Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
Read More
8
Fish oil benefits hypothyroid function
We set out to understand how fish oil, specifically eicosapentaenoic acid ethyl ester (EPA-E), might affect thyroid function in individuals with hypothyroidism. Previous observations noted that while plasma free fatty acid (FFA) levels are typically normal in people with hypothyroidism, some patients exhibited higher levels. Surprisingly, those with elevated FFA levels reported milder symptoms compared to those with lower concentrations.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
Read More
7
Fish oil improves mitochondrial function
We explored how fish oil, specifically omega-3 fatty acids, impacts mitochondrial function in hypothyroid rats compared to normal thyroid function. By examining mitochondrial proton leak—essentially how efficiently energy is used in cells—we found that hypothyroid rats had lower proton leak rates than those with normal thyroid function.
Interestingly, when hypothyroid rats were fed a diet with 5% omega-3 fatty acids, their proton leak rates dropped even further. We also noted this same trend in euthyroid rats that consumed the higher omega-3 diet, suggesting that increasing dietary omega-3 content can improve mitochondrial efficiency, regardless of thyroid status.
Our findings pointed to significant changes in the membranes of mitochondria, specifically with levels of omega-3 fatty acids being higher. This change corresponds with a favorable shift in the balance between omega-6 and omega-3 fatty acids, across several important phospholipid categories. Overall, it appears that both the hypothyroid state and the omega-3 dietary influence seem to work through similar biological pathways.
While the study clearly demonstrates how fish oil can affect mitochondrial function in thyroid-related conditions, it does highlight the complex interactions between diet and hormone status. Therefore, while fish oil shows promise, it operates within a broader context that includes both dietary and hormonal factors.
Interestingly, when hypothyroid rats were fed a diet with 5% omega-3 fatty acids, their proton leak rates dropped even further. We also noted this same trend in euthyroid rats that consumed the higher omega-3 diet, suggesting that increasing dietary omega-3 content can improve mitochondrial efficiency, regardless of thyroid status.
Our findings pointed to significant changes in the membranes of mitochondria, specifically with levels of omega-3 fatty acids being higher. This change corresponds with a favorable shift in the balance between omega-6 and omega-3 fatty acids, across several important phospholipid categories. Overall, it appears that both the hypothyroid state and the omega-3 dietary influence seem to work through similar biological pathways.
While the study clearly demonstrates how fish oil can affect mitochondrial function in thyroid-related conditions, it does highlight the complex interactions between diet and hormone status. Therefore, while fish oil shows promise, it operates within a broader context that includes both dietary and hormonal factors.
Read More
Most Useful Reviews
7.5
Improved symptoms
One of the best omega forms. I consume this regularly, and it has alleviated symptoms associated with my hypothyroidism, such as skin deterioration, concentration loss, sleep issues, irritability, mood swings, chronic fatigue, and worsened allergies. I rely on it due to my AIT and Hashimoto's disease, and my eldest son, aged 16, also takes it as he experiences fatigue from studying remotely.
Read More
7.5
Increased dosage
I regularly take this omega with my husband. Due to my hypothyroidism, I've been advised to increase my intake, so I now take three capsules daily.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
- All Researches
9
We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.
Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.
Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.
Read More
9
We investigated how omega-3 fatty acids, found in fish oil, could influence brain development in a rat model with hypothyroidism. Our focus was on understanding whether these fatty acids could help prevent neuronal apoptosis—a type of programmed cell death that can be harmful during brain development.
To study this, we supplemented pregnant and nursing rats with a mix of two important omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Meanwhile, we induced hypothyroidism in these rats using a medication known as methimazole. We then examined the cerebellums of their offspring at a specific age, looking for indicators of neuronal health and apoptosis.
Our findings showed that the supplement significantly reduced DNA fragmentation and the activation of caspase-3, another indicator of apoptosis, in the developing brains of hypothyroid pups. Additionally, omega-3 fatty acids helped to increase levels of protective proteins that fight apoptosis, such as Bcl-2 and Bcl-x(L). They also reinstated normal levels of signaling molecules affected by hypothyroid conditions.
Overall, this suggests that omega-3 fatty acids could play a protective role in brain development, especially under stress conditions like hypothyroidism. Through this research, we gained valuable insights into how fish oil might help support neuronal health in challenging developmental situations.
To study this, we supplemented pregnant and nursing rats with a mix of two important omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Meanwhile, we induced hypothyroidism in these rats using a medication known as methimazole. We then examined the cerebellums of their offspring at a specific age, looking for indicators of neuronal health and apoptosis.
Our findings showed that the supplement significantly reduced DNA fragmentation and the activation of caspase-3, another indicator of apoptosis, in the developing brains of hypothyroid pups. Additionally, omega-3 fatty acids helped to increase levels of protective proteins that fight apoptosis, such as Bcl-2 and Bcl-x(L). They also reinstated normal levels of signaling molecules affected by hypothyroid conditions.
Overall, this suggests that omega-3 fatty acids could play a protective role in brain development, especially under stress conditions like hypothyroidism. Through this research, we gained valuable insights into how fish oil might help support neuronal health in challenging developmental situations.
Read More
8
We observed the effects of Omega 3 fatty acids (O3FA) on hypothyroidism caused by the endocrine-disrupting chemical Bisphenol F (BPF) in a controlled study with male Wistar rats. The rats were divided into four groups: a control group, a BPF-only group, and two intervention groups receiving different doses of O3FA alongside BPF.
Our findings revealed that both low and high doses of O3FA significantly improved sperm quality, hormonal levels, and antioxidant defenses, which were adversely affected by BPF. Notably, the treatment with O3FA restored important enzymes and prevented harmful increases in certain inflammatory markers, showing its protective role against testicular dysfunction linked to thyroid issues.
Overall, this study indicates that incorporating Omega 3 fatty acids could be an effective strategy to counteract the negative impacts of BPF-induced hypothyroidism and support male reproductive health.
Our findings revealed that both low and high doses of O3FA significantly improved sperm quality, hormonal levels, and antioxidant defenses, which were adversely affected by BPF. Notably, the treatment with O3FA restored important enzymes and prevented harmful increases in certain inflammatory markers, showing its protective role against testicular dysfunction linked to thyroid issues.
Overall, this study indicates that incorporating Omega 3 fatty acids could be an effective strategy to counteract the negative impacts of BPF-induced hypothyroidism and support male reproductive health.
Read More
8
Fish oil benefits hypothyroid function
We set out to understand how fish oil, specifically eicosapentaenoic acid ethyl ester (EPA-E), might affect thyroid function in individuals with hypothyroidism. Previous observations noted that while plasma free fatty acid (FFA) levels are typically normal in people with hypothyroidism, some patients exhibited higher levels. Surprisingly, those with elevated FFA levels reported milder symptoms compared to those with lower concentrations.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
To investigate this further, we utilized an animal model involving rats that had been induced with hypothyroidism using a substance known as 1-methyl-2-imidazolethiol (MMI). By orally administering EPA-E, we aimed to see if it could counteract the hormonal disruptions caused by the MMI treatment. Our findings revealed that EPA-E played a positive role in maintaining thyroid hormone levels and preserving the structure of thyroid follicles.
Overall, our study suggests that higher levels of FFAs might influence thyroid function positively, and that EPA-E could potentially help mitigate some of the adverse effects of hypothyroidism. These insights could pave the way for exploring fish oil as a beneficial treatment option for those affected by thyroid dysfunction.
Read More
7
Fish oil improves mitochondrial function
We explored how fish oil, specifically omega-3 fatty acids, impacts mitochondrial function in hypothyroid rats compared to normal thyroid function. By examining mitochondrial proton leak—essentially how efficiently energy is used in cells—we found that hypothyroid rats had lower proton leak rates than those with normal thyroid function.
Interestingly, when hypothyroid rats were fed a diet with 5% omega-3 fatty acids, their proton leak rates dropped even further. We also noted this same trend in euthyroid rats that consumed the higher omega-3 diet, suggesting that increasing dietary omega-3 content can improve mitochondrial efficiency, regardless of thyroid status.
Our findings pointed to significant changes in the membranes of mitochondria, specifically with levels of omega-3 fatty acids being higher. This change corresponds with a favorable shift in the balance between omega-6 and omega-3 fatty acids, across several important phospholipid categories. Overall, it appears that both the hypothyroid state and the omega-3 dietary influence seem to work through similar biological pathways.
While the study clearly demonstrates how fish oil can affect mitochondrial function in thyroid-related conditions, it does highlight the complex interactions between diet and hormone status. Therefore, while fish oil shows promise, it operates within a broader context that includes both dietary and hormonal factors.
Interestingly, when hypothyroid rats were fed a diet with 5% omega-3 fatty acids, their proton leak rates dropped even further. We also noted this same trend in euthyroid rats that consumed the higher omega-3 diet, suggesting that increasing dietary omega-3 content can improve mitochondrial efficiency, regardless of thyroid status.
Our findings pointed to significant changes in the membranes of mitochondria, specifically with levels of omega-3 fatty acids being higher. This change corresponds with a favorable shift in the balance between omega-6 and omega-3 fatty acids, across several important phospholipid categories. Overall, it appears that both the hypothyroid state and the omega-3 dietary influence seem to work through similar biological pathways.
While the study clearly demonstrates how fish oil can affect mitochondrial function in thyroid-related conditions, it does highlight the complex interactions between diet and hormone status. Therefore, while fish oil shows promise, it operates within a broader context that includes both dietary and hormonal factors.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved symptoms
One of the best omega forms. I consume this regularly, and it has alleviated symptoms associated with my hypothyroidism, such as skin deterioration, concentration loss, sleep issues, irritability, mood swings, chronic fatigue, and worsened allergies. I rely on it due to my AIT and Hashimoto's disease, and my eldest son, aged 16, also takes it as he experiences fatigue from studying remotely.
Read More
7.5
Increased dosage
I regularly take this omega with my husband. Due to my hypothyroidism, I've been advised to increase my intake, so I now take three capsules daily.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Odetayo AF, Olayaki LA. Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities. JBRA Assist Reprod. 2024;28:471. 10.5935/1518-0557.20240033
- Abd Allah ES, Gomaa AM, Sayed MM. The effect of omega-3 on cognition in hypothyroid adult male rats. Acta Physiol Hung. 2014;101:362. 10.1556/APhysiol.101.2014.3.11
- Souza LL, Cordeiro A, Oliveira LS, de Paula GS, Faustino LC, et al. Thyroid hormone contributes to the hypolipidemic effect of polyunsaturated fatty acids from fish oil: in vivo evidence for cross talking mechanisms. J Endocrinol. 2011;211:65. 10.1530/JOE-11-0142
- Sinha RA, Khare P, Rai A, Maurya SK, Pathak A, et al. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci. 2009;27:377. 10.1016/j.ijdevneu.2009.02.003
- Makino M, Oda N, Miura N, Imamura S, Yamamoto K, et al. Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. J Endocrinol. 2001;171:259.
- Pehowich DJ. Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak. Biochim Biophys Acta. 1999;1411:192.
- Prigge WF, Gebhard RL. Oral acetylsalicylic acid induces biliary cholesterol secretion in the rat. Lipids. 1997;32:753.
- Prigge WF, Ketover SR, Gebhard RL. Thyroid hormone is required for dietary fish oil to induce hypersecretion of biliary cholesterol in the rat. Lipids. 1995;30:833.
- Simonides WS, van Hardeveld C. Effects of hypothyroidism on the distribution and fatty acyl composition of phospholipids in sarcoplasmic reticulum of fast skeletal muscle of the rat. Biochim Biophys Acta. 1987;924:204.
