Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.
Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
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9
We examined how docosahexaenoic acid, particularly its metabolite resolvin D2, influences allergic reactions and inflammation. Our focus was on type 2 inflammatory responses, often seen in allergic conditions. Through rigorous methodologies, including control groups, the study assessed how resolvin D2 can help in regulating these responses and promote the resolution of allergy-related inflammation in mice.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
Our findings revealed that resolvin D2 plays a significant role in effectively managing allergic inflammation. It helps to mitigate the intense reactions typically associated with allergies, providing a clearer path toward alleviating symptoms.
This research demonstrates the potential of docosahexaenoic acid in offering therapeutic benefits for those suffering from type 2 inflammation due to allergies, and suggests that targeted treatments could improve overall allergen management.
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9
We explored the impact of dietary eicosapentaenoic acid (EPA) in children suffering from atopic dermatitis, a common allergic skin condition. In a well-structured study, forty-eight children were divided into two groups: one received 250 mg of EPA twice daily, while the other was given a placebo for four weeks.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
The study aimed to measure the effectiveness of EPA by examining improvements in the SCORing Atopic Dermatitis (SCORAD) index and the need for topical corticosteroids. What we found was quite promising—after just two weeks, the EPA group showed significant improvement in their SCORAD scores compared to the placebo group.
Additionally, by the end of four weeks, fewer children in the EPA group required corticosteroids, indicating a potential reduction in the severity of their condition. Overall, the results suggest that EPA supplementation is both effective and well-tolerated among young patients with atopic dermatitis, offering a supportive strategy for managing this allergy-related issue.
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Most Useful Reviews
9
Allergy improvement
2 people found this helpful
Super Omega! This was recommended by my nutritionist. It’s well-tolerated, with no side effects. After a few days, my allergy symptoms vanished, and my dermatitis cleared up. My sleep improved and my joints are more flexible without the discomfort I previously experienced. The results were excellent and exceeded my expectations!
Read More
9
Allergy relief
This fish oil works wonders for me and my husband; we no longer suffer from allergies and our focus has improved.
Read More
9
Reduced allergies
This supplement made a difference for my son, who is allergic. His immunity improved and his allergies decreased significantly. I highly recommend it for lowering cholesterol, reducing inflammation, and enhancing heart function.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.1
- All Researches
9.5
Docosahexaenoic acid helps asthma
We explored the potential of lipid mediators derived from docosahexaenoic acid (DHA) for alleviating allergic asthma. Using a model where mice were challenged with ovalbumin (OVA) to induce asthma-like symptoms, we administered lipid mediators that included 17S-monohydroxy DHA, resolvin D5, and protectin DX. These treatments led to significant improvements in key aspects of asthma such as reduced inflammatory cell infiltration and lower levels of Th2 cytokines.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
Following treatment with the lipid mediators, we observed decreased levels of interleukin-6, tumor necrosis factor-α, and IgE—important markers associated with allergic reactions. There was a notable reduction in inflammation and oxidative stress in lung tissues, which suggests a protective effect on the lungs. Additionally, histological examinations revealed fewer signs of inflammation and mucus secretion.
The results indicate that DHA-derived lipid mediators may effectively mitigate the symptoms of allergic asthma and offer a promising new approach for treatment. They seem to act by reducing inflammation and improving antioxidant defenses within the lungs.
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9.5
We set out to assess a new extensively hydrolyzed whey-protein formula, which includes docosahexaenoic acid (DHA), for infants with cow's milk allergy (CMA). This study involved 34 children, primarily with IgE-mediated reactions, participating in a double-blind, placebo-controlled food challenge. Remarkably, all the children tolerated the new formula during the trial. This is significant since the American Academy of Pediatrics states that successful tolerance in over 90% of CMA children is crucial for a product to be considered hypoallergenic.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
Although our focus was on the overall efficacy and safety of this formula, it's important to note that while DHA was included, we stopped short of isolating its specific impact on allergy outcomes. Thus, while we noted that this new formula is well-tolerated and associated with healthy growth and gastrointestinal tolerability, we cannot definitively state the effect of DHA alone on allergies. We recognize that further research would be needed to explore DHA's specific role in allergy management.
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9
ARA and DHA enhance allergy tolerance
Our study focused on the effects of dietary supplementation with arachidonic acid (ARA) and docosahexaenoic acid (DHA) during suckling and weaning phases in allergy-prone Brown Norway rats. We aimed to understand how this supplementation might influence the development of oral tolerance to allergens.
By dividing the mother rats into two groups, one receiving a standard diet and the other supplemented with ARA and DHA, we tracked the outcomes in their offspring. Following weaning, the pups continued on either diet before being exposed to an allergen. We assessed intestinal health and immune responses by examining key indicators like secretory immunoglobulin A (sIgA) and various cytokines that can help build an allergy-tolerant environment.
The results were promising. We observed that the ARA and DHA supplementation effectively increased DHA levels in the intestines, particularly in phospholipids during weaning. Additionally, the levels of protective molecules like sIgA, IL-2, and TGF-β were enhanced, suggesting that this dietary intervention plays a beneficial role in fostering a tolerogenic intestinal atmosphere.
Overall, our findings indicate that early dietary ARA and DHA supplementation may help reduce allergy development by promoting a healthier immune system during critical developmental periods.
By dividing the mother rats into two groups, one receiving a standard diet and the other supplemented with ARA and DHA, we tracked the outcomes in their offspring. Following weaning, the pups continued on either diet before being exposed to an allergen. We assessed intestinal health and immune responses by examining key indicators like secretory immunoglobulin A (sIgA) and various cytokines that can help build an allergy-tolerant environment.
The results were promising. We observed that the ARA and DHA supplementation effectively increased DHA levels in the intestines, particularly in phospholipids during weaning. Additionally, the levels of protective molecules like sIgA, IL-2, and TGF-β were enhanced, suggesting that this dietary intervention plays a beneficial role in fostering a tolerogenic intestinal atmosphere.
Overall, our findings indicate that early dietary ARA and DHA supplementation may help reduce allergy development by promoting a healthier immune system during critical developmental periods.
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9
We explored the effects of omega-3 fatty acids, specifically in the context of treating atopic dermatitis (AD) in children. This involved a well-structured clinical trial featuring 52 children, divided into two groups: one receiving a blend of omega-3 and omega-6 fatty acids and the other receiving a placebo.
Over a course of four months, we observed significant improvements in children taking the active product. Those in the treatment group experienced a marked decrease in AD severity and reduced reliance on topical corticosteroids. Improvements were also noted in terms of itch intensity, sleep quality, and overall family quality of life.
Although the study utilized a combination of omega-3 fatty acids, gamma-linolenic acid, and vitamin D, the findings suggest that this specific blend may offer a safe and effective way to alleviate symptoms of atopic dermatitis in pediatric patients. Therefore, omega-3 fatty acids like DHA may play a beneficial role in managing allergies, particularly in children suffering from AD.
Over a course of four months, we observed significant improvements in children taking the active product. Those in the treatment group experienced a marked decrease in AD severity and reduced reliance on topical corticosteroids. Improvements were also noted in terms of itch intensity, sleep quality, and overall family quality of life.
Although the study utilized a combination of omega-3 fatty acids, gamma-linolenic acid, and vitamin D, the findings suggest that this specific blend may offer a safe and effective way to alleviate symptoms of atopic dermatitis in pediatric patients. Therefore, omega-3 fatty acids like DHA may play a beneficial role in managing allergies, particularly in children suffering from AD.
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9
We explored how a specific formula, known as mixture X, affects infants with allergic symptoms, particularly those showing signs of atopic dermatitis. This formula contains vital ingredients like 2'-fucosyllactose (2'-FL), Bifidobacterium lactis, DHA, ARA, and nucleotides.
Our findings suggest that this mixture not only provides essential nutrients for infants but also helps in mitigating the symptoms of atopic dermatitis. We observed a significant reduction in skin signs of allergies, with scores dropping from 32.8 to 16.1, signaling improvement.
Furthermore, we noted enhancements in overall health metrics, such as increased weight, height, and blood cell counts. This outcome suggests that DHA, along with other components, may play a beneficial role in managing allergies in newborns.
However, it's essential to recognize that while the results are promising, the combined effect of all ingredients makes it challenging to isolate DHA's specific impact on allergies. Thus, more focused research could provide clearer insights into DHA's role.
Our findings suggest that this mixture not only provides essential nutrients for infants but also helps in mitigating the symptoms of atopic dermatitis. We observed a significant reduction in skin signs of allergies, with scores dropping from 32.8 to 16.1, signaling improvement.
Furthermore, we noted enhancements in overall health metrics, such as increased weight, height, and blood cell counts. This outcome suggests that DHA, along with other components, may play a beneficial role in managing allergies in newborns.
However, it's essential to recognize that while the results are promising, the combined effect of all ingredients makes it challenging to isolate DHA's specific impact on allergies. Thus, more focused research could provide clearer insights into DHA's role.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Allergy improvement
2 people found this helpful
Super Omega! This was recommended by my nutritionist. It’s well-tolerated, with no side effects. After a few days, my allergy symptoms vanished, and my dermatitis cleared up. My sleep improved and my joints are more flexible without the discomfort I previously experienced. The results were excellent and exceeded my expectations!
Read More
9
Allergy relief
This fish oil works wonders for me and my husband; we no longer suffer from allergies and our focus has improved.
Read More
9
Reduced allergies
This supplement made a difference for my son, who is allergic. His immunity improved and his allergies decreased significantly. I highly recommend it for lowering cholesterol, reducing inflammation, and enhancing heart function.
Read More
9
No allergies
Excellent Omega 3. It did not upset my stomach, improved my hair and nails, and did not cause any allergies.
Read More
7.5
No more allergies
This Omega-3 has a great composition! I took it to recover from Covid, and it helped with my allergies. After six months, I feel much better, although I'm still regaining my sense of smell. I experienced no allergies or other side effects. I appreciate IHerb for this supplement.
Read More
Frequently Asked Questions
9
Allergy improvement
2 people found this helpful
Super Omega! This was recommended by my nutritionist. It’s well-tolerated, with no side effects. After a few days, my allergy symptoms vanished, and my dermatitis cleared up. My sleep improved and my joints are more flexible without the discomfort I previously experienced. The results were excellent and exceeded my expectations!
9
Reduced allergies
This supplement made a difference for my son, who is allergic. His immunity improved and his allergies decreased significantly. I highly recommend it for lowering cholesterol, reducing inflammation, and enhancing heart function.
7.5
No more allergies
This Omega-3 has a great composition! I took it to recover from Covid, and it helped with my allergies. After six months, I feel much better, although I'm still regaining my sense of smell. I experienced no allergies or other side effects. I appreciate IHerb for this supplement.
9
Allergy relief
This fish oil works wonders for me and my husband; we no longer suffer from allergies and our focus has improved.
8
We sought to understand how docosahexaenoic acid (DHA) might influence allergies, particularly in the context of atopic dermatitis (AD). Our research used a method called Mendelian randomization to investigate the potential causal relationship between DHA and AD, using publicly available data from Genome-Wide Association Studies (GWAS).
Through our analysis, we observed a significant negative correlation between DHA levels and the risk of developing AD. Specifically, the odds ratio was 0.915, indicating that higher DHA levels may lower the likelihood of onset. We also looked at the role of TNFSF14, a protein associated with inflammation, and found it could mediate the effects of DHA on AD risk.
While our findings suggest that DHA might play a valuable role in reducing the chances of developing atopic dermatitis, it's important to acknowledge that further research is needed to fully understand the mechanisms at play. Overall, these insights can pave the way for more focused studies on DHA as a possible treatment for allergy-related conditions.
Through our analysis, we observed a significant negative correlation between DHA levels and the risk of developing AD. Specifically, the odds ratio was 0.915, indicating that higher DHA levels may lower the likelihood of onset. We also looked at the role of TNFSF14, a protein associated with inflammation, and found it could mediate the effects of DHA on AD risk.
While our findings suggest that DHA might play a valuable role in reducing the chances of developing atopic dermatitis, it's important to acknowledge that further research is needed to fully understand the mechanisms at play. Overall, these insights can pave the way for more focused studies on DHA as a possible treatment for allergy-related conditions.
8
We investigated how docosahexaenoic acid (DHA), along with arachidonic acid (AA), might affect the development of oral tolerance to allergens in young allergy-prone mice. During the study, breastfeeding mothers were divided into two groups: one received a diet enriched with DHA and AA, while the other had a control diet with no DHA or AA.
After three weeks of breastfeeding, the pups transitioned to weaning diets that matched their mother's dietary group. To test oral tolerance, pups were given ovalbumin, a common egg protein, while their immune responses were carefully measured. We observed that the young mice whose mothers consumed DHA and AA showed significant differences in their immune response compared to the control group.
Notably, those who were fed the DHA and AA diet had lower levels of certain antibodies like IgE and produced fewer inflammatory cytokines in response to ovalbumin. This suggests that early supplementation with these fatty acids may support a more robust immune response and aid in developing tolerance to food allergens. We found that this approach promotes T helper type-1 immune responses, which are beneficial for allergy prevention. However, the effects of DHA alone were challenging to isolate since AA was also included in the study.
After three weeks of breastfeeding, the pups transitioned to weaning diets that matched their mother's dietary group. To test oral tolerance, pups were given ovalbumin, a common egg protein, while their immune responses were carefully measured. We observed that the young mice whose mothers consumed DHA and AA showed significant differences in their immune response compared to the control group.
Notably, those who were fed the DHA and AA diet had lower levels of certain antibodies like IgE and produced fewer inflammatory cytokines in response to ovalbumin. This suggests that early supplementation with these fatty acids may support a more robust immune response and aid in developing tolerance to food allergens. We found that this approach promotes T helper type-1 immune responses, which are beneficial for allergy prevention. However, the effects of DHA alone were challenging to isolate since AA was also included in the study.
7
We investigated the effects of docosahexaenoic acid (DHA) on allergic inflammation in human primary conjunctival goblet cells (CjGCs). Through a carefully designed experiment using histamine to trigger allergic reactions in these cells, we measured pro-inflammatory and specialized pro-resolving mediators secreted in extracellular vesicles (EVs).
Our findings revealed a significant increase in specialized pro-resolving mediators LXA4 and RvD1 in the EVs of female cells after 18 hours of histamine stimulation, while the male cells did not show this increase. Specifically, the female-derived EVs exhibited a remarkable mean fold increase of 3.9 for LXA4 and 3.4 for RvD1. When we added DHA to the culture medium during this allergic response, the results were even more pronounced, with mean fold increases of 5.3 and 6.9 for LXA4 and RvD1, respectively, in females. However, DHA seemed to have minimal effects on the male cells.
This study highlights important sex differences in allergic responses, showcasing how DHA may enhance the resolution of inflammation specifically in females. These insights could contribute to better understanding and treatment options for allergic conjunctivitis, particularly in addressing the male predisposition to severe forms of the condition.
Our findings revealed a significant increase in specialized pro-resolving mediators LXA4 and RvD1 in the EVs of female cells after 18 hours of histamine stimulation, while the male cells did not show this increase. Specifically, the female-derived EVs exhibited a remarkable mean fold increase of 3.9 for LXA4 and 3.4 for RvD1. When we added DHA to the culture medium during this allergic response, the results were even more pronounced, with mean fold increases of 5.3 and 6.9 for LXA4 and RvD1, respectively, in females. However, DHA seemed to have minimal effects on the male cells.
This study highlights important sex differences in allergic responses, showcasing how DHA may enhance the resolution of inflammation specifically in females. These insights could contribute to better understanding and treatment options for allergic conjunctivitis, particularly in addressing the male predisposition to severe forms of the condition.
References
- Wang R, Patel D, Goruk S, Richard C, Field CJ. Feeding Docosahexaenoic Acid and Arachidonic Acid during Suckling and Weaning Contributes to Oral Tolerance Development by Beneficially Modulating the Intestinal Cytokine and Immunoglobulin Levels in an Allergy-Prone Brown Norway Rat Model. J Nutr. 2024;154:3790. doi:10.1016/j.tjnut.2024.10.021
- Lee C, Dartt DA. Sex-dependent differential increase of specialized pro-resolving mediators in extracellular vesicles secreted by human primary conjunctival goblet cells during allergic inflammation. Life Sci. 2024;357:123058. doi:10.1016/j.lfs.2024.123058
- Niseteo T, Hojsak I, Ožanić Bulić S, Pustišek N. Effect of Omega-3 Polyunsaturated Fatty Acid Supplementation on Clinical Outcome of Atopic Dermatitis in Children. Nutrients. 2024;16. doi:10.3390/nu16172829
- Ramirez-Farias C, Oliver JS, Schlezinger J, Stutts JT. Tolerance of Infants Fed a Hydrolyzed Rice Infant Formula with 2'-Fucosyllactose (2'-FL) Human Milk Oligosaccharide (HMO). Nutrients. 2024;16. doi:10.3390/nu16121863
- Segarra S, Bošnjak I, Mioč I, Čurčija B, Csik VA, et al. Yeast-Derived Nucleotides Enhance Fibroblast Migration and Proliferation and Provide Clinical Benefits in Atopic Dermatitis. Int J Mol Sci. 2024;25. doi:10.3390/ijms25052890
- Huang XW, Pang SW, Yang LZ, Han T, Chen JM, et al. TNFSF14 mediates the impact of docosahexaenoic acid on atopic dermatitis: a Mendelian randomization study. Eur Rev Med Pharmacol Sci. 2024;28:107. doi:10.26355/eurrev_202401_34896
- Patel D, Munhoz J, Goruk S, Richard C, Field CJ. The Programming Effect of Plant-Based DHA, Along with Equivalent AA, on Immune System and Oral Tolerance Development in Six-Week Allergy Prone BALB/c Pups. J Nutr. 2023;153:2482. doi:10.1016/j.tjnut.2023.06.002
- Bezruk VV, Godovanets OS, Buriak OH, Voytkevich NI, Makarova OV, et al. The use of hydrolyzed formulas as a method of correction of feeding and clinical rehabilitation of infants with atopy signs. J Med Life. 2022;15:1536. doi:10.25122/jml-2022-0254
- Figueroa-Garduño I, Escamilla-Núñez C, Barraza-Villarreal A, Hernández-Cadena L, Onofre-Pardo EN, et al. Docosahexaenoic Acid Effect on Prenatal Exposure to Arsenic and Atopic Dermatitis in Mexican Preschoolers. Biol Trace Elem Res. 2023;201:3152. doi:10.1007/s12011-022-03411-3
- Patel D, Goruk S, Richard C, Field CJ. Combined Supplementation with Arachidonic and Docosahexaenoic Acids in T Helper Type-2 Skewed Brown Norway Rat Offspring is Beneficial in the Induction of Oral Tolerance toward Ovalbumin and Immune System Development. J Nutr. 2022;152:2165. doi:10.1093/jn/nxac118
- Yu CX, Shi ZA, Ou GC, Chen XJ, Liu Q, et al. Maresin-2 alleviates allergic airway inflammation in mice by inhibiting the activation of NLRP3 inflammasome, Th2 type immune response and oxidative stress. Mol Immunol. 2022;146:78. doi:10.1016/j.molimm.2022.03.118
- Decsi T, Marosvölgyi T, Muszil E, Bódy B, Szabó É. Long-Chain Polyunsaturated Fatty Acid Status at Birth and Development of Childhood Allergy: A Systematic Review. Life (Basel). 2022;12. doi:10.3390/life12040526
- Su Y, Choi HS, Kwon SK, Han Y, Cho SC, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase alleviate ovalbumin‑induced allergic asthma in mice by reducing airway inflammation and oxidative stress. Mol Med Rep. 2025;31. doi:10.3892/mmr.2025.13451
- Sato A, Sato G, Yabuki A, Ogawa Y, Nemoto H, et al. Ameliorative effects of squid phospholipids from Todarodes pacificus on atopic dermatitis-like lesions in NC/Nga mice. Arch Dermatol Res. 2025;317:239. doi:10.1007/s00403-024-03773-9
- Peh HY, Brüggemann TR, Duvall MG, Nshimiyimana R, Nijmeh J, et al. Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation. Allergy. 2024;79:739. doi:10.1111/all.15920
- Patel D, Munhoz J, Goruk S, Tsai S, Richard C, et al. Correction: Maternal diet supplementation with high-docosahexaenoic-acid canola oil, along with arachidonic acid, promotes immune system development in allergy-prone BALB/c mouse ofspring at 3 weeks of age. Eur J Nutr. 2024;63:341. doi:10.1007/s00394-023-03264-z
- Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. doi:10.1111/pai.14004
- Dahdah L, Roelofs M, Knipping K, de Vries E, Rijnierse A, et al. Hypoallergenicity assessment of an extensively hydrolyzed whey-protein formula in cow's milk allergic infants. Pediatr Allergy Immunol. 2022;33:e13814. doi:10.1111/pai.13814
- Li SY, Zheng PY, Zhai YY, Zhang YD, Gan H, et al. [Analysis of the effect of early subcutaneous specific immunotherapy on the levels of dust mite allergen-specific antibodies and polyunsaturated fatty acid metabolism]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:778. doi:10.3760/cma.j.cn112150-20240124-00083
- Mirrahimi B, Moazemi M, Eslami N, Jamshidi E, Mir M, et al. Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial. J Pediatr Pharmacol Ther. 2023;28:29. doi:10.5863/1551-6776-28.1.29
- Imai T, Takada Y, Watanabe K. Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes. J Clin Med Res. 2022;14:466. doi:10.14740/jocmr4825
- Saika A, Nagatake T, Hirata SI, Sawane K, Adachi J, et al. ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α. FASEB J. 2021;35:e21354. doi:10.1096/fj.202001687R
- Kanda N, Hoashi T, Saeki H. Nutrition and Atopic Dermatitis. J Nippon Med Sch. 2021;88:171. doi:10.1272/jnms.JNMS.2021_88-317
- Miles EA, Childs CE, Calder PC. Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review. Nutrients. 2021;13. doi:10.3390/nu13010247
- Barman M, Rabe H, Hesselmar B, Johansen S, Sandberg AS, et al. Cord Blood Levels of EPA, a Marker of Fish Intake, Correlate with Infants' T- and B-Lymphocyte Phenotypes and Risk for Allergic Disease. Nutrients. 2020;12. doi:10.3390/nu12103000
- Hoppenbrouwers T, Fogliano V, Garssen J, Pellegrini N, Willemsen LEM, et al. Specific Polyunsaturated Fatty Acids Can Modulate Human moDC2s and Subsequent Th2 Cytokine Release. Front Immunol. 2020;11:748. doi:10.3389/fimmu.2020.00748
- Saika A, Nagatake T, Kishino S, Park SB, Honda T, et al. 17(),18()-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression. FASEB Bioadv. 2020;2:59. doi:10.1096/fba.2019-00061
