Last update
5/4/2025

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Selenium (elemental) (from 5 mg L-Selenomethionine)
25 mcg
45%
N-Acetyl Cysteine (NAC)
600 mg

Top Medical Research Studies

7
Selenium showed no significant effects
We examined a clinical trial that investigates whether selenium supplementation can help alleviate migraine symptoms. In this randomized, double-blinded study, 72 patients were divided into two groups: one received a daily selenium supplement while the other got a placebo, all over 12 weeks.

We tracked headache severity, frequency, and mental health markers like anxiety and depression, alongside measuring oxidative stress biomarkers. Despite the hopes for selenium’s antioxidant benefits, the trial did not find significant improvements in migraine symptoms or related health measures.
7
Selenium low in migraine patients
We assessed the link between selenium levels and migraine in a case-control study involving 31 migraine patients and 30 healthy controls. Our findings revealed that migraine patients had significantly lower selenium levels and higher levels of malondialdehyde, a marker of oxidative stress.

Intriguingly, those with the lowest selenium levels were about eleven times more likely to experience migraines compared to those with the highest levels. However, no significant differences were observed in total antioxidant capacity between the two groups, indicating that while selenium appears connected to migraine risk, it does not directly reduce migraine frequency.

Most Useful Reviews

9
Life-saving supplement
13 people found this helpful
This is a miracle supplement! I have chronic inflammatory issues and have tried countless remedies since 2013 with no success. Since taking this along with L-glutamine, my migraine symptoms are virtually gone, and my energy and mood have improved significantly.
7.5
Great antioxidant
4 people found this helpful
This was the best-priced option when I purchased it. I started with 2-4 a day while dealing with severe migraines and sensitivities. I feel this has made a significant difference. When I sense a headache coming on, I take a couple, and it seems to stop it. NAC is a great antioxidant and more affordable than glutathione.
6
Saves money
6 people found this helpful
Exactly what I needed! I use NAC to enhance my other medications for fibromyalgia. It helps my body process the medicine more efficiently, allowing me to stay at a low dose. I've also found it beneficial for migraines and insomnia.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
  • All Researches
7
Selenium showed no significant effects
We examined a clinical trial that investigates whether selenium supplementation can help alleviate migraine symptoms. In this randomized, double-blinded study, 72 patients were divided into two groups: one received a daily selenium supplement while the other got a placebo, all over 12 weeks.

We tracked headache severity, frequency, and mental health markers like anxiety and depression, alongside measuring oxidative stress biomarkers. Despite the hopes for selenium’s antioxidant benefits, the trial did not find significant improvements in migraine symptoms or related health measures.
7
Selenium low in migraine patients
We assessed the link between selenium levels and migraine in a case-control study involving 31 migraine patients and 30 healthy controls. Our findings revealed that migraine patients had significantly lower selenium levels and higher levels of malondialdehyde, a marker of oxidative stress.

Intriguingly, those with the lowest selenium levels were about eleven times more likely to experience migraines compared to those with the highest levels. However, no significant differences were observed in total antioxidant capacity between the two groups, indicating that while selenium appears connected to migraine risk, it does not directly reduce migraine frequency.

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Life-saving supplement
13 people found this helpful
This is a miracle supplement! I have chronic inflammatory issues and have tried countless remedies since 2013 with no success. Since taking this along with L-glutamine, my migraine symptoms are virtually gone, and my energy and mood have improved significantly.
7.5
Great antioxidant
4 people found this helpful
This was the best-priced option when I purchased it. I started with 2-4 a day while dealing with severe migraines and sensitivities. I feel this has made a significant difference. When I sense a headache coming on, I take a couple, and it seems to stop it. NAC is a great antioxidant and more affordable than glutathione.
6
Saves money
6 people found this helpful
Exactly what I needed! I use NAC to enhance my other medications for fibromyalgia. It helps my body process the medicine more efficiently, allowing me to stay at a low dose. I've also found it beneficial for migraines and insomnia.

Frequently Asked Questions

No FAQs are available for this product and symptom.

References

  1. Balali A, Sadeghi O, Anjom-Shoae J, Rouhani MH, Khorvash F, et al. The effect of selenium supplementation on oxidative stress, clinical symptoms and mental health status in patients with migraine: a study protocol for a double-blinded randomized clinical trial. Trials. 2024;25:209. 10.1186/s13063-024-08018-8
  2. Talaie A, Jafary H, Faraji F, Malekirad AA. The Serum Oxidative Stress Biomarkers and Selenium Levels in a Group of Migraine Patients Compared with Healthy Controls: a Case-Control Study. Biol Trace Elem Res. 2022;200:4250. 10.1007/s12011-021-03024-2
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