Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.2
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9.5
We conducted a 12-week randomized, double-blind clinical trial to evaluate the effects of eicosapentaenoic acid (EPA) on episodic migraine. Seventy participants were divided into two groups, one receiving EPA-rich fish oil and the other a placebo.
Results showed that individuals taking EPA experienced a significant decrease in migraine frequency and severity compared to the placebo group. This included fewer migraine days and improved psychological well-being.
Notably, women appeared to benefit the most, highlighting EPA's potential as a promising preventive treatment for migraine.
Results showed that individuals taking EPA experienced a significant decrease in migraine frequency and severity compared to the placebo group. This included fewer migraine days and improved psychological well-being.
Notably, women appeared to benefit the most, highlighting EPA's potential as a promising preventive treatment for migraine.
Read More
9.5
We analyzed various studies to see how effective high dosage omega-3 fatty acids, specifically EPA and DHA, are in preventing migraines. The results were quite promising!
With 40 randomized controlled trials included, we found that these omega-3 supplements led to a significant decrease in both the frequency and severity of migraines compared to placebo.
Notably, they also had the highest acceptability rates among all treatments reviewed. This evidence suggests that high-dose omega-3s could be a top choice for migraine prevention.
With 40 randomized controlled trials included, we found that these omega-3 supplements led to a significant decrease in both the frequency and severity of migraines compared to placebo.
Notably, they also had the highest acceptability rates among all treatments reviewed. This evidence suggests that high-dose omega-3s could be a top choice for migraine prevention.
Read More
9
We investigated how the intake of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, might affect the frequency of migraine attacks. In a study involving 105 migraine patients aged 15 to 50, we examined their usual dietary habits through a food frequency questionnaire and tracked their migraine occurrences over a month.
Our findings revealed a notable trend: lower consumption of EPA was tied to an increased number of migraine attacks. Specifically, participants with reduced EPA intake experienced a higher frequency of migraines, with data indicating a significant statistical relationship. We also found that this connection held true for both men and women alike, emphasizing the potential importance of dietary choices in managing migraines.
Conversely, we did not observe any significant link between saturated fatty acids (SFA) and migraine frequency, suggesting that not all dietary fats impact migraines the same way. Overall, our results point to a promising association between omega-3 fatty acids, particularly EPA, and reduced migraine attacks, inviting further research to deepen our understanding of this relationship.
Our findings revealed a notable trend: lower consumption of EPA was tied to an increased number of migraine attacks. Specifically, participants with reduced EPA intake experienced a higher frequency of migraines, with data indicating a significant statistical relationship. We also found that this connection held true for both men and women alike, emphasizing the potential importance of dietary choices in managing migraines.
Conversely, we did not observe any significant link between saturated fatty acids (SFA) and migraine frequency, suggesting that not all dietary fats impact migraines the same way. Overall, our results point to a promising association between omega-3 fatty acids, particularly EPA, and reduced migraine attacks, inviting further research to deepen our understanding of this relationship.
Read More
Most Useful Reviews
9
Migraine prevention
32 people found this helpful
"Mega" omega! This fish oil supplement contains polyunsaturated fatty acids like EPA and DHA, which significantly lower cholesterol and help prevent cardiovascular diseases. Omega-3 is effective for various conditions, including skin diseases and gastric ulcers. It also benefits brain function and helps reduce migraine symptoms. After starting the capsules, I noticed improvements in my migraines and overall health. I take three capsules daily with meals. If my review is helpful, please click "YES" below and check my other reviews. Wishing you good health!
Read More
9
Migraine improvement
1 people found this helpful
After three weeks of taking these capsules, my frequent migraines, which occurred every 2-3 days, have stopped. I take only one capsule instead of the recommended four. I've also seen improvements in my hair, nails, and skin.
Read More
7.5
Migraine relief
17 people found this helpful
This Omega 3 supplement is essential for those leading an active lifestyle. It supports heart, endocrine, and overall body health. The polyunsaturated fatty acids are beneficial for cardiovascular issues, migraines, and nervous system diseases. I have found it effective for my chronic migraines, experiencing no side effects.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.2
- All Researches
9.5
We conducted a 12-week randomized, double-blind clinical trial to evaluate the effects of eicosapentaenoic acid (EPA) on episodic migraine. Seventy participants were divided into two groups, one receiving EPA-rich fish oil and the other a placebo.
Results showed that individuals taking EPA experienced a significant decrease in migraine frequency and severity compared to the placebo group. This included fewer migraine days and improved psychological well-being.
Notably, women appeared to benefit the most, highlighting EPA's potential as a promising preventive treatment for migraine.
Results showed that individuals taking EPA experienced a significant decrease in migraine frequency and severity compared to the placebo group. This included fewer migraine days and improved psychological well-being.
Notably, women appeared to benefit the most, highlighting EPA's potential as a promising preventive treatment for migraine.
Read More
9.5
We analyzed various studies to see how effective high dosage omega-3 fatty acids, specifically EPA and DHA, are in preventing migraines. The results were quite promising!
With 40 randomized controlled trials included, we found that these omega-3 supplements led to a significant decrease in both the frequency and severity of migraines compared to placebo.
Notably, they also had the highest acceptability rates among all treatments reviewed. This evidence suggests that high-dose omega-3s could be a top choice for migraine prevention.
With 40 randomized controlled trials included, we found that these omega-3 supplements led to a significant decrease in both the frequency and severity of migraines compared to placebo.
Notably, they also had the highest acceptability rates among all treatments reviewed. This evidence suggests that high-dose omega-3s could be a top choice for migraine prevention.
Read More
9
We investigated how the intake of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, might affect the frequency of migraine attacks. In a study involving 105 migraine patients aged 15 to 50, we examined their usual dietary habits through a food frequency questionnaire and tracked their migraine occurrences over a month.
Our findings revealed a notable trend: lower consumption of EPA was tied to an increased number of migraine attacks. Specifically, participants with reduced EPA intake experienced a higher frequency of migraines, with data indicating a significant statistical relationship. We also found that this connection held true for both men and women alike, emphasizing the potential importance of dietary choices in managing migraines.
Conversely, we did not observe any significant link between saturated fatty acids (SFA) and migraine frequency, suggesting that not all dietary fats impact migraines the same way. Overall, our results point to a promising association between omega-3 fatty acids, particularly EPA, and reduced migraine attacks, inviting further research to deepen our understanding of this relationship.
Our findings revealed a notable trend: lower consumption of EPA was tied to an increased number of migraine attacks. Specifically, participants with reduced EPA intake experienced a higher frequency of migraines, with data indicating a significant statistical relationship. We also found that this connection held true for both men and women alike, emphasizing the potential importance of dietary choices in managing migraines.
Conversely, we did not observe any significant link between saturated fatty acids (SFA) and migraine frequency, suggesting that not all dietary fats impact migraines the same way. Overall, our results point to a promising association between omega-3 fatty acids, particularly EPA, and reduced migraine attacks, inviting further research to deepen our understanding of this relationship.
Read More
9
We conducted a randomized trial to understand how modifying dietary omega-3 and omega-6 fatty acids influences chronic headache conditions, particularly migraines. Patients with daily headaches followed two different dietary plans: one that included a high level of omega-3 and a low level of omega-6, and another that just reduced omega-6 intake. Over 12 weeks, we gathered both clinical and biochemical data to evaluate the outcomes.
Interestingly, the results highlighted that the group consuming more omega-3 fatty acids had significant improvements in their headache symptoms. They reported fewer headache days per month and spent less time each day suffering from headaches compared to those who only lowered their omega-6 intake. Additionally, we noted notable changes at the biochemical level, indicating increased levels of certain markers related to pain relief in the higher omega-3 group.
Our findings suggest that enhancing omega-3 intake while reducing omega-6 can lead to better management of chronic headaches, altering pain-related lipid mediators and ultimately improving quality of life for those suffering from such conditions.
Interestingly, the results highlighted that the group consuming more omega-3 fatty acids had significant improvements in their headache symptoms. They reported fewer headache days per month and spent less time each day suffering from headaches compared to those who only lowered their omega-6 intake. Additionally, we noted notable changes at the biochemical level, indicating increased levels of certain markers related to pain relief in the higher omega-3 group.
Our findings suggest that enhancing omega-3 intake while reducing omega-6 can lead to better management of chronic headaches, altering pain-related lipid mediators and ultimately improving quality of life for those suffering from such conditions.
Read More
8
We examined the effectiveness of daily 2000 mg eicosapentaenoic acid (EPA) supplementation in individuals suffering from chronic migraines. In a randomized, double-blind study, participants received either EPA or a placebo for eight weeks.
Results indicated that EPA supplementation could help reduce the number of migraine attacks, lessen headache severity, and improve overall quality of life. So, while we see promise in this omega-3 fatty acid for migraine relief, further studies are warranted to determine its full potential.
Results indicated that EPA supplementation could help reduce the number of migraine attacks, lessen headache severity, and improve overall quality of life. So, while we see promise in this omega-3 fatty acid for migraine relief, further studies are warranted to determine its full potential.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Migraine prevention
32 people found this helpful
"Mega" omega! This fish oil supplement contains polyunsaturated fatty acids like EPA and DHA, which significantly lower cholesterol and help prevent cardiovascular diseases. Omega-3 is effective for various conditions, including skin diseases and gastric ulcers. It also benefits brain function and helps reduce migraine symptoms. After starting the capsules, I noticed improvements in my migraines and overall health. I take three capsules daily with meals. If my review is helpful, please click "YES" below and check my other reviews. Wishing you good health!
Read More
9
Migraine improvement
1 people found this helpful
After three weeks of taking these capsules, my frequent migraines, which occurred every 2-3 days, have stopped. I take only one capsule instead of the recommended four. I've also seen improvements in my hair, nails, and skin.
Read More
7.5
Migraine relief
17 people found this helpful
This Omega 3 supplement is essential for those leading an active lifestyle. It supports heart, endocrine, and overall body health. The polyunsaturated fatty acids are beneficial for cardiovascular issues, migraines, and nervous system diseases. I have found it effective for my chronic migraines, experiencing no side effects.
Read More
7.5
Migraine elimination
2 people found this helpful
I can attest to the benefits of polyunsaturated acids, as I noticed a significant improvement in my condition, with migraines essentially stopping. I recommend this supplement for anyone struggling with similar issues!
Read More
7.5
Migraine frequency
My family and I have started taking this supplement, and I feel it is essential for long-term health. I’ve experienced fewer migraines, only suffering once in a month, which was due to wine. I continue to observe positive changes.
Read More
Frequently Asked Questions
9
Migraine improvement
1 people found this helpful
After three weeks of taking these capsules, my frequent migraines, which occurred every 2-3 days, have stopped. I take only one capsule instead of the recommended four. I've also seen improvements in my hair, nails, and skin.
7.5
Migraine relief
17 people found this helpful
This Omega 3 supplement is essential for those leading an active lifestyle. It supports heart, endocrine, and overall body health. The polyunsaturated fatty acids are beneficial for cardiovascular issues, migraines, and nervous system diseases. I have found it effective for my chronic migraines, experiencing no side effects.
7.5
Migraine elimination
2 people found this helpful
I can attest to the benefits of polyunsaturated acids, as I noticed a significant improvement in my condition, with migraines essentially stopping. I recommend this supplement for anyone struggling with similar issues!
7.5
Migraine frequency
My family and I have started taking this supplement, and I feel it is essential for long-term health. I’ve experienced fewer migraines, only suffering once in a month, which was due to wine. I continue to observe positive changes.
7.5
Migraine reduction
1 people found this helpful
I started taking Omega-3 without prior knowledge and noticed a reduction in my migraines, needing fewer pain relief medications. I take one capsule each morning and evening. This supplement is proving effective for me.
7.5
Migraine relief
I'm eating steadily. One for three? I’ve been taking this and eating calcium regularly, which has eased my migraine symptoms.
7.5
Migraine support
A diet rich in omega-3 fatty acids has helped reduce my migraine headaches and is good for heart health.
9.5
We conducted a 12-week randomized, double-blind clinical trial to evaluate the effects of eicosapentaenoic acid (EPA) on episodic migraine. Seventy participants were divided into two groups, one receiving EPA-rich fish oil and the other a placebo.
Results showed that individuals taking EPA experienced a significant decrease in migraine frequency and severity compared to the placebo group. This included fewer migraine days and improved psychological well-being.
Notably, women appeared to benefit the most, highlighting EPA's potential as a promising preventive treatment for migraine.
Results showed that individuals taking EPA experienced a significant decrease in migraine frequency and severity compared to the placebo group. This included fewer migraine days and improved psychological well-being.
Notably, women appeared to benefit the most, highlighting EPA's potential as a promising preventive treatment for migraine.
9.5
We analyzed various studies to see how effective high dosage omega-3 fatty acids, specifically EPA and DHA, are in preventing migraines. The results were quite promising!
With 40 randomized controlled trials included, we found that these omega-3 supplements led to a significant decrease in both the frequency and severity of migraines compared to placebo.
Notably, they also had the highest acceptability rates among all treatments reviewed. This evidence suggests that high-dose omega-3s could be a top choice for migraine prevention.
With 40 randomized controlled trials included, we found that these omega-3 supplements led to a significant decrease in both the frequency and severity of migraines compared to placebo.
Notably, they also had the highest acceptability rates among all treatments reviewed. This evidence suggests that high-dose omega-3s could be a top choice for migraine prevention.
7
Omega-3s reduce migraine duration
We analyzed a systematic review and meta-analysis looking into how omega-3 fatty acids might influence migraine attacks. By examining 13 randomized controlled trials, we found that omega-3s did not significantly change the frequency or severity of migraines.
However, there was a noteworthy finding: omega-3 intake could reduce the duration of migraine attacks by about 3.44 hours.
This highlights a potential benefit of omega-3s, but more high-quality trials are needed to truly confirm these results.
However, there was a noteworthy finding: omega-3 intake could reduce the duration of migraine attacks by about 3.44 hours.
This highlights a potential benefit of omega-3s, but more high-quality trials are needed to truly confirm these results.
8
We examined the effectiveness of daily 2000 mg eicosapentaenoic acid (EPA) supplementation in individuals suffering from chronic migraines. In a randomized, double-blind study, participants received either EPA or a placebo for eight weeks.
Results indicated that EPA supplementation could help reduce the number of migraine attacks, lessen headache severity, and improve overall quality of life. So, while we see promise in this omega-3 fatty acid for migraine relief, further studies are warranted to determine its full potential.
Results indicated that EPA supplementation could help reduce the number of migraine attacks, lessen headache severity, and improve overall quality of life. So, while we see promise in this omega-3 fatty acid for migraine relief, further studies are warranted to determine its full potential.
8
Eicosapentaenoic acid ineffective for migraines
We explored the effects of eicosapentaenoic acid on episodic migraine through a 12-week randomized double-blind clinical trial. This type of study is designed to rigorously assess the effectiveness of treatments by ensuring that neither the participants nor the researchers know who is receiving the actual treatment or a placebo.
Our goal was to see whether this omega-3 fatty acid could provide relief for those suffering from migraines. We observed how participants responded and measured the frequency and severity of their migraine attacks. Unfortunately, the results did not show a significant benefit of eicosapentaenoic acid in reducing migraine occurrences or intensity.
It is essential for those looking for migraine treatments to be aware that while eicosapentaenoic acid has been noted for various health benefits, our study concluded it does not effectively alleviate episodic migraines. Therefore, it may not be a viable option for migraine relief.
Our goal was to see whether this omega-3 fatty acid could provide relief for those suffering from migraines. We observed how participants responded and measured the frequency and severity of their migraine attacks. Unfortunately, the results did not show a significant benefit of eicosapentaenoic acid in reducing migraine occurrences or intensity.
It is essential for those looking for migraine treatments to be aware that while eicosapentaenoic acid has been noted for various health benefits, our study concluded it does not effectively alleviate episodic migraines. Therefore, it may not be a viable option for migraine relief.
References
- Yeh EL, Yang CP, Lin SW, Wang HF. Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients. Brain Behav. 2024;14:e70149. 10.1002/brb3.70149
- Mohammadnezhad G, Assarzadegan F, Koosha M, Esmaily H. Eicosapentaenoic acid versus placebo as adjunctive therapy in chronic migraine: A randomized controlled trial. Headache. 2025;65:153. 10.1111/head.14808
- Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. 10.1016/j.bbi.2024.03.019
- Tseng PT, Zeng BY, Chen JJ, Kuo CH, Zeng BS, et al. High Dosage Omega-3 Fatty Acids Outperform Existing Pharmacological Options for Migraine Prophylaxis: A Network Meta-Analysis. Adv Nutr. 2024;15:100163. 10.1016/j.advnut.2023.100163
- Djalali M, Talebi S, Djalali E, Abdolahi M, Travica N, et al. The effect of omega-3 fatty acids supplementation on inflammatory biomarkers in subjects with migraine: a randomized, double-blind, placebo-controlled trial. Immunopharmacol Immunotoxicol. 2023;45:565. 10.1080/08923973.2023.2196600
- Faurot KR, Cole WR, MacIntosh BA, Dunlap M, Moore CB, et al. Targeted dietary interventions to reduce pain in persistent post-traumatic headache among service members: Protocol for a randomized, controlled parallel-group trial. Contemp Clin Trials. 2022;119:106851. 10.1016/j.cct.2022.106851
- Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, et al. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. BMJ. 2021;374:n1448. 10.1136/bmj.n1448
- Abdolahi M, Karimi E, Sarraf P, Tafakhori A, Siri G, et al. The omega-3 and Nano-curcumin effects on vascular cell adhesion molecule (VCAM) in episodic migraine patients: a randomized clinical trial. BMC Res Notes. 2021;14:283. 10.1186/s13104-021-05700-x
- Cardia L, Calapai F, Mondello C, Quattrone D, Elisa Sorbara E, et al. Clinical use of omega-3 fatty acids in migraine: A narrative review. Medicine (Baltimore). 2020;99:e22253. 10.1097/MD.0000000000022253
- Honarvar NM, Soveid N, Abdolahi M, Djalali M, Hatami M, et al. Anti-Neuroinflammatory Properties of n-3 Fatty Acids and Nano- Curcumin on Migraine Patients from Cellular to Clinical Insight: A Randomized, Double-Blind and Placebo-Controlled Trial. Endocr Metab Immune Disord Drug Targets. 2021;21:365. 10.2174/1871530320666200729144430
- Abdolahi M, Jafarieh A, Sarraf P, Sedighiyan M, Yousefi A, et al. The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms. Endocr Metab Immune Disord Drug Targets. 2019;19:874. 10.2174/1871530319666190212170140
- Sanders AE, Shaikh SR, Slade GD. Long-chain omega-3 fatty acids and headache in the U.S. population. Prostaglandins Leukot Essent Fatty Acids. 2018;135:47. 10.1016/j.plefa.2018.06.008
- Soveyd N, Abdolahi M, Djalali M, Hatami M, Tafakhori A, et al. The Combined Effects of ω -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients. CNS Neurol Disord Drug Targets. 2018;16:1120. 10.2174/1871527317666171213154749
- Maghsoumi-Norouzabad L, Mansoori A, Abed R, Shishehbor F. Effects of omega-3 fatty acids on the frequency, severity, and duration of migraine attacks: A systematic review and meta-analysis of randomized controlled trials. Nutr Neurosci. 2018;21:614. 10.1080/1028415X.2017.1344371
- Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, et al. The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients. Immunogenetics. 2017;69:371. 10.1007/s00251-017-0992-8
- Soares AA, Louçana PMC, Nasi EP, Sousa KMH, Sá OMS, et al. A double- blind, randomized, and placebo-controlled clinical trial with omega-3 polyunsaturated fatty acids (OPFA ɷ-3) for the prevention of migraine in chronic migraine patients using amitriptyline. Nutr Neurosci. 2018;21:219. 10.1080/1028415X.2016.1266133
- Pradalier A, Bakouche P, Baudesson G, Delage A, Cornaille-Lafage G, et al. Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. Cephalalgia. 2001;21:818.
- You ZB, Cao P. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;121:121. 10.1016/j.bbi.2024.07.014
- Chen TB, Yang CC, Tsai IJ, Yang HW, Hsu YC, et al. Neuroimmunological effects of omega-3 fatty acids on migraine: a review. Front Neurol. 2024;15:1366372. 10.3389/fneur.2024.1366372
- Mann JD, Faurot KR, MacIntosh B, Palsson OS, Suchindran CM, et al. A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol. Prostaglandins Leukot Essent Fatty Acids. 2018;128:41. 10.1016/j.plefa.2017.11.002
- Sadeghi O, Maghsoudi Z, Khorvash F, Ghiasvand R, Askari G. The relationship between different fatty acids intake and frequency of migraine attacks. Iran J Nurs Midwifery Res. 2015;20:334.
- Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441. 10.1016/j.pain.2013.07.028
- Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002;21:495.
