' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.9
USERS' SCORE
Good
Based on 5 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
Critical exploration of 12-HEPE
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Read More
9
Docosahexaenoic acid's anti-inflammatory effects
Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation.
High relevance to allergy treatment
We examined how docosahexaenoic acid, particularly its metabolite resolvin D2, influences allergic reactions and inflammation. Our focus was on type 2 inflammatory responses, often seen in allergic conditions. Through rigorous methodologies, including control groups, the study assessed how resolvin D2 can help in regulating these responses and promote the resolution of allergy-related inflammation in mice.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Read More
9
Eicosapentaenoic acid benefits allergies
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
Directly addresses EPA for allergies
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
Read More
Most Useful Reviews
9.5
Allergy improvement
Super Omega! This was recommended by my nutritionist. It’s well-tolerated, with no side effects. After a few days, my allergy symptoms vanished, and my dermatitis cleared up. My sleep improved and my joints are more flexible without the discomfort I previously experienced. The results were excellent and exceeded my expectations!
Read More
9.5
Allergy relief
This fish oil works wonders for me and my husband; we no longer suffer from allergies and our focus has improved.
Read More
9.5
Reduced allergies
This supplement made a difference for my son, who is allergic. His immunity improved and his allergies decreased significantly. I highly recommend it for lowering cholesterol, reducing inflammation, and enhancing heart function.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.9
9.5
Docosahexaenoic acid helps asthma
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress.
Study examines DHA's anti-asthmatic effects
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Read More
9.5
New hypoallergenic formula shows promise
Hypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants.
Impact of DHA on allergies unclear
We set out to assess a new extensively hydrolyzed whey-protein formula, which includes docosahexaenoic acid (DHA), for infants with cow's milk allergy (CMA). This study involved 34 children, primarily with IgE-mediated reactions, participating in a double-blind, placebo-controlled food challenge. Remarkably, all the children tolerated the new formula during the trial. This is significant since the American Academy of Pediatrics states that successful tolerance in over 90% of CMA children is crucial for a product to be considered hypoallergenic.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Read More
9
DHA and ARA enhance immune tolerance
Feeding Docosahexaenoic Acid and Arachidonic Acid during Suckling and Weaning Contributes to Oral Tolerance Development by Beneficially Modulating the Intestinal Cytokine and Immunoglobulin Levels in an Allergy-Prone Brown Norway Rat Model.
Significant findings on allergy prevention
We explored how adding docosahexaenoic acid (DHA) and arachidonic acid (ARA) in the diets of allergy-prone Brown Norway rats affects allergy responses. Our study involved feeding these essential fatty acids to both mother rats and their pups during the crucial suckling and weaning periods.
By comparing groups that received these supplements to those that did not, we aimed to understand how these dietary changes might influence immune development and oral tolerance—the body’s ability to accept food without triggering an allergy.
At the end of our study, we found that the ARA + DHA supplementation during early life boosted DHA levels in the intestinal fats and increased important immunological markers such as secretory IgA and specific cytokines. This suggests that DHA and ARA may help create an environment in the gut that supports healthy immune responses and reduces allergy risk.
Overall, our findings highlight the potential benefits of these fatty acids for nurturing a more tolerant immune system in the early stages of life.
By comparing groups that received these supplements to those that did not, we aimed to understand how these dietary changes might influence immune development and oral tolerance—the body’s ability to accept food without triggering an allergy.
At the end of our study, we found that the ARA + DHA supplementation during early life boosted DHA levels in the intestinal fats and increased important immunological markers such as secretory IgA and specific cytokines. This suggests that DHA and ARA may help create an environment in the gut that supports healthy immune responses and reduces allergy risk.
Overall, our findings highlight the potential benefits of these fatty acids for nurturing a more tolerant immune system in the early stages of life.
Read More
9
DHA enhances allergy response mediators
Sex-dependent differential increase of specialized pro-resolving mediators in extracellular vesicles secreted by human primary conjunctival goblet cells during allergic inflammation.
Direct effect on allergic inflammation
We investigated how docosahexaenoic acid (DHA) influences allergic responses in conjunctival goblet cells, the cells that help maintain eye surface health. By stimulating human primary conjunctival goblet cells with histamine, we measured various lipid mediators in the extracellular vesicles they secreted.
Our findings revealed that in the presence of DHA during allergic inflammation, we observed a significant increase in two specialized pro-resolving mediators, LXA4 and RvD1. This increase was especially pronounced in female cells, showing respective fold increases of 5.3 and 6.9, while male responses remained markedly lower with only 0.5 and 0.8.
These results suggest that DHA not only enhances the production of beneficial mediators but also highlights a notable difference between male and female responses to allergic reactions. This novel insight could improve our understanding of allergy treatment, especially regarding why males may experience more severe allergic conjunctivitis.
Our findings revealed that in the presence of DHA during allergic inflammation, we observed a significant increase in two specialized pro-resolving mediators, LXA4 and RvD1. This increase was especially pronounced in female cells, showing respective fold increases of 5.3 and 6.9, while male responses remained markedly lower with only 0.5 and 0.8.
These results suggest that DHA not only enhances the production of beneficial mediators but also highlights a notable difference between male and female responses to allergic reactions. This novel insight could improve our understanding of allergy treatment, especially regarding why males may experience more severe allergic conjunctivitis.
Read More
9
Docosahexaenoic acid's anti-inflammatory effects
Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation.
High relevance to allergy treatment
We examined how docosahexaenoic acid, particularly its metabolite resolvin D2, influences allergic reactions and inflammation. Our focus was on type 2 inflammatory responses, often seen in allergic conditions. Through rigorous methodologies, including control groups, the study assessed how resolvin D2 can help in regulating these responses and promote the resolution of allergy-related inflammation in mice.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.8
9.5
Allergy improvement
Super Omega! This was recommended by my nutritionist. It’s well-tolerated, with no side effects. After a few days, my allergy symptoms vanished, and my dermatitis cleared up. My sleep improved and my joints are more flexible without the discomfort I previously experienced. The results were excellent and exceeded my expectations!
Read More
9.5
Allergy relief
This fish oil works wonders for me and my husband; we no longer suffer from allergies and our focus has improved.
9.5
No allergies
Excellent Omega 3. It did not upset my stomach, improved my hair and nails, and did not cause any allergies.
9.5
Reduced allergies
This supplement made a difference for my son, who is allergic. His immunity improved and his allergies decreased significantly. I highly recommend it for lowering cholesterol, reducing inflammation, and enhancing heart function.
8.8
No more allergies
This Omega-3 has a great composition! I took it to recover from Covid, and it helped with my allergies. After six months, I feel much better, although I'm still regaining my sense of smell. I experienced no allergies or other side effects. I appreciate IHerb for this supplement.
