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SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 5 Reviews
8.1
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid aids pancreatic health
N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis.
Clearly significant findings on treatment
We investigated the effects of eicosapentaenoic acid (EPA) on pancreatic injury, particularly in the context of conditions that mimic pancreatitis. Our study began by creating a mouse model with a deficiency in n-3 polyunsaturated fatty acids (PUFAs) to evaluate how this lack impacts pancreatic function and injury.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
Read More
9
DHA reduces pancreatitis damage
Algal Oil Mitigates Sodium Taurocholate-Induced Pancreatitis by Alleviating Calcium Overload, Oxidative Stress, and NF-κB Activation in Pancreatic Acinar Cells.
High relevance to pancreatitis treatment
We explored the impact of docosahexaenoic acid (DHA) found in algal oil on pancreatitis, specifically looking at how it influences the health of pancreatic acinar cells. The study involved rat pancreatic acinar AR42J cells, which were pretreated with varying concentrations of DHA before being exposed to sodium taurocholate (STC), a compound that induces pancreatitis.
Our findings revealed that when these cells were treated with DHA before STC exposure, they experienced significant benefits. We observed a notable reduction in the harmful effects associated with pancreatitis, such as excessive intracellular calcium levels, oxidative stress, and the activation of inflammatory markers like tumor necrosis factor-α and interleukin-6. These factors are typically elevated during pancreatitis and can lead to further cell damage.
Moreover, cells that received higher doses of DHA showed improved mitochondrial function and less oxidative damage. This was evidenced by a healthier mitochondrial membrane potential and lower levels of lipid peroxidation compared to untreated cells. Importantly, DHA also appeared to dampen the activation of NF-κB, a key player in the inflammation process.
In summary, our study suggests that DHA from algal oil can help protect pancreatic acinar cells from damage and may offer a promising avenue for treating pancreatitis by addressing both calcium overload and oxidative stress.
Our findings revealed that when these cells were treated with DHA before STC exposure, they experienced significant benefits. We observed a notable reduction in the harmful effects associated with pancreatitis, such as excessive intracellular calcium levels, oxidative stress, and the activation of inflammatory markers like tumor necrosis factor-α and interleukin-6. These factors are typically elevated during pancreatitis and can lead to further cell damage.
Moreover, cells that received higher doses of DHA showed improved mitochondrial function and less oxidative damage. This was evidenced by a healthier mitochondrial membrane potential and lower levels of lipid peroxidation compared to untreated cells. Importantly, DHA also appeared to dampen the activation of NF-κB, a key player in the inflammation process.
In summary, our study suggests that DHA from algal oil can help protect pancreatic acinar cells from damage and may offer a promising avenue for treating pancreatitis by addressing both calcium overload and oxidative stress.
Read More
9
DHA mitigates inflammation in PSCs
Docosahexaenoic Acid Inhibits Cytokine Expression by Reducing Reactive Oxygen Species in Pancreatic Stellate Cells.
High relevance to pancreatic inflammation
We explored how docosahexaenoic acid (DHA) can influence inflammation in pancreatic stellate cells (PSCs), which are key players in the progression of chronic pancreatitis. The study specifically looked at whether DHA could help suppress the expression of certain cytokines activated by inflammatory signals, such as TNF-α and viral mimic polyinosinic-polycytidylic acid (poly (I:C)).
By pre-treating PSCs with either DHA or an antioxidant called N-acetylcysteine (NAC), we observed significant changes when the cells were stimulated with TNF-α or poly (I:C). Notably, we saw that DHA treatment reduced the production of molecules related to inflammation, such as monocyte chemoattractant protein 1 (MCP-1) and chemokine C-X3-C motif ligand 1 (CX3CL1).
Additionally, DHA helped lower levels of reactive oxygen species (ROS)—chemicals that can cause cell damage and are often increased during inflammation. This reduction in ROS levels led to a decline in the activation of NF-κB, a protein that further drives inflammatory processes. Essentially, DHA acted as a protective barrier, helping to maintain mitochondrial stability and lessening the impact of inflammatory cytokines.
The findings suggest that consuming DHA-rich foods could be an effective strategy for potentially preventing or alleviating the effects of chronic pancreatitis by dampening inflammatory responses in PSCs.
By pre-treating PSCs with either DHA or an antioxidant called N-acetylcysteine (NAC), we observed significant changes when the cells were stimulated with TNF-α or poly (I:C). Notably, we saw that DHA treatment reduced the production of molecules related to inflammation, such as monocyte chemoattractant protein 1 (MCP-1) and chemokine C-X3-C motif ligand 1 (CX3CL1).
Additionally, DHA helped lower levels of reactive oxygen species (ROS)—chemicals that can cause cell damage and are often increased during inflammation. This reduction in ROS levels led to a decline in the activation of NF-κB, a protein that further drives inflammatory processes. Essentially, DHA acted as a protective barrier, helping to maintain mitochondrial stability and lessening the impact of inflammatory cytokines.
The findings suggest that consuming DHA-rich foods could be an effective strategy for potentially preventing or alleviating the effects of chronic pancreatitis by dampening inflammatory responses in PSCs.
Read More
Most Useful Reviews
9.5
No exacerbations
Good omega, but should be taken with caution in pancreatitis. I took 1 capsule after meals and had no issues or exacerbations.
Read More
9.5
Weight loss
I’ve finished two cans and regret not starting sooner. With chronic pancreatitis, I can’t eat much fish, but this has helped me become more stress-resistant and shed about 4 kg. I will continue to order it and recommend it.
Read More
7
Improved condition
Good Omega-3! I trust this brand and have taken it several times. There’s no fish smell or taste. My son takes two capsules twice daily as advised by an endocrinologist and has seen improvements. I had some discomfort, but overall it was beneficial for him.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
9
Eicosapentaenoic acid aids pancreatic health
N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis.
Clearly significant findings on treatment
We investigated the effects of eicosapentaenoic acid (EPA) on pancreatic injury, particularly in the context of conditions that mimic pancreatitis. Our study began by creating a mouse model with a deficiency in n-3 polyunsaturated fatty acids (PUFAs) to evaluate how this lack impacts pancreatic function and injury.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.
Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.
Read More
9
DHA reduces pancreatitis damage
Algal Oil Mitigates Sodium Taurocholate-Induced Pancreatitis by Alleviating Calcium Overload, Oxidative Stress, and NF-κB Activation in Pancreatic Acinar Cells.
High relevance to pancreatitis treatment
We explored the impact of docosahexaenoic acid (DHA) found in algal oil on pancreatitis, specifically looking at how it influences the health of pancreatic acinar cells. The study involved rat pancreatic acinar AR42J cells, which were pretreated with varying concentrations of DHA before being exposed to sodium taurocholate (STC), a compound that induces pancreatitis.
Our findings revealed that when these cells were treated with DHA before STC exposure, they experienced significant benefits. We observed a notable reduction in the harmful effects associated with pancreatitis, such as excessive intracellular calcium levels, oxidative stress, and the activation of inflammatory markers like tumor necrosis factor-α and interleukin-6. These factors are typically elevated during pancreatitis and can lead to further cell damage.
Moreover, cells that received higher doses of DHA showed improved mitochondrial function and less oxidative damage. This was evidenced by a healthier mitochondrial membrane potential and lower levels of lipid peroxidation compared to untreated cells. Importantly, DHA also appeared to dampen the activation of NF-κB, a key player in the inflammation process.
In summary, our study suggests that DHA from algal oil can help protect pancreatic acinar cells from damage and may offer a promising avenue for treating pancreatitis by addressing both calcium overload and oxidative stress.
Our findings revealed that when these cells were treated with DHA before STC exposure, they experienced significant benefits. We observed a notable reduction in the harmful effects associated with pancreatitis, such as excessive intracellular calcium levels, oxidative stress, and the activation of inflammatory markers like tumor necrosis factor-α and interleukin-6. These factors are typically elevated during pancreatitis and can lead to further cell damage.
Moreover, cells that received higher doses of DHA showed improved mitochondrial function and less oxidative damage. This was evidenced by a healthier mitochondrial membrane potential and lower levels of lipid peroxidation compared to untreated cells. Importantly, DHA also appeared to dampen the activation of NF-κB, a key player in the inflammation process.
In summary, our study suggests that DHA from algal oil can help protect pancreatic acinar cells from damage and may offer a promising avenue for treating pancreatitis by addressing both calcium overload and oxidative stress.
Read More
9
DHA protects against pancreatic injury
N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis.
Moderate relevance; focuses on DHA
We explored the impact of a deficiency in n-3 polyunsaturated fatty acids (PUFAs) on pancreatic injury and whether supplementing with docosahexaenoic acid (DHA) could help. In our study, we used a mouse model deliberately deprived of n-3 PUFAs for 30 days, which allowed us to see the effects of this deficiency on pancreatic health.
The results highlighted that n-3 PUFA deficiency made the pancreas more susceptible to injury caused by streptozotocin, a compound known to harm insulin-producing cells. We observed that the insulin levels dropped significantly, along with key indicators of healthy β-cell function. *But when we introduced DHA and eicosapentaenoic acid (EPA) for 15 days prior to the injury, things changed dramatically.* Insulin levels and other critical indicators of pancreatic health improved remarkably compared to the deficient group.
Additionally, our findings pointed to the mechanisms behind these benefits. DHA and EPA reduced oxidative stress and inflammation in pancreatic cells while also helping to prevent the apoptosis, or death, of these vital cells. This study suggests that dietary intervention with n-3 PUFAs like DHA could help alleviate pancreatic injury and highlights potential new strategies for protecting against pancreatic diseases.
The results highlighted that n-3 PUFA deficiency made the pancreas more susceptible to injury caused by streptozotocin, a compound known to harm insulin-producing cells. We observed that the insulin levels dropped significantly, along with key indicators of healthy β-cell function. *But when we introduced DHA and eicosapentaenoic acid (EPA) for 15 days prior to the injury, things changed dramatically.* Insulin levels and other critical indicators of pancreatic health improved remarkably compared to the deficient group.
Additionally, our findings pointed to the mechanisms behind these benefits. DHA and EPA reduced oxidative stress and inflammation in pancreatic cells while also helping to prevent the apoptosis, or death, of these vital cells. This study suggests that dietary intervention with n-3 PUFAs like DHA could help alleviate pancreatic injury and highlights potential new strategies for protecting against pancreatic diseases.
Read More
9
DHA mitigates inflammation in PSCs
Docosahexaenoic Acid Inhibits Cytokine Expression by Reducing Reactive Oxygen Species in Pancreatic Stellate Cells.
High relevance to pancreatic inflammation
We explored how docosahexaenoic acid (DHA) can influence inflammation in pancreatic stellate cells (PSCs), which are key players in the progression of chronic pancreatitis. The study specifically looked at whether DHA could help suppress the expression of certain cytokines activated by inflammatory signals, such as TNF-α and viral mimic polyinosinic-polycytidylic acid (poly (I:C)).
By pre-treating PSCs with either DHA or an antioxidant called N-acetylcysteine (NAC), we observed significant changes when the cells were stimulated with TNF-α or poly (I:C). Notably, we saw that DHA treatment reduced the production of molecules related to inflammation, such as monocyte chemoattractant protein 1 (MCP-1) and chemokine C-X3-C motif ligand 1 (CX3CL1).
Additionally, DHA helped lower levels of reactive oxygen species (ROS)—chemicals that can cause cell damage and are often increased during inflammation. This reduction in ROS levels led to a decline in the activation of NF-κB, a protein that further drives inflammatory processes. Essentially, DHA acted as a protective barrier, helping to maintain mitochondrial stability and lessening the impact of inflammatory cytokines.
The findings suggest that consuming DHA-rich foods could be an effective strategy for potentially preventing or alleviating the effects of chronic pancreatitis by dampening inflammatory responses in PSCs.
By pre-treating PSCs with either DHA or an antioxidant called N-acetylcysteine (NAC), we observed significant changes when the cells were stimulated with TNF-α or poly (I:C). Notably, we saw that DHA treatment reduced the production of molecules related to inflammation, such as monocyte chemoattractant protein 1 (MCP-1) and chemokine C-X3-C motif ligand 1 (CX3CL1).
Additionally, DHA helped lower levels of reactive oxygen species (ROS)—chemicals that can cause cell damage and are often increased during inflammation. This reduction in ROS levels led to a decline in the activation of NF-κB, a protein that further drives inflammatory processes. Essentially, DHA acted as a protective barrier, helping to maintain mitochondrial stability and lessening the impact of inflammatory cytokines.
The findings suggest that consuming DHA-rich foods could be an effective strategy for potentially preventing or alleviating the effects of chronic pancreatitis by dampening inflammatory responses in PSCs.
Read More
9
Protectin D1 alleviates pancreatitis
Protectin D1 decreases pancreatitis severity in mice by inhibiting neutrophil extracellular trap formation.
Significant focus on DHA's effects
We investigated how protectin D1, a compound derived from docosahexaenoic acid (DHA), affects pancreatitis, a condition marked by inflammation in the pancreas. Our research utilized three different models of acute pancreatitis in male mice, where we introduced the inflammatory condition using caerulein, L-arginine, and pancreatic duct ligation.
Through these models, we discovered that treatement with protectin D1 helped decrease the severity of the condition. Specifically, we observed reduced levels of key enzymes in the blood that are indicators of pancreatic damage, alongside lower concentrations of inflammatory cytokines. Moreover, protectin D1 appeared to protect the pancreas from structural damage, potentially extending survival in more severe cases.
Notably, we found that the treatment decreased the early infiltration of harmful neutrophils and the formation of neutrophil extracellular traps, which usually exacerbate inflammation. Furthermore, in laboratory settings, protectin D1 reduced markers associated with neutrophil activity. However, when we used a specific inhibitor to block the cells' activation, the protective benefits of protectin D1 were diminished, indicating its effectiveness may rely on a specific immune response.
Our findings suggest that protectin D1 from DHA could play an important role in managing acute pancreatitis, providing a potential therapeutic avenue to explore further.
Through these models, we discovered that treatement with protectin D1 helped decrease the severity of the condition. Specifically, we observed reduced levels of key enzymes in the blood that are indicators of pancreatic damage, alongside lower concentrations of inflammatory cytokines. Moreover, protectin D1 appeared to protect the pancreas from structural damage, potentially extending survival in more severe cases.
Notably, we found that the treatment decreased the early infiltration of harmful neutrophils and the formation of neutrophil extracellular traps, which usually exacerbate inflammation. Furthermore, in laboratory settings, protectin D1 reduced markers associated with neutrophil activity. However, when we used a specific inhibitor to block the cells' activation, the protective benefits of protectin D1 were diminished, indicating its effectiveness may rely on a specific immune response.
Our findings suggest that protectin D1 from DHA could play an important role in managing acute pancreatitis, providing a potential therapeutic avenue to explore further.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.1
9.5
No exacerbations
Good omega, but should be taken with caution in pancreatitis. I took 1 capsule after meals and had no issues or exacerbations.
9.5
Weight loss
I’ve finished two cans and regret not starting sooner. With chronic pancreatitis, I can’t eat much fish, but this has helped me become more stress-resistant and shed about 4 kg. I will continue to order it and recommend it.
7
Improved condition
Good Omega-3! I trust this brand and have taken it several times. There’s no fish smell or taste. My son takes two capsules twice daily as advised by an endocrinologist and has seen improvements. I had some discomfort, but overall it was beneficial for him.
7
No exacerbation
I’ve taken this omega before and like it. I consume it with food twice daily. My chronic gastritis hasn't worsened. However, those with gastrointestinal issues should consult their doctor before trying, as fish oil can exacerbate pancreatitis and gastritis.
3.8
Care needed
After having two children, I felt weak, and my hair fell out. I tried omega, but it made me feel nauseous, particularly in the morning. It aggravated my pancreatitis, so I plan to continue but with caution—perhaps just one capsule a day.
