Last update
3/21/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Selenium (elemental) (from 5 mg L-Selenomethionine)
25 mcg
45%
N-Acetyl Cysteine (NAC)
600 mg
†
Top Medical Research Studies
9.5
Selenium nanoparticles reduce liver toxicity
We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
Read More
8
We examined how selenium nanoparticles might help combat liver damage caused by cadmium, a dangerous environmental toxin. By studying both animal models and liver cells, we found that these nanoparticles could reduce cell injuries linked to a damaging process called ferroptosis.
Our findings indicated that achieving this protective effect involves enhancing certain liver enzyme activities and altering several protein levels associated with oxidative stress. Overall, while selenium shows promise in mitigating liver damage, particularly against cadmium toxicity, further research could better clarify its mechanisms and potential benefits.
Our findings indicated that achieving this protective effect involves enhancing certain liver enzyme activities and altering several protein levels associated with oxidative stress. Overall, while selenium shows promise in mitigating liver damage, particularly against cadmium toxicity, further research could better clarify its mechanisms and potential benefits.
Read More
9
We explored the potential of selenium in addressing liver damage caused by alcohol. The study employed both in vitro and in vivo methods to assess how selenium affects liver cells exposed to ethanol.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Read More
Most Useful Reviews
9
Restores liver health
45 people found this helpful
I've relied on this for 15 years, recommending it widely for liver repair and restoration. My son reversed his fatty liver disease within months. We never faced the reported "spotting" issues, and I appreciate the natural sulphur smell, indicating glutathione production by the liver. Despite its age, I trust its quality and find it effective for maintaining liver health.
Read More
9
Essential liver protection
92 people found this helpful
Excellent product! I discovered it while searching for a liver protector against Acetaminophen. N-acetyl cysteine (NAC) has proven invaluable in defending against lethal health threats, including acetaminophen toxicity leading to acute liver failure. It replenishes antioxidant glutathione levels and regulates genes related to oxidative stress and inflammation. NAC benefits include protection against influenza and various chronic diseases, making it a vital addition for overall health.
Read More
7.5
Boosts liver detoxification
28 people found this helpful
I take this under my doctor's advice for Hashimoto's. N-acetyl cysteine is a trusted antioxidant, detoxifying agent, and free-radical scavenger. It enhances glutathione levels, crucial for liver detox, especially for those with diabetes. After adjusting my dosage, I experienced no issues and continue to rely on this high-quality product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
- All Researches
9.5
Selenium nanoparticles reduce liver toxicity
We investigated how selenium nanoparticles (Se-NPs) and chitosan-encapsulated selenium nanoparticles (Se-CS-NPs) can mitigate liver toxicity induced by carbon tetrachloride (CCl) in rats. In our study, eighty rats were divided into eight groups, including placebo and control.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
The findings indicated that both forms of selenium helped in reducing liver damage by influencing key biological markers. Notably, while selenium was effective, encapsulating it with chitosan did not provide additional benefits. Overall, these nanoparticles could be a valuable treatment option against liver toxicity.
Read More
9
We aimed to investigate the role of selenium and coenzyme Q in addressing liver damage caused by a methionine choline-deficient diet in mice. Over four weeks, mice receiving the combination treatment showed significant reductions in liver inflammation, fibrosis, and oxidative stress.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
The results suggested that this combined supplementation might hold therapeutic potential against metabolic dysfunction-associated liver injury. While our findings are promising, they are based on an animal model, and further research is necessary to explore their implications for human liver disease.
Read More
9
Selenium enhances liver health
We set out to investigate if selenium, along with glutathione, can help reduce liver injury caused by a cancer-inducing substance in mice. Over 20 weeks, we divided male mice into different groups, some receiving selenium and others just glutathione, while monitoring their liver function.
Our findings revealed that both supplements significantly improved liver conditions and antioxidant levels. Interestingly, adding selenium to glutathione treatment worked even better, enhancing the liver’s ability to handle oxidative stress. Overall, selenium appears to be a promising ally in supporting liver health and reducing injury.
Our findings revealed that both supplements significantly improved liver conditions and antioxidant levels. Interestingly, adding selenium to glutathione treatment worked even better, enhancing the liver’s ability to handle oxidative stress. Overall, selenium appears to be a promising ally in supporting liver health and reducing injury.
Read More
9
We explored the potential of selenium in addressing liver damage caused by alcohol. The study employed both in vitro and in vivo methods to assess how selenium affects liver cells exposed to ethanol.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Our findings indicated that selenium improved cell viability, reduced oxidative stress markers, and altered certain protein expressions related to cell death. In particular, selenomethionine showed a notable impact in protecting liver cells.
Overall, selenium appears promising for alleviating ethanol-induced liver injury by regulating important cellular processes. However, results suggest that further research is needed to fully understand its effectiveness.
Read More
8
We investigated whether selenium-modified Bletilla striata polysaccharide (Se-BSP) could effectively reduce liver fibrosis. Our findings revealed that Se-BSP not only improved its antioxidant properties but also showed greater efficacy in alleviating liver fibrosis compared to its unmodified version at a specific concentration. This study underscores the potential of Se-BSP as a promising treatment for liver fibrosis, a condition that can lead to more severe liver diseases.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Restores liver health
45 people found this helpful
I've relied on this for 15 years, recommending it widely for liver repair and restoration. My son reversed his fatty liver disease within months. We never faced the reported "spotting" issues, and I appreciate the natural sulphur smell, indicating glutathione production by the liver. Despite its age, I trust its quality and find it effective for maintaining liver health.
Read More
9
Essential liver protection
92 people found this helpful
Excellent product! I discovered it while searching for a liver protector against Acetaminophen. N-acetyl cysteine (NAC) has proven invaluable in defending against lethal health threats, including acetaminophen toxicity leading to acute liver failure. It replenishes antioxidant glutathione levels and regulates genes related to oxidative stress and inflammation. NAC benefits include protection against influenza and various chronic diseases, making it a vital addition for overall health.
Read More
7.5
Boosts liver detoxification
28 people found this helpful
I take this under my doctor's advice for Hashimoto's. N-acetyl cysteine is a trusted antioxidant, detoxifying agent, and free-radical scavenger. It enhances glutathione levels, crucial for liver detox, especially for those with diabetes. After adjusting my dosage, I experienced no issues and continue to rely on this high-quality product.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Jiang G, Kong H, Wang Y, Wang Y, Zhou J, et al. Antioxidant and hepatic fibrosis-alleviating effects of selenium-modified Bletilla striata polysaccharide. Int J Biol Macromol. 2025;301:140234. 10.1016/j.ijbiomac.2025.140234
- Choi H, Choi J, Go Y, Chung J. Coenzyme Q and Selenium Co-Supplementation Alleviate Methionine Choline-Deficient Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice. Nutrients. 2025;17. 10.3390/nu17020229
- Guo W, Weng T, Song Y. Association of serum selenium with MASLD and liver fibrosis: A cross-sectional study. PLoS One. 2024;19:e0314780. 10.1371/journal.pone.0314780
- Yang Z, Lian J, Li J, Guo W, Ni L, et al. Intestinal Microbiomics and Liver Metabolomics Insights into the Ameliorative Effects of Selenium-Enriched FZU3103 on Alcohol-Induced Liver Injury in Mice. J Agric Food Chem. 2025;73:3232. 10.1021/acs.jafc.4c06072
- Shen Q, Liu Y, Li J, Zhou D. Nano-Selenium Modulates NF-κB/NLRP3 Pathway and Mitochondrial Dynamics to Attenuate Microplastic-Induced Liver Injury. Nutrients. 2024;16. 10.3390/nu16223878
- Liu Q, Bi J, Fan G, Wu M, Qin X, et al. Association between multiple metals exposure and metabolic dysfunction-associated fatty liver disease among Chinese adults. J Trace Elem Med Biol. 2024;86:127566. 10.1016/j.jtemb.2024.127566
- Chen X, Lin X. Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway. Poult Sci. 2025;104:104449. 10.1016/j.psj.2024.104449
- Mrwad AA, El-Shafey SE, Said NM. Chitosan-encapsulated selenium nanoparticles alleviate CCl induced hepatotoxicity through synergistically modulating NF-κB and Nrf2 signaling pathways and regulating Bcl-2 and Caspase-3 expression: A comprehensive study with multiple regression analysis. J Trace Elem Med Biol. 2024;86:127563. 10.1016/j.jtemb.2024.127563
- Hsiao YF, Huang SC, Cheng SB, Hsu CC, Huang YC. Glutathione and Selenium Supplementation Attenuates Liver Injury in Diethylnitrosamine-Induced Hepatocarcinogenic Mice by Enhancing Glutathione-Related Antioxidant Capacities. Int J Mol Sci. 2024;25. 10.3390/ijms252111339
- Cengiz M, Gür B, Gür F, Şahintürk V, Bayrakdar A, et al. The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats. Heliyon. 2024;10:e38713. 10.1016/j.heliyon.2024.e38713
- Chen F, Li Q, Xu X, Wang F. Selenium Attenuates Ethanol-induced Hepatocellular Injury by Regulating Ferroptosis and Apoptosis. Turk J Gastroenterol. 2024;35:778. 10.5152/tjg.2024.24159
- Abdel-Wahhab KG, Ashry M, Hassan LK, El-Azma MH, Elqattan GM, et al. Hepatic and immune modulatory effectiveness of lactoferrin loaded Selenium nanoparticles on bleomycin induced hepatic injury. Sci Rep. 2024;14:21066. 10.1038/s41598-024-70894-6
- Shao C, Luo T, Wang S, Li Z, Yu X, et al. Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro. Chemosphere. 2024;364:143004. 10.1016/j.chemosphere.2024.143004
- Liu Y, Wang R. Association between serum selenium and non-alcoholic fatty liver disease: Results from NHANES: An observational study. Medicine (Baltimore). 2024;103:e38845. 10.1097/MD.0000000000038845
- Huertas-Abril PV, Prieto-Álamo MJ, Jurado J, Pérez J, Molina-Hernández V, et al. Transcriptional and biochemical changes in mouse liver following exposure to a metal/drug cocktail. Attenuating effect of a selenium-enriched diet. Food Chem Toxicol. 2024;191:114845. 10.1016/j.fct.2024.114845
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