Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9.5
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) can impact episodic migraines. In a carefully designed study, we gathered 70 participants who experienced these migraines and divided them into two groups. One group received a high dose of EPA, while the other was given a placebo. This approach ensured that we could see the true effects of EPA without bias.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
Read More
8
In a recent study aimed at understanding the role of eicosapentaenoic acid (EPA) in treating chronic migraines, we conducted a random, placebo-controlled trial with participants diagnosed with chronic migraines. The participants were split into two groups; one group received 1000 mg of EPA twice daily for eight weeks, while the other group took placebo softgels.
Our main focus was to evaluate whether daily EPA supplementation could reduce the frequency of migraine attacks and improve overall quality of life. We carefully tracked symptoms at four and eight weeks, relying on established measures like the Headache Impact Test-6 to quantify changes.
The results from this study were promising. We observed that taking 2000 mg of EPA daily showed potential benefits as a preventative treatment for chronic migraines. Participants reported a decrease in migraine headache days and lower severity levels, making it a valuable option to consider in managing chronic migraines effectively.
Our main focus was to evaluate whether daily EPA supplementation could reduce the frequency of migraine attacks and improve overall quality of life. We carefully tracked symptoms at four and eight weeks, relying on established measures like the Headache Impact Test-6 to quantify changes.
The results from this study were promising. We observed that taking 2000 mg of EPA daily showed potential benefits as a preventative treatment for chronic migraines. Participants reported a decrease in migraine headache days and lower severity levels, making it a valuable option to consider in managing chronic migraines effectively.
Read More
8
Eicosapentaenoic acid ineffective for migraines
We explored the effects of eicosapentaenoic acid on episodic migraine through a 12-week randomized double-blind clinical trial. This type of study is designed to rigorously assess the effectiveness of treatments by ensuring that neither the participants nor the researchers know who is receiving the actual treatment or a placebo.
Our goal was to see whether this omega-3 fatty acid could provide relief for those suffering from migraines. We observed how participants responded and measured the frequency and severity of their migraine attacks. Unfortunately, the results did not show a significant benefit of eicosapentaenoic acid in reducing migraine occurrences or intensity.
It is essential for those looking for migraine treatments to be aware that while eicosapentaenoic acid has been noted for various health benefits, our study concluded it does not effectively alleviate episodic migraines. Therefore, it may not be a viable option for migraine relief.
Our goal was to see whether this omega-3 fatty acid could provide relief for those suffering from migraines. We observed how participants responded and measured the frequency and severity of their migraine attacks. Unfortunately, the results did not show a significant benefit of eicosapentaenoic acid in reducing migraine occurrences or intensity.
It is essential for those looking for migraine treatments to be aware that while eicosapentaenoic acid has been noted for various health benefits, our study concluded it does not effectively alleviate episodic migraines. Therefore, it may not be a viable option for migraine relief.
Read More
Most Useful Reviews
7.5
Helpful migraine relief
107 people found this helpful
Best! I love this fish oil! It has undoubtedly rejuvenated my skin, which has become more elastic and smoother. At 56, post-menopause, my skin was fading despite hormonal treatments. This supplement, which I call “fish”, has saved my skin, hair, and nails. My sister’s thin hair has become stronger too. The high docosahexaenoic acid content is great for cardiovascular health and brain function. My migraines have reduced significantly. I highly recommend it, but remember to consult your doctor about the dosage.
Read More
7.5
Omega 3 benefits
2 people found this helpful
I’ve been taking Omega 3 for many years after a stroke and for migraines, and it truly is our lifeguard. I bought this Omega for its highly valued acid content. My husband and I take it for general health rather than specific effects, but I recommend it wholeheartedly.
Read More
10
Migraine cure
Excellent! It’s the only thing that effectively alleviates my migraines. I take two to three at once, and within an hour or two, my migraine subsides. It’s important to note that this is for real migraines, which do not respond to common pain relief.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9.5
We examined the effectiveness of high doses of omega-3 fatty acids, specifically EPA and DHA, in reducing migraine frequency and severity. By conducting a thorough analysis of randomized controlled trials involving over 6,600 participants, we found that these omega-3 supplements resulted in a significant reduction in migraine occurrences and intensity compared to a placebo.
Moreover, the acceptability rates for high dosage EPA/DHA were notably favorable, making it a strong candidate for migraine prevention. This evidence suggests that omega-3 fatty acids may be a top choice for those seeking effective migraine management.
Moreover, the acceptability rates for high dosage EPA/DHA were notably favorable, making it a strong candidate for migraine prevention. This evidence suggests that omega-3 fatty acids may be a top choice for those seeking effective migraine management.
Read More
9.5
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) can impact episodic migraines. In a carefully designed study, we gathered 70 participants who experienced these migraines and divided them into two groups. One group received a high dose of EPA, while the other was given a placebo. This approach ensured that we could see the true effects of EPA without bias.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.
Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.
This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.
Read More
9
We conducted a thorough investigation into how dietary adjustments, particularly focusing on the balance of omega-3 and omega-6 fatty acids, can help reduce the frequency and intensity of chronic headaches, which are often debilitating for many individuals. Our study involved a randomized, controlled trial with participants who were experiencing chronic daily headaches. After a four-week pre-intervention phase, we divided them into two groups, one receiving a high omega-3 plus low omega-6 dietary intervention and the other following a lower omega-6 intake only.
Throughout the 12-week intervention, we observed that those in the high omega-3 group not only reported significant improvements in their headache impact scores but also experienced fewer headache days and reduced headache hours per day. One of the key findings was the increased levels of specific antinociceptive biomarkers related to omega-3 fatty acids, which suggests that enhancing omega-3 intake can alter pain-relieving pathways in the body.
Although the study highlighted the benefits of this dietary approach, it’s important to note that isolating the specific impact of docosahexaenoic acid (DHA) alone was challenging due to the combined dietary changes implemented. Nevertheless, the general evidence suggests that shifting towards more omega-3 fatty acids while lowering omega-6 can lead to meaningful relief from chronic headaches, enhancing not only physical comfort but also the quality of life for individuals suffering from migraines.
Throughout the 12-week intervention, we observed that those in the high omega-3 group not only reported significant improvements in their headache impact scores but also experienced fewer headache days and reduced headache hours per day. One of the key findings was the increased levels of specific antinociceptive biomarkers related to omega-3 fatty acids, which suggests that enhancing omega-3 intake can alter pain-relieving pathways in the body.
Although the study highlighted the benefits of this dietary approach, it’s important to note that isolating the specific impact of docosahexaenoic acid (DHA) alone was challenging due to the combined dietary changes implemented. Nevertheless, the general evidence suggests that shifting towards more omega-3 fatty acids while lowering omega-6 can lead to meaningful relief from chronic headaches, enhancing not only physical comfort but also the quality of life for individuals suffering from migraines.
Read More
8
We explored the relationship between dietary intake of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, and the frequency of migraine attacks among migraine sufferers. In our study, we examined 105 participants aged 15 to 50, assessing their usual dietary habits through a food frequency questionnaire.
Our analysis revealed a significant finding: lower intakes of DHA were associated with more frequent migraine attacks. Specifically, we noticed that for each decrease in DHA consumption, there appeared to be a higher frequency of migraines, indicating a potential link between this fatty acid and migraine management. Notably, this trend was consistent across both men and women.
However, we did not find any significant relationship between the intake of saturated fatty acids (SFA) and migraine frequency. This suggests that while DHA may play a role in regulating migraine frequency, SFA does not appear to have the same effect. Overall, our findings point to the importance of omega-3 fatty acids in managing migraine symptoms, but further research is needed to deepen our understanding of this relationship.
Our analysis revealed a significant finding: lower intakes of DHA were associated with more frequent migraine attacks. Specifically, we noticed that for each decrease in DHA consumption, there appeared to be a higher frequency of migraines, indicating a potential link between this fatty acid and migraine management. Notably, this trend was consistent across both men and women.
However, we did not find any significant relationship between the intake of saturated fatty acids (SFA) and migraine frequency. This suggests that while DHA may play a role in regulating migraine frequency, SFA does not appear to have the same effect. Overall, our findings point to the importance of omega-3 fatty acids in managing migraine symptoms, but further research is needed to deepen our understanding of this relationship.
Read More
8
In a recent study aimed at understanding the role of eicosapentaenoic acid (EPA) in treating chronic migraines, we conducted a random, placebo-controlled trial with participants diagnosed with chronic migraines. The participants were split into two groups; one group received 1000 mg of EPA twice daily for eight weeks, while the other group took placebo softgels.
Our main focus was to evaluate whether daily EPA supplementation could reduce the frequency of migraine attacks and improve overall quality of life. We carefully tracked symptoms at four and eight weeks, relying on established measures like the Headache Impact Test-6 to quantify changes.
The results from this study were promising. We observed that taking 2000 mg of EPA daily showed potential benefits as a preventative treatment for chronic migraines. Participants reported a decrease in migraine headache days and lower severity levels, making it a valuable option to consider in managing chronic migraines effectively.
Our main focus was to evaluate whether daily EPA supplementation could reduce the frequency of migraine attacks and improve overall quality of life. We carefully tracked symptoms at four and eight weeks, relying on established measures like the Headache Impact Test-6 to quantify changes.
The results from this study were promising. We observed that taking 2000 mg of EPA daily showed potential benefits as a preventative treatment for chronic migraines. Participants reported a decrease in migraine headache days and lower severity levels, making it a valuable option to consider in managing chronic migraines effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Helpful migraine relief
107 people found this helpful
Best! I love this fish oil! It has undoubtedly rejuvenated my skin, which has become more elastic and smoother. At 56, post-menopause, my skin was fading despite hormonal treatments. This supplement, which I call “fish”, has saved my skin, hair, and nails. My sister’s thin hair has become stronger too. The high docosahexaenoic acid content is great for cardiovascular health and brain function. My migraines have reduced significantly. I highly recommend it, but remember to consult your doctor about the dosage.
Read More
7.5
Omega 3 benefits
2 people found this helpful
I’ve been taking Omega 3 for many years after a stroke and for migraines, and it truly is our lifeguard. I bought this Omega for its highly valued acid content. My husband and I take it for general health rather than specific effects, but I recommend it wholeheartedly.
Read More
10
Migraine cure
Excellent! It’s the only thing that effectively alleviates my migraines. I take two to three at once, and within an hour or two, my migraine subsides. It’s important to note that this is for real migraines, which do not respond to common pain relief.
Read More
9
Effective for migraines
I have been taking Omega 3 double concentration for over two weeks now. Previously, I used lower concentrations, but this higher ratio of DHA-500 is particularly beneficial for brain health and significantly aids in migraine relief. Thank you to the manufacturer!
Read More
9
Migraine relief achieved
I have been taking DHA500 for over nine months, with two capsules daily. I immediately felt more energetic and sporty, and my skin remained moisturised despite frequent washing. My hair is less split and more vibrant. I fell ill less often this year, and even during mild Covid, I largely escaped severe symptoms thanks to fish oil. Migraines during PMS have disappeared too. I’m very pleased and intend to continue.
Read More
Frequently Asked Questions
10
Migraine cure
Excellent! It’s the only thing that effectively alleviates my migraines. I take two to three at once, and within an hour or two, my migraine subsides. It’s important to note that this is for real migraines, which do not respond to common pain relief.
9
Effective for migraines
I have been taking Omega 3 double concentration for over two weeks now. Previously, I used lower concentrations, but this higher ratio of DHA-500 is particularly beneficial for brain health and significantly aids in migraine relief. Thank you to the manufacturer!
9
Migraine relief achieved
I have been taking DHA500 for over nine months, with two capsules daily. I immediately felt more energetic and sporty, and my skin remained moisturised despite frequent washing. My hair is less split and more vibrant. I fell ill less often this year, and even during mild Covid, I largely escaped severe symptoms thanks to fish oil. Migraines during PMS have disappeared too. I’m very pleased and intend to continue.
7.5
Omega 3 benefits
2 people found this helpful
I’ve been taking Omega 3 for many years after a stroke and for migraines, and it truly is our lifeguard. I bought this Omega for its highly valued acid content. My husband and I take it for general health rather than specific effects, but I recommend it wholeheartedly.
8
Migraines improved
These capsules are easy to swallow, reasonably sized, and do not repeat. The high EPA content was recommended for my migraines and arthritis, and I can attest that they’ve helped with both after taking two daily. I definitely recommend them!
9.5
We examined the effectiveness of high doses of omega-3 fatty acids, specifically EPA and DHA, in reducing migraine frequency and severity. By conducting a thorough analysis of randomized controlled trials involving over 6,600 participants, we found that these omega-3 supplements resulted in a significant reduction in migraine occurrences and intensity compared to a placebo.
Moreover, the acceptability rates for high dosage EPA/DHA were notably favorable, making it a strong candidate for migraine prevention. This evidence suggests that omega-3 fatty acids may be a top choice for those seeking effective migraine management.
Moreover, the acceptability rates for high dosage EPA/DHA were notably favorable, making it a strong candidate for migraine prevention. This evidence suggests that omega-3 fatty acids may be a top choice for those seeking effective migraine management.
9
We conducted a thorough investigation into how dietary adjustments, particularly focusing on the balance of omega-3 and omega-6 fatty acids, can help reduce the frequency and intensity of chronic headaches, which are often debilitating for many individuals. Our study involved a randomized, controlled trial with participants who were experiencing chronic daily headaches. After a four-week pre-intervention phase, we divided them into two groups, one receiving a high omega-3 plus low omega-6 dietary intervention and the other following a lower omega-6 intake only.
Throughout the 12-week intervention, we observed that those in the high omega-3 group not only reported significant improvements in their headache impact scores but also experienced fewer headache days and reduced headache hours per day. One of the key findings was the increased levels of specific antinociceptive biomarkers related to omega-3 fatty acids, which suggests that enhancing omega-3 intake can alter pain-relieving pathways in the body.
Although the study highlighted the benefits of this dietary approach, it’s important to note that isolating the specific impact of docosahexaenoic acid (DHA) alone was challenging due to the combined dietary changes implemented. Nevertheless, the general evidence suggests that shifting towards more omega-3 fatty acids while lowering omega-6 can lead to meaningful relief from chronic headaches, enhancing not only physical comfort but also the quality of life for individuals suffering from migraines.
Throughout the 12-week intervention, we observed that those in the high omega-3 group not only reported significant improvements in their headache impact scores but also experienced fewer headache days and reduced headache hours per day. One of the key findings was the increased levels of specific antinociceptive biomarkers related to omega-3 fatty acids, which suggests that enhancing omega-3 intake can alter pain-relieving pathways in the body.
Although the study highlighted the benefits of this dietary approach, it’s important to note that isolating the specific impact of docosahexaenoic acid (DHA) alone was challenging due to the combined dietary changes implemented. Nevertheless, the general evidence suggests that shifting towards more omega-3 fatty acids while lowering omega-6 can lead to meaningful relief from chronic headaches, enhancing not only physical comfort but also the quality of life for individuals suffering from migraines.
8
Eicosapentaenoic acid ineffective for migraines
We explored the effects of eicosapentaenoic acid on episodic migraine through a 12-week randomized double-blind clinical trial. This type of study is designed to rigorously assess the effectiveness of treatments by ensuring that neither the participants nor the researchers know who is receiving the actual treatment or a placebo.
Our goal was to see whether this omega-3 fatty acid could provide relief for those suffering from migraines. We observed how participants responded and measured the frequency and severity of their migraine attacks. Unfortunately, the results did not show a significant benefit of eicosapentaenoic acid in reducing migraine occurrences or intensity.
It is essential for those looking for migraine treatments to be aware that while eicosapentaenoic acid has been noted for various health benefits, our study concluded it does not effectively alleviate episodic migraines. Therefore, it may not be a viable option for migraine relief.
Our goal was to see whether this omega-3 fatty acid could provide relief for those suffering from migraines. We observed how participants responded and measured the frequency and severity of their migraine attacks. Unfortunately, the results did not show a significant benefit of eicosapentaenoic acid in reducing migraine occurrences or intensity.
It is essential for those looking for migraine treatments to be aware that while eicosapentaenoic acid has been noted for various health benefits, our study concluded it does not effectively alleviate episodic migraines. Therefore, it may not be a viable option for migraine relief.
We designed a study to explore how adjustments in our diet, specifically through increasing eicosapentaenoic acid (EPA), might influence migraine symptoms. This was a thorough, sixteen-week trial involving 153 participants dealing with episodic migraines. They were divided into three groups, each following a different dietary regimen aimed at altering their omega-3 and omega-6 fatty acid intake.
Participants received specific oils and foods to support their diets while undergoing a four-week baseline assessment. We wanted to find out if these dietary changes would lead to a reduction in the frequency and severity of migraines. Throughout the study, participants were unaware of the dietary hypothesis they were assigned to, and the assessors were also blinded to treatment assignments.
Our findings will provide insight into whether increasing EPA and potentially reducing linoleic acid in our daily meals can help reshape the biochemical pathways related to migraine pain. The hope is that we can identify a dietary approach to lessen headache symptoms and enhance overall quality of life for those plagued by frequent migraines.
Participants received specific oils and foods to support their diets while undergoing a four-week baseline assessment. We wanted to find out if these dietary changes would lead to a reduction in the frequency and severity of migraines. Throughout the study, participants were unaware of the dietary hypothesis they were assigned to, and the assessors were also blinded to treatment assignments.
Our findings will provide insight into whether increasing EPA and potentially reducing linoleic acid in our daily meals can help reshape the biochemical pathways related to migraine pain. The hope is that we can identify a dietary approach to lessen headache symptoms and enhance overall quality of life for those plagued by frequent migraines.
We conducted a study to determine if dietary changes, particularly increasing omega-3 fatty acids like docosahexaenoic acid (DHA), can alleviate migraines in active-duty service members who experience persistent post-traumatic headaches.
The trial involved 122 adult participants with diagnosed traumatic brain injury and frequent migraines. They followed a 4-week baseline period before being randomly assigned to one of two dietary regimens: one that increased omega-3s while reducing omega-6 fatty acids, and a control group maintaining a typical U.S. diet. Participants received oils and foods tailored to their diet for a significant portion of their nutritional needs, along with comprehensive dietary advice.
Throughout the study, we tracked daily headache occurrences and assessed clinical outcomes, including the impact on headaches through standardized measurement tools. While our focus was on DHA and its potential benefits for migraine relief, the study outcomes also depended significantly on other dietary modifications, which makes it challenging to isolate the effect of DHA alone.
As we analyzed the results, we found that dietary alterations targeting omega-3s might influence headache symptoms, but we need to be cautious in drawing definitive conclusions about DHA's individual effectiveness given the study's structure.
The trial involved 122 adult participants with diagnosed traumatic brain injury and frequent migraines. They followed a 4-week baseline period before being randomly assigned to one of two dietary regimens: one that increased omega-3s while reducing omega-6 fatty acids, and a control group maintaining a typical U.S. diet. Participants received oils and foods tailored to their diet for a significant portion of their nutritional needs, along with comprehensive dietary advice.
Throughout the study, we tracked daily headache occurrences and assessed clinical outcomes, including the impact on headaches through standardized measurement tools. While our focus was on DHA and its potential benefits for migraine relief, the study outcomes also depended significantly on other dietary modifications, which makes it challenging to isolate the effect of DHA alone.
As we analyzed the results, we found that dietary alterations targeting omega-3s might influence headache symptoms, but we need to be cautious in drawing definitive conclusions about DHA's individual effectiveness given the study's structure.
References
- Tseng PT, Zeng BY, Chen JJ, Kuo CH, Zeng BS, et al. High Dosage Omega-3 Fatty Acids Outperform Existing Pharmacological Options for Migraine Prophylaxis: A Network Meta-Analysis. Adv Nutr. 2024;15:100163. doi:10.1016/j.advnut.2023.100163
- Djalali M, Talebi S, Djalali E, Abdolahi M, Travica N, et al. The effect of omega-3 fatty acids supplementation on inflammatory biomarkers in subjects with migraine: a randomized, double-blind, placebo-controlled trial. Immunopharmacol Immunotoxicol. 2023;45:565. doi:10.1080/08923973.2023.2196600
- Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, et al. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. BMJ. 2021;374:n1448. doi:10.1136/bmj.n1448
- Sanders AE, Shaikh SR, Slade GD. Long-chain omega-3 fatty acids and headache in the U.S. population. Prostaglandins Leukot Essent Fatty Acids. 2018;135:47. doi:10.1016/j.plefa.2018.06.008
- Faurot KR, Cole WR, MacIntosh BA, Dunlap M, Moore CB, et al. Targeted dietary interventions to reduce pain in persistent post-traumatic headache among service members: Protocol for a randomized, controlled parallel-group trial. Contemp Clin Trials. 2022;119:106851. doi:10.1016/j.cct.2022.106851
- Maghsoumi-Norouzabad L, Mansoori A, Abed R, Shishehbor F. Effects of omega-3 fatty acids on the frequency, severity, and duration of migraine attacks: A systematic review and meta-analysis of randomized controlled trials. Nutr Neurosci. 2018;21:614. doi:10.1080/1028415X.2017.1344371
- Sadeghi O, Maghsoudi Z, Khorvash F, Ghiasvand R, Askari G. The relationship between different fatty acids intake and frequency of migraine attacks. Iran J Nurs Midwifery Res. 2015;20:334.
- Ramsden CE, Faurot KR, Zamora D, Suchindran CM, MacIntosh BA, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154:2441. doi:10.1016/j.pain.2013.07.028
- Pradalier A, Bakouche P, Baudesson G, Delage A, Cornaille-Lafage G, et al. Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. Cephalalgia. 2001;21:818.
- Mohammadnezhad G, Assarzadegan F, Koosha M, Esmaily H. Eicosapentaenoic acid versus placebo as adjunctive therapy in chronic migraine: A randomized controlled trial. Headache. 2025;65:153. doi:10.1111/head.14808
- You ZB, Cao P. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;121:121. doi:10.1016/j.bbi.2024.07.014
- Chen TB, Yang CC, Tsai IJ, Yang HW, Hsu YC, et al. Neuroimmunological effects of omega-3 fatty acids on migraine: a review. Front Neurol. 2024;15:1366372. doi:10.3389/fneur.2024.1366372
- Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. doi:10.1016/j.bbi.2024.03.019
- Mann JD, Faurot KR, MacIntosh B, Palsson OS, Suchindran CM, et al. A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol. Prostaglandins Leukot Essent Fatty Acids. 2018;128:41. doi:10.1016/j.plefa.2017.11.002
- Soares AA, Louçana PMC, Nasi EP, Sousa KMH, Sá OMS, et al. A double- blind, randomized, and placebo-controlled clinical trial with omega-3 polyunsaturated fatty acids (OPFA ɷ-3) for the prevention of migraine in chronic migraine patients using amitriptyline. Nutr Neurosci. 2018;21:219. doi:10.1080/1028415X.2016.1266133
- Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002;21:495.
