Last update
5/30/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Rutin Powder (non-citrus source)(Sophora japonica) (Flower Bud)
450 mg
*
Top Medical Research Studies
9
We investigated the impact of rutin on ulcers caused by indomethacin in a controlled study with rats. By administering rutin prior to indomethacin, we found that it effectively protected gastric tissues.
Pre-treatment with rutin led to significant reductions in ulcer severity and improved gastric health, supporting its role as a powerful antioxidant. This suggests that rutin may inhibit harmful processes like neutrophil infiltration and oxidative stress, enhancing gastric protection without affecting acidity levels.
Pre-treatment with rutin led to significant reductions in ulcer severity and improved gastric health, supporting its role as a powerful antioxidant. This suggests that rutin may inhibit harmful processes like neutrophil infiltration and oxidative stress, enhancing gastric protection without affecting acidity levels.
Read More
8
Aesculus hippocastanum shows ulcer improvement
We examined the potential of Aesculus hippocastanum (AH) seeds to treat gastric ulcers in rats. In our research, rats were divided into various groups, some receiving AH seed extracts while others were given a standard medication called ranitidine.
After treatment, we observed that the rats treated with AH seeds showed improved stomach health, including better membrane integrity and increased mucus thickness. The findings also indicated that AH seeds might work by boosting antioxidant levels, which can help lower harmful substances associated with ulcers.
Overall, while this study emphasizes AH seeds' positive effects, further research is needed to confirm these benefits in a broader context.
After treatment, we observed that the rats treated with AH seeds showed improved stomach health, including better membrane integrity and increased mucus thickness. The findings also indicated that AH seeds might work by boosting antioxidant levels, which can help lower harmful substances associated with ulcers.
Overall, while this study emphasizes AH seeds' positive effects, further research is needed to confirm these benefits in a broader context.
Read More
8
We investigated the anti-inflammatory and anti-ulcer benefits of L. cv. Ismailawi fruits. Using various extracts of these fruits, we found that both petroleum ether and defatted methanol extracts significantly reduced inflammation and ulcer severity compared to standard treatments.
Importantly, at a dosage of 200 mg/kg, these extracts effectively lowered both the number and severity of ulcers, outperforming ranitidine, a commonly used anti-ulcer drug. Our histopathological analysis backed these exciting findings, indicating the potential therapeutic value of rutin and other components found in the fruits.
Importantly, at a dosage of 200 mg/kg, these extracts effectively lowered both the number and severity of ulcers, outperforming ranitidine, a commonly used anti-ulcer drug. Our histopathological analysis backed these exciting findings, indicating the potential therapeutic value of rutin and other components found in the fruits.
Read More
Most Useful Reviews
7.5
Reduces pain and swelling
My husband suffers from varicose veins and deep vein thrombosis. He refuses to see a phlebologist, so we try to prevent vein disease with various supplements. Every morning, he takes nattokinase on an empty stomach, diosmin/hesperidin in the afternoon, and rutin with vitamin C in the evening. There has been a noticeable effect; he experiences no swelling or pain even after long periods on his feet. The small vessels are less pronounced, which is vital, especially with a painful vascular node near a trophic ulcer. Thanks to IHERB, we can maintain our health as we age.
Read More
7.5
Helps with ulcers
Rutin assists in improving appetite for those with stomach and duodenal ulcers and may help with internal bleeding due to tuberculosis in its early stages. It has also been noted to help with hair loss.
Read More
7.5
Supports ulcer treatment
Rutin is a bioflavonoid, a plant pigment present in various vegetables and fruits, particularly abundant in the peel of green citrus fruits, rose hips, and blackcurrants. Known as Vitamin P in alternative medicine, it enhances the effects of vitamin C, supports blood circulation, acts as an antioxidant, and contributes to treating allergies, viruses, arthritis, and other inflammatory conditions. Its healing properties are diverse; it regulates blood pressure, possesses anti-inflammatory, antitumour, and choleretic properties, prevents bruises and swelling after minor injuries, and fights allergies and ulcers while supporting thyroid function.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
- All Researches
9
Antiulcer effects of T. argentea extract
We investigated the potential of the hydroethanolic extract from Terminalia argentea leaves to promote healing and protection against ulcers. Through various in vivo and in vitro experiments, we administered different doses and concentrations of this extract, observing its effects on stomach health.
Our findings demonstrated that the extract effectively prevented and treated ulcers by enhancing gastric mucus production and reducing inflammation. The beneficial effects are likely due to a mix of natural compounds found in the leaves. Overall, this study underscores the traditional use of T. argentea in promoting gastric health.
Our findings demonstrated that the extract effectively prevented and treated ulcers by enhancing gastric mucus production and reducing inflammation. The beneficial effects are likely due to a mix of natural compounds found in the leaves. Overall, this study underscores the traditional use of T. argentea in promoting gastric health.
Read More
9
We investigated the impact of rutin on ulcers caused by indomethacin in a controlled study with rats. By administering rutin prior to indomethacin, we found that it effectively protected gastric tissues.
Pre-treatment with rutin led to significant reductions in ulcer severity and improved gastric health, supporting its role as a powerful antioxidant. This suggests that rutin may inhibit harmful processes like neutrophil infiltration and oxidative stress, enhancing gastric protection without affecting acidity levels.
Pre-treatment with rutin led to significant reductions in ulcer severity and improved gastric health, supporting its role as a powerful antioxidant. This suggests that rutin may inhibit harmful processes like neutrophil infiltration and oxidative stress, enhancing gastric protection without affecting acidity levels.
Read More
8
Aesculus hippocastanum shows ulcer improvement
We examined the potential of Aesculus hippocastanum (AH) seeds to treat gastric ulcers in rats. In our research, rats were divided into various groups, some receiving AH seed extracts while others were given a standard medication called ranitidine.
After treatment, we observed that the rats treated with AH seeds showed improved stomach health, including better membrane integrity and increased mucus thickness. The findings also indicated that AH seeds might work by boosting antioxidant levels, which can help lower harmful substances associated with ulcers.
Overall, while this study emphasizes AH seeds' positive effects, further research is needed to confirm these benefits in a broader context.
After treatment, we observed that the rats treated with AH seeds showed improved stomach health, including better membrane integrity and increased mucus thickness. The findings also indicated that AH seeds might work by boosting antioxidant levels, which can help lower harmful substances associated with ulcers.
Overall, while this study emphasizes AH seeds' positive effects, further research is needed to confirm these benefits in a broader context.
Read More
8
We investigated the anti-inflammatory and anti-ulcer benefits of L. cv. Ismailawi fruits. Using various extracts of these fruits, we found that both petroleum ether and defatted methanol extracts significantly reduced inflammation and ulcer severity compared to standard treatments.
Importantly, at a dosage of 200 mg/kg, these extracts effectively lowered both the number and severity of ulcers, outperforming ranitidine, a commonly used anti-ulcer drug. Our histopathological analysis backed these exciting findings, indicating the potential therapeutic value of rutin and other components found in the fruits.
Importantly, at a dosage of 200 mg/kg, these extracts effectively lowered both the number and severity of ulcers, outperforming ranitidine, a commonly used anti-ulcer drug. Our histopathological analysis backed these exciting findings, indicating the potential therapeutic value of rutin and other components found in the fruits.
Read More
8
We investigated the effects of Sicilian prickly pear juice on ulcers, particularly its influence on ulcerogenic activity caused by ethanol in rats. The juice contains beneficial compounds like rutin and has demonstrated strong antioxidant properties.
During our study, we observed that when administered preventively, the juice significantly inhibited ulcer formation. This effect was linked to an increase in mucus production and a restoration of the normal lining of the stomach. Overall, our findings suggest that incorporating this juice into our diets may offer protective benefits against stomach ulcers.
During our study, we observed that when administered preventively, the juice significantly inhibited ulcer formation. This effect was linked to an increase in mucus production and a restoration of the normal lining of the stomach. Overall, our findings suggest that incorporating this juice into our diets may offer protective benefits against stomach ulcers.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduces pain and swelling
My husband suffers from varicose veins and deep vein thrombosis. He refuses to see a phlebologist, so we try to prevent vein disease with various supplements. Every morning, he takes nattokinase on an empty stomach, diosmin/hesperidin in the afternoon, and rutin with vitamin C in the evening. There has been a noticeable effect; he experiences no swelling or pain even after long periods on his feet. The small vessels are less pronounced, which is vital, especially with a painful vascular node near a trophic ulcer. Thanks to IHERB, we can maintain our health as we age.
Read More
7.5
Helps with ulcers
Rutin assists in improving appetite for those with stomach and duodenal ulcers and may help with internal bleeding due to tuberculosis in its early stages. It has also been noted to help with hair loss.
Read More
7.5
Supports ulcer treatment
Rutin is a bioflavonoid, a plant pigment present in various vegetables and fruits, particularly abundant in the peel of green citrus fruits, rose hips, and blackcurrants. Known as Vitamin P in alternative medicine, it enhances the effects of vitamin C, supports blood circulation, acts as an antioxidant, and contributes to treating allergies, viruses, arthritis, and other inflammatory conditions. Its healing properties are diverse; it regulates blood pressure, possesses anti-inflammatory, antitumour, and choleretic properties, prevents bruises and swelling after minor injuries, and fights allergies and ulcers while supporting thyroid function.
Read More
6
Reduces vascular fragility
Rutin greatly helps with leg issues! It works best with vitamin C. This "vascular permeability factor" is highly soluble in water, containing beneficial substances that improve capillary stability, reduce fragility, and enhance conductivity. It regulates blood pressure, has anti-inflammatory and antitumour effects, and helps combat bruising and swelling. Rutin fights allergies and ulcers effectively, especially when paired with vitamin C from foods like parsley and cabbage. I'm taking rutin to bolster my blood vessels and lessen the vascular network on my legs, and it proves highly beneficial!
Read More
0
No side effects noticed
1 people found this helpful
I purchased it for my mother, who has varicose veins. Following her doctor's recommendations, she found the routine unsuitable due to stomach discomfort, especially since she has a history of stomach ulcers. I decided to take it myself, as a phlebologist advised taking a routine course annually. For me, it has no side effects and appears beneficial.
Read More
Frequently Asked Questions
7.5
Helps with ulcers
Rutin assists in improving appetite for those with stomach and duodenal ulcers and may help with internal bleeding due to tuberculosis in its early stages. It has also been noted to help with hair loss.
0
No side effects noticed
1 people found this helpful
I purchased it for my mother, who has varicose veins. Following her doctor's recommendations, she found the routine unsuitable due to stomach discomfort, especially since she has a history of stomach ulcers. I decided to take it myself, as a phlebologist advised taking a routine course annually. For me, it has no side effects and appears beneficial.
7.5
Reduces pain and swelling
My husband suffers from varicose veins and deep vein thrombosis. He refuses to see a phlebologist, so we try to prevent vein disease with various supplements. Every morning, he takes nattokinase on an empty stomach, diosmin/hesperidin in the afternoon, and rutin with vitamin C in the evening. There has been a noticeable effect; he experiences no swelling or pain even after long periods on his feet. The small vessels are less pronounced, which is vital, especially with a painful vascular node near a trophic ulcer. Thanks to IHERB, we can maintain our health as we age.
6
Reduces vascular fragility
Rutin greatly helps with leg issues! It works best with vitamin C. This "vascular permeability factor" is highly soluble in water, containing beneficial substances that improve capillary stability, reduce fragility, and enhance conductivity. It regulates blood pressure, has anti-inflammatory and antitumour effects, and helps combat bruising and swelling. Rutin fights allergies and ulcers effectively, especially when paired with vitamin C from foods like parsley and cabbage. I'm taking rutin to bolster my blood vessels and lessen the vascular network on my legs, and it proves highly beneficial!
4
Preventive treatment
Rutin is crucial for those with weak blood vessels, particularly in preventing varicose veins when combined with vitamin C. Since it is not synthesized in the body, my doctor prescribed it for daily use to avoid ulcers from ruptured vessels.
References
- Venturini CL, Damazo AS, Silva MJD, Muller JAI, Oliveira DM, et al. Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models. J Ethnopharmacol. 2024;318:116972. 10.1016/j.jep.2023.116972
- Idris S, Mishra A, Khushtar M. Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis. Chin J Integr Med. 2023;29:818. 10.1007/s11655-023-3734-9
- Moustafa SF, Gabr NM, Zaki JT, El Awdan SA, Mina SA. The anti-inflammatory, anti-ulcer activities and phytochemical investigation of L. cv. Ismailawi fruits. Nat Prod Res. 2021;35:5934. 10.1080/14786419.2020.1803314
- Abdel-Raheem IT. Gastroprotective effect of rutin against indomethacin-induced ulcers in rats. Basic Clin Pharmacol Toxicol. 2010;107:742. 10.1111/j.1742-7843.2010.00568.x
- Galati EM, Mondello MR, Giuffrida D, Dugo G, Miceli N, et al. Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. J Agric Food Chem. 2003;51:4903. PubMed
