Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
9
Selenium's potential in depression treatment
This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.
Read More
8
Selenium compound alleviates depression symptoms
We observed the effects of a synthetic compound called 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) on mice suffering from sleep deprivation-induced depression.
The study involved assessing behavioral changes after administering SeBZF1, alongside a known antidepressant, fluoxetine.
Remarkably, SeBZF1 not only reversed depressive-like behaviors and memory deficits but also reduced oxidative stress in the brain.
This research suggests that SeBZF1 could be a promising avenue for treating sleep-related neurobehavioral issues.
The study involved assessing behavioral changes after administering SeBZF1, alongside a known antidepressant, fluoxetine.
Remarkably, SeBZF1 not only reversed depressive-like behaviors and memory deficits but also reduced oxidative stress in the brain.
This research suggests that SeBZF1 could be a promising avenue for treating sleep-related neurobehavioral issues.
Read More
8
New selenium compound shows promise
We explored the effects of a new compound, CFSePB, to see if it could help alleviate depression-like symptoms in mice. Using several tests like the forced swimming test, we looked at how this selenium-rich compound influenced the serotonergic and noradrenergic systems.
While the results indicate that CFSePB has potential antidepressant-like effects, the study is still in its early stages. More research is needed to fully understand its efficacy and how it may be applied to human treatments for depression.
While the results indicate that CFSePB has potential antidepressant-like effects, the study is still in its early stages. More research is needed to fully understand its efficacy and how it may be applied to human treatments for depression.
Read More
Most Useful Reviews
9
Significant improvement
96 people found this helpful
This product has been a life changer for me. I felt a great deal of fatigue and depression. Now, I've never been in better shape in my life and have lost 14 pounds. I've been eating healthier and exercising more than ever before, and this vitamin has helped me return to my healthiest self without any supplements.
Read More
9
Energy boost
92 people found this helpful
I received my first box of vitamin a while ago, and I was delighted with the results. After just one day, I experienced a surge of energy and felt significantly better overall. The vitamin also helped reduce my depression levels to normal for the first time in months, which is incredibly encouraging.
Read More
7.5
Depression relief
2 people found this helpful
Indistinguishable from zinc, this capsule has the same shape as a zinc tablet. In a nutrition therapy book, it mentioned that taking vitamin D, A, and selenium together could be energising, so while I'm unsure of the effect of selenium alone, I take 200mcg daily. By increasing my protein intake and continuing this combination, symptoms of winter and depression lasting over 20 years have almost vanished, so it seems selenium is effective.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
Selenium's potential in depression treatment
This study explored how a selenium-containing compound, SeI, impacts depression-like behavior in mice. During behavioral tests, this compound reduced immobility, signaling an antidepressant-like effect without affecting movement.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.
Notably, blocking specific serotonin receptors changed the results, indicating the serotonergic system's involvement. With a low potential for side effects, SeI shows promise for developing new treatments for major depressive disorder (MDD).
However, it's important to note this research was conducted in mice, so effects in humans remain unconfirmed.
Read More
8
We studied the connection between adherence to the Planetary Health Diet Index (PHDI) and depression using data from the National Health and Nutrition Examination Survey. Our analysis revealed a strong negative correlation between higher PHDI scores and the likelihood of experiencing depression.
Specifically, individuals in the highest quartile of PHDI showed significantly reduced depression risks. Vitamins and nutrients like Vitamin C, Fiber, and Selenium played notable roles in this relationship. Essentially, the data suggests that a diet aligned with sustainable practices may help protect mental health.
Specifically, individuals in the highest quartile of PHDI showed significantly reduced depression risks. Vitamins and nutrients like Vitamin C, Fiber, and Selenium played notable roles in this relationship. Essentially, the data suggests that a diet aligned with sustainable practices may help protect mental health.
Read More
8
Selenium compound alleviates depression symptoms
We observed the effects of a synthetic compound called 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) on mice suffering from sleep deprivation-induced depression.
The study involved assessing behavioral changes after administering SeBZF1, alongside a known antidepressant, fluoxetine.
Remarkably, SeBZF1 not only reversed depressive-like behaviors and memory deficits but also reduced oxidative stress in the brain.
This research suggests that SeBZF1 could be a promising avenue for treating sleep-related neurobehavioral issues.
The study involved assessing behavioral changes after administering SeBZF1, alongside a known antidepressant, fluoxetine.
Remarkably, SeBZF1 not only reversed depressive-like behaviors and memory deficits but also reduced oxidative stress in the brain.
This research suggests that SeBZF1 could be a promising avenue for treating sleep-related neurobehavioral issues.
Read More
8
We examined how selenium-enriched fermented goat milk, made from Lactobacillus paracasei, impacts depression in mice exposed to chronic stress. The findings revealed that this treatment significantly reduced depressive behaviors and helped counteract inflammation and glucocorticoid resistance.
Additionally, we observed improvements in oxidative stress within critical brain areas. Changes in gut bacteria composition further supported the treatment’s potential effects. Overall, these insights lay a foundation for future probiotic supplements aimed at supporting mental health in depressed individuals.
Additionally, we observed improvements in oxidative stress within critical brain areas. Changes in gut bacteria composition further supported the treatment’s potential effects. Overall, these insights lay a foundation for future probiotic supplements aimed at supporting mental health in depressed individuals.
Read More
8
New selenium compound shows promise
We explored the effects of a new compound, CFSePB, to see if it could help alleviate depression-like symptoms in mice. Using several tests like the forced swimming test, we looked at how this selenium-rich compound influenced the serotonergic and noradrenergic systems.
While the results indicate that CFSePB has potential antidepressant-like effects, the study is still in its early stages. More research is needed to fully understand its efficacy and how it may be applied to human treatments for depression.
While the results indicate that CFSePB has potential antidepressant-like effects, the study is still in its early stages. More research is needed to fully understand its efficacy and how it may be applied to human treatments for depression.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant improvement
96 people found this helpful
This product has been a life changer for me. I felt a great deal of fatigue and depression. Now, I've never been in better shape in my life and have lost 14 pounds. I've been eating healthier and exercising more than ever before, and this vitamin has helped me return to my healthiest self without any supplements.
Read More
9
Energy boost
92 people found this helpful
I received my first box of vitamin a while ago, and I was delighted with the results. After just one day, I experienced a surge of energy and felt significantly better overall. The vitamin also helped reduce my depression levels to normal for the first time in months, which is incredibly encouraging.
Read More
7.5
Depression relief
2 people found this helpful
Indistinguishable from zinc, this capsule has the same shape as a zinc tablet. In a nutrition therapy book, it mentioned that taking vitamin D, A, and selenium together could be energising, so while I'm unsure of the effect of selenium alone, I take 200mcg daily. By increasing my protein intake and continuing this combination, symptoms of winter and depression lasting over 20 years have almost vanished, so it seems selenium is effective.
Read More
9
Health improvement
1 people found this helpful
I ordered this drug to enhance my health on my nutritionist's recommendation. My health improved markedly; I felt more vigorous and my depression reduced. It was hard to swallow previously, but within a week of taking it, those symptoms vanished. I recommend it!
Read More
7.5
Mood enhancement
Selenium for immunity has a stabilising effect on insomnia, depression, autonomic disorders, and other conditions such as menopause or old age. The quality ingredients are natural and relieve excess stress, stimulate brain function, improve concentration, increase performance, and normalise sleep and mood. The capsules are medium-sized. GABA improves sleep quality, crucially at night when growth hormone is released, limiting stress effects and ensuring deeper, more effective sleep.
Read More
Frequently Asked Questions
9
Energy boost
92 people found this helpful
I received my first box of vitamin a while ago, and I was delighted with the results. After just one day, I experienced a surge of energy and felt significantly better overall. The vitamin also helped reduce my depression levels to normal for the first time in months, which is incredibly encouraging.
9
Health improvement
1 people found this helpful
I ordered this drug to enhance my health on my nutritionist's recommendation. My health improved markedly; I felt more vigorous and my depression reduced. It was hard to swallow previously, but within a week of taking it, those symptoms vanished. I recommend it!
7.5
Depression relief
2 people found this helpful
Indistinguishable from zinc, this capsule has the same shape as a zinc tablet. In a nutrition therapy book, it mentioned that taking vitamin D, A, and selenium together could be energising, so while I'm unsure of the effect of selenium alone, I take 200mcg daily. By increasing my protein intake and continuing this combination, symptoms of winter and depression lasting over 20 years have almost vanished, so it seems selenium is effective.
9
Significant improvement
96 people found this helpful
This product has been a life changer for me. I felt a great deal of fatigue and depression. Now, I've never been in better shape in my life and have lost 14 pounds. I've been eating healthier and exercising more than ever before, and this vitamin has helped me return to my healthiest self without any supplements.
8
We explored the relationship between antioxidant supplements, like selenium, and their effects on depression in a comprehensive meta-analysis of randomized controlled trials.
Analyzing data from 52 studies involving over 4,000 participants, we found that antioxidant supplementation, including selenium, significantly improved depressive symptoms and even showed notable benefits for anxiety.
However, it’s worth noting that the study didn't impose strict limitations on participant characteristics, which may influence the results. Overall, these findings suggest that antioxidant supplementation could be a valuable addition to traditional antidepressant therapies.
Analyzing data from 52 studies involving over 4,000 participants, we found that antioxidant supplementation, including selenium, significantly improved depressive symptoms and even showed notable benefits for anxiety.
However, it’s worth noting that the study didn't impose strict limitations on participant characteristics, which may influence the results. Overall, these findings suggest that antioxidant supplementation could be a valuable addition to traditional antidepressant therapies.
8
We examined how selenium-enriched fermented goat milk, made from Lactobacillus paracasei, impacts depression in mice exposed to chronic stress. The findings revealed that this treatment significantly reduced depressive behaviors and helped counteract inflammation and glucocorticoid resistance.
Additionally, we observed improvements in oxidative stress within critical brain areas. Changes in gut bacteria composition further supported the treatment’s potential effects. Overall, these insights lay a foundation for future probiotic supplements aimed at supporting mental health in depressed individuals.
Additionally, we observed improvements in oxidative stress within critical brain areas. Changes in gut bacteria composition further supported the treatment’s potential effects. Overall, these insights lay a foundation for future probiotic supplements aimed at supporting mental health in depressed individuals.
8
Selenium mitigates infertility-related depression
We analyzed data from 4,949 women to explore whether selenium intake helps alleviate depressive symptoms linked to infertility. Our findings revealed that women experiencing infertility faced a 54% higher risk of depression.
Interestingly, those consuming at least 55 μg of selenium tended to have a lower risk of depressive symptoms. We noted that selenium significantly moderated the relationship between infertility and depression, but not at levels above 55 μg.
Ultimately, while selenium shows potential benefits, it isn't a cure-all, especially for those with infertility struggles.
Interestingly, those consuming at least 55 μg of selenium tended to have a lower risk of depressive symptoms. We noted that selenium significantly moderated the relationship between infertility and depression, but not at levels above 55 μg.
Ultimately, while selenium shows potential benefits, it isn't a cure-all, especially for those with infertility struggles.
7
We explored the relationship between selenium and depression through a thorough review of existing observational and interventional studies. Despite examining 20 studies, we found no clear difference in selenium levels between those with depression and healthy individuals.
Additionally, we didn’t observe a significant link between selenium levels and depression scores. However, it’s noteworthy that higher selenium intake appeared to lower the risk of postpartum depression, and selenium supplementation showed promise in alleviating depressive symptoms.
While these hints suggest selenium might offer protective benefits, more research is needed to really understand its role in treating depression.
Additionally, we didn’t observe a significant link between selenium levels and depression scores. However, it’s noteworthy that higher selenium intake appeared to lower the risk of postpartum depression, and selenium supplementation showed promise in alleviating depressive symptoms.
While these hints suggest selenium might offer protective benefits, more research is needed to really understand its role in treating depression.
References
- Jiang C, Choi S, Gong H. From planetary health diet (PHD) to mental health: Higher PHD index protects against depression among the U.S. population. J Psychiatr Res. 2025;183:31. 10.1016/j.jpsychires.2025.02.006
- Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. 10.3390/nu16213690
- Gonçalves LDS, Rusch G, Alves AG, Krüger LD, Paim MP, et al. Acute 2-phenyl-3-(phenylselanyl)benzofuran treatment reverses the neurobehavioral alterations induced by sleep deprivation in mice. Biochem Pharmacol. 2024;226:116339. 10.1016/j.bcp.2024.116339
- Sun Y, Zhao H, Chang M, Yue T, Yuan Y, et al. Fermented goat milk by selenium-enriched Lactobacillus paracasei alleviates depressive psychological disturbance. J Food Sci. 2024;89:4480. 10.1111/1750-3841.17167
- Pires CS, da Rocha MJ, Presa MH, Zuge NP, Kuntz NEB, et al. N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system. Psychopharmacology (Berl). 2024;241:1663. 10.1007/s00213-024-06588-8
- Wang W, Shi Y, Zhang J, Wang Y, Cheteu Wabo TM, et al. Association of dietary overall antioxidant intake with all-cause and cause-specific mortality among adults with depression: evidence from NHANES 2005-2018. Food Funct. 2024;15:4603. 10.1039/d4fo00236a
- Wang Z, Xiao T, Qi G. The moderating effect of dietary selenium intake on the risk of infertility-associated depressive symptoms in female. J Obstet Gynaecol Res. 2024;50:899. 10.1111/jog.15912
- da Rocha MJ, Pires CS, Presa MH, Besckow EM, Nunes GD, et al. Involvement of the serotonergic system in the antidepressant-like effect of 1-(phenylselanyl)-2-(p-tolyl)indolizine in mice. Psychopharmacology (Berl). 2023;240:373. 10.1007/s00213-023-06313-x
- Wang H, Jin M, Xie M, Yang Y, Xue F, et al. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials. J Affect Disord. 2023;323:264. 10.1016/j.jad.2022.11.072
- Xu Q, Qian X, Sun F, Liu H, Dou Z, et al. Independent and joint associations of dietary antioxidant intake with risk of post-stroke depression and all-cause mortality. J Affect Disord. 2023;322:84. 10.1016/j.jad.2022.11.013
- Garcia CS, Besckow EM, da Silva Espíndola CN, D'Avila Nunes G, Zuge NP, et al. Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT Receptors. ACS Chem Neurosci. 2022;13:1746. 10.1021/acschemneuro.2c00129
- Sajjadi SS, Foshati S, Haddadian-Khouzani S, Rouhani MH. The role of selenium in depression: a systematic review and meta-analysis of human observational and interventional studies. Sci Rep. 2022;12:1045. 10.1038/s41598-022-05078-1
- Yang J, Li H, Hao Z, Jing X, Zhao Y, et al. Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway. ACS Appl Mater Interfaces. 2022;14:3685. 10.1021/acsami.1c18417
- de Oliveira RL, Voss GT, da C Rodrigues K, Pinz MP, Biondi JV, et al. Prospecting for a quinoline containing selenium for comorbidities depression and memory impairment induced by restriction stress in mice. Psychopharmacology (Berl). 2022;239:59. 10.1007/s00213-021-06039-8
- Ferriani LO, Silva DA, Molina MDCB, Mill JG, Brunoni AR, et al. Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Affect Disord. 2022;297:259. 10.1016/j.jad.2021.10.027
- Domingues M, Casaril AM, Smaniotto TÂ, Birmann PT, Lourenço DA, et al. Selanylimidazopyridine abolishes inflammation- and stress-induced depressive-like behaviors by modulating the oxido-nitrosative system. Eur J Pharmacol. 2022;914:174570. 10.1016/j.ejphar.2021.174570
