Last update
3/15/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
10 mg (10,000 mcg)
416,667%
Top Medical Research Studies
8
We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
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7
We explored a case involving a 41-year-old woman who experienced unstable walking due to a vitamin B12 deficiency. Her symptoms were related to subacute combined degeneration of the spinal cord, which affected her nerve health.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
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9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Read More
Most Useful Reviews
9
Diabetic relief
2 people found this helpful
This product works well for my neuropathy caused by diabetes. My healthcare provider suggested it, and I have ordered a second bottle. I recommend consulting your doctor before trying it for neuropathy.
Read More
7.5
Improved symptoms
6 people found this helpful
I bought this for the carpal tunnel pain in my wrists and the neuropathy in my feet, which I've had for years. After two days, the numbness, tingling, and pain improved. It dissolves easily in my mouth and tastes good. I will definitely continue taking it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
- All Researches
We examined a unique case involving a 33-year-old woman with HIV who experienced sudden vision loss linked to vitamin B12 deficiency. Initially treated with B12 tablets for severe peripheral neuropathy, her condition escalated to optic neuritis. Upon diagnosis, she received prednisolone and daily B12 injections. After five months of this treatment, she reported a significant recovery in her vision. This case highlights the importance of recognizing vitamin B12 deficiency’s potential eye-related symptoms, especially in patients with underlying health conditions like HIV, to ensure timely intervention.
Read More
9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Read More
8
We examined the case of a 40-year-old woman suffering from a decade of vague symptoms, including pain and cognitive issues, before being diagnosed with vitamin B12 deficiency due to pernicious anemia.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
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8
We explored the effectiveness of steroid treatment versus vitamin B12 therapy for improving diabetic ocular nerve palsy. Our study involved fifty participants, with half receiving steroids and the other half vitamin B12 injections.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
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8
We explored the connection between nitrous oxide use and vitamin B12 deficiency, specifically focusing on neurological issues like peripheral neuropathy. Through a reported case of nitrous oxide-induced subacute combined degeneration of the spinal cord, we identified a functional B12 deficiency despite normal serum levels.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Diabetic relief
2 people found this helpful
This product works well for my neuropathy caused by diabetes. My healthcare provider suggested it, and I have ordered a second bottle. I recommend consulting your doctor before trying it for neuropathy.
Read More
7.5
Improved symptoms
6 people found this helpful
I bought this for the carpal tunnel pain in my wrists and the neuropathy in my feet, which I've had for years. After two days, the numbness, tingling, and pain improved. It dissolves easily in my mouth and tastes good. I will definitely continue taking it.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
- El-Najjar SE, Naser IA, Al-Wahidi KM. Is Functional Vitamin B12 Deficiency a Risk Factor for the Development of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients?. Asian Pac J Cancer Prev. 2025;26:375. 10.31557/APJCP.2025.26.2.375
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. 10.7759/cureus.75656
- Kyaw KY, Lwin MT, Lwin ZT. Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report. Cureus. 2024;16:e74383. 10.7759/cureus.74383
- Bandara P, Wijenayake W, Fernando S, Padeniya P, Mettananda S. Vitamin B12 responsive developmental and epileptic encephalopathy due to a novel mutation in the FUT2 gene: a case report. BMC Pediatr. 2024;24:622. 10.1186/s12887-024-05106-1
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. 10.3390/nu16183045
- Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. 10.11604/pamj.2024.47.164.43048
- Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. 10.1177/03795721241226886
- Pino S, Vega E, Fragoso M, Salazar G. Nitrous Oxide as an Emerging Cause of Subacute Combined Degeneration and Polyneuropathy: A Two-Case Report. Cureus. 2024;16:e63003. 10.7759/cureus.63003
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. 10.59556/japi.72.0493
- Zhu M, Yu C, Xu Z, Zhang H, Huang H. Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report. Medicine (Baltimore). 2024;103:e37605. 10.1097/MD.0000000000037605
- Hu S, Brown-Kunin S, Martin P, Wang Y. Association of co-existing vitamin B6 and B12 deficiency with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome: a case report. BMC Neurol. 2025;25:54. 10.1186/s12883-025-04069-9
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. 10.1111/1753-0407.70045
- Kulkantrakorn K, Chunhachatrachai P, Kulkantrakorn W. Nitrous oxide abuse and associated neurological diseases. BMC Neurol. 2024;24:461. 10.1186/s12883-024-03966-9
- Hotta K, Mano Y. Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma. J Pharmacol Toxicol Methods. 2024;129:107552. 10.1016/j.vascn.2024.107552
Data last updated:
