Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.4
USERS' SCORE
Good
Based on 15 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
We explored the effects of DHA and EPA supplementation on children with autism spectrum disorder (ASD) through a randomized, double-blind, placebo-controlled trial. Involving 54 children aged 2 to 6, we tracked changes in their omega-3 fatty acid profiles and plasma cytokines over 6 months.
Despite hopes for positive outcomes, our findings revealed no significant clinical improvements or anti-inflammatory benefits from the supplementation. This suggests that such dietary interventions may not be warranted unless specific omega-3 deficiencies are confirmed.
Despite hopes for positive outcomes, our findings revealed no significant clinical improvements or anti-inflammatory benefits from the supplementation. This suggests that such dietary interventions may not be warranted unless specific omega-3 deficiencies are confirmed.
Read More
9
We investigated how docosahexaenoic acid (DHA) could help with autism by testing it on juvenile mice designed to model fragile X syndrome. Through our study, we found that DHA significantly improves the behavior and synaptic function by helping synaptic proteins move to the right places in the brain. Notably, DHA works independently of typical signaling pathways, creating stable synaptic components and correcting imbalances that are often seen in neurodevelopmental disorders. These results suggest that DHA may provide a new avenue for therapeutic strategies in autism spectrum disorders.
Read More
8
We examined the effects of vitamin D and DHA, a type of omega-3 fatty acid, on irritability and hyperactivity in children with Autism Spectrum Disorder (ASD). Over a year, children aged 2.5 to 8 years participated in a careful trial where some received these supplements while others got a placebo.
Our findings revealed that both DHA and vitamin D significantly reduced irritability. Additionally, vitamin D was shown to decrease hyperactivity as well. These results are encouraging for families seeking non-pharmacological options to manage challenging behaviors in their children with ASD.
Our findings revealed that both DHA and vitamin D significantly reduced irritability. Additionally, vitamin D was shown to decrease hyperactivity as well. These results are encouraging for families seeking non-pharmacological options to manage challenging behaviors in their children with ASD.
Read More
Most Useful Reviews
9
Cognitive progress noted
5 people found this helpful
I purchased the DHA-500 for my 5-year-old son on the autism spectrum, and he has been taking it for over a month. He swallows the capsule with a spoonful of lemon water easily. In this past month, I've noticed significant progress in his cognitive development and motor skills. There’s no fishy aftertaste; I take it with lemon water too. I've already bought a second bottle!
Read More
10
Visible results seen
The quality is super; my 15-year-old son with autism drinks it daily and the results are visible. We’ve all started taking this omega and I recommend it to everyone. 👍
Read More
9
Natural quality ingredients
It is an excellent product that I highly recommend. I give it to my 7-year-old child with autism, and it works remarkably well. I appreciate the natural composition of the ingredients, which are of very good quality and harmless to our families.
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Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.4
- All Researches
9
We investigated how docosahexaenoic acid (DHA) could help with autism by testing it on juvenile mice designed to model fragile X syndrome. Through our study, we found that DHA significantly improves the behavior and synaptic function by helping synaptic proteins move to the right places in the brain. Notably, DHA works independently of typical signaling pathways, creating stable synaptic components and correcting imbalances that are often seen in neurodevelopmental disorders. These results suggest that DHA may provide a new avenue for therapeutic strategies in autism spectrum disorders.
Read More
8
We examined the effects of vitamin D and DHA, a type of omega-3 fatty acid, on irritability and hyperactivity in children with Autism Spectrum Disorder (ASD). Over a year, children aged 2.5 to 8 years participated in a careful trial where some received these supplements while others got a placebo.
Our findings revealed that both DHA and vitamin D significantly reduced irritability. Additionally, vitamin D was shown to decrease hyperactivity as well. These results are encouraging for families seeking non-pharmacological options to manage challenging behaviors in their children with ASD.
Our findings revealed that both DHA and vitamin D significantly reduced irritability. Additionally, vitamin D was shown to decrease hyperactivity as well. These results are encouraging for families seeking non-pharmacological options to manage challenging behaviors in their children with ASD.
Read More
8
Case study highlights beneficial supplementation
We examined a case involving a 23-year-old man with autism who experienced significant behavioral challenges. After identifying an imbalance in fatty acids and a vitamin D deficiency, he began a 24-month regimen of omega-3 and vitamin D co-supplementation. Remarkably, his core autism symptoms showed notable improvements throughout the treatment period.
Although this case presents promising results, a broader scope of research is necessary to confirm the effectiveness of this approach for all individuals with autism.
Although this case presents promising results, a broader scope of research is necessary to confirm the effectiveness of this approach for all individuals with autism.
Read More
7
We explored the impact of omega-3 fatty acids, particularly DHA, on cognitive skills in children with autism. Using a systematic review of 11 studies, we found that supplementation might help improve memory, attention, and executive functioning.
However, the results were inconsistent due to variations in study design, dosage, and methods. This means that while there is potential, we didn't reach definitive conclusions. More research is needed to better understand the effects and optimize treatment approaches.
However, the results were inconsistent due to variations in study design, dosage, and methods. This means that while there is potential, we didn't reach definitive conclusions. More research is needed to better understand the effects and optimize treatment approaches.
Read More
7
Omega-3-6-9 may aid preterm toddlers
This study aimed to see how omega-3-6-9 supplementation affects behavior and sleep in toddlers born very preterm who showed signs of autism.
Over 90 days, 31 children participated in a double-blind, placebo-controlled trial, where some received omega-3-6-9 and others a canola oil placebo.
Although there were promising signs, findings suggest a need for larger trials to confirm these results and better understand the potential benefits for socioemotional development in these toddlers.
Over 90 days, 31 children participated in a double-blind, placebo-controlled trial, where some received omega-3-6-9 and others a canola oil placebo.
Although there were promising signs, findings suggest a need for larger trials to confirm these results and better understand the potential benefits for socioemotional development in these toddlers.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cognitive progress noted
5 people found this helpful
I purchased the DHA-500 for my 5-year-old son on the autism spectrum, and he has been taking it for over a month. He swallows the capsule with a spoonful of lemon water easily. In this past month, I've noticed significant progress in his cognitive development and motor skills. There’s no fishy aftertaste; I take it with lemon water too. I've already bought a second bottle!
Read More
10
Visible results seen
The quality is super; my 15-year-old son with autism drinks it daily and the results are visible. We’ve all started taking this omega and I recommend it to everyone. 👍
Read More
9
Natural quality ingredients
It is an excellent product that I highly recommend. I give it to my 7-year-old child with autism, and it works remarkably well. I appreciate the natural composition of the ingredients, which are of very good quality and harmless to our families.
Read More
9
Enhanced attentiveness
Excellent high-quality product; it has been very useful for my child with autism, making him more attentive and focused.
Read More
9
Helpful for concentration
It's very good. I have been using it for years with my son with autism, and it helps him a great deal in concentrating and understanding things. I'll purchase more as I save on shipping costs with larger orders.
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Frequently Asked Questions
9
Cognitive progress noted
5 people found this helpful
I purchased the DHA-500 for my 5-year-old son on the autism spectrum, and he has been taking it for over a month. He swallows the capsule with a spoonful of lemon water easily. In this past month, I've noticed significant progress in his cognitive development and motor skills. There’s no fishy aftertaste; I take it with lemon water too. I've already bought a second bottle!
10
Visible results seen
The quality is super; my 15-year-old son with autism drinks it daily and the results are visible. We’ve all started taking this omega and I recommend it to everyone. 👍
9
Developmental improvements
We have taken this fish oil for 1.5 years. The omega-3 components support proper white blood cell function, control inflammation, and foster stem cell production. The DHA component is especially beneficial for children, particularly those with developmental delays. My child has progressed remarkably, nearly catching up with peers! Despite the large capsules, they’re still manageable for my 4-year-old.
9
Language development aid
Excellent product! It’s a great purchase. It helps my daughter with autism develop more language skills, and she is more focused in school. It’s easy to digest by pricking the pill. I appreciate that it lasts long and aligns well with the protocol.
9
Enhanced attentiveness
Excellent high-quality product; it has been very useful for my child with autism, making him more attentive and focused.
7.5
DHA supports development
1 people found this helpful
We use the DHA as part of the Nemecheck Protocol for our sons with autism. The quality and ingredients are excellent, and the packaging is safe, even for shipping to the Philippines. Most parents of children with autism, including myself, trust this brand to enhance our sons’ DHA intake and brain development. It is my preferred source of DHA.
9
Effective for autism
Good DHA; it's part of the autism protocol and truly effective.
7.5
More verbal communication
2 people found this helpful
It helps my son with autism; he is more verbal.
7.5
Effective for skills
This powerful omega 3 has been given to my son with autism, following the German protocol. We observed significant effects, but it's not solely due to the protocol. I also started giving it to my younger daughter, and the results have been remarkable, breaking through with numerous skills and phrases by age two.
9
We investigated how docosahexaenoic acid (DHA) could help with autism by testing it on juvenile mice designed to model fragile X syndrome. Through our study, we found that DHA significantly improves the behavior and synaptic function by helping synaptic proteins move to the right places in the brain. Notably, DHA works independently of typical signaling pathways, creating stable synaptic components and correcting imbalances that are often seen in neurodevelopmental disorders. These results suggest that DHA may provide a new avenue for therapeutic strategies in autism spectrum disorders.
7
We explored the impact of omega-3 fatty acids, particularly DHA, on cognitive skills in children with autism. Using a systematic review of 11 studies, we found that supplementation might help improve memory, attention, and executive functioning.
However, the results were inconsistent due to variations in study design, dosage, and methods. This means that while there is potential, we didn't reach definitive conclusions. More research is needed to better understand the effects and optimize treatment approaches.
However, the results were inconsistent due to variations in study design, dosage, and methods. This means that while there is potential, we didn't reach definitive conclusions. More research is needed to better understand the effects and optimize treatment approaches.
We explored the effects of DHA and EPA supplementation on children with autism spectrum disorder (ASD) through a randomized, double-blind, placebo-controlled trial. Involving 54 children aged 2 to 6, we tracked changes in their omega-3 fatty acid profiles and plasma cytokines over 6 months.
Despite hopes for positive outcomes, our findings revealed no significant clinical improvements or anti-inflammatory benefits from the supplementation. This suggests that such dietary interventions may not be warranted unless specific omega-3 deficiencies are confirmed.
Despite hopes for positive outcomes, our findings revealed no significant clinical improvements or anti-inflammatory benefits from the supplementation. This suggests that such dietary interventions may not be warranted unless specific omega-3 deficiencies are confirmed.
7
Omega-3s show promise for autism
We explored the effects of omega-3 fatty acids, particularly DHA, as a treatment for autism spectrum disorder (ASD). Recent studies point toward these essential nutrients potentially improving symptoms like lethargy and hyperactivity.
The review highlights that higher doses (1,300-1,500 mg/d) over 16-24 weeks can be beneficial. However, while there are positive reports, it's important to note that results can depend on individual factors like inflammation and the baseline omega-3 levels. Overall, the findings show promise but also suggest that response varies widely among youth with autism.
The review highlights that higher doses (1,300-1,500 mg/d) over 16-24 weeks can be beneficial. However, while there are positive reports, it's important to note that results can depend on individual factors like inflammation and the baseline omega-3 levels. Overall, the findings show promise but also suggest that response varies widely among youth with autism.
References
- Arsenault J, Kong T, Saghian R, Weng OY, Pathak SS, et al. Essential lipids enrich membrane-associated condensates to rescue synaptic morpho-functional deficits in a mouse model of autism. Cell Rep. 2025;44:115573. 10.1016/j.celrep.2025.115573
- Sumra B, Kocherry C, Shamim H, Jhakri K, Al-Shudifat M, et al. Impact of Omega-3 Fatty Acids on Cognitive Outcomes in Children With Autism Spectrum Disorder: A Systematic Review. Cureus. 2025;17:e80291. 10.7759/cureus.80291
- Boone KM, Klebanoff MA, Rogers LK, Rausch J, Coury DL, et al. Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial. Early Hum Dev. 2022;169:105588. 10.1016/j.earlhumdev.2022.105588
- de la Torre-Aguilar MJ, Gomez-Fernandez A, Flores-Rojas K, Martin-Borreguero P, Mesa MD, et al. Docosahexaenoic and Eicosapentaenoic Intervention Modifies Plasma and Erythrocyte Omega-3 Fatty Acid Profiles But Not the Clinical Course of Children With Autism Spectrum Disorder: A Randomized Control Trial. Front Nutr. 2022;9:790250. 10.3389/fnut.2022.790250
- Yui K, Imataka G, Sasaki H, Shiroki R, Koshiba M. Lipid Peroxidation With Implication of Organic Pollution in Autistic Behaviors. Cureus. 2021;13:e14188. 10.7759/cureus.14188
- Chang JP, Su KP. Nutritional Neuroscience as Mainstream of Psychiatry: The Evidence- Based Treatment Guidelines for Using Omega-3 Fatty Acids as a New Treatment for Psychiatric Disorders in Children and Adolescents. Clin Psychopharmacol Neurosci. 2020;18:469. 10.9758/cpn.2020.18.4.469
- Boone KM, Parrott A, Rausch J, Yeates KO, Klebanoff MA, et al. Fatty Acid Supplementation and Socioemotional Outcomes: Secondary Analysis of a Randomized Trial. Pediatrics. 2020;146. 10.1542/peds.2020-0284
- Martins BP, Bandarra NM, Figueiredo-Braga M. The role of marine omega-3 in human neurodevelopment, including Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder - a review. Crit Rev Food Sci Nutr. 2020;60:1431. 10.1080/10408398.2019.1573800
- Yang B, Li R, Woo T, Browning JD, Song H, et al. Maternal Dietary Docosahexaenoic Acid Alters Lipid Peroxidation Products and (n-3)/(n-6) Fatty Acid Balance in Offspring Mice. Metabolites. 2019;9. 10.3390/metabo9030040
- Mazahery H, Conlon CA, Beck KL, Mugridge O, Kruger MC, et al. A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder. J Steroid Biochem Mol Biol. 2019;187:9. 10.1016/j.jsbmb.2018.10.017
- Infante M, Sears B, Rizzo AM, Mariani Cerati D, Caprio M, et al. Omega-3 PUFAs and vitamin D co-supplementation as a safe-effective therapeutic approach for core symptoms of autism spectrum disorder: case report and literature review. Nutr Neurosci. 2020;23:779. 10.1080/1028415X.2018.1557385
- Adams JB, Audhya T, Geis E, Gehn E, Fimbres V, et al. Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial. Nutrients. 2018;10. 10.3390/nu10030369
- Keim SA, Gracious B, Boone KM, Klebanoff MA, Rogers LK, et al. ω-3 and ω-6 Fatty Acid Supplementation May Reduce Autism Symptoms Based on Parent Report in Preterm Toddlers. J Nutr. 2018;148:227. 10.1093/jn/nxx047
- Matsui F, Hecht P, Yoshimoto K, Watanabe Y, Morimoto M, et al. DHA Mitigates Autistic Behaviors Accompanied by Dopaminergic Change in a Gene/Prenatal Stress Mouse Model. Neuroscience. 2018;371:407. 10.1016/j.neuroscience.2017.12.029
- Boone KM, Gracious B, Klebanoff MA, Rogers LK, Rausch J, et al. Omega-3 and -6 fatty acid supplementation and sensory processing in toddlers with ASD symptomology born preterm: A randomized controlled trial. Early Hum Dev. 2017;115:64. 10.1016/j.earlhumdev.2017.09.015
- Mazahery H, Stonehouse W, Delshad M, Kruger MC, Conlon CA, et al. Relationship between Long Chain n-3 Polyunsaturated Fatty Acids and Autism Spectrum Disorder: Systematic Review and Meta-Analysis of Case-Control and Randomised Controlled Trials. Nutrients. 2017;9. 10.3390/nu9020155
