' 
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Polygonum cuspidatum Extract Complex (Root/Rhizome) (Japanese Knotweed) (Trans-Resveratrol - 200 mg)
400 mg
**
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
10 mg
**
Top Medical Research Studies
9
Resveratrol protects brain health
Neuroprotection elicited by resveratrol in a rat model of hypothyroidism: Possible involvement of cholinergic signaling and redox status.
High relevance to hypothyroidism research
We investigated the impact of resveratrol on brain health in a rat model of hypothyroidism, a condition marked by low thyroid hormone levels that can lead to cognitive decline. Our study primarily focused on how resveratrol could influence the cholinergic system, which is crucial for neurotransmission, and the overall oxidative stress status in these rats.
Notably, hypothyroidism led to an increase in an enzyme called acetylcholinesterase (AChE), which can harm memory function by breaking down an essential neurotransmitter. Additionally, we observed an uptick in harmful reactive oxygen species (ROS) levels in the brain, showcasing a troubling balance in oxidative stress.
Following resveratrol treatment, we noticed a significant reduction in AChE levels in the brain, implying a protective effect on neurotransmission. Moreover, resveratrol improved redox status, as evidenced by lower ROS levels and better preservation of neuronal health indicators.
Overall, our findings strongly suggest that resveratrol may offer protective benefits against cognitive decline associated with hypothyroidism. It highlights the potential of this natural compound in promoting brain health when thyroid function is compromised.
Notably, hypothyroidism led to an increase in an enzyme called acetylcholinesterase (AChE), which can harm memory function by breaking down an essential neurotransmitter. Additionally, we observed an uptick in harmful reactive oxygen species (ROS) levels in the brain, showcasing a troubling balance in oxidative stress.
Following resveratrol treatment, we noticed a significant reduction in AChE levels in the brain, implying a protective effect on neurotransmission. Moreover, resveratrol improved redox status, as evidenced by lower ROS levels and better preservation of neuronal health indicators.
Overall, our findings strongly suggest that resveratrol may offer protective benefits against cognitive decline associated with hypothyroidism. It highlights the potential of this natural compound in promoting brain health when thyroid function is compromised.
Read More
9
Resveratrol improves hypothyroid cognition
Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization.
Direct investigation of effects
We explored the impact of resveratrol—a natural compound—on spatial learning and memory in rats suffering from subclinical hypothyroidism (SCH). This condition was induced in our study through a surgical method known as hemi-thyroid electrocauterization, which allowed us to observe the resulting changes in behavior and brain function.
Using tasks like the Morris water maze and Y-maze, we tested the learning and memory capabilities of these rats and found notable impairments due to SCH. Fortunately, when we administered resveratrol (at a dose of 15 mg/kg), alongside levothyroxine, we observed significant improvements in both learning and memory functions. Interestingly, resveratrol appeared to lower elevated levels of thyroid-stimulating hormone (TSH), indicating a positive effect on the hypothalamus-pituitary-thyroid (HPT) axis, which is often disrupted in hypothyroidism.
Beyond hormone levels, resveratrol treatment also increased the expression of crucial proteins in the brain linked to memory and learning, particularly synaptotagmin-1 (syt-1) and brain-derived neurotrophic factor (BDNF). Overall, these findings suggest that resveratrol could benefit cognitive functions in hypothyroid states by addressing hormonal imbalances and enhancing brain health.
Using tasks like the Morris water maze and Y-maze, we tested the learning and memory capabilities of these rats and found notable impairments due to SCH. Fortunately, when we administered resveratrol (at a dose of 15 mg/kg), alongside levothyroxine, we observed significant improvements in both learning and memory functions. Interestingly, resveratrol appeared to lower elevated levels of thyroid-stimulating hormone (TSH), indicating a positive effect on the hypothalamus-pituitary-thyroid (HPT) axis, which is often disrupted in hypothyroidism.
Beyond hormone levels, resveratrol treatment also increased the expression of crucial proteins in the brain linked to memory and learning, particularly synaptotagmin-1 (syt-1) and brain-derived neurotrophic factor (BDNF). Overall, these findings suggest that resveratrol could benefit cognitive functions in hypothyroid states by addressing hormonal imbalances and enhancing brain health.
Read More
8
Resveratrol improves hypothyroidism symptoms
Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway.
Study highlights resveratrol's potential
We aimed to explore the effects of resveratrol on anxiety and depression-like behaviors in rats with subclinical hypothyroidism (SCH). In our study, we induced an SCH model in rats and treated them with either resveratrol or a conventional thyroid hormone replacement therapy called levothyroxine (LT4). Over a 16-day period, we observed changes in behavior, hormone levels, and several brain pathways linked to these conditions.
Our findings indicated that resveratrol effectively reduced elevated thyroid-stimulating hormone levels and improved behavioral outcomes. Rats receiving resveratrol exhibited a noticeable increase in exploratory activity and a decrease in depressive-like behavior. Specifically, they showed greater tendencies to explore and preferred sweet solutions over plain water, which are indicators of improved mood and motivation.
Furthermore, the treatment with resveratrol was associated with lowered stress hormone levels, reflecting a calmer state in the rats. We also noted that resveratrol positively influenced certain brain pathways related to mood regulation, which could explain its antidepressant effects. Overall, our research suggests that resveratrol may offer a promising avenue for alleviating anxiety and depression associated with hypothyroidism.
Our findings indicated that resveratrol effectively reduced elevated thyroid-stimulating hormone levels and improved behavioral outcomes. Rats receiving resveratrol exhibited a noticeable increase in exploratory activity and a decrease in depressive-like behavior. Specifically, they showed greater tendencies to explore and preferred sweet solutions over plain water, which are indicators of improved mood and motivation.
Furthermore, the treatment with resveratrol was associated with lowered stress hormone levels, reflecting a calmer state in the rats. We also noted that resveratrol positively influenced certain brain pathways related to mood regulation, which could explain its antidepressant effects. Overall, our research suggests that resveratrol may offer a promising avenue for alleviating anxiety and depression associated with hypothyroidism.
Read More
Most Useful Reviews
8.8
Unique treatment effect
Rasveratrol is a unique antiviral and antibacterial drug that binds free radicals and offers cardioprotective benefits. I was recommended this by an endocrinologist to manage my hypothyroidism and improve my well-being. I take one capsule daily after breakfast and feel it's safe for long-term use. I will definitely order again.
Read More
9.5
Improved well-being
After taking L-thyroxin for my hypothyroidism, I felt quite unwell with fatigue and weakness. However, since I switched to this new treatment, I feel significantly better.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
9
Resveratrol protects brain health
Neuroprotection elicited by resveratrol in a rat model of hypothyroidism: Possible involvement of cholinergic signaling and redox status.
High relevance to hypothyroidism research
We investigated the impact of resveratrol on brain health in a rat model of hypothyroidism, a condition marked by low thyroid hormone levels that can lead to cognitive decline. Our study primarily focused on how resveratrol could influence the cholinergic system, which is crucial for neurotransmission, and the overall oxidative stress status in these rats.
Notably, hypothyroidism led to an increase in an enzyme called acetylcholinesterase (AChE), which can harm memory function by breaking down an essential neurotransmitter. Additionally, we observed an uptick in harmful reactive oxygen species (ROS) levels in the brain, showcasing a troubling balance in oxidative stress.
Following resveratrol treatment, we noticed a significant reduction in AChE levels in the brain, implying a protective effect on neurotransmission. Moreover, resveratrol improved redox status, as evidenced by lower ROS levels and better preservation of neuronal health indicators.
Overall, our findings strongly suggest that resveratrol may offer protective benefits against cognitive decline associated with hypothyroidism. It highlights the potential of this natural compound in promoting brain health when thyroid function is compromised.
Notably, hypothyroidism led to an increase in an enzyme called acetylcholinesterase (AChE), which can harm memory function by breaking down an essential neurotransmitter. Additionally, we observed an uptick in harmful reactive oxygen species (ROS) levels in the brain, showcasing a troubling balance in oxidative stress.
Following resveratrol treatment, we noticed a significant reduction in AChE levels in the brain, implying a protective effect on neurotransmission. Moreover, resveratrol improved redox status, as evidenced by lower ROS levels and better preservation of neuronal health indicators.
Overall, our findings strongly suggest that resveratrol may offer protective benefits against cognitive decline associated with hypothyroidism. It highlights the potential of this natural compound in promoting brain health when thyroid function is compromised.
Read More
9
Resveratrol improves hypothyroid cognition
Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization.
Direct investigation of effects
We explored the impact of resveratrol—a natural compound—on spatial learning and memory in rats suffering from subclinical hypothyroidism (SCH). This condition was induced in our study through a surgical method known as hemi-thyroid electrocauterization, which allowed us to observe the resulting changes in behavior and brain function.
Using tasks like the Morris water maze and Y-maze, we tested the learning and memory capabilities of these rats and found notable impairments due to SCH. Fortunately, when we administered resveratrol (at a dose of 15 mg/kg), alongside levothyroxine, we observed significant improvements in both learning and memory functions. Interestingly, resveratrol appeared to lower elevated levels of thyroid-stimulating hormone (TSH), indicating a positive effect on the hypothalamus-pituitary-thyroid (HPT) axis, which is often disrupted in hypothyroidism.
Beyond hormone levels, resveratrol treatment also increased the expression of crucial proteins in the brain linked to memory and learning, particularly synaptotagmin-1 (syt-1) and brain-derived neurotrophic factor (BDNF). Overall, these findings suggest that resveratrol could benefit cognitive functions in hypothyroid states by addressing hormonal imbalances and enhancing brain health.
Using tasks like the Morris water maze and Y-maze, we tested the learning and memory capabilities of these rats and found notable impairments due to SCH. Fortunately, when we administered resveratrol (at a dose of 15 mg/kg), alongside levothyroxine, we observed significant improvements in both learning and memory functions. Interestingly, resveratrol appeared to lower elevated levels of thyroid-stimulating hormone (TSH), indicating a positive effect on the hypothalamus-pituitary-thyroid (HPT) axis, which is often disrupted in hypothyroidism.
Beyond hormone levels, resveratrol treatment also increased the expression of crucial proteins in the brain linked to memory and learning, particularly synaptotagmin-1 (syt-1) and brain-derived neurotrophic factor (BDNF). Overall, these findings suggest that resveratrol could benefit cognitive functions in hypothyroid states by addressing hormonal imbalances and enhancing brain health.
Read More
8
Resveratrol improves hypothyroidism symptoms
Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway.
Study highlights resveratrol's potential
We aimed to explore the effects of resveratrol on anxiety and depression-like behaviors in rats with subclinical hypothyroidism (SCH). In our study, we induced an SCH model in rats and treated them with either resveratrol or a conventional thyroid hormone replacement therapy called levothyroxine (LT4). Over a 16-day period, we observed changes in behavior, hormone levels, and several brain pathways linked to these conditions.
Our findings indicated that resveratrol effectively reduced elevated thyroid-stimulating hormone levels and improved behavioral outcomes. Rats receiving resveratrol exhibited a noticeable increase in exploratory activity and a decrease in depressive-like behavior. Specifically, they showed greater tendencies to explore and preferred sweet solutions over plain water, which are indicators of improved mood and motivation.
Furthermore, the treatment with resveratrol was associated with lowered stress hormone levels, reflecting a calmer state in the rats. We also noted that resveratrol positively influenced certain brain pathways related to mood regulation, which could explain its antidepressant effects. Overall, our research suggests that resveratrol may offer a promising avenue for alleviating anxiety and depression associated with hypothyroidism.
Our findings indicated that resveratrol effectively reduced elevated thyroid-stimulating hormone levels and improved behavioral outcomes. Rats receiving resveratrol exhibited a noticeable increase in exploratory activity and a decrease in depressive-like behavior. Specifically, they showed greater tendencies to explore and preferred sweet solutions over plain water, which are indicators of improved mood and motivation.
Furthermore, the treatment with resveratrol was associated with lowered stress hormone levels, reflecting a calmer state in the rats. We also noted that resveratrol positively influenced certain brain pathways related to mood regulation, which could explain its antidepressant effects. Overall, our research suggests that resveratrol may offer a promising avenue for alleviating anxiety and depression associated with hypothyroidism.
Read More
7
Resveratrol aids thyroid health
Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity.
Mixed potential in treatment
We investigated the effects of resveratrol, along with lipoic acid and quercetin, on thyroid hormone alterations related to long-term obesity. Female C57BL/6 mice were divided into groups and fed a high-fat diet, with some receiving lipoic acid, resveratrol, or quercetin, while others followed a normal diet over 26 weeks.
Our findings revealed that the high-fat diet led to increased body weight and blood pressure and a decrease in plasma levels of triiodothyronine, a key thyroid hormone. Notably, resveratrol, along with lipoic acid and quercetin, helped mitigate weight gain and restored some thyroid hormone levels. We observed improvements in oxidative stress markers as well, indicating that these compounds function as antioxidants.
Resveratrol seemed to play a role in decreasing the expression of TRα1, a thyroid hormone receptor, while increasing the activity of specific deiodinase enzymes which help convert thyroid hormones to their active forms. Additionally, resveratrol supplementation significantly reduced the activity of angiotensin-converting enzyme (ACE), which is often linked to cardiovascular problems.
Overall, our research suggests that resveratrol, along with the other compounds tested, shows potential benefits in balancing thyroid hormone levels and reducing oxidative stress in the context of obesity. This insight may open doors to treating heart diseases associated with thyroid dysfunction and obesity.
Our findings revealed that the high-fat diet led to increased body weight and blood pressure and a decrease in plasma levels of triiodothyronine, a key thyroid hormone. Notably, resveratrol, along with lipoic acid and quercetin, helped mitigate weight gain and restored some thyroid hormone levels. We observed improvements in oxidative stress markers as well, indicating that these compounds function as antioxidants.
Resveratrol seemed to play a role in decreasing the expression of TRα1, a thyroid hormone receptor, while increasing the activity of specific deiodinase enzymes which help convert thyroid hormones to their active forms. Additionally, resveratrol supplementation significantly reduced the activity of angiotensin-converting enzyme (ACE), which is often linked to cardiovascular problems.
Overall, our research suggests that resveratrol, along with the other compounds tested, shows potential benefits in balancing thyroid hormone levels and reducing oxidative stress in the context of obesity. This insight may open doors to treating heart diseases associated with thyroid dysfunction and obesity.
Read More
7
Resveratrol's role in hypothyroidism
NEW INSIGHTS INTO THE HYPOTHALAMIC-PITUITARY-THYROID AXIS.
Relevant to thyroid disease insight
We examined the potential benefits of resveratrol in treating hypothyroidism, particularly in cases where patients also experience anxiety or depression. Recent research revealed that resveratrol could adjust the hypothalamic-pituitary-thyroid (HPT) axis, which is crucial for regulating thyroid function.
The study highlights that resveratrol significantly lowers the expression of both TSH and TRH mRNA. This means it might help make the thyroid function more balanced, especially in subclinical hypothyroid patients. Alongside this, resveratrol has shown anxiolytic and antidepressant effects in research involving rats, prompting considerations for using it as an adjunct treatment in hypothyroidism.
However, it’s essential to remain aware of other factors that can influence the HPT axis, such as existing medications and health conditions. Overall, our findings suggest that resveratrol could be a promising adjunct therapy for those dealing with hypothyroid conditions, particularly when mental health issues are also present.
The study highlights that resveratrol significantly lowers the expression of both TSH and TRH mRNA. This means it might help make the thyroid function more balanced, especially in subclinical hypothyroid patients. Alongside this, resveratrol has shown anxiolytic and antidepressant effects in research involving rats, prompting considerations for using it as an adjunct treatment in hypothyroidism.
However, it’s essential to remain aware of other factors that can influence the HPT axis, such as existing medications and health conditions. Overall, our findings suggest that resveratrol could be a promising adjunct therapy for those dealing with hypothyroid conditions, particularly when mental health issues are also present.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Improved well-being
After taking L-thyroxin for my hypothyroidism, I felt quite unwell with fatigue and weakness. However, since I switched to this new treatment, I feel significantly better.
8.8
Unique treatment effect
Rasveratrol is a unique antiviral and antibacterial drug that binds free radicals and offers cardioprotective benefits. I was recommended this by an endocrinologist to manage my hypothyroidism and improve my well-being. I take one capsule daily after breakfast and feel it's safe for long-term use. I will definitely order again.
Read More
