Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
Supplement Facts
Serving Size: 2 Veg Capsules
Serving Per Container: 60
Amount Per Serving
%DV
BioCell Collagen® (Hydrolyzed Chicken Sternal Cartilage Extract) providing
1 g (1,000 mg)
**
Hydrolyzed Type II Collagen
570 mg
**
Chondroitin Sulfate
190 mg
**
Hyaluronic Acid
95 mg
**
Top Medical Research Studies
8
We looked into how a new treatment combining hyaluronic acid with a peptide from fibroblast growth factor 2 could help combat acne. This method targets specific receptors involved in acne development, showing promise by reducing both acne lesions and excess oil production in lab tests. Importantly, our study revealed that this treatment does not encourage certain reactions that would typically hinder acne management. While the results are positive, we acknowledge that ongoing research is necessary for further confirmation of these findings.
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9
In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
Read More
9
We explored the effectiveness of a high-concentration (4.5%) hyaluronic acid filler designed to treat facial acne scars. Participants received two treatments, and we evaluated improvements after four months.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Read More
Most Useful Reviews
0
Acne emergence
2 people found this helpful
This product caused acne for me.
Read More
7.5
Skin improvement
This is the best collagen I’ve ever tried. After taking it for two weeks, I really like it. It’s notable that the acne beneath my skin began to appear as I started using it (two capsules daily), leading to more elastic and nourished skin.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
- All Researches
9
In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
Read More
9
We set out to explore the effectiveness of collagen treatment for atrophic acne scars using two different approaches: polycaprolactone (PCL) threads and microneedling combined with platelet-rich plasma (PRP). In our research, 24 patients participated in a split-face study where one side of the face was treated with PCL threads, and the other side underwent microneedling with PRP. Each participant received four sessions of microneedling on one side, while the other side was treated with just one session of threads.
After monitoring the patients for six months, we observed a significant improvement in skin texture and scar appearance. Specifically, 95.8% of patients noted progress on the side treated with threads compared to 83.3% on the microneedling side. Additionally, satisfaction ratings were notably higher among those who received the thread treatment.
Both procedures were associated with mild side effects, like transient swelling and redness, which cleared up quickly. Our findings suggest that PCL threads could be a promising collagen-boosting alternative for treating acne scars, providing effective results with minimal discomfort.
After monitoring the patients for six months, we observed a significant improvement in skin texture and scar appearance. Specifically, 95.8% of patients noted progress on the side treated with threads compared to 83.3% on the microneedling side. Additionally, satisfaction ratings were notably higher among those who received the thread treatment.
Both procedures were associated with mild side effects, like transient swelling and redness, which cleared up quickly. Our findings suggest that PCL threads could be a promising collagen-boosting alternative for treating acne scars, providing effective results with minimal discomfort.
Read More
9
We explored the effectiveness of a high-concentration (4.5%) hyaluronic acid filler designed to treat facial acne scars. Participants received two treatments, and we evaluated improvements after four months.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Notably, patients experienced a 12% improvement in scar severity shortly after treatment and a significant 31% improvement after four months. The skin's depth measurement also showed a 20% reduction in acne scar deepness with no serious side effects reported.
These promising results suggest that this hyaluronic acid formulation could be a valuable option for individuals seeking to improve their acne scarring.
Read More
9
Promising treatment for acne scars
We examined how needle-free electronic pneumatic injections of hyaluronic acid could treat facial acne scars. In a carefully designed study, thirty Japanese participants received treatments on one side of their face, with follow-ups conducted for three months after completing three sessions.
Remarkably, 48.3% of the treated sides showed significant improvement, while none of the untreated sides did. Participants reported high satisfaction rates and the results were confirmed by imaging analysis. Overall, this treatment demonstrated promising effects on rolling acne scars with minimal side effects.
Remarkably, 48.3% of the treated sides showed significant improvement, while none of the untreated sides did. Participants reported high satisfaction rates and the results were confirmed by imaging analysis. Overall, this treatment demonstrated promising effects on rolling acne scars with minimal side effects.
Read More
9
Hyaluronic acid shows scar improvement
This study explored the effectiveness of using hyaluronic acid filler alongside subcision for treating post-acne scars.
In a controlled trial with 40 participants, we observed that both the subcision combined with hyaluronic acid and with fractional CO laser treatments showed significant improvements.
However, when comparing the two enhanced methods, neither was found to be statistically better than the other. Importantly, subcision alone still provided some improvement, even if modest. Overall, combining these treatments appears beneficial without serious side effects.
In a controlled trial with 40 participants, we observed that both the subcision combined with hyaluronic acid and with fractional CO laser treatments showed significant improvements.
However, when comparing the two enhanced methods, neither was found to be statistically better than the other. Importantly, subcision alone still provided some improvement, even if modest. Overall, combining these treatments appears beneficial without serious side effects.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
0
Acne emergence
2 people found this helpful
This product caused acne for me.
Read More
7.5
Skin improvement
This is the best collagen I’ve ever tried. After taking it for two weeks, I really like it. It’s notable that the acne beneath my skin began to appear as I started using it (two capsules daily), leading to more elastic and nourished skin.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Huang Y, Liu C, Fu Z, Li C, Wu Y, et al. The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway. Eur J Pharmacol. 2025;989:177233. doi:10.1016/j.ejphar.2024.177233
- Lyu J, Jiang L, Tang M, Zheng L, Liu S. Microneedle fractional radiofrequency associated with drug delivery for facial atrophic acne scars and skin rejuvenation. J Cosmet Laser Ther. 2024;26:61. doi:10.1080/14764172.2024.2372342
- Barone M, De Bernardis R, Persichetti P. Minimally Invasive Post-Acne Scars Treatment with the Hybrid Filler HArmonyCa™. Aesthetic Plast Surg. 2024. doi:10.1007/s00266-024-04046-6
- Ozer K, Gunes D. Comment on "A Split-Face Study to Evaluate Efficacy of Autologous Injectable Platelet-Rich Fibrin With Microneedling Against Microneedling With Normal Saline (Placebo Control) in Atrophic Acne Scars". Dermatol Surg. 2024;50:693. doi:10.1097/DSS.0000000000004150
- El-Domyati M, Moftah NH, Ahmed AM, Ibrahim MR. Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study. Int J Dermatol. 2024;63:632. doi:10.1111/ijd.17006
- Khattab FM, Samir MA, El Khouly SS, Atwa EM. Efficacy of Polycaprolactone Threads in Treating Atrophic Acne Scars: A Split-face Comparative Study. J Clin Aesthet Dermatol. 2023;16:33.
- Stefancu ME, Barattini DF, Botnaru I, Vizman C, Stucchi L, et al. Performance and Safety of the Medical Device Ialuxid Gel in the Treatment of Mild-Moderate Acne Vulgaris: An Open-Label, Noncomparative Multicentre Interventional Clinical Trial. J Cosmet Dermatol. 2025;24:e70084. doi:10.1111/jocd.70084
- Sparavigna A, Grimolizzi F, Cigni C, Lualdi R, Bellia G. Dual-Plane Treatment With Highly Concentrated Hybrid Cooperative Complexes of Hyaluronans for Facial Atrophic Acne Scars. Dermatol Surg. 2025;51:152. doi:10.1097/DSS.0000000000004387
- Mohamed SH, Omar GA, Hamdy AE. Microneedling with Topical Insulin Versus Microneedling with Non-Cross-Linked Hyaluronic Acid for Atrophic Post-Acne Scars: A Split-Face Study. Dermatol Pract Concept. 2024;14. doi:10.5826/dpc.1403a183
- Dastgheib M, Heidari S, Azizipour A, Kavyani M, Lajevardi V, et al. Investigating the impact of added Profhilo mesogel to subcision versus subcision monotherapy in treating acne scars; a single-blinded, split-face randomized trial. J Cosmet Dermatol. 2024;23:1992. doi:10.1111/jocd.16258
- Bano R, Brar BK, Kumar S. Comparative Evaluation of Therapeutic Efficacy and Safety of Microneedling Alone Versus Microneedling with Hyaluronic Acid in Post-Acne Scarring. J Cutan Aesthet Surg. 2023;16:279. doi:10.4103/JCAS.JCAS_6_23
- Behrangi E, Dehghani A, Sheikhzadeh F, Goodarzi A, Roohaninasab M. Evaluation and comparison of the efficacy and safety of cross-linked and non-cross-linked hyaluronic acid in combination with botulinum toxin type A in the treatment of atrophic acne scars: A double-blind randomized clinical trial. Skin Res Technol. 2024;30:e13541. doi:10.1111/srt.13541
- Kaminaka C, Sakata M, Nishiguchi M, Kunimoto K, Mikita N, et al. Clinical evaluation of needle-free electronic pneumatic hyaluronic acid injection treatment for facial atrophic acne scars: A prospective, randomized comparative trial. J Dermatol. 2023;50:971. doi:10.1111/1346-8138.16830
- Mehrabi J, Shehadeh W, Gallo ES, Artzi O, Horovitz T. Comparison of 2 Hyaluronic Acid-based Fillers for the Treatment of Acne Scars: Structural Lifting Versus Biostimulatory Effect. Dermatol Surg. 2023;49:581. doi:10.1097/DSS.0000000000003789
- Su Z, Zhang Y, Cao J, Sun Y, Cai Y, et al. Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist. J Nanobiotechnology. 2023;21:55. doi:10.1186/s12951-023-01812-7
- Abdelwahab AA, Omar GAB, Hamdino M. A combined subcision approach with either fractional CO laser (10,600 nm) or cross-linked hyaluronic acid versus subcision alone in atrophic post-acne scar treatment. Lasers Med Sci. 2022;38:20. doi:10.1007/s10103-022-03677-y
- Mohammed GF, Al-Dhubaibi MS. Triple steps acne scar revision technique: A new combination therapeutic modality for atrophic acne scars. J Cosmet Dermatol. 2022;21:4659. doi:10.1111/jocd.14944
- Ebrahim HM, Nassar A, ElKashishy K, Artima AYM, Morsi HM. A combined approach of subcision with either cross-linked hyaluronic acid or threads in the treatment of atrophic acne scars. J Cosmet Dermatol. 2022;21:3334. doi:10.1111/jocd.14675
- MacGillis D, Vinshtok Y. High-velocity pneumatic injection of non-crosslinked hyaluronic acid for skin regeneration and scar remodeling: A retrospective analysis of 115 patients. J Cosmet Dermatol. 2021;20:1098. doi:10.1111/jocd.14002
