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SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
Top Medical Research Studies
9
Vitamin A benefits thyroid function
The effect of vitamin A supplementation on thyroid function in premenopausal women.
High relevance to hypothyroidism
We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Read More
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
Directly relates to hypothyroidism treatment
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
8
Vitamin D3 improves thyroid function
Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
High relevance to hypothyroidism
We evaluated the effects of vitamin D3 supplementation on hypothyroidism, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved 12 randomized controlled trials, comparing the outcomes of individuals receiving vitamin D3 against those given a placebo or no treatment at all.
Through this thorough examination, we found that vitamin D3 did promote significant improvements in thyroid function and immune response. Specifically, we observed a reduction in two key antibodies: anti-thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (TG-Ab). These reductions suggest a positive effect on the autoimmune process involved in Hashimoto's thyroiditis.
Additionally, we noted improvements in thyroid hormone levels, including free thyroxine (FT4) and free triiodothyronine (FT3), while thyroid-stimulating hormone (TSH) levels showed a decrease. These findings indicate that vitamin D3 supplementation may benefit thyroid health and help manage hypothyroidism more effectively.
For those considering vitamin D3 as a treatment option, particularly those who have been on vitamin D for longer than 12 weeks, the results suggest a more pronounced effect on improving antibody levels and thyroid function. Thus, there appears to be a compelling case for vitamin D3 as a supportive treatment in managing Hashimoto's thyroiditis and related hypothyroidism.
Through this thorough examination, we found that vitamin D3 did promote significant improvements in thyroid function and immune response. Specifically, we observed a reduction in two key antibodies: anti-thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (TG-Ab). These reductions suggest a positive effect on the autoimmune process involved in Hashimoto's thyroiditis.
Additionally, we noted improvements in thyroid hormone levels, including free thyroxine (FT4) and free triiodothyronine (FT3), while thyroid-stimulating hormone (TSH) levels showed a decrease. These findings indicate that vitamin D3 supplementation may benefit thyroid health and help manage hypothyroidism more effectively.
For those considering vitamin D3 as a treatment option, particularly those who have been on vitamin D for longer than 12 weeks, the results suggest a more pronounced effect on improving antibody levels and thyroid function. Thus, there appears to be a compelling case for vitamin D3 as a supportive treatment in managing Hashimoto's thyroiditis and related hypothyroidism.
Read More
Most Useful Reviews
8.3
Thyroid support
Vitamin A in retinol palmitate form aids the absorption of beta-carotene, alongside vitamins D and E. Research shows that vitamin A deficiency in hypothyroidism links to autoimmune thyroiditis and low T3 levels. It protects the thyroid even with iodine deficiency. Since it’s hard to replenish vitamin A from plant sources, I take one capsule daily.
Read More
8.8
Moisturised skin
I take cod liver oil for vitamin A due to hypothyroidism, as this form is essential for me. My skin stops feeling dry after taking it. If I miss doses for 2-3 months, severe dryness returns. The absorption of vitamin A from food is poor in hypothyroidism for me. One capsule suffices, even if it’s not 100% of the daily requirement. Wishing everyone good health!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.1
9
Vitamin A benefits thyroid function
The effect of vitamin A supplementation on thyroid function in premenopausal women.
High relevance to hypothyroidism
We conducted a thorough investigation into how vitamin A supplementation might impact thyroid function, particularly focusing on women who are premenopausal and have varying body weights. Our study was a robust, four-month randomized controlled trial involving 84 healthy women aged 17 to 50. Among them, 56 women were classified as obese, while 28 fell into the nonobese category.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Throughout the study, we administered 25,000 IU of vitamin A or a placebo to the obese participants, while nonobese participants received vitamin A as well. Before and after the supplementation period, we measured key thyroid markers, including thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), and proteins associated with vitamin A transport.
Our findings revealed that vitamin A supplementation significantly reduced TSH concentrations in both the obese and nonobese groups, suggesting it may help mitigate the risk of subclinical hypothyroidism. Interestingly, we also noticed an increase in serum T3 levels among those treated with vitamin A. However, T4 levels decreased across all groups, including those not receiving vitamin A.
Overall, it appears that vitamin A may serve as a beneficial intervention for thyroid function in women, particularly those at risk for hypothyroidism. This research highlights an accessible avenue to better support thyroid health through dietary supplementation.
Read More
9
Keratoconjunctivitis and hypothyroidism in horses
Keratoconjunctivitis sicca attributable to parasympathetic facial nerve dysfunction associated with hypothyroidism in a horse.
Moderate relevance; treatment not isolated
We observed a case of a German Warmblood gelding exhibiting signs of keratoconjunctivitis sicca and other neurological symptoms, which were ultimately linked to hypothyroidism. As part of the treatment for this condition, vitamin A ointment was applied topically to the horse's eyes, alongside other therapies.
While vitamin A is traditionally known for its role in maintaining healthy eyes, the specific effectiveness of vitamin A in treating hypothyroidism remains unclear in this case. The primary treatment involved levothyroxine, which significantly improved the horse's thyroid function and correlated with the resolution of many clinical signs, including the eye issues.
Thus, while vitamin A was included in the treatment regimen, its distinct impact on the overall condition cannot be confidently isolated from the benefits observed with levothyroxine therapy. This underscores the need for more controlled studies to better understand the interplay between vitamin A and thyroid health.
While vitamin A is traditionally known for its role in maintaining healthy eyes, the specific effectiveness of vitamin A in treating hypothyroidism remains unclear in this case. The primary treatment involved levothyroxine, which significantly improved the horse's thyroid function and correlated with the resolution of many clinical signs, including the eye issues.
Thus, while vitamin A was included in the treatment regimen, its distinct impact on the overall condition cannot be confidently isolated from the benefits observed with levothyroxine therapy. This underscores the need for more controlled studies to better understand the interplay between vitamin A and thyroid health.
Read More
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
Directly relates to hypothyroidism treatment
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
9
Vitamin D3 and iodine benefits
Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D Supplementation in High Iodide Intake-Induced Hypothyroid Offspring Rats.
Vitamin D3 effect remains unclear
We investigated the potential benefits of vitamin D3 in treating hypothyroidism caused by high iodide intake in a study involving pregnant rats. The study involved adjusting iodide intake and supplementing with 1,25-dihydroxy-vitamin D (the active form of vitamin D) to see if these interventions could positively impact thyroid function and related complications.
The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.
Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.
These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.
Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.
These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
Read More
8
Vitamin A supports thyroid function
Interactions of vitamin A and iodine deficiencies: effects on the pituitary-thyroid axis.
Moderate relevance to hypothyroidism
We explored the relationship between vitamin A deficiency (VAD) and hypothyroidism, particularly how these deficiencies impact the pituitary-thyroid axis in the body. Our understanding comes from various studies, including those involving children in Africa, where VAD combined with iodine deficiency disorders (IDD) often leads to unique hormonal responses.
In children suffering from both VAD and IDD, we observed that higher levels of thyroid-stimulating hormone (TSH) may actually help in preventing hypothyroidism, despite existing conditions. Interestingly, research in rats showed that moderate VAD alone did not significantly affect the pituitary-thyroid axis. However, when VAD accompanies iodine deficiency, it can lead to more serious cases of primary hypothyroidism than iodine deficiency on its own.
When it comes to treatment, we noted that high doses of vitamin A could correct thyroid dysfunction caused by iodine deficiency. Therefore, while vitamin A does play a role, it doesn't diminish the effectiveness of iodine repletion. Our findings suggest that vitamin A supplementation can help manage thyroid stimulation, especially in individuals affected by both deficiencies.
Thus, we can conclude that while vitamin A isn’t a standalone solution for hypothyroidism, it certainly plays a supportive role in improving treatment outcomes when iodine levels are restored.
In children suffering from both VAD and IDD, we observed that higher levels of thyroid-stimulating hormone (TSH) may actually help in preventing hypothyroidism, despite existing conditions. Interestingly, research in rats showed that moderate VAD alone did not significantly affect the pituitary-thyroid axis. However, when VAD accompanies iodine deficiency, it can lead to more serious cases of primary hypothyroidism than iodine deficiency on its own.
When it comes to treatment, we noted that high doses of vitamin A could correct thyroid dysfunction caused by iodine deficiency. Therefore, while vitamin A does play a role, it doesn't diminish the effectiveness of iodine repletion. Our findings suggest that vitamin A supplementation can help manage thyroid stimulation, especially in individuals affected by both deficiencies.
Thus, we can conclude that while vitamin A isn’t a standalone solution for hypothyroidism, it certainly plays a supportive role in improving treatment outcomes when iodine levels are restored.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.8
Moisturised skin
I take cod liver oil for vitamin A due to hypothyroidism, as this form is essential for me. My skin stops feeling dry after taking it. If I miss doses for 2-3 months, severe dryness returns. The absorption of vitamin A from food is poor in hypothyroidism for me. One capsule suffices, even if it’s not 100% of the daily requirement. Wishing everyone good health!
Read More
8.3
Thyroid support
Vitamin A in retinol palmitate form aids the absorption of beta-carotene, alongside vitamins D and E. Research shows that vitamin A deficiency in hypothyroidism links to autoimmune thyroiditis and low T3 levels. It protects the thyroid even with iodine deficiency. Since it’s hard to replenish vitamin A from plant sources, I take one capsule daily.
Read More
