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SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid benefits hypertension
5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.
Clear focus on hypertension treatment
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
8
Eicosapentaenoic acid lowers blood pressure
Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats.
High relevance to hypertension treatment
We examined the impact of eicosapentaenoic acid (EPA) lactone on hypertension, particularly in a model where rats undergo a 5/6 nephrectomy. This condition is known to induce high blood pressure and related vascular dysfunction. Our research involved administering the EPA lactone to these hypertensive rats over five days while measuring their blood pressure, kidney function, and other relevant health metrics.
Through our study, we found that the EPA lactone significantly lowered blood pressure. It achieved this by promoting improved dilation of the blood vessels, which is essential for maintaining healthy circulation. Notably, the mechanism involved calcium-dependent potassium channels in the endothelium, contributing to better vessel relaxation and function.
Our findings suggest that the EPA lactone may hold promise as a dietary supplement for individuals dealing with hypertension, particularly those experiencing issues related to microvascular dysfunction. This study enhances our understanding of how this specific metabolite can play a role in managing high blood pressure effectively.
Through our study, we found that the EPA lactone significantly lowered blood pressure. It achieved this by promoting improved dilation of the blood vessels, which is essential for maintaining healthy circulation. Notably, the mechanism involved calcium-dependent potassium channels in the endothelium, contributing to better vessel relaxation and function.
Our findings suggest that the EPA lactone may hold promise as a dietary supplement for individuals dealing with hypertension, particularly those experiencing issues related to microvascular dysfunction. This study enhances our understanding of how this specific metabolite can play a role in managing high blood pressure effectively.
Read More
7
DHA and EPA relax blood vessels
Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels.
Significant findings on vasodilation
We investigated how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects blood vessel relaxation, particularly in relation to hypertension. The study involved examining mouse aorta and mesenteric arteries to see how they respond to DHA and another omega-3 fatty acid, eicosapentaenoic acid (EPA).
Our findings revealed that both DHA and EPA can cause vasodilation, which is the widening of blood vessels. This relaxation response was observed even when we blocked certain potassium channels, which are typically involved in regulating vascular tone. Interestingly, removing the endothelium, the inner lining of blood vessels, had some effect on how arteries reacted to DHA, but not to EPA.
We also looked at smooth muscle cells in the aorta and found that DHA did not activate potassium currents as expected. This led us to conclude that the relaxed state induced by DHA and EPA is not directly linked to the activity of potassium channels. In summary, while DHA and EPA help relax blood vessels, the mechanisms behind this effect do not appear to involve potassium channels, suggesting a different pathway may be at play in combating hypertension.
Our findings revealed that both DHA and EPA can cause vasodilation, which is the widening of blood vessels. This relaxation response was observed even when we blocked certain potassium channels, which are typically involved in regulating vascular tone. Interestingly, removing the endothelium, the inner lining of blood vessels, had some effect on how arteries reacted to DHA, but not to EPA.
We also looked at smooth muscle cells in the aorta and found that DHA did not activate potassium currents as expected. This led us to conclude that the relaxed state induced by DHA and EPA is not directly linked to the activity of potassium channels. In summary, while DHA and EPA help relax blood vessels, the mechanisms behind this effect do not appear to involve potassium channels, suggesting a different pathway may be at play in combating hypertension.
Read More
Most Useful Reviews
9.5
Healthy brain development
Necessary for pregnant women! From conception to 2 years, consuming DHA is vital for a child’s brain, nervous system, and eye development. The World Health Organization recommends at least 500 mg of DHA daily for pregnant and breastfeeding women. A study from the University of Kansas demonstrated that a daily intake of 600 mg of DHA during pregnancy aids heart development and may protect against hypertension with excess weight.
Read More
8.8
Recommended for hypertension
The best omega! This dosage is recommended for pregnant women and for treating hypertension by endocrinologists.
Read More
8.8
Improves cardiovascular health
Works wonderfully! Omega-3s are effective! Each capsule contains 750 mg of acids, which I prescribe to patients with cardiovascular issues, including hypertension and arrhythmias. However, it’s important to note that some individuals may have a specific intolerance to components of the drug.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.6
9
DHA associated with lower mortality
Association between dietary intake of omega-3 polyunsaturated fatty acids and all-cause and cardiovascular mortality among hypertensive adults: Results from NHANES 1999-2018.
Significant benefits seen overall
We investigated the effects of dietary docosahexaenoic acid (DHA) on hypertension and related mortality risks. Our study included nearly 27,000 hypertensive adults who participated in the National Health and Nutrition Examination Surveys between 1999 and 2018. Through this comprehensive approach, we sought to understand if higher DHA intake could lead to better health outcomes for individuals living with hypertension.
Findings from our analysis indicated that those with higher dietary intake of omega-3 polyunsaturated fatty acids, including DHA, generally had a lower risk of all-cause and cardiovascular mortality. Specifically, individuals consuming more ALA, EPA, and DPA alongside DHA showed notable benefits.
While we noted these positive associations with omega-3 fatty acids, it’s essential to recognize that DHA was part of a broader group of beneficial fats. This makes it difficult to isolate its specific impact purely on hypertension outcomes. Nonetheless, these results suggest that increasing dietary intake of omega-3s, including DHA, might be a helpful strategy for managing hypertension and its related risks.
Findings from our analysis indicated that those with higher dietary intake of omega-3 polyunsaturated fatty acids, including DHA, generally had a lower risk of all-cause and cardiovascular mortality. Specifically, individuals consuming more ALA, EPA, and DPA alongside DHA showed notable benefits.
While we noted these positive associations with omega-3 fatty acids, it’s essential to recognize that DHA was part of a broader group of beneficial fats. This makes it difficult to isolate its specific impact purely on hypertension outcomes. Nonetheless, these results suggest that increasing dietary intake of omega-3s, including DHA, might be a helpful strategy for managing hypertension and its related risks.
Read More
9
Exercise aids hypertension-related BBB issues
Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries.
Study focuses on exercise impact
We investigated how hypertension affects the blood-brain barrier (BBB) and whether exercise training could improve its function. Our study involved spontaneously hypertensive rats (SHR) and Wistar rats, which we divided into groups that either underwent treadmill training or remained sedentary for four weeks. We found that hypertension led to an increase in blood pressure and heart rate, as well as a decrease in the protective Mfsd2a protein, which plays a crucial role in maintaining BBB integrity.
Interestingly, when the hypertensive rats participated in exercise training, we noticed a restoration of Mfsd2a levels, a reduction in another protein called caveolin-1, and importantly, a normalization of BBB permeability in the paraventricular nucleus of the hypothalamus. This change was also accompanied by improvements in heart rate and blood pressure variability, indicating enhanced autonomic control.
However, we saw no significant changes in the Wistar group between training and sedentary states, suggesting that the exercise's effects were specific to the hypertensive condition. This highlights that while docosahexaenoic acid (DHA) transport through Mfsd2a is beneficial, the direct impact of DHA alone on hypertension wasn't the focus of our study.
Ultimately, we concluded that exercise training is an effective way to improve both the BBB function and autonomic regulation in hypertensive individuals. It emphasizes the potential therapeutic benefits of lifestyle interventions, like regular exercise, in managing hypertension-related complications.
Interestingly, when the hypertensive rats participated in exercise training, we noticed a restoration of Mfsd2a levels, a reduction in another protein called caveolin-1, and importantly, a normalization of BBB permeability in the paraventricular nucleus of the hypothalamus. This change was also accompanied by improvements in heart rate and blood pressure variability, indicating enhanced autonomic control.
However, we saw no significant changes in the Wistar group between training and sedentary states, suggesting that the exercise's effects were specific to the hypertensive condition. This highlights that while docosahexaenoic acid (DHA) transport through Mfsd2a is beneficial, the direct impact of DHA alone on hypertension wasn't the focus of our study.
Ultimately, we concluded that exercise training is an effective way to improve both the BBB function and autonomic regulation in hypertensive individuals. It emphasizes the potential therapeutic benefits of lifestyle interventions, like regular exercise, in managing hypertension-related complications.
Read More
9
Eicosapentaenoic acid benefits hypertension
5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.
Clear focus on hypertension treatment
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
9
Eicosapentaenoic acid's role in hypertension
Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
Study relevance moderately established
We explored the impact of Resolvin E1 (RvE1)—a compound derived from eicosapentaenoic acid—on hypertension and the corresponding vascular changes associated with it. This research utilized a model where hypertension was induced in mice through a substance called angiotensin II. We administered RvE1 via injection to see how it affected both blood pressure and blood vessel integrity.
Our findings showed that RvE1 could lower high blood pressure and reduce certain harmful changes in the blood vessels. Specifically, it lessened the thickening of artery walls and decreased the buildup of scar tissue in these areas. These improvements were linked to RvE1’s ability to reduce the presence of immune cells that can cause inflammation, which is crucial in the development of hypertension.
We noted that RvE1 works by activating specific cellular pathways that help mediate immune responses and cell growth. Interestingly, levels of RvE1 were found to be lower in patients suffering from hypertension, suggesting that restoring this compound could have therapeutic benefits.
In summary, RvE1 derived from eicosapentaenoic acid shows promise as a potential treatment avenue for managing hypertension and its associated vascular challenges by promoting a healthy resolution of inflammation and regulating cell behavior.
Our findings showed that RvE1 could lower high blood pressure and reduce certain harmful changes in the blood vessels. Specifically, it lessened the thickening of artery walls and decreased the buildup of scar tissue in these areas. These improvements were linked to RvE1’s ability to reduce the presence of immune cells that can cause inflammation, which is crucial in the development of hypertension.
We noted that RvE1 works by activating specific cellular pathways that help mediate immune responses and cell growth. Interestingly, levels of RvE1 were found to be lower in patients suffering from hypertension, suggesting that restoring this compound could have therapeutic benefits.
In summary, RvE1 derived from eicosapentaenoic acid shows promise as a potential treatment avenue for managing hypertension and its associated vascular challenges by promoting a healthy resolution of inflammation and regulating cell behavior.
Read More
9
Eicosapentaenoic Acid Improves Kidney Health
EPA-Enriched Phospholipids Alleviate Renal Interstitial Fibrosis in Spontaneously Hypertensive Rats by Regulating TGF-β Signaling Pathways.
Relevant effects on hypertension observed
We set out to investigate how eicosapentaenoic acid (EPA) enriched in phospholipids—termed EPA-PL—affects hypertension and kidney health, particularly in spontaneously hypertensive rats (SHRs). Our research focused on understanding whether dietary EPA-PL could provide protective benefits against kidney damage associated with chronic high blood pressure.
Over three weeks, we treated SHRs with EPA-PL and observed a significant reduction in blood pressure. This drop in blood pressure appeared to be linked to its regulation of the renin-angiotensin system, an important player in blood pressure management. In addition to improved blood pressure, we found notable improvements in kidney function. Measurements of plasma creatinine, blood urea nitrogen, and 24-hour proteinuria showed that EPA-PL treatment led to less kidney dysfunction.
Further investigation into the microscopic structure of the kidneys revealed that EPA-PL helps alleviate renal injury and tubulointerstitial fibrosis, conditions that are often detrimental in hypertensive kidney disease. Mechanistically, we observed that the treatment inhibited a protein called TGF-β, while also affecting other important pathways related to cell survival and inflammatory responses, leading to less oxidative stress in the kidneys.
Overall, our findings suggest that EPA-PL holds promising potential as a therapeutic approach for preventing and alleviating the damaging effects of hypertension on kidney health.
Over three weeks, we treated SHRs with EPA-PL and observed a significant reduction in blood pressure. This drop in blood pressure appeared to be linked to its regulation of the renin-angiotensin system, an important player in blood pressure management. In addition to improved blood pressure, we found notable improvements in kidney function. Measurements of plasma creatinine, blood urea nitrogen, and 24-hour proteinuria showed that EPA-PL treatment led to less kidney dysfunction.
Further investigation into the microscopic structure of the kidneys revealed that EPA-PL helps alleviate renal injury and tubulointerstitial fibrosis, conditions that are often detrimental in hypertensive kidney disease. Mechanistically, we observed that the treatment inhibited a protein called TGF-β, while also affecting other important pathways related to cell survival and inflammatory responses, leading to less oxidative stress in the kidneys.
Overall, our findings suggest that EPA-PL holds promising potential as a therapeutic approach for preventing and alleviating the damaging effects of hypertension on kidney health.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Healthy brain development
Necessary for pregnant women! From conception to 2 years, consuming DHA is vital for a child’s brain, nervous system, and eye development. The World Health Organization recommends at least 500 mg of DHA daily for pregnant and breastfeeding women. A study from the University of Kansas demonstrated that a daily intake of 600 mg of DHA during pregnancy aids heart development and may protect against hypertension with excess weight.
Read More
8.8
Recommended for hypertension
The best omega! This dosage is recommended for pregnant women and for treating hypertension by endocrinologists.
8.8
Improves cardiovascular health
Works wonderfully! Omega-3s are effective! Each capsule contains 750 mg of acids, which I prescribe to patients with cardiovascular issues, including hypertension and arrhythmias. However, it’s important to note that some individuals may have a specific intolerance to components of the drug.
Read More
8.8
Better than omega-3
Good. Better than standard omega-3. For those who don't often buy regular omega-3s, I recommend DHA, the most valuable fatty acid that enhances health. I have hypertension, and after taking this, I've felt an improvement.
