way.
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We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Read More
9.5
Maternal omega-3 reduces allergy risks
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Read More
Most Useful Reviews
9
Preventing allergies
122 people found this helpful
Omega-3 is vital for health, especially to prevent allergies and cardiovascular diseases. These acids are crucial as a deficiency can lead to serious health issues. The product contains effective doses of DHA and EPA, essential for overall well-being. Given their importance, I take these regularly and have observed positive health improvements.
Read More
9
Relieved allergies
108 people found this helpful
My family and I take good Omega-3, especially during school as it helps relieve allergies.
Read More
9
Essential for health
60 people found this helpful
Don't hesitate to take Omega-3; it's essential for our health. There's a significant deficiency of Omega-3 in our diet. This product meets the minimum daily requirement for these crucial fatty acids. I’ve experienced improvements in my health, including reduced allergies, after a year of use.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 37 Researches
7.8
- All Researches
9.5
Maternal omega-3 reduces allergy risks
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Read More
9.5
Docosahexaenoic acid helps asthma
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
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9.5
We set out to assess a new extensively hydrolyzed whey-protein formula, which includes docosahexaenoic acid (DHA), for infants with cow's milk allergy (CMA). This study involved 34 children, primarily with IgE-mediated reactions, participating in a double-blind, placebo-controlled food challenge. Remarkably, all the children tolerated the new formula during the trial. This is significant since the American Academy of Pediatrics states that successful tolerance in over 90% of CMA children is crucial for a product to be considered hypoallergenic.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
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9
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
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9
We assessed how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences airway inflammation related to allergies in university athletes. In our study, we had 23 male participants divided into three groups based on their levels of airway inflammation, measured by fractional exhaled nitric oxide (FeNO).
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
These athletes took daily supplements containing 600 mg of EPA for three weeks. During this time, we tracked changes in their FeNO levels and other respiratory factors. Our findings revealed a significant drop in FeNO levels among athletes with eosinophilic airway inflammation, indicating a reduction in airway inflammation.
Notably, while the athletes with high FeNO levels benefited from the supplementation, those without eosinophilic characteristics saw no significant changes in their respiratory status. This suggests that EPA may be particularly effective for certain allergy-related conditions, rather than universally beneficial for all types of respiratory issues.
Read More
User Reviews
USERS' SCORE
Good
Based on 24 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Preventing allergies
122 people found this helpful
Omega-3 is vital for health, especially to prevent allergies and cardiovascular diseases. These acids are crucial as a deficiency can lead to serious health issues. The product contains effective doses of DHA and EPA, essential for overall well-being. Given their importance, I take these regularly and have observed positive health improvements.
Read More
9
Relieved allergies
108 people found this helpful
My family and I take good Omega-3, especially during school as it helps relieve allergies.
Read More
9
Essential for health
60 people found this helpful
Don't hesitate to take Omega-3; it's essential for our health. There's a significant deficiency of Omega-3 in our diet. This product meets the minimum daily requirement for these crucial fatty acids. I’ve experienced improvements in my health, including reduced allergies, after a year of use.
Read More
0
Severe reaction
19 people found this helpful
I decided to buy this Omega 3 due to its positive reviews and affordable price. Although I thought it was normal to feel some discomfort, after taking one capsule, I had a severe allergic reaction, leading to painful pimples on my face and a day of nausea.
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9
Dryness relief
3 people found this helpful
I've been taking Omega-3 for two winter seasons now. It has stopped the dryness and cracking of my skin, which I discovered was related to my cold allergies. After three weeks, my skin improved significantly, and I've noticed increased energy levels.
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Frequently Asked Questions
9
Dryness relief
3 people found this helpful
I've been taking Omega-3 for two winter seasons now. It has stopped the dryness and cracking of my skin, which I discovered was related to my cold allergies. After three weeks, my skin improved significantly, and I've noticed increased energy levels.
9
Allergy improvement
I take this omega for one month, four times a year, and the effect is noticeable. My skin is no longer dry, and periodic skin allergies have disappeared, along with various other benefits that I hadn't noticed before.
9
Essential for health
60 people found this helpful
Don't hesitate to take Omega-3; it's essential for our health. There's a significant deficiency of Omega-3 in our diet. This product meets the minimum daily requirement for these crucial fatty acids. I’ve experienced improvements in my health, including reduced allergies, after a year of use.
9
Allergy relief
1 people found this helpful
This is not my first purchase! I initially bought it for my husband, who has serious allergies to detergents. Since starting omega, he seldom gets sick and his allergy symptoms have disappeared. I have noticed that he rarely sneezes or catches colds.
6
Reducing allergies
1 people found this helpful
Omega-3 enhances the cardiovascular system, fights skin aging, and protects against allergies. It also supports joint health and overall vitality, making me eager to purchase more of this brand.
0
Severe reaction
19 people found this helpful
I decided to buy this Omega 3 due to its positive reviews and affordable price. Although I thought it was normal to feel some discomfort, after taking one capsule, I had a severe allergic reaction, leading to painful pimples on my face and a day of nausea.
0
Allergy reaction
I couldn't rate this Omega. The delivery was quick, and I had heard great reviews. However, after taking two capsules, I developed an allergy, so I had to stop using it. Previously, I had been taking a German brand without any adverse reactions.
9
Relieved allergies
108 people found this helpful
My family and I take good Omega-3, especially during school as it helps relieve allergies.
7
Allergy symptoms lessen
1 people found this helpful
This Fish Oil from "Now" has numerous benefits, including slowing the ageing process and alleviating skin inflammations and allergies. I take 1-2 capsules daily and have seen significant improvements in my fatigue, sleep quality, and skin condition within just a few weeks.
7.5
No allergies
244 people found this helpful
My wife introduced me to dietary supplements, and I decided to continue taking them. I initially tried a small amount to check for allergies, and fortunately, I experienced none. The consumption rate is 2 capsules twice daily. I've noticed an increase in stamina and improved health, as I did not fall ill during winter. I'm definitely going to order a larger quantity.
7.5
Allergy relief achieved
I took one Omega capsule daily; initially, it caused allergies but that soon passed. This company's Omega is excellent in terms of price and quality. I also ordered for my parents, and they feel fantastic. The capsules are convenient and odourless. I highly recommend them.
8
Omega-3 postbiotics reduce allergies
We examined how certain omega-3 postbiotics might address allergic reactions, specifically in mice.
Through our study, we found that a metabolite called t10,c15-18:2, derived from omega-3 fatty acids, effectively reduced skin inflammation associated with contact allergies.
It was particularly successful in easing symptoms like swelling and edema, distinguishing its effectiveness from another compound. This action seemed connected to its ability to inhibit a molecule that increases blood vessel activity, offering potential for therapeutic use in managing allergic conditions.
Through our study, we found that a metabolite called t10,c15-18:2, derived from omega-3 fatty acids, effectively reduced skin inflammation associated with contact allergies.
It was particularly successful in easing symptoms like swelling and edema, distinguishing its effectiveness from another compound. This action seemed connected to its ability to inhibit a molecule that increases blood vessel activity, offering potential for therapeutic use in managing allergic conditions.
9.5
Maternal omega-3 reduces allergy risks
We conducted a comprehensive meta-analysis to explore how omega-3 supplementation affects food allergy risks in children, focusing on whether maternal intake during pregnancy or childhood supplementation is more effective.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
Our findings revealed that mothers who took omega-3 during pregnancy and lactation significantly lowered the chances of their infants developing allergies to eggs and peanuts.
However, omega-3 consumption later in childhood did not show similar benefits in allergy prevention. This emphasizes the critical timing of supplementation in allergy risk management.
8
We explored how a mother’s omega-3 fatty acid intake affects the allergic responses of their pups. By focusing on the diets high in omega-3s, we investigated how these fatty acids influence breast milk composition and ultimately reduce the chances of allergic conditions in infants.
Our findings indicate that omega-3 fatty acids lead to beneficial changes in immune responses in infant mice, specifically reducing skin allergies. However, it's important to note that while these results are encouraging, further studies are needed to confirm this effect in humans.
Our findings indicate that omega-3 fatty acids lead to beneficial changes in immune responses in infant mice, specifically reducing skin allergies. However, it's important to note that while these results are encouraging, further studies are needed to confirm this effect in humans.
7
Omega-3 supplementation's weak effectiveness
We conducted a systematic review and meta-analysis to explore whether omega-3 fatty acids taken during pregnancy affect allergic outcomes in children.
While our findings indicate that starting omega-3 supplementation during pregnancy may reduce the risk of sensitization to foods like egg and peanut, the overall evidence is somewhat limited.
This stems from the small number of studies available and concerns regarding their reliability, making it hard to draw definitive conclusions about omega-3's effects on allergies.
While our findings indicate that starting omega-3 supplementation during pregnancy may reduce the risk of sensitization to foods like egg and peanut, the overall evidence is somewhat limited.
This stems from the small number of studies available and concerns regarding their reliability, making it hard to draw definitive conclusions about omega-3's effects on allergies.
4
We explored the effects of eicosapentaenoic acid, a key component of fish oil, on allergic diseases in infants. In a double-blind trial involving 439 pregnant women, participants were divided into four groups: those receiving fish oil, those receiving probiotics, those receiving both, and a control group getting placebos. Supplements were taken from early pregnancy until six months after birth.
Our findings indicated that, overall, the use of fish oil and/or probiotics did not significantly lower the risk of childhood allergic diseases or atopy. The only notable outcome was linked to the probiotic group, which showed a decreased risk of recurrent wheezing by the time the children were two years old. Unfortunately, we could not isolate the specific impact of eicosapentaenoic acid alone on allergy prevention since it was combined with probiotics.
This suggests that while eicosapentaenoic acid is promising, its benefits for allergies remain unclear and need to be further investigated in future research.
Our findings indicated that, overall, the use of fish oil and/or probiotics did not significantly lower the risk of childhood allergic diseases or atopy. The only notable outcome was linked to the probiotic group, which showed a decreased risk of recurrent wheezing by the time the children were two years old. Unfortunately, we could not isolate the specific impact of eicosapentaenoic acid alone on allergy prevention since it was combined with probiotics.
This suggests that while eicosapentaenoic acid is promising, its benefits for allergies remain unclear and need to be further investigated in future research.
References
- Saika A, Nagatake T, Kishino S, Kitamura N, Honda T, et al. The omega-3 postbiotic -10--15-octadecadienoic acid attenuates contact hypersensitivity in mice through downregulation of vascular endothelial growth factor A. Front Cell Infect Microbiol. 2024;14:1355679. 10.3389/fcimb.2024.1355679
- Tsuji S, Adachi Y, Tsuchida A, Hamazaki K, Matsumura K, et al. Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study. Allergol Int. 2024;73:282. 10.1016/j.alit.2023.12.004
- Huynh LBP, Nguyen NN, Fan HY, Huang SY, Huang CH, et al. Maternal Omega-3 Supplementation During Pregnancy, but Not Childhood Supplementation, Reduces the Risk of Food Allergy Diseases in Offspring. J Allergy Clin Immunol Pract. 2023;11:2862. 10.1016/j.jaip.2023.06.005
- Peng S, Du Z, He Y, Zhao F, Chen Y, et al. Association of Maternal Erythrocyte PUFA during Pregnancy with Offspring Allergy in the Chinese Population. Nutrients. 2022;14. 10.3390/nu14112312
- Adjibade M, Davisse-Paturet C, Bernard JY, Adel-Patient K, Divaret-Chauveau A, et al. Enrichment of infant formula with long-chain polyunsaturated fatty acids and risk of infection and allergy in the nationwide ELFE birth cohort. Allergy. 2022;77:1522. 10.1111/all.15137
- Miles EA, Childs CE, Calder PC. Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review. Nutrients. 2021;13. 10.3390/nu13010247
- Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, et al. Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy. 2020;75:1939. 10.1111/all.14217
- Huhmann R, Mueller RS. A cream containing omega-3-fatty acids, humectants and emollients as an aid in the treatment of equine Culicoides hypersensitivity. Vet Dermatol. 2019;30:155. 10.1111/vde.12728
- Vahdaninia M, Mackenzie H, Dean T, Helps S. ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring: A systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2019;122:302. 10.1016/j.anai.2018.12.008
- Hirakata T, Lee HC, Ohba M, Saeki K, Okuno T, et al. Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T2 immune responses. FASEB J. 2019;33:3392. 10.1096/fj.201801805R
- Clausen M, Jonasson K, Keil T, Beyer K, Sigurdardottir ST. Fish oil in infancy protects against food allergy in Iceland-Results from a birth cohort study. Allergy. 2018;73:1305. 10.1111/all.13385
- Hansen S, Strøm M, Maslova E, Dahl R, Hoffmann HJ, et al. Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring. J Allergy Clin Immunol. 2017;139:104. 10.1016/j.jaci.2016.02.042
- Best KP, Sullivan T, Palmer D, Gold M, Kennedy DJ, et al. Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial. Pediatrics. 2016;137. 10.1542/peds.2015-4443
- Willemsen LEM. Dietary n-3 long chain polyunsaturated fatty acids in allergy prevention and asthma treatment. Eur J Pharmacol. 2016;785:174. 10.1016/j.ejphar.2016.03.062
- Warstedt K, Furuhjelm C, Fälth-Magnusson K, Fagerås M, Duchén K. High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy. Acta Paediatr. 2016;105:1337. 10.1111/apa.13395
- Ahmed N, Barrow CJ, Suphioglu C. Exploring the Effects of Omega-3 and Omega-6 Fatty Acids on Allergy Using a HEK-Blue Cell Line. Int J Mol Sci. 2016;17:220. 10.3390/ijms17020220
- Li SY, Zheng PY, Zhai YY, Zhang YD, Gan H, et al. [Analysis of the effect of early subcutaneous specific immunotherapy on the levels of dust mite allergen-specific antibodies and polyunsaturated fatty acid metabolism]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:778. 10.3760/cma.j.cn112150-20240124-00083
- Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. 10.1111/pai.14004
- Mirrahimi B, Moazemi M, Eslami N, Jamshidi E, Mir M, et al. Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial. J Pediatr Pharmacol Ther. 2023;28:29. 10.5863/1551-6776-28.1.29
- Imai T, Takada Y, Watanabe K. Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes. J Clin Med Res. 2022;14:466. 10.14740/jocmr4825
- Decsi T, Marosvölgyi T, Muszil E, Bódy B, Szabó É. Long-Chain Polyunsaturated Fatty Acid Status at Birth and Development of Childhood Allergy: A Systematic Review. Life (Basel). 2022;12. 10.3390/life12040526
- Saika A, Nagatake T, Hirata SI, Sawane K, Adachi J, et al. ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α. FASEB J. 2021;35:e21354. 10.1096/fj.202001687R
- Kanda N, Hoashi T, Saeki H. Nutrition and Atopic Dermatitis. J Nippon Med Sch. 2021;88:171. 10.1272/jnms.JNMS.2021_88-317
- Barman M, Rabe H, Hesselmar B, Johansen S, Sandberg AS, et al. Cord Blood Levels of EPA, a Marker of Fish Intake, Correlate with Infants' T- and B-Lymphocyte Phenotypes and Risk for Allergic Disease. Nutrients. 2020;12. 10.3390/nu12103000
- Hoppenbrouwers T, Fogliano V, Garssen J, Pellegrini N, Willemsen LEM, et al. Specific Polyunsaturated Fatty Acids Can Modulate Human moDC2s and Subsequent Th2 Cytokine Release. Front Immunol. 2020;11:748. 10.3389/fimmu.2020.00748
- Saika A, Nagatake T, Kishino S, Park SB, Honda T, et al. 17(),18()-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression. FASEB Bioadv. 2020;2:59. 10.1096/fba.2019-00061
- Su Y, Choi HS, Kwon SK, Han Y, Cho SC, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress. Mol Med Rep. 2025;31. 10.3892/mmr.2025.13451
- Sato A, Sato G, Yabuki A, Ogawa Y, Nemoto H, et al. Ameliorative effects of squid phospholipids from Todarodes pacificus on atopic dermatitis-like lesions in NC/Nga mice. Arch Dermatol Res. 2025;317:239. 10.1007/s00403-024-03773-9
- Wang R, Patel D, Goruk S, Richard C, Field CJ. Feeding Docosahexaenoic Acid and Arachidonic Acid during Suckling and Weaning Contributes to Oral Tolerance Development by Beneficially Modulating the Intestinal Cytokine and Immunoglobulin Levels in an Allergy-Prone Brown Norway Rat Model. J Nutr. 2024;154:3790. 10.1016/j.tjnut.2024.10.021
- Lee C, Dartt DA. Sex-dependent differential increase of specialized pro-resolving mediators in extracellular vesicles secreted by human primary conjunctival goblet cells during allergic inflammation. Life Sci. 2024;357:123058. 10.1016/j.lfs.2024.123058
- Huang XW, Pang SW, Yang LZ, Han T, Chen JM, et al. TNFSF14 mediates the impact of docosahexaenoic acid on atopic dermatitis: a Mendelian randomization study. Eur Rev Med Pharmacol Sci. 2024;28:107. 10.26355/eurrev_202401_34896
- Peh HY, Brüggemann TR, Duvall MG, Nshimiyimana R, Nijmeh J, et al. Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation. Allergy. 2024;79:739. 10.1111/all.15920
- Patel D, Munhoz J, Goruk S, Tsai S, Richard C, et al. Correction: Maternal diet supplementation with high-docosahexaenoic-acid canola oil, along with arachidonic acid, promotes immune system development in allergy-prone BALB/c mouse ofspring at 3 weeks of age. Eur J Nutr. 2024;63:341. 10.1007/s00394-023-03264-z
- Patel D, Munhoz J, Goruk S, Richard C, Field CJ. The Programming Effect of Plant-Based DHA, Along with Equivalent AA, on Immune System and Oral Tolerance Development in Six-Week Allergy Prone BALB/c Pups. J Nutr. 2023;153:2482. 10.1016/j.tjnut.2023.06.002
- Figueroa-Garduño I, Escamilla-Núñez C, Barraza-Villarreal A, Hernández-Cadena L, Onofre-Pardo EN, et al. Docosahexaenoic Acid Effect on Prenatal Exposure to Arsenic and Atopic Dermatitis in Mexican Preschoolers. Biol Trace Elem Res. 2023;201:3152. 10.1007/s12011-022-03411-3
- Dahdah L, Roelofs M, Knipping K, de Vries E, Rijnierse A, et al. Hypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants. Pediatr Allergy Immunol. 2022;33:e13814. 10.1111/pai.13814
- Patel D, Goruk S, Richard C, Field CJ. Combined Supplementation with Arachidonic and Docosahexaenoic Acids in T Helper Type-2 Skewed Brown Norway Rat Offspring is Beneficial in the Induction of Oral Tolerance toward Ovalbumin and Immune System Development. J Nutr. 2022;152:2165. 10.1093/jn/nxac118
