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SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
Omega-3 benefits in hypothyroidism
The effect of omega-3 on cognition in hypothyroid adult male rats.
Significant relevance to treatment
We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
Read More
8
Fish oil benefits hypothyroid function
Effect of eicosapentaenoic acid ethyl ester on hypothyroid function.
Directly explores fish oil's effects
We set out to understand how fish oil, specifically eicosapentaenoic acid ethyl ester (EPA-E), might affect thyroid function in individuals with hypothyroidism. Previous observations noted that while plasma free fatty acid (FFA) levels are typically normal in people with hypothyroidism, some patients exhibited higher levels. Surprisingly, those with elevated FFA levels reported milder symptoms compared to those with lower concentrations.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
Read More
8
Eicosapentaenoic acid supports hypothyroidism
Effect of eicosapentaenoic acid ethyl ester on hypothyroid function.
High relevance to hypothyroidism research
We aimed to investigate how eicosapentaenoic acid ethyl ester, a form of omega-3 fatty acid derived from fish oil, influences thyroid function in patients with hypothyroidism. Interestingly, while it has generally been observed that plasma free fatty acid (FFA) levels remain normal in hypothyroid individuals, our findings indicated that some patients exhibited elevated FFA concentrations. This was compelling, as those with higher FFA levels showed milder symptoms of thyroid dysfunction compared to others with lower levels.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
Read More
Most Useful Reviews
8.8
Improved symptoms
One of the best omega forms. I consume this regularly, and it has alleviated symptoms associated with my hypothyroidism, such as skin deterioration, concentration loss, sleep issues, irritability, mood swings, chronic fatigue, and worsened allergies. I rely on it due to my AIT and Hashimoto's disease, and my eldest son, aged 16, also takes it as he experiences fatigue from studying remotely.
Read More
8.8
Increased dosage
I regularly take this omega with my husband. Due to my hypothyroidism, I've been advised to increase my intake, so I now take three capsules daily.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
9
Omega-3 benefits in hypothyroidism
The effect of omega-3 on cognition in hypothyroid adult male rats.
Significant relevance to treatment
We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
Read More
9
Omega-3s support brain development
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Moderate relevance to fish oil effect
We investigated how omega-3 fatty acids, found in fish oil, could influence brain development in a rat model with hypothyroidism. Our focus was on understanding whether these fatty acids could help prevent neuronal apoptosis—a type of programmed cell death that can be harmful during brain development.
To study this, we supplemented pregnant and nursing rats with a mix of two important omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Meanwhile, we induced hypothyroidism in these rats using a medication known as methimazole. We then examined the cerebellums of their offspring at a specific age, looking for indicators of neuronal health and apoptosis.
Our findings showed that the supplement significantly reduced DNA fragmentation and the activation of caspase-3, another indicator of apoptosis, in the developing brains of hypothyroid pups. Additionally, omega-3 fatty acids helped to increase levels of protective proteins that fight apoptosis, such as Bcl-2 and Bcl-x(L). They also reinstated normal levels of signaling molecules affected by hypothyroid conditions.
Overall, this suggests that omega-3 fatty acids could play a protective role in brain development, especially under stress conditions like hypothyroidism. Through this research, we gained valuable insights into how fish oil might help support neuronal health in challenging developmental situations.
To study this, we supplemented pregnant and nursing rats with a mix of two important omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Meanwhile, we induced hypothyroidism in these rats using a medication known as methimazole. We then examined the cerebellums of their offspring at a specific age, looking for indicators of neuronal health and apoptosis.
Our findings showed that the supplement significantly reduced DNA fragmentation and the activation of caspase-3, another indicator of apoptosis, in the developing brains of hypothyroid pups. Additionally, omega-3 fatty acids helped to increase levels of protective proteins that fight apoptosis, such as Bcl-2 and Bcl-x(L). They also reinstated normal levels of signaling molecules affected by hypothyroid conditions.
Overall, this suggests that omega-3 fatty acids could play a protective role in brain development, especially under stress conditions like hypothyroidism. Through this research, we gained valuable insights into how fish oil might help support neuronal health in challenging developmental situations.
Read More
9
DHA promotes brain development in hypothyroidism
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Study highlights DHA's protective role
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in a study designed to understand its role in overcoming hypothyroidism-induced neuronal apoptosis, especially during crucial cerebellar development. Our research involved supplementing pregnant and lactating rats with a mixture of DHA and eicosapentaenoic acid (EPA) while inducing hypothyroidism using methimazole.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
Read More
9
Eicosapentaenoic Acid supports brain development
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Effectiveness of EPA treatment analyzed
We investigated the role of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in the context of hypothyroidism and its effects on brain development. Our study used a rat model where hypothyroidism was induced, allowing us to examine how EPA influences neuronal health during this critical phase of development.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Read More
8
Omega 3 protects against thyroid damage
Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities.
Study connects O3FA with thyroid issues
We observed the effects of Omega 3 fatty acids (O3FA) on hypothyroidism caused by the endocrine-disrupting chemical Bisphenol F (BPF) in a controlled study with male Wistar rats. The rats were divided into four groups: a control group, a BPF-only group, and two intervention groups receiving different doses of O3FA alongside BPF.
Our findings revealed that both low and high doses of O3FA significantly improved sperm quality, hormonal levels, and antioxidant defenses, which were adversely affected by BPF. Notably, the treatment with O3FA restored important enzymes and prevented harmful increases in certain inflammatory markers, showing its protective role against testicular dysfunction linked to thyroid issues.
Overall, this study indicates that incorporating Omega 3 fatty acids could be an effective strategy to counteract the negative impacts of BPF-induced hypothyroidism and support male reproductive health.
Our findings revealed that both low and high doses of O3FA significantly improved sperm quality, hormonal levels, and antioxidant defenses, which were adversely affected by BPF. Notably, the treatment with O3FA restored important enzymes and prevented harmful increases in certain inflammatory markers, showing its protective role against testicular dysfunction linked to thyroid issues.
Overall, this study indicates that incorporating Omega 3 fatty acids could be an effective strategy to counteract the negative impacts of BPF-induced hypothyroidism and support male reproductive health.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
8.8
Improved symptoms
One of the best omega forms. I consume this regularly, and it has alleviated symptoms associated with my hypothyroidism, such as skin deterioration, concentration loss, sleep issues, irritability, mood swings, chronic fatigue, and worsened allergies. I rely on it due to my AIT and Hashimoto's disease, and my eldest son, aged 16, also takes it as he experiences fatigue from studying remotely.
Read More
8.8
Increased dosage
I regularly take this omega with my husband. Due to my hypothyroidism, I've been advised to increase my intake, so I now take three capsules daily.
