Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
Eicosapentaenoic acid benefits hypertension
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
8
Eicosapentaenoic acid lowers blood pressure
We examined the impact of eicosapentaenoic acid (EPA) lactone on hypertension, particularly in a model where rats undergo a 5/6 nephrectomy. This condition is known to induce high blood pressure and related vascular dysfunction. Our research involved administering the EPA lactone to these hypertensive rats over five days while measuring their blood pressure, kidney function, and other relevant health metrics.
Through our study, we found that the EPA lactone significantly lowered blood pressure. It achieved this by promoting improved dilation of the blood vessels, which is essential for maintaining healthy circulation. Notably, the mechanism involved calcium-dependent potassium channels in the endothelium, contributing to better vessel relaxation and function.
Our findings suggest that the EPA lactone may hold promise as a dietary supplement for individuals dealing with hypertension, particularly those experiencing issues related to microvascular dysfunction. This study enhances our understanding of how this specific metabolite can play a role in managing high blood pressure effectively.
Through our study, we found that the EPA lactone significantly lowered blood pressure. It achieved this by promoting improved dilation of the blood vessels, which is essential for maintaining healthy circulation. Notably, the mechanism involved calcium-dependent potassium channels in the endothelium, contributing to better vessel relaxation and function.
Our findings suggest that the EPA lactone may hold promise as a dietary supplement for individuals dealing with hypertension, particularly those experiencing issues related to microvascular dysfunction. This study enhances our understanding of how this specific metabolite can play a role in managing high blood pressure effectively.
Read More
7
We investigated how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects blood vessel relaxation, particularly in relation to hypertension. The study involved examining mouse aorta and mesenteric arteries to see how they respond to DHA and another omega-3 fatty acid, eicosapentaenoic acid (EPA).
Our findings revealed that both DHA and EPA can cause vasodilation, which is the widening of blood vessels. This relaxation response was observed even when we blocked certain potassium channels, which are typically involved in regulating vascular tone. Interestingly, removing the endothelium, the inner lining of blood vessels, had some effect on how arteries reacted to DHA, but not to EPA.
We also looked at smooth muscle cells in the aorta and found that DHA did not activate potassium currents as expected. This led us to conclude that the relaxed state induced by DHA and EPA is not directly linked to the activity of potassium channels. In summary, while DHA and EPA help relax blood vessels, the mechanisms behind this effect do not appear to involve potassium channels, suggesting a different pathway may be at play in combating hypertension.
Our findings revealed that both DHA and EPA can cause vasodilation, which is the widening of blood vessels. This relaxation response was observed even when we blocked certain potassium channels, which are typically involved in regulating vascular tone. Interestingly, removing the endothelium, the inner lining of blood vessels, had some effect on how arteries reacted to DHA, but not to EPA.
We also looked at smooth muscle cells in the aorta and found that DHA did not activate potassium currents as expected. This led us to conclude that the relaxed state induced by DHA and EPA is not directly linked to the activity of potassium channels. In summary, while DHA and EPA help relax blood vessels, the mechanisms behind this effect do not appear to involve potassium channels, suggesting a different pathway may be at play in combating hypertension.
Read More
Most Useful Reviews
9
Healthy brain development
3 people found this helpful
Necessary for pregnant women! From conception to 2 years, consuming DHA is vital for a child’s brain, nervous system, and eye development. The World Health Organization recommends at least 500 mg of DHA daily for pregnant and breastfeeding women. A study from the University of Kansas demonstrated that a daily intake of 600 mg of DHA during pregnancy aids heart development and may protect against hypertension with excess weight.
Read More
7.5
Recommended for hypertension
The best omega! This dosage is recommended for pregnant women and for treating hypertension by endocrinologists.
Read More
7.5
Improves cardiovascular health
Works wonderfully! Omega-3s are effective! Each capsule contains 750 mg of acids, which I prescribe to patients with cardiovascular issues, including hypertension and arrhythmias. However, it’s important to note that some individuals may have a specific intolerance to components of the drug.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.8
- All Researches
9
DHA associated with lower mortality
We investigated the effects of dietary docosahexaenoic acid (DHA) on hypertension and related mortality risks. Our study included nearly 27,000 hypertensive adults who participated in the National Health and Nutrition Examination Surveys between 1999 and 2018. Through this comprehensive approach, we sought to understand if higher DHA intake could lead to better health outcomes for individuals living with hypertension.
Findings from our analysis indicated that those with higher dietary intake of omega-3 polyunsaturated fatty acids, including DHA, generally had a lower risk of all-cause and cardiovascular mortality. Specifically, individuals consuming more ALA, EPA, and DPA alongside DHA showed notable benefits.
While we noted these positive associations with omega-3 fatty acids, it’s essential to recognize that DHA was part of a broader group of beneficial fats. This makes it difficult to isolate its specific impact purely on hypertension outcomes. Nonetheless, these results suggest that increasing dietary intake of omega-3s, including DHA, might be a helpful strategy for managing hypertension and its related risks.
Findings from our analysis indicated that those with higher dietary intake of omega-3 polyunsaturated fatty acids, including DHA, generally had a lower risk of all-cause and cardiovascular mortality. Specifically, individuals consuming more ALA, EPA, and DPA alongside DHA showed notable benefits.
While we noted these positive associations with omega-3 fatty acids, it’s essential to recognize that DHA was part of a broader group of beneficial fats. This makes it difficult to isolate its specific impact purely on hypertension outcomes. Nonetheless, these results suggest that increasing dietary intake of omega-3s, including DHA, might be a helpful strategy for managing hypertension and its related risks.
Read More
9
Exercise aids hypertension-related BBB issues
We investigated how hypertension affects the blood-brain barrier (BBB) and whether exercise training could improve its function. Our study involved spontaneously hypertensive rats (SHR) and Wistar rats, which we divided into groups that either underwent treadmill training or remained sedentary for four weeks. We found that hypertension led to an increase in blood pressure and heart rate, as well as a decrease in the protective Mfsd2a protein, which plays a crucial role in maintaining BBB integrity.
Interestingly, when the hypertensive rats participated in exercise training, we noticed a restoration of Mfsd2a levels, a reduction in another protein called caveolin-1, and importantly, a normalization of BBB permeability in the paraventricular nucleus of the hypothalamus. This change was also accompanied by improvements in heart rate and blood pressure variability, indicating enhanced autonomic control.
However, we saw no significant changes in the Wistar group between training and sedentary states, suggesting that the exercise's effects were specific to the hypertensive condition. This highlights that while docosahexaenoic acid (DHA) transport through Mfsd2a is beneficial, the direct impact of DHA alone on hypertension wasn't the focus of our study.
Ultimately, we concluded that exercise training is an effective way to improve both the BBB function and autonomic regulation in hypertensive individuals. It emphasizes the potential therapeutic benefits of lifestyle interventions, like regular exercise, in managing hypertension-related complications.
Interestingly, when the hypertensive rats participated in exercise training, we noticed a restoration of Mfsd2a levels, a reduction in another protein called caveolin-1, and importantly, a normalization of BBB permeability in the paraventricular nucleus of the hypothalamus. This change was also accompanied by improvements in heart rate and blood pressure variability, indicating enhanced autonomic control.
However, we saw no significant changes in the Wistar group between training and sedentary states, suggesting that the exercise's effects were specific to the hypertensive condition. This highlights that while docosahexaenoic acid (DHA) transport through Mfsd2a is beneficial, the direct impact of DHA alone on hypertension wasn't the focus of our study.
Ultimately, we concluded that exercise training is an effective way to improve both the BBB function and autonomic regulation in hypertensive individuals. It emphasizes the potential therapeutic benefits of lifestyle interventions, like regular exercise, in managing hypertension-related complications.
Read More
9
Eicosapentaenoic acid benefits hypertension
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
9
We explored the impact of Resolvin E1 (RvE1)—a compound derived from eicosapentaenoic acid—on hypertension and the corresponding vascular changes associated with it. This research utilized a model where hypertension was induced in mice through a substance called angiotensin II. We administered RvE1 via injection to see how it affected both blood pressure and blood vessel integrity.
Our findings showed that RvE1 could lower high blood pressure and reduce certain harmful changes in the blood vessels. Specifically, it lessened the thickening of artery walls and decreased the buildup of scar tissue in these areas. These improvements were linked to RvE1’s ability to reduce the presence of immune cells that can cause inflammation, which is crucial in the development of hypertension.
We noted that RvE1 works by activating specific cellular pathways that help mediate immune responses and cell growth. Interestingly, levels of RvE1 were found to be lower in patients suffering from hypertension, suggesting that restoring this compound could have therapeutic benefits.
In summary, RvE1 derived from eicosapentaenoic acid shows promise as a potential treatment avenue for managing hypertension and its associated vascular challenges by promoting a healthy resolution of inflammation and regulating cell behavior.
Our findings showed that RvE1 could lower high blood pressure and reduce certain harmful changes in the blood vessels. Specifically, it lessened the thickening of artery walls and decreased the buildup of scar tissue in these areas. These improvements were linked to RvE1’s ability to reduce the presence of immune cells that can cause inflammation, which is crucial in the development of hypertension.
We noted that RvE1 works by activating specific cellular pathways that help mediate immune responses and cell growth. Interestingly, levels of RvE1 were found to be lower in patients suffering from hypertension, suggesting that restoring this compound could have therapeutic benefits.
In summary, RvE1 derived from eicosapentaenoic acid shows promise as a potential treatment avenue for managing hypertension and its associated vascular challenges by promoting a healthy resolution of inflammation and regulating cell behavior.
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9
We set out to investigate how eicosapentaenoic acid (EPA) enriched in phospholipids—termed EPA-PL—affects hypertension and kidney health, particularly in spontaneously hypertensive rats (SHRs). Our research focused on understanding whether dietary EPA-PL could provide protective benefits against kidney damage associated with chronic high blood pressure.
Over three weeks, we treated SHRs with EPA-PL and observed a significant reduction in blood pressure. This drop in blood pressure appeared to be linked to its regulation of the renin-angiotensin system, an important player in blood pressure management. In addition to improved blood pressure, we found notable improvements in kidney function. Measurements of plasma creatinine, blood urea nitrogen, and 24-hour proteinuria showed that EPA-PL treatment led to less kidney dysfunction.
Further investigation into the microscopic structure of the kidneys revealed that EPA-PL helps alleviate renal injury and tubulointerstitial fibrosis, conditions that are often detrimental in hypertensive kidney disease. Mechanistically, we observed that the treatment inhibited a protein called TGF-β, while also affecting other important pathways related to cell survival and inflammatory responses, leading to less oxidative stress in the kidneys.
Overall, our findings suggest that EPA-PL holds promising potential as a therapeutic approach for preventing and alleviating the damaging effects of hypertension on kidney health.
Over three weeks, we treated SHRs with EPA-PL and observed a significant reduction in blood pressure. This drop in blood pressure appeared to be linked to its regulation of the renin-angiotensin system, an important player in blood pressure management. In addition to improved blood pressure, we found notable improvements in kidney function. Measurements of plasma creatinine, blood urea nitrogen, and 24-hour proteinuria showed that EPA-PL treatment led to less kidney dysfunction.
Further investigation into the microscopic structure of the kidneys revealed that EPA-PL helps alleviate renal injury and tubulointerstitial fibrosis, conditions that are often detrimental in hypertensive kidney disease. Mechanistically, we observed that the treatment inhibited a protein called TGF-β, while also affecting other important pathways related to cell survival and inflammatory responses, leading to less oxidative stress in the kidneys.
Overall, our findings suggest that EPA-PL holds promising potential as a therapeutic approach for preventing and alleviating the damaging effects of hypertension on kidney health.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Healthy brain development
3 people found this helpful
Necessary for pregnant women! From conception to 2 years, consuming DHA is vital for a child’s brain, nervous system, and eye development. The World Health Organization recommends at least 500 mg of DHA daily for pregnant and breastfeeding women. A study from the University of Kansas demonstrated that a daily intake of 600 mg of DHA during pregnancy aids heart development and may protect against hypertension with excess weight.
Read More
7.5
Recommended for hypertension
The best omega! This dosage is recommended for pregnant women and for treating hypertension by endocrinologists.
Read More
7.5
Improves cardiovascular health
Works wonderfully! Omega-3s are effective! Each capsule contains 750 mg of acids, which I prescribe to patients with cardiovascular issues, including hypertension and arrhythmias. However, it’s important to note that some individuals may have a specific intolerance to components of the drug.
Read More
7.5
Better than omega-3
Good. Better than standard omega-3. For those who don't often buy regular omega-3s, I recommend DHA, the most valuable fatty acid that enhances health. I have hypertension, and after taking this, I've felt an improvement.
Read More
Frequently Asked Questions
7.5
Better than omega-3
Good. Better than standard omega-3. For those who don't often buy regular omega-3s, I recommend DHA, the most valuable fatty acid that enhances health. I have hypertension, and after taking this, I've felt an improvement.
7.5
Improves cardiovascular health
Works wonderfully! Omega-3s are effective! Each capsule contains 750 mg of acids, which I prescribe to patients with cardiovascular issues, including hypertension and arrhythmias. However, it’s important to note that some individuals may have a specific intolerance to components of the drug.
7.5
Recommended for hypertension
The best omega! This dosage is recommended for pregnant women and for treating hypertension by endocrinologists.
9
Healthy brain development
3 people found this helpful
Necessary for pregnant women! From conception to 2 years, consuming DHA is vital for a child’s brain, nervous system, and eye development. The World Health Organization recommends at least 500 mg of DHA daily for pregnant and breastfeeding women. A study from the University of Kansas demonstrated that a daily intake of 600 mg of DHA during pregnancy aids heart development and may protect against hypertension with excess weight.
8
DHA may modestly lower blood pressure
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid found in marine oils, can affect hypertension. Recent findings suggest that incorporating DHA into our diet may lead to a moderate reduction in blood pressure levels.
While there is a strong consensus on the benefits of marine oils in general, isolating the effects of DHA specifically can be more complex. Still, we found that studies consistently indicate that consumption of marine oils—especially those rich in DHA—can be particularly beneficial for managing blood pressure.
We also noticed that dietary patterns which include plant-based foods, dairy, and even yogurt seem to have a positive impact on blood pressure, regardless of fat content. Interestingly, reducing total fat intake hasn't shown a direct relationship with blood pressure, unless it's part of a weight-loss strategy.
Overall, while DHA might play a role in lowering blood pressure, its effects are most significant when combined with a broader healthy eating approach that includes various nutrients.
While there is a strong consensus on the benefits of marine oils in general, isolating the effects of DHA specifically can be more complex. Still, we found that studies consistently indicate that consumption of marine oils—especially those rich in DHA—can be particularly beneficial for managing blood pressure.
We also noticed that dietary patterns which include plant-based foods, dairy, and even yogurt seem to have a positive impact on blood pressure, regardless of fat content. Interestingly, reducing total fat intake hasn't shown a direct relationship with blood pressure, unless it's part of a weight-loss strategy.
Overall, while DHA might play a role in lowering blood pressure, its effects are most significant when combined with a broader healthy eating approach that includes various nutrients.
8
DHA's Potential in Hypertension Management
We delved into how docosahexaenoic acid, commonly known as DHA, relates to hypertension, a significant risk factor for heart disease. Recent findings have shown that DHA, found in fatty fish and algae, plays an important role in managing blood pressure levels. It seems that this particular fatty acid can help regulate inflammation and improve overall vascular function, both crucial elements in maintaining a healthy blood pressure.
Different studies suggest that incorporating DHA into our diets might be beneficial for those looking to manage high blood pressure. While some evidence points to promising effects on reducing hypertension, it’s important to note that results can vary based on individual factors, dietary habits, and overall health. Therefore, DHA might be one part of a broader solution for hypertension prevention.
We also noted that lifestyle choices, such as diet, exercise, and even smoking, can significantly impact how effective DHA may be in managing high blood pressure. As we explore the possibilities, it appears that creating a balanced dietary approach that includes DHA could contribute positively to our cardiovascular health.
Different studies suggest that incorporating DHA into our diets might be beneficial for those looking to manage high blood pressure. While some evidence points to promising effects on reducing hypertension, it’s important to note that results can vary based on individual factors, dietary habits, and overall health. Therefore, DHA might be one part of a broader solution for hypertension prevention.
We also noted that lifestyle choices, such as diet, exercise, and even smoking, can significantly impact how effective DHA may be in managing high blood pressure. As we explore the possibilities, it appears that creating a balanced dietary approach that includes DHA could contribute positively to our cardiovascular health.
8
We aimed to understand how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects blood pressure in older adults with hypertension. Through a thorough review of studies published from 2003 to 2022, we focused on randomized controlled trials that specifically assessed DHA’s impact compared to placebo.
Our analysis revealed that DHA was among the dietary supplements found to help lower systolic blood pressure. Alongside other supplements like eicosapentaenoic acid and inorganic nitrates, DHA showed a more significant effect than a placebo. However, it's important to note that while DHA was effective, the study also highlighted that the differences observed were not statistically significant when compared to other supplements we examined.
This means while DHA may have some benefits, caution is warranted in interpreting these results due to potential biases in some of the included studies. In the end, while DHA may contribute to lower blood pressure, further research is necessary to draw definite conclusions about its effectiveness.
Our analysis revealed that DHA was among the dietary supplements found to help lower systolic blood pressure. Alongside other supplements like eicosapentaenoic acid and inorganic nitrates, DHA showed a more significant effect than a placebo. However, it's important to note that while DHA was effective, the study also highlighted that the differences observed were not statistically significant when compared to other supplements we examined.
This means while DHA may have some benefits, caution is warranted in interpreting these results due to potential biases in some of the included studies. In the end, while DHA may contribute to lower blood pressure, further research is necessary to draw definite conclusions about its effectiveness.
8
DHA's role in hypertension
We investigated how docosahexaenoic acid (DHA), an omega-3 fatty acid, plays a role in managing hypertension, a widespread health issue affecting millions. Studies have revealed that DHA is known to have anti-hypertensive properties, which can support heart health and overall cardiovascular functions.
Our exploration highlighted how DHA can potentially aid in lowering blood pressure. This action may be attributed to its effects on blood vessel health and inflammation reduction. While promising, it’s crucial to note that the exact impact of DHA may vary, especially when evaluated alongside other treatments. Thus, there are nuances to consider regarding its effectiveness for hypertension when it is tested in isolation.
Ultimately, our examination reveals that while DHA presents beneficial qualities, understanding its role involves further research to unravel its full potential against hypertension. As such, those seeking natural approaches to support heart health might find interest in incorporating DHA-rich sources into their diets, such as fish oil.
Our exploration highlighted how DHA can potentially aid in lowering blood pressure. This action may be attributed to its effects on blood vessel health and inflammation reduction. While promising, it’s crucial to note that the exact impact of DHA may vary, especially when evaluated alongside other treatments. Thus, there are nuances to consider regarding its effectiveness for hypertension when it is tested in isolation.
Ultimately, our examination reveals that while DHA presents beneficial qualities, understanding its role involves further research to unravel its full potential against hypertension. As such, those seeking natural approaches to support heart health might find interest in incorporating DHA-rich sources into their diets, such as fish oil.
7
We aimed to understand how a single dose of docosahexaenoic acid (DHA), part of omega-3 fatty acids, impacts blood pressure, particularly in middle-aged men. In our study, we provided participants with a high dose of omega-3, containing 4020 mg of DHA and 720 mg of eicosapentaenoic acid (EPA), or a placebo, alongside a standardized meal of Greek yogurt.
After about 3.5 to 4 hours, we noticed some interesting results. While there were no significant changes in cognitive performance from the omega-3 intake, there was a notable reduction in aortic systolic blood pressure. Specifically, we observed a decrease of 4.11 mmHg in those who consumed omega-3, compared to a smaller, non-significant drop of 1.39 mmHg in the placebo group.
Overall, our findings suggest that while DHA may not offer cognitive benefits in the short term for middle-aged males, it appears to have a positive impact on lowering blood pressure. Further studies are needed, especially involving women and individuals with hypertension, to explore these effects in more depth.
After about 3.5 to 4 hours, we noticed some interesting results. While there were no significant changes in cognitive performance from the omega-3 intake, there was a notable reduction in aortic systolic blood pressure. Specifically, we observed a decrease of 4.11 mmHg in those who consumed omega-3, compared to a smaller, non-significant drop of 1.39 mmHg in the placebo group.
Overall, our findings suggest that while DHA may not offer cognitive benefits in the short term for middle-aged males, it appears to have a positive impact on lowering blood pressure. Further studies are needed, especially involving women and individuals with hypertension, to explore these effects in more depth.
References
- Arghavani H, Bilodeau JF, Rudkowska I. Association Between Circulating Fatty Acids and Blood Pressure: A Review. Curr Nutr Rep. 2025;14:15. doi:10.1007/s13668-024-00602-3
- Nestel PJ, Mori TA. Diet to Stop Hypertension: Should Fats be Included?. Curr Hypertens Rep. 2024;26:409. doi:10.1007/s11906-024-01310-7
- Kujawska A, Bromage S, Simoes JA, Zupkauskienė J, McMahon N, et al. The impact of dietary supplements on blood pressure in older adults: A network meta-analysis of randomized controlled trials. Heliyon. 2024;10:e25615. doi:10.1016/j.heliyon.2024.e25615
- Chen H, Leng X, Liu S, Zeng Z, Huang F, et al. Association between dietary intake of omega-3 polyunsaturated fatty acids and all-cause and cardiovascular mortality among hypertensive adults: Results from NHANES 1999-2018. Clin Nutr. 2023;42:2434. doi:10.1016/j.clnu.2023.09.011
- Perego SM, Raquel HA, Candido VB, Masson GS, Martins MM, et al. Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries. Am J Physiol Regul Integr Comp Physiol. 2023;325:R299. doi:10.1152/ajpregu.00049.2023
- Pipingas A, Reddan JM, Gauci S, Young LM, Kennedy G, et al. Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study. Nutrients. 2023;15. doi:10.3390/nu15092198
- Brosolo G, Da Porto A, Marcante S, Picci A, Capilupi F, et al. Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?. Int J Mol Sci. 2023;24. doi:10.3390/ijms24119520
- Imig JD. Bioactive lipids in hypertension. Adv Pharmacol. 2023;97:1. doi:10.1016/bs.apha.2023.01.001
- Bercea C, Limbu R, Behnam K, Ng KE, Aziz Q, et al. Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels. Front Physiol. 2022;13:1033216. doi:10.3389/fphys.2022.1033216
- Zavala MR, Longarzo ML, Vázquez RF, Vélez Rueda O, Maté SM, et al. Polyunsaturated ω3 fatty acids prevent the cardiac hypertrophy in hypertensive rats. Biochim Biophys Acta Gen Subj. 2023;1867:130278. doi:10.1016/j.bbagen.2022.130278
- Zhang X, Ritonja JA, Zhou N, Chen BE, Li X. Omega-3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2022;11:e025071. doi:10.1161/JAHA.121.025071
- Asulin M, Gorodetzer N, Fridman R, Shelly Ben-Shushan R, Cohen Z, et al. 5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway. Biochem Biophys Res Commun. 2024;700:149585. doi:10.1016/j.bbrc.2024.149585
- Zhang J, Yin Z, Xu Y, Wei C, Peng S, et al. Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice. Hypertension. 2023;80:2650. doi:10.1161/HYPERTENSIONAHA.123.21348
- Gharraee N, Wang Z, Pflum A, Medina-Hernandez D, Herrington D, et al. Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats. J Lipid Res. 2022;63:100292. doi:10.1016/j.jlr.2022.100292
- Pinhas S, Amram E, Slutsky-Smith E, Ertracht O, Atar S, et al. Paraoxonase 1 hydrolysis of EPA-derived lactone impairs endothelial-mediated vasodilation. Prostaglandins Other Lipid Mediat. 2022;162:106665. doi:10.1016/j.prostaglandins.2022.106665
- Shi HH, Zhang LY, Chen LP, Yang JY, Wang CC, et al. EPA-Enriched Phospholipids Alleviate Renal Interstitial Fibrosis in Spontaneously Hypertensive Rats by Regulating TGF-β Signaling Pathways. Mar Drugs. 2022;20. doi:10.3390/md20020152
- Ni S, Zhong Z, Wei J, Zhou J, Cai L, et al. Association between dietary intake of polyunsaturated fatty acid and prevalence of hypertension in U.S. adults: A cross-sectional study using data from NHANES 2009-2016. Hypertens Res. 2022;45:516. doi:10.1038/s41440-021-00849-1
- Barsheshet M, Ertracht O, Boginya A, Reuveni T, Atar S, et al. Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:159031. doi:10.1016/j.bbalip.2021.159031
