Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
â€
Top Medical Research Studies
9
We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Read More
9
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
8
We aimed to understand how vitamin A deficiency (VAD) and its supplementation can affect thyroid function in children living in areas with goiter issues. In a double-blind, randomized trial, we followed 138 Moroccan children who received either vitamin A or a placebo alongside iodized salt for ten months. Our results showed that higher levels of VAD correlated with increased thyroid volume and TSH levels, while vitamin A supplementation led to significant reductions in these factors. Overall, vitamin A appears beneficial in improving thyroid function in children affected by iodine deficiency.
Read More
Most Useful Reviews
9
Thyroid support
3 people found this helpful
Vitamin A in retinol palmitate form aids the absorption of beta-carotene, alongside vitamins D and E. Research shows that vitamin A deficiency in hypothyroidism links to autoimmune thyroiditis and low T3 levels. It protects the thyroid even with iodine deficiency. Since it’s hard to replenish vitamin A from plant sources, I take one capsule daily.
Read More
7.5
Moisturised skin
1 people found this helpful
I take cod liver oil for vitamin A due to hypothyroidism, as this form is essential for me. My skin stops feeling dry after taking it. If I miss doses for 2-3 months, severe dryness returns. The absorption of vitamin A from food is poor in hypothyroidism for me. One capsule suffices, even if it’s not 100% of the daily requirement. Wishing everyone good health!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.1
- All Researches
9
We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Read More
9
We observed a case of a German Warmblood gelding exhibiting signs of keratoconjunctivitis sicca and other neurological symptoms, which were ultimately linked to hypothyroidism. As part of the treatment for this condition, vitamin A ointment was applied topically to the horse's eyes, alongside other therapies.
While vitamin A is traditionally known for its role in maintaining healthy eyes, the specific effectiveness of vitamin A in treating hypothyroidism remains unclear in this case. The primary treatment involved levothyroxine, which significantly improved the horse's thyroid function and correlated with the resolution of many clinical signs, including the eye issues.
Thus, while vitamin A was included in the treatment regimen, its distinct impact on the overall condition cannot be confidently isolated from the benefits observed with levothyroxine therapy. This underscores the need for more controlled studies to better understand the interplay between vitamin A and thyroid health.
While vitamin A is traditionally known for its role in maintaining healthy eyes, the specific effectiveness of vitamin A in treating hypothyroidism remains unclear in this case. The primary treatment involved levothyroxine, which significantly improved the horse's thyroid function and correlated with the resolution of many clinical signs, including the eye issues.
Thus, while vitamin A was included in the treatment regimen, its distinct impact on the overall condition cannot be confidently isolated from the benefits observed with levothyroxine therapy. This underscores the need for more controlled studies to better understand the interplay between vitamin A and thyroid health.
Read More
9
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
We investigated the potential benefits of vitamin D3 in treating hypothyroidism caused by high iodide intake in a study involving pregnant rats. The study involved adjusting iodide intake and supplementing with 1,25-dihydroxy-vitamin D (the active form of vitamin D) to see if these interventions could positively impact thyroid function and related complications.
The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.
Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.
These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.
Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.
These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
Read More
8
Vitamin A supports thyroid function
We explored the relationship between vitamin A deficiency (VAD) and hypothyroidism, particularly how these deficiencies impact the pituitary-thyroid axis in the body. Our understanding comes from various studies, including those involving children in Africa, where VAD combined with iodine deficiency disorders (IDD) often leads to unique hormonal responses.
In children suffering from both VAD and IDD, we observed that higher levels of thyroid-stimulating hormone (TSH) may actually help in preventing hypothyroidism, despite existing conditions. Interestingly, research in rats showed that moderate VAD alone did not significantly affect the pituitary-thyroid axis. However, when VAD accompanies iodine deficiency, it can lead to more serious cases of primary hypothyroidism than iodine deficiency on its own.
When it comes to treatment, we noted that high doses of vitamin A could correct thyroid dysfunction caused by iodine deficiency. Therefore, while vitamin A does play a role, it doesn't diminish the effectiveness of iodine repletion. Our findings suggest that vitamin A supplementation can help manage thyroid stimulation, especially in individuals affected by both deficiencies.
Thus, we can conclude that while vitamin A isn’t a standalone solution for hypothyroidism, it certainly plays a supportive role in improving treatment outcomes when iodine levels are restored.
In children suffering from both VAD and IDD, we observed that higher levels of thyroid-stimulating hormone (TSH) may actually help in preventing hypothyroidism, despite existing conditions. Interestingly, research in rats showed that moderate VAD alone did not significantly affect the pituitary-thyroid axis. However, when VAD accompanies iodine deficiency, it can lead to more serious cases of primary hypothyroidism than iodine deficiency on its own.
When it comes to treatment, we noted that high doses of vitamin A could correct thyroid dysfunction caused by iodine deficiency. Therefore, while vitamin A does play a role, it doesn't diminish the effectiveness of iodine repletion. Our findings suggest that vitamin A supplementation can help manage thyroid stimulation, especially in individuals affected by both deficiencies.
Thus, we can conclude that while vitamin A isn’t a standalone solution for hypothyroidism, it certainly plays a supportive role in improving treatment outcomes when iodine levels are restored.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Thyroid support
3 people found this helpful
Vitamin A in retinol palmitate form aids the absorption of beta-carotene, alongside vitamins D and E. Research shows that vitamin A deficiency in hypothyroidism links to autoimmune thyroiditis and low T3 levels. It protects the thyroid even with iodine deficiency. Since it’s hard to replenish vitamin A from plant sources, I take one capsule daily.
Read More
7.5
Moisturised skin
1 people found this helpful
I take cod liver oil for vitamin A due to hypothyroidism, as this form is essential for me. My skin stops feeling dry after taking it. If I miss doses for 2-3 months, severe dryness returns. The absorption of vitamin A from food is poor in hypothyroidism for me. One capsule suffices, even if it’s not 100% of the daily requirement. Wishing everyone good health!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. 10.47176/mjiri.38.133
- Mao G, Chen M, Huang L, Mo Z, Su D, et al. Differences in Vitamin A Levels and Their Association with the Atherogenic Index of Plasma and Subclinical Hypothyroidism in Adults: A Cross-Sectional Analysis in China. Nutrients. 2024;16. 10.3390/nu16162613
- Elfimova AE, Tipisova EV, Bichkaeva FA, Molodovskaya IN, Vlasova OS, et al. [Relationship of vitamin A and thyroid function in Arctic residents]. Vopr Pitan. 2023;92:66. 10.33029/0042-8833-2023-92-4-66-73
- Ma B, Yang P, Gao J, Du L, Sheng C, et al. Relationship of Vitamin A and Thyroid Function in Individuals With Obesity and After Laparoscopic Sleeve Gastrectomy. Front Nutr. 2022;9:824193. 10.3389/fnut.2022.824193
- Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. The effect of vitamin A supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2012;31:268.
- Senatore V, Cione E, Gnoni A, Genchi G. Retinoylation reactions are inversely related to the cardiolipin level in testes mitochondria from hypothyroid rats. J Bioenerg Biomembr. 2010;42:321. 10.1007/s10863-010-9293-8
- Schwarz BC, Sallmutter T, Nell B. Keratoconjunctivitis sicca attributable to parasympathetic facial nerve dysfunction associated with hypothyroidism in a horse. J Am Vet Med Assoc. 2008;233:1761. 10.2460/javma.233.11.1761
- Zimmermann MB. Interactions of vitamin A and iodine deficiencies: effects on the pituitary-thyroid axis. Int J Vitam Nutr Res. 2007;77:236.
- Biebinger R, Arnold M, Langhans W, Hurrell RF, Zimmermann MB. Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces thyroid hyperstimulation and thyroid size. J Nutr. 2007;137:573.
- Enderlin V, Vallortigara J, Alfos S, Féart C, Pallet V, et al. Retinoic acid reverses the PTU related decrease in neurogranin level in mice brain. J Physiol Biochem. 2004;60:191.
- Rabbani E, Golgiri F, Janani L, Moradi N, Fallah S, et al. Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism. Biol Trace Elem Res. 2021;199:4074. 10.1007/s12011-020-02548-3
- Zimmermann MB, Wegmüller R, Zeder C, Chaouki N, Torresani T. The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children. J Clin Endocrinol Metab. 2004;89:5441.
- Tang J, Shan S, Li F, Yun P. Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e36759. 10.1097/MD.0000000000036759
- Waterhouse M, Pham H, Rahman ST, Baxter C, Duarte Romero B, et al. The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial. Thyroid. 2023;33:1302. 10.1089/thy.2023.0317
- Bhakat B, Pal J, Das S, Charaborty SK, SircarMedical NR. A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis. J Assoc Physicians India. 2023;71:1.
- Liu Q, Zhang Y, Zhao H, Yao X. Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D Supplementation in High Iodide Intake-Induced Hypothyroid Offspring Rats. Front Physiol. 2021;12:669652. 10.3389/fphys.2021.669652
- ElRawi HA, Ghanem NS, ElSayed NM, Ali HM, Rashed LA, et al. Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients. J Thyroid Res. 2019;2019:3583250. 10.1155/2019/3583250
- Ucan B, Sahin M, Sayki Arslan M, Colak Bozkurt N, Kizilgul M, et al. Vitamin D Treatment in Patients with Hashimoto's Thyroiditis may Decrease the Development of Hypothyroidism. Int J Vitam Nutr Res. 2016;86:9. 10.1024/0300-9831/a000269
- Anaraki PV, Aminorroaya A, Amini M, Feizi A, Iraj B, et al. Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. J Res Med Sci. 2017;22:5. 10.4103/1735-1995.199090
- Mansournia N, Mansournia MA, Saeedi S, Dehghan J. The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis. J Endocrinol Invest. 2014;37:473. 10.1007/s40618-014-0064-y
- Kemmochi S, Fujimoto H, Woo GH, Hirose M, Nishikawa A, et al. Preventive effects of calcitriol on the development of capsular invasive carcinomas in a rat two-stage thyroid carcinogenesis model. J Vet Med Sci. 2011;73:655.
