Overview
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.8
USERS' SCORE
Good
Based on 8 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
We explored the connection between docosahexaenoic acid (DHA), a type of polyunsaturated fatty acid (PUFA), and the risk of developing acne. Using genetic data from over 478,000 participants, we used a method called Mendelian randomization to determine if higher levels of DHA could truly lead to lower acne risk.
Our findings were quite enlightening. We discovered that higher DHA levels were significantly associated with a decreased risk of acne. Specifically, when looking at the percentage of total fatty acids that were DHA, we saw even stronger protective effects against acne flare-ups. In contrast, we found that higher levels of linoleic acid (LA) and a higher omega-6 to omega-3 ratio were linked to an increased risk of acne.
Notably, the results hinted at a connection to a genetic variant related to the fatty acid desaturase 1 (FADS1) gene, emphasizing that genetics plays a role in how these fatty acids affect skin health. Overall, our study supports the idea that boosting DHA intake could be beneficial for acne prevention, while cautioning against high intakes of LA.
Our findings were quite enlightening. We discovered that higher DHA levels were significantly associated with a decreased risk of acne. Specifically, when looking at the percentage of total fatty acids that were DHA, we saw even stronger protective effects against acne flare-ups. In contrast, we found that higher levels of linoleic acid (LA) and a higher omega-6 to omega-3 ratio were linked to an increased risk of acne.
Notably, the results hinted at a connection to a genetic variant related to the fatty acid desaturase 1 (FADS1) gene, emphasizing that genetics plays a role in how these fatty acids affect skin health. Overall, our study supports the idea that boosting DHA intake could be beneficial for acne prevention, while cautioning against high intakes of LA.
Read More
9
We investigated the effects of omega-3 fatty acids, specifically docosahexaenoic acid (DHA), on acne severity. Our study involved 60 patients who were asked to follow a Mediterranean diet and take oral algae-derived DHA and eicosapentaenoic acid (EPA) supplements over a period of 16 weeks.
Throughout this time, we monitored the patients' blood levels of DHA and EPA, alongside clinical assessments of their acne. The findings were quite striking. At the beginning of the study, nearly all participants had low levels of DHA and EPA. By the end of the 16 weeks, these levels significantly increased, leading to marked improvements in both inflammatory and non-inflammatory acne lesions.
Moreover, the overall quality of life for these individuals improved—particularly those with acne papulopustulosa. Although a few participants reported worsened self-perception, the overall trend was positive, indicating that increasing DHA can indeed help alleviate acne severity when levels are elevated to a target range.
This study highlights that many acne patients may benefit from dietary changes and supplementation to address omega-3 deficiencies, which can contribute to improving their skin condition.
Throughout this time, we monitored the patients' blood levels of DHA and EPA, alongside clinical assessments of their acne. The findings were quite striking. At the beginning of the study, nearly all participants had low levels of DHA and EPA. By the end of the 16 weeks, these levels significantly increased, leading to marked improvements in both inflammatory and non-inflammatory acne lesions.
Moreover, the overall quality of life for these individuals improved—particularly those with acne papulopustulosa. Although a few participants reported worsened self-perception, the overall trend was positive, indicating that increasing DHA can indeed help alleviate acne severity when levels are elevated to a target range.
This study highlights that many acne patients may benefit from dietary changes and supplementation to address omega-3 deficiencies, which can contribute to improving their skin condition.
Read More
4
We evaluated the relationship between eicosapentaenoic acid (EPA) levels and acne vulgaris to better understand how this fatty acid influences skin health. Our study included serum samples from 21 healthy individuals and 31 patients with acne. We measured various fatty acids, along with specific proteins linked to inflammation and fat metabolism.
The findings showed that EPA levels were significantly lower in acne patients compared to the control group. This decrease in EPA was coupled with an increase in the ratio of arachidonic acid to EPA, suggesting a shift towards a more inflammatory state in those suffering from acne.
Additionally, we noted higher activity levels of secretory phospholipase A2 and lipoprotein lipase in acne patients. Increased LPL activity might actually provide some protective effects against skin issues related to lipid imbalance.
This study is pivotal as it highlights the potential role of omega-3 fatty acids, like EPA, in acne management. While more research is needed, the results suggest that incorporating EPA may complement existing acne treatments, potentially addressing inflammation and helping to improve skin health.
The findings showed that EPA levels were significantly lower in acne patients compared to the control group. This decrease in EPA was coupled with an increase in the ratio of arachidonic acid to EPA, suggesting a shift towards a more inflammatory state in those suffering from acne.
Additionally, we noted higher activity levels of secretory phospholipase A2 and lipoprotein lipase in acne patients. Increased LPL activity might actually provide some protective effects against skin issues related to lipid imbalance.
This study is pivotal as it highlights the potential role of omega-3 fatty acids, like EPA, in acne management. While more research is needed, the results suggest that incorporating EPA may complement existing acne treatments, potentially addressing inflammation and helping to improve skin health.
Read More
Most Useful Reviews
10
Smoother skin texture
I've been using this for three years now. My nails are less brittle, bruises fewer, and my skin is smoother, with peeling and acne now gone. I take three capsules daily and will keep using it.
Read More
9
Clearer, brighter skin
A beautiful product that diminishes acne and makes my skin bright and lovely.
Read More
9
Hydrated, clear skin
My skin feels hydrated and nearly free of acne after six months of use. I will definitely order more.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.8
- All Researches
9
We explored the connection between docosahexaenoic acid (DHA), a type of polyunsaturated fatty acid (PUFA), and the risk of developing acne. Using genetic data from over 478,000 participants, we used a method called Mendelian randomization to determine if higher levels of DHA could truly lead to lower acne risk.
Our findings were quite enlightening. We discovered that higher DHA levels were significantly associated with a decreased risk of acne. Specifically, when looking at the percentage of total fatty acids that were DHA, we saw even stronger protective effects against acne flare-ups. In contrast, we found that higher levels of linoleic acid (LA) and a higher omega-6 to omega-3 ratio were linked to an increased risk of acne.
Notably, the results hinted at a connection to a genetic variant related to the fatty acid desaturase 1 (FADS1) gene, emphasizing that genetics plays a role in how these fatty acids affect skin health. Overall, our study supports the idea that boosting DHA intake could be beneficial for acne prevention, while cautioning against high intakes of LA.
Our findings were quite enlightening. We discovered that higher DHA levels were significantly associated with a decreased risk of acne. Specifically, when looking at the percentage of total fatty acids that were DHA, we saw even stronger protective effects against acne flare-ups. In contrast, we found that higher levels of linoleic acid (LA) and a higher omega-6 to omega-3 ratio were linked to an increased risk of acne.
Notably, the results hinted at a connection to a genetic variant related to the fatty acid desaturase 1 (FADS1) gene, emphasizing that genetics plays a role in how these fatty acids affect skin health. Overall, our study supports the idea that boosting DHA intake could be beneficial for acne prevention, while cautioning against high intakes of LA.
Read More
9
We investigated the effects of omega-3 fatty acids, specifically docosahexaenoic acid (DHA), on acne severity. Our study involved 60 patients who were asked to follow a Mediterranean diet and take oral algae-derived DHA and eicosapentaenoic acid (EPA) supplements over a period of 16 weeks.
Throughout this time, we monitored the patients' blood levels of DHA and EPA, alongside clinical assessments of their acne. The findings were quite striking. At the beginning of the study, nearly all participants had low levels of DHA and EPA. By the end of the 16 weeks, these levels significantly increased, leading to marked improvements in both inflammatory and non-inflammatory acne lesions.
Moreover, the overall quality of life for these individuals improved—particularly those with acne papulopustulosa. Although a few participants reported worsened self-perception, the overall trend was positive, indicating that increasing DHA can indeed help alleviate acne severity when levels are elevated to a target range.
This study highlights that many acne patients may benefit from dietary changes and supplementation to address omega-3 deficiencies, which can contribute to improving their skin condition.
Throughout this time, we monitored the patients' blood levels of DHA and EPA, alongside clinical assessments of their acne. The findings were quite striking. At the beginning of the study, nearly all participants had low levels of DHA and EPA. By the end of the 16 weeks, these levels significantly increased, leading to marked improvements in both inflammatory and non-inflammatory acne lesions.
Moreover, the overall quality of life for these individuals improved—particularly those with acne papulopustulosa. Although a few participants reported worsened self-perception, the overall trend was positive, indicating that increasing DHA can indeed help alleviate acne severity when levels are elevated to a target range.
This study highlights that many acne patients may benefit from dietary changes and supplementation to address omega-3 deficiencies, which can contribute to improving their skin condition.
Read More
8
We conducted an interesting study to understand how docosahexaenoic acid (a type of omega-3 fatty acid) influences acne treatment. Over 10 weeks, 45 participants with mild to moderate acne were divided into three groups: one receiving omega-3 fatty acids, another taking gamma-linoleic acid, and a control group.
Remarkably, those who received omega-3 and gamma-linoleic acid experienced significant reductions in both inflammatory and non-inflammatory acne lesions. This improvement was reflected in participants’ personal assessments, highlighting their positive experiences with the treatment.
Additionally, we observed that laboratory tests showed decreased inflammation and a reduction in levels of interleukin-8, a marker linked to acne inflammation. Importantly, there were no serious side effects reported, which is encouraging for considering these supplements as adjunct treatments for acne.
Overall, our findings suggest that incorporating omega-3 fatty acids, like docosahexaenoic acid, may be beneficial for individuals struggling with acne, providing a natural option alongside conventional treatments.
Remarkably, those who received omega-3 and gamma-linoleic acid experienced significant reductions in both inflammatory and non-inflammatory acne lesions. This improvement was reflected in participants’ personal assessments, highlighting their positive experiences with the treatment.
Additionally, we observed that laboratory tests showed decreased inflammation and a reduction in levels of interleukin-8, a marker linked to acne inflammation. Importantly, there were no serious side effects reported, which is encouraging for considering these supplements as adjunct treatments for acne.
Overall, our findings suggest that incorporating omega-3 fatty acids, like docosahexaenoic acid, may be beneficial for individuals struggling with acne, providing a natural option alongside conventional treatments.
Read More
8
We aimed to explore the effectiveness of eicosapentaenoic acid (EPA) along with other long-chain polyunsaturated fatty acids (LC-PUFAs) in treating acne and superficial infections caused by the bacteria Propionibacterium acnes and Staphylococcus aureus. In our investigation, we found that these fatty acids exhibited antibacterial properties, with a range of effectiveness against the two types of bacteria.
The study revealed that P. acnes showed more sensitivity to the growth-inhibiting effects of LC-PUFAs compared to S. aureus. Interestingly, while these compounds were capable of stopping P. acnes growth, they were only bactericidal, meaning they could kill S. aureus. Our findings also included the discovery of the antibacterial activity in previously unreported fatty acids such as 15-hydroxyeicosapentaenoic acid (15-OHEPA) and 15-hydroxyeicosatrienoic acid (HETrE).
Additionally, we noted that when S. aureus was exposed to these fatty acids, the bacteria were effectively killed within a short timeframe, specifically between 15 to 30 minutes. Combining these LC-PUFAs with established treatments did not reduce their effectiveness and revealed potential potentiation of action, particularly in combinations with commonly used acne medications like benzoyl peroxide and neomycin.
In conclusion, our observations suggest that eicosapentaenoic acid and other LC-PUFAs may be valuable new options for treating skin infections caused by P. acnes and S. aureus, especially when used alongside conventional therapies. However, further studies are needed to fully understand their potential in clinical settings.
The study revealed that P. acnes showed more sensitivity to the growth-inhibiting effects of LC-PUFAs compared to S. aureus. Interestingly, while these compounds were capable of stopping P. acnes growth, they were only bactericidal, meaning they could kill S. aureus. Our findings also included the discovery of the antibacterial activity in previously unreported fatty acids such as 15-hydroxyeicosapentaenoic acid (15-OHEPA) and 15-hydroxyeicosatrienoic acid (HETrE).
Additionally, we noted that when S. aureus was exposed to these fatty acids, the bacteria were effectively killed within a short timeframe, specifically between 15 to 30 minutes. Combining these LC-PUFAs with established treatments did not reduce their effectiveness and revealed potential potentiation of action, particularly in combinations with commonly used acne medications like benzoyl peroxide and neomycin.
In conclusion, our observations suggest that eicosapentaenoic acid and other LC-PUFAs may be valuable new options for treating skin infections caused by P. acnes and S. aureus, especially when used alongside conventional therapies. However, further studies are needed to fully understand their potential in clinical settings.
Read More
7
Eicosapentaenoic acid potentially helps acne
We explored the impact of eicosapentaenoic acid (EPA) on acne among individuals who often experience psychological challenges alongside their skin condition. Acne vulgaris is not only a prevalent skin issue but is also linked to feelings of depression, anxiety, and other emotional struggles. Given that many individuals with such conditions frequently turn to dietary supplements, we investigated whether EPA, an omega-3 fatty acid, could provide relief for both skin symptoms and mood issues.
In our observations, five cases of patients who self-administered EPA along with antioxidant nutrients showed signs of improvement in their inflammatory acne lesions and overall well-being. While the results are promising, showcasing potential benefits of such a combination, it is crucial to note that the specific effect of EPA alone cannot be completely determined due to the presence of other nutrients in the treatment.
The findings point to a compelling link between nutrition and skin health, particularly for those struggling with both acne and mental health problems. However, to firmly establish these effects, further controlled trials are necessary. This helps ensure that the relationship we are seeing is accurate and meaningful for those seeking relief from acne.
In our observations, five cases of patients who self-administered EPA along with antioxidant nutrients showed signs of improvement in their inflammatory acne lesions and overall well-being. While the results are promising, showcasing potential benefits of such a combination, it is crucial to note that the specific effect of EPA alone cannot be completely determined due to the presence of other nutrients in the treatment.
The findings point to a compelling link between nutrition and skin health, particularly for those struggling with both acne and mental health problems. However, to firmly establish these effects, further controlled trials are necessary. This helps ensure that the relationship we are seeing is accurate and meaningful for those seeking relief from acne.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Smoother skin texture
I've been using this for three years now. My nails are less brittle, bruises fewer, and my skin is smoother, with peeling and acne now gone. I take three capsules daily and will keep using it.
Read More
9
Clearer, brighter skin
A beautiful product that diminishes acne and makes my skin bright and lovely.
Read More
9
Hydrated, clear skin
My skin feels hydrated and nearly free of acne after six months of use. I will definitely order more.
Read More
9
Balanced, clearer skin
The quality of the fish oil is excellent, and I noticed benefits quite quickly. Having struggled with dry skin and acne for 30 years, I realised I needed a good DHA supplement. After about a month, my skin improved significantly, reducing my lotion use, and I experience no fishy burps with this easy-to-swallow tablet.
Read More
2
No acne improvement
3 people found this helpful
I take it as my means for Omega 3 fatty acids and I'm starting to feel like it was a placebo effect. I've used this for 3 years and haven't seen much improvement. I also tried using it to cure my acne and it hasn't worked; I took up to 8 pills at one point, but it just didn’t do anything.
Read More
Frequently Asked Questions
7.5
Reduced inflamed skin
1 people found this helpful
After taking it daily for a month, my skin looks less inflamed and red, with no new acne spots. The capsules are quite large, but I managed to take them without any issue. There was no aftertaste.
9
Balanced, clearer skin
The quality of the fish oil is excellent, and I noticed benefits quite quickly. Having struggled with dry skin and acne for 30 years, I realised I needed a good DHA supplement. After about a month, my skin improved significantly, reducing my lotion use, and I experience no fishy burps with this easy-to-swallow tablet.
9
Hydrated, clear skin
My skin feels hydrated and nearly free of acne after six months of use. I will definitely order more.
10
Smoother skin texture
I've been using this for three years now. My nails are less brittle, bruises fewer, and my skin is smoother, with peeling and acne now gone. I take three capsules daily and will keep using it.
9
Clearer, brighter skin
A beautiful product that diminishes acne and makes my skin bright and lovely.
7.5
Acne prevention
The Omega-3 fatty acids in fish oil help reduce acne and prevent it. My cosmetologist notes its beneficial effects on skin, nails, and hair, promoting their growth and strength.
7.5
Improved acne condition
This product has so many benefits, particularly in reducing inflammation, which I found essential. My husband also experienced improvement in his acne.
9
We explored the connection between docosahexaenoic acid (DHA), a type of polyunsaturated fatty acid (PUFA), and the risk of developing acne. Using genetic data from over 478,000 participants, we used a method called Mendelian randomization to determine if higher levels of DHA could truly lead to lower acne risk.
Our findings were quite enlightening. We discovered that higher DHA levels were significantly associated with a decreased risk of acne. Specifically, when looking at the percentage of total fatty acids that were DHA, we saw even stronger protective effects against acne flare-ups. In contrast, we found that higher levels of linoleic acid (LA) and a higher omega-6 to omega-3 ratio were linked to an increased risk of acne.
Notably, the results hinted at a connection to a genetic variant related to the fatty acid desaturase 1 (FADS1) gene, emphasizing that genetics plays a role in how these fatty acids affect skin health. Overall, our study supports the idea that boosting DHA intake could be beneficial for acne prevention, while cautioning against high intakes of LA.
Our findings were quite enlightening. We discovered that higher DHA levels were significantly associated with a decreased risk of acne. Specifically, when looking at the percentage of total fatty acids that were DHA, we saw even stronger protective effects against acne flare-ups. In contrast, we found that higher levels of linoleic acid (LA) and a higher omega-6 to omega-3 ratio were linked to an increased risk of acne.
Notably, the results hinted at a connection to a genetic variant related to the fatty acid desaturase 1 (FADS1) gene, emphasizing that genetics plays a role in how these fatty acids affect skin health. Overall, our study supports the idea that boosting DHA intake could be beneficial for acne prevention, while cautioning against high intakes of LA.
9
We investigated the effects of omega-3 fatty acids, specifically docosahexaenoic acid (DHA), on acne severity. Our study involved 60 patients who were asked to follow a Mediterranean diet and take oral algae-derived DHA and eicosapentaenoic acid (EPA) supplements over a period of 16 weeks.
Throughout this time, we monitored the patients' blood levels of DHA and EPA, alongside clinical assessments of their acne. The findings were quite striking. At the beginning of the study, nearly all participants had low levels of DHA and EPA. By the end of the 16 weeks, these levels significantly increased, leading to marked improvements in both inflammatory and non-inflammatory acne lesions.
Moreover, the overall quality of life for these individuals improved—particularly those with acne papulopustulosa. Although a few participants reported worsened self-perception, the overall trend was positive, indicating that increasing DHA can indeed help alleviate acne severity when levels are elevated to a target range.
This study highlights that many acne patients may benefit from dietary changes and supplementation to address omega-3 deficiencies, which can contribute to improving their skin condition.
Throughout this time, we monitored the patients' blood levels of DHA and EPA, alongside clinical assessments of their acne. The findings were quite striking. At the beginning of the study, nearly all participants had low levels of DHA and EPA. By the end of the 16 weeks, these levels significantly increased, leading to marked improvements in both inflammatory and non-inflammatory acne lesions.
Moreover, the overall quality of life for these individuals improved—particularly those with acne papulopustulosa. Although a few participants reported worsened self-perception, the overall trend was positive, indicating that increasing DHA can indeed help alleviate acne severity when levels are elevated to a target range.
This study highlights that many acne patients may benefit from dietary changes and supplementation to address omega-3 deficiencies, which can contribute to improving their skin condition.
8
We conducted an interesting study to understand how docosahexaenoic acid (a type of omega-3 fatty acid) influences acne treatment. Over 10 weeks, 45 participants with mild to moderate acne were divided into three groups: one receiving omega-3 fatty acids, another taking gamma-linoleic acid, and a control group.
Remarkably, those who received omega-3 and gamma-linoleic acid experienced significant reductions in both inflammatory and non-inflammatory acne lesions. This improvement was reflected in participants’ personal assessments, highlighting their positive experiences with the treatment.
Additionally, we observed that laboratory tests showed decreased inflammation and a reduction in levels of interleukin-8, a marker linked to acne inflammation. Importantly, there were no serious side effects reported, which is encouraging for considering these supplements as adjunct treatments for acne.
Overall, our findings suggest that incorporating omega-3 fatty acids, like docosahexaenoic acid, may be beneficial for individuals struggling with acne, providing a natural option alongside conventional treatments.
Remarkably, those who received omega-3 and gamma-linoleic acid experienced significant reductions in both inflammatory and non-inflammatory acne lesions. This improvement was reflected in participants’ personal assessments, highlighting their positive experiences with the treatment.
Additionally, we observed that laboratory tests showed decreased inflammation and a reduction in levels of interleukin-8, a marker linked to acne inflammation. Importantly, there were no serious side effects reported, which is encouraging for considering these supplements as adjunct treatments for acne.
Overall, our findings suggest that incorporating omega-3 fatty acids, like docosahexaenoic acid, may be beneficial for individuals struggling with acne, providing a natural option alongside conventional treatments.
References
- Kim BR, Kim G, Jin SP, Choi CW, Kim J, et al. The causal association between polyunsaturated fatty acids and acne: A two-sample Mendelian randomization study. Br J Dermatol. 2025. doi:10.1093/bjd/ljaf052
- Guertler A, Neu K, Lill D, Clanner-Engelshofen B, French LE, et al. Exploring the potential of omega-3 fatty acids in acne patients: A prospective intervention study. J Cosmet Dermatol. 2024;23:3295. doi:10.1111/jocd.16434
- Jarratt MT, Jones TM, Chang-Lin JE, Tong W, Berk DR, et al. Safety and Pharmacokinetics of Once-Daily Dapsone Gel, 7.5% in Patients With Moderate Acne Vulgaris. J Drugs Dermatol. 2016;15:1250.
- Chrousos GP, Peck GL, Gross EG, Cutler GB, Loriaux DL. Adrenal function in women with idiopathic acne. J Invest Dermatol. 1982;78:468.
- Jung JY, Kwon HH, Hong JS, Yoon JY, Park MS, et al. Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. Acta Derm Venereol. 2014;94:521. doi:10.2340/00015555-1802
- Aslan İ, Özcan F, Karaarslan T, Kıraç E, Aslan M. Decreased eicosapentaenoic acid levels in acne vulgaris reveals the presence of a proinflammatory state. Prostaglandins Other Lipid Mediat. 2017;128-129:1. doi:10.1016/j.prostaglandins.2016.12.001
- Desbois AP, Lawlor KC. Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus. Mar Drugs. 2013;11:4544. doi:10.3390/md11114544
- Rubin MG, Kim K, Logan AC. Acne vulgaris, mental health and omega-3 fatty acids: a report of cases. Lipids Health Dis. 2008;7:36. doi:10.1186/1476-511X-7-36
