' 
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid reduces fibromyalgia pain
Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model.
Significant effects on pain mechanisms
We explored how eicosapentaenoic acid (EPA) affects fibromyalgia, a complex pain condition characterized by widespread muscle pain, fatigue, and various psychological issues. To study this, we created a mouse model of fibromyalgia using intermittent cold stress and measured pain responses through a von Frey test. Our results showed a significant reduction in mechanical pain after administering EPA.
We observed that the administration of EPA not only alleviated mechanical pain but also helped in reducing thermal hyperalgesia, indicating a broader impact on pain sensitivity. Additionally, we discovered overexpression of proteins in the TRPV1 pain signaling pathway in different brain regions associated with pain perception, including areas like the thalamus and prefrontal cortex. Importantly, administering EPA significantly decreased this overactivity, suggesting a potential therapeutic effect.
Using a novel chemogenetics method, we inhibited certain brain regions to further understand the mechanism. The findings demonstrated an analgesic effect through the TRPV1 pathway, reinforcing the relevance of targeting this pathway for treating fibromyalgia. Overall, our study provides important insights about EPA as a possible treatment avenue for managing this challenging condition.
We observed that the administration of EPA not only alleviated mechanical pain but also helped in reducing thermal hyperalgesia, indicating a broader impact on pain sensitivity. Additionally, we discovered overexpression of proteins in the TRPV1 pain signaling pathway in different brain regions associated with pain perception, including areas like the thalamus and prefrontal cortex. Importantly, administering EPA significantly decreased this overactivity, suggesting a potential therapeutic effect.
Using a novel chemogenetics method, we inhibited certain brain regions to further understand the mechanism. The findings demonstrated an analgesic effect through the TRPV1 pathway, reinforcing the relevance of targeting this pathway for treating fibromyalgia. Overall, our study provides important insights about EPA as a possible treatment avenue for managing this challenging condition.
Read More
Most Useful Reviews
9.5
Cardiovascular benefits
Excellent product for those seeking good cardiovascular health. It aids in lowering cholesterol and alleviating signs of fibromyalgia.
Read More
7.5
Improved energy levels
Smells peculiar and the capsule is large, but it’s definitely worth it! I have PCOS and have learnt that Omega-3s are quite important. Since I began taking these alongside some other supplements, I've noticed a difference in how my body feels. My bowels are now more regular and firm, and I have more energy, which is beneficial for my fibromyalgia and POTS.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
Eicosapentaenoic acid reduces fibromyalgia pain
Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model.
Significant effects on pain mechanisms
We explored how eicosapentaenoic acid (EPA) affects fibromyalgia, a complex pain condition characterized by widespread muscle pain, fatigue, and various psychological issues. To study this, we created a mouse model of fibromyalgia using intermittent cold stress and measured pain responses through a von Frey test. Our results showed a significant reduction in mechanical pain after administering EPA.
We observed that the administration of EPA not only alleviated mechanical pain but also helped in reducing thermal hyperalgesia, indicating a broader impact on pain sensitivity. Additionally, we discovered overexpression of proteins in the TRPV1 pain signaling pathway in different brain regions associated with pain perception, including areas like the thalamus and prefrontal cortex. Importantly, administering EPA significantly decreased this overactivity, suggesting a potential therapeutic effect.
Using a novel chemogenetics method, we inhibited certain brain regions to further understand the mechanism. The findings demonstrated an analgesic effect through the TRPV1 pathway, reinforcing the relevance of targeting this pathway for treating fibromyalgia. Overall, our study provides important insights about EPA as a possible treatment avenue for managing this challenging condition.
We observed that the administration of EPA not only alleviated mechanical pain but also helped in reducing thermal hyperalgesia, indicating a broader impact on pain sensitivity. Additionally, we discovered overexpression of proteins in the TRPV1 pain signaling pathway in different brain regions associated with pain perception, including areas like the thalamus and prefrontal cortex. Importantly, administering EPA significantly decreased this overactivity, suggesting a potential therapeutic effect.
Using a novel chemogenetics method, we inhibited certain brain regions to further understand the mechanism. The findings demonstrated an analgesic effect through the TRPV1 pathway, reinforcing the relevance of targeting this pathway for treating fibromyalgia. Overall, our study provides important insights about EPA as a possible treatment avenue for managing this challenging condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Cardiovascular benefits
Excellent product for those seeking good cardiovascular health. It aids in lowering cholesterol and alleviating signs of fibromyalgia.
7.5
Improved energy levels
Smells peculiar and the capsule is large, but it’s definitely worth it! I have PCOS and have learnt that Omega-3s are quite important. Since I began taking these alongside some other supplements, I've noticed a difference in how my body feels. My bowels are now more regular and firm, and I have more energy, which is beneficial for my fibromyalgia and POTS.
Read More
