Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 11 Reviews
8.1
Supplement Facts
Serving Size: 1 Fish Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Cholesterol
<5 mg
1%
Vitamin D3 (as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Fish Oil Concentrate
1.2 g (1,200 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
600 mg
†
Docosahexaenoic Acid (DHA)
300 mg
†
Top Medical Research Studies
7
We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness.
Read More
8
We explored the relationship between omega-3 fatty acids and mental health using data from over 102,000 participants in the UK Biobank. Our analysis showed that higher plasma levels of omega-3s were linked to a lower risk of depression and anxiety. Specifically, those with the highest levels exhibited a significant reduction in depressive symptoms and better brain white matter microstructure. This suggests that omega-3 fatty acids may play an important role in enhancing mental well-being, supporting their use as a potential intervention for mental health issues.
Read More
8
EPA demonstrates antidepressant efficacy
We investigated how omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), impact depressive behaviors in mice suffering from chronic sleep deprivation. Our findings revealed that EPA significantly outperformed DHA in reducing signs of depression and improving overall well-being.
Both fatty acids helped in mitigating myelin damage and inflammation, but EPA's effects were more pronounced. The study also shed light on the underlying biological mechanisms, particularly focusing on their roles in controlling the signaling pathways involved in depression. Overall, EPA showed a clear advantage in treating depression-related symptoms.
Both fatty acids helped in mitigating myelin damage and inflammation, but EPA's effects were more pronounced. The study also shed light on the underlying biological mechanisms, particularly focusing on their roles in controlling the signaling pathways involved in depression. Overall, EPA showed a clear advantage in treating depression-related symptoms.
Read More
Most Useful Reviews
7.5
Relief from symptoms
Following my doctor's advice, I used ultra Omega, which yielded excellent results. My son suffers from depression, and this product has significantly alleviated his symptoms. I appreciate the manufacturer's efforts.
Read More
7.5
Mental health boost
Excellent product! This is the third time I've purchased the Ultra Omega 3-D 600EPA 300 DHA, and it is now a daily supplement for me. It helps significantly in maintaining my mental health during winter, which is when I typically suffer from seasonal depression.
Read More
7.5
Lifts mood
2 people found this helpful
Best Omega on the site! This is my favourite! The rich composition of Omega, along with vitamin D, is fantastic! I ordered another jar for my daughter and me. The skin cleared up, and my mood improves significantly during spring when I usually feel down. I have more energy and strength now. Doctors recommend a pattern of three months on, two months off, which I’ll continue all year round. Capsules are large but easy to swallow with no fishy smell. This is my absolute favourite!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
- All Researches
8
We investigated how eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish oil, can influence depression. In our study with mice, we observed that administering EPA for five weeks helped reduce stress-induced neuronal damage and improved brain synaptic functions.
Additionally, EPA demonstrated its ability to lower neuroinflammation linked to depressive behaviors. The findings highlight the potential of EPA as an effective option for managing depression related to inflammation. While further research is needed, these results are promising for its future clinical applications.
Additionally, EPA demonstrated its ability to lower neuroinflammation linked to depressive behaviors. The findings highlight the potential of EPA as an effective option for managing depression related to inflammation. While further research is needed, these results are promising for its future clinical applications.
Read More
8
We aimed to understand how omega-3 fatty acids could benefit maternal behaviors affected by chronic stress during pregnancy. Our study involved three groups of rats: a control, a stress group, and a group receiving omega-3 supplementation.
The results showed that stressed rats displayed poor maternal behaviors, but omega-3 supplementation significantly improved their care for pups. It appeared to enhance the serotonin system, reduce inflammation, and aid in restoring neuronal function.
This research suggests that omega-3 fish oil might offer a promising approach to help mothers dealing with stress-related behavioral issues.
The results showed that stressed rats displayed poor maternal behaviors, but omega-3 supplementation significantly improved their care for pups. It appeared to enhance the serotonin system, reduce inflammation, and aid in restoring neuronal function.
This research suggests that omega-3 fish oil might offer a promising approach to help mothers dealing with stress-related behavioral issues.
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8
We explored how omega-3 fatty acids, alongside Vitamin D, may influence depression management. Our review included a broad search of scientific literature, focusing on studies that evaluate these nutrients' effects on mood and cognitive function.
The results indicate that omega-3 fatty acids can help reduce depressive symptoms, particularly for those with nutritional deficiencies. However, the variety in study designs and dosages makes it challenging to draw clear conclusions.
Overall, while omega-3s show potential as a supportive treatment for depression, more research is essential to solidify these findings.
The results indicate that omega-3 fatty acids can help reduce depressive symptoms, particularly for those with nutritional deficiencies. However, the variety in study designs and dosages makes it challenging to draw clear conclusions.
Overall, while omega-3s show potential as a supportive treatment for depression, more research is essential to solidify these findings.
Read More
8
We explored the relationship between omega-3 fatty acids and mental health using data from over 102,000 participants in the UK Biobank. Our analysis showed that higher plasma levels of omega-3s were linked to a lower risk of depression and anxiety. Specifically, those with the highest levels exhibited a significant reduction in depressive symptoms and better brain white matter microstructure. This suggests that omega-3 fatty acids may play an important role in enhancing mental well-being, supporting their use as a potential intervention for mental health issues.
Read More
8
EPA demonstrates antidepressant efficacy
We investigated how omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), impact depressive behaviors in mice suffering from chronic sleep deprivation. Our findings revealed that EPA significantly outperformed DHA in reducing signs of depression and improving overall well-being.
Both fatty acids helped in mitigating myelin damage and inflammation, but EPA's effects were more pronounced. The study also shed light on the underlying biological mechanisms, particularly focusing on their roles in controlling the signaling pathways involved in depression. Overall, EPA showed a clear advantage in treating depression-related symptoms.
Both fatty acids helped in mitigating myelin damage and inflammation, but EPA's effects were more pronounced. The study also shed light on the underlying biological mechanisms, particularly focusing on their roles in controlling the signaling pathways involved in depression. Overall, EPA showed a clear advantage in treating depression-related symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Relief from symptoms
Following my doctor's advice, I used ultra Omega, which yielded excellent results. My son suffers from depression, and this product has significantly alleviated his symptoms. I appreciate the manufacturer's efforts.
Read More
7.5
Mental health boost
Excellent product! This is the third time I've purchased the Ultra Omega 3-D 600EPA 300 DHA, and it is now a daily supplement for me. It helps significantly in maintaining my mental health during winter, which is when I typically suffer from seasonal depression.
Read More
7.5
Lifts mood
2 people found this helpful
Best Omega on the site! This is my favourite! The rich composition of Omega, along with vitamin D, is fantastic! I ordered another jar for my daughter and me. The skin cleared up, and my mood improves significantly during spring when I usually feel down. I have more energy and strength now. Doctors recommend a pattern of three months on, two months off, which I’ll continue all year round. Capsules are large but easy to swallow with no fishy smell. This is my absolute favourite!
Read More
9
Essential supplement
1 people found this helpful
Omega-3 is an essential supplement for both children and adults, preventing cardiovascular diseases and joint inflammation. It aids in weight management by regulating fat metabolism, slows aging as a strong antioxidant, and significantly combats depression by increasing serotonin levels. Omega-3 fatty acids are crucial for a health-focused diet, yet the body cannot produce them independently—they must be obtained through food.
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7.5
Mental health improvement
I love this product due to its beneficial effects on mental health, particularly concerning depression. The packaging is excellent, and I keep it in the fridge after opening. The quality exceeds expectations, as there is no oily aftertaste, making it easy to consume. It offers numerous benefits for heart health, hair, and inflammation.
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Frequently Asked Questions
7.5
Mood enhancement
This is incredible! It improves my mood, combats depression, and boosts immunity! The effectiveness in ether form is superb! Excellent for cholesterol prevention; I truly like it. I've used it consistently for three months.
7.5
Lifts mood
2 people found this helpful
Best Omega on the site! This is my favourite! The rich composition of Omega, along with vitamin D, is fantastic! I ordered another jar for my daughter and me. The skin cleared up, and my mood improves significantly during spring when I usually feel down. I have more energy and strength now. Doctors recommend a pattern of three months on, two months off, which I’ll continue all year round. Capsules are large but easy to swallow with no fishy smell. This is my absolute favourite!
7.5
Risk reduction
This product from Now Foods is unique. The omega-3 is enhanced with vitamin D3, making the formula more effective as vitamin D3 contributes to over 2000 processes in the body. Docosahexaenoic acid regulates serotonin levels, which helps improve mood, reduce the risk of depression, and shorten treatment duration.
7.5
Relief from symptoms
Following my doctor's advice, I used ultra Omega, which yielded excellent results. My son suffers from depression, and this product has significantly alleviated his symptoms. I appreciate the manufacturer's efforts.
7.5
Mental health boost
Excellent product! This is the third time I've purchased the Ultra Omega 3-D 600EPA 300 DHA, and it is now a daily supplement for me. It helps significantly in maintaining my mental health during winter, which is when I typically suffer from seasonal depression.
7.5
Memory enhancement
This is the best omega-3 supplement I've used, coupled with an excellent Vitamin D3 formula. Taking omega-3 regularly has improved my memory and brain activity while reducing symptoms of depression. I highly recommend it.
8
Postpartum support
1 people found this helpful
I bought a large dose of omega-3 to support myself after giving birth and to avoid postpartum depression.
7
We set out to understand how omega-3 fish oil and other anti-inflammatory treatments affect depression in older adults. This comprehensive review analyzed 31 randomized controlled trials to see if these interventions could reduce depressive symptoms. The findings showed that older adults had a moderate decrease in depression scores, particularly benefiting from omega-3 treatments. While this suggests a positive impact, it's important to note the studies had some variability in results. This calls for more focused research to pinpoint the best treatments for depression in this age group.
8
We explored the relationship between omega-3 fatty acids and mental health using data from over 102,000 participants in the UK Biobank. Our analysis showed that higher plasma levels of omega-3s were linked to a lower risk of depression and anxiety. Specifically, those with the highest levels exhibited a significant reduction in depressive symptoms and better brain white matter microstructure. This suggests that omega-3 fatty acids may play an important role in enhancing mental well-being, supporting their use as a potential intervention for mental health issues.
4
We analyzed five trials involving 228 participants to investigate the effects of omega-3 fatty acids on depression in children and adolescents. While omega-3 supplementation showed a potential to reduce self-reported depression symptoms, the evidence is quite uncertain.
In fact, there's little to no difference observed in the reduction of clinical depression symptoms when compared to a placebo.
Additionally, attrition rates and adverse effects between groups were similar, with mild issues reported. Overall, while omega-3s may help some, more rigorous studies are needed to better understand their role in treating adolescent depression.
In fact, there's little to no difference observed in the reduction of clinical depression symptoms when compared to a placebo.
Additionally, attrition rates and adverse effects between groups were similar, with mild issues reported. Overall, while omega-3s may help some, more rigorous studies are needed to better understand their role in treating adolescent depression.
4
We delved into the effects of omega-3 fatty acids, like EPA and DHA, on depression. While some research highlights their potential to reduce depressive symptoms, others found little to no effect. Factors like dosage and individual nutritional needs seem to influence these outcomes. Additionally, omega-3s may complement traditional antidepressants but results aren’t consistent across various studies. Overall, there's still a need for more research to create clear guidelines for omega-3 use in treating depression.
7
We examined recent clinical trials investigating omega-3 polyunsaturated fatty acids (PUFAs) to see how they might help with major depressive disorder (MDD).
The analysis focused on high doses of eicosapentaenoic acid (EPA), showing improvements especially in patients with inflammation-related depression and younger individuals.
Although results are encouraging, particularly for specific subpopulations, establishing the best doses and treatment durations requires further research.
The analysis focused on high doses of eicosapentaenoic acid (EPA), showing improvements especially in patients with inflammation-related depression and younger individuals.
Although results are encouraging, particularly for specific subpopulations, establishing the best doses and treatment durations requires further research.
8
We explored how omega-3 fatty acids, alongside Vitamin D, may influence depression management. Our review included a broad search of scientific literature, focusing on studies that evaluate these nutrients' effects on mood and cognitive function.
The results indicate that omega-3 fatty acids can help reduce depressive symptoms, particularly for those with nutritional deficiencies. However, the variety in study designs and dosages makes it challenging to draw clear conclusions.
Overall, while omega-3s show potential as a supportive treatment for depression, more research is essential to solidify these findings.
The results indicate that omega-3 fatty acids can help reduce depressive symptoms, particularly for those with nutritional deficiencies. However, the variety in study designs and dosages makes it challenging to draw clear conclusions.
Overall, while omega-3s show potential as a supportive treatment for depression, more research is essential to solidify these findings.
References
- Gong H, Su WJ, Deng SL, Luo J, Du ZL, et al. Anti-inflammatory interventions for the treatment and prevention of depression among older adults: a systematic review and meta-analysis. Transl Psychiatry. 2025;15:114. 10.1038/s41398-025-03317-3
- Yu Q, Li H, Chen M, Pan Y, Zhou L, et al. GPR120 internalization: a key mechanism for EPA in antidepressant action. Food Funct. 2025;16:2893. 10.1039/d5fo00252d
- Dyall SC, Malau IA, Su KP. Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials. Curr Opin Clin Nutr Metab Care. 2025;28:66. 10.1097/MCO.0000000000001077
- Al Sinani M, Johnson M, Crawford M, Al Maqbali M, Al-Adawi S. Depression and anxiety in the pregnant Omani population in relation to their fatty acid intake and levels. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102668. 10.1016/j.plefa.2025.102668
- Wang B, Liu P, Gao X, Yang F, Sun J, et al. Exploring the ameliorative effects of omega-3 fatty acid supplementation on maternal behavioral abnormalities induced by prenatal chronic restraint stress. Behav Brain Res. 2025;483:115458. 10.1016/j.bbr.2025.115458
- Raza ML, Hassan ST, Jamil S, Fatima W, Fatima M. Nutritional interventions in depression: The role of vitamin D and omega-3 fatty acids in neuropsychiatric health. Clin Nutr. 2025;45:270. 10.1016/j.clnu.2025.01.009
- Faulkner P, Gibson EL, Dyall SC. Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102664. 10.1016/j.plefa.2025.102664
- Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. 10.3390/nu16234065
- Campisi SC, Zasowski C, Bradley-Ridout G, Schumacher A, Szatmari P, et al. Omega-3 fatty acid supplementation for depression in children and adolescents. Cochrane Database Syst Rev. 2024;11:CD014803. 10.1002/14651858.CD014803.pub2
- Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. 10.3390/nu16213688
- Jastrzebska J, Frankowska M, Wesołowska J, Filip M, Smaga I. Dietary Intervention with Omega-3 Fatty Acids Mitigates Maternal High-Fat Diet-Induced Behavioral and Myelin-Related Alterations in Adult Offspring. Curr Neuropharmacol. 2025;23:329. 10.2174/1570159X23666241014164940
- Chen L, Yang Y, Zhang N, Che H, Wang Z, et al. DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis. Free Radic Biol Med. 2024;225:654. 10.1016/j.freeradbiomed.2024.10.298
- Cheng YC, Chen WY, Lin C, Lee SH, Chiu CC, et al. The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial. J Affect Disord. 2025;369:8. 10.1016/j.jad.2024.09.129
- Serefko A, Jach ME, Pietraszuk M, Świąder M, Świąder K, et al. Omega-3 Polyunsaturated Fatty Acids in Depression. Int J Mol Sci. 2024;25. 10.3390/ijms25168675
- Lam C, Han L, McIntyre RS, Teopiz KM, Cao B. Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis. J Child Adolesc Psychopharmacol. 2024;34:282. 10.1089/cap.2024.0017
- Carnegie R, Borges MC, Jones HJ, Zheng J, Haycock P, et al. Omega-3 fatty acids and major depression: a Mendelian randomization study. Transl Psychiatry. 2024;14:222. 10.1038/s41398-024-02932-w
