Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.1
USERS' SCORE
Good
Based on 24 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
9
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Read More
9
We explored the effectiveness of echinochrome A (Ech A) in treating dry mouth, a common issue during menopause, using ovariectomized rats to simulate this condition. The study involved different groups of rats, including those treated with Ech A.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
Read More
8
We explored how iron treatments can address salivary gland issues that often arise after menopause. By observing ovariectomized rats, we found that using deferoxamine and ferrostatin-1 helped reduce inflammation and reverse some damage to the salivary glands.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Read More
Most Useful Reviews
9
Ferritin level increase
16 people found this helpful
I started taking iron supplements when my ferritin was in the thirties. After three months, my level rose to the sixties, which I consider effective. I plan to continue taking it since my meals have not been sufficient, especially during menopause.
Read More
9
Regained vitality
12 people found this helpful
I had been taking female hormones for menopause, but they stopped working, leaving me feeling depressed. After reading Dr. Ishihara's book and trying this iron supplement, I quickly regained my energy and motivation. My hair and nails have improved, and I am very thankful.
Read More
9
Essential for wellbeing
3 people found this helpful
Suffering from postpartum depression after my first child, I began taking iron on my doctor’s advice. After a long struggle, my ferritin rose, and my health improved significantly. I was unable to take it during my second pregnancy, but I realised it is essential for me, especially during menopause. Please, don't stop carrying this product, iHerb!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.1
- All Researches
9
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Read More
9
We explored the effectiveness of echinochrome A (Ech A) in treating dry mouth, a common issue during menopause, using ovariectomized rats to simulate this condition. The study involved different groups of rats, including those treated with Ech A.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
We observed that rats receiving Ech A showed improved salivary gland function compared to untreated ovariectomized rats. Key markers linked to dryness reduced significantly in the treated groups, suggesting Ech A may help in alleviating menopausal dry mouth by promoting salivation and reducing harmful effects on salivary tissues.
Read More
8
We looked into how iron levels affect cognitive performance in women experiencing menopause. Our research involved non-anemic women who had either low or normal iron levels for their age and background. They provided blood samples, underwent MRI scans to assess brain iron levels, and participated in cognitive tasks while we recorded their brain activity through EEG.
What we found was quite interesting. Higher iron status in these women was linked to better cognitive performance and improved brain activity. This included benefits associated with oxygen transport, which is crucial for brain function. However, we didn’t discover any direct connections between iron levels in the blood and the iron present in the brain.
Despite the lack of a clear relationship between systemic and brain iron, our findings suggest that addressing low iron levels during the menopausal transition may help reduce the cognitive struggles, often referred to as "brain fog," that many women experience during this time. So, while the study didn’t evaluate specific iron treatments, it opens the door to thinking about iron status as a factor worth considering for overall cognitive health in menopausal women.
What we found was quite interesting. Higher iron status in these women was linked to better cognitive performance and improved brain activity. This included benefits associated with oxygen transport, which is crucial for brain function. However, we didn’t discover any direct connections between iron levels in the blood and the iron present in the brain.
Despite the lack of a clear relationship between systemic and brain iron, our findings suggest that addressing low iron levels during the menopausal transition may help reduce the cognitive struggles, often referred to as "brain fog," that many women experience during this time. So, while the study didn’t evaluate specific iron treatments, it opens the door to thinking about iron status as a factor worth considering for overall cognitive health in menopausal women.
Read More
8
We explored how iron treatments can address salivary gland issues that often arise after menopause. By observing ovariectomized rats, we found that using deferoxamine and ferrostatin-1 helped reduce inflammation and reverse some damage to the salivary glands.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Both treatments improved the function of these glands and decreased harmful iron accumulation. However, more studies are needed to confirm their effectiveness in humans. Overall, the findings suggest potential new avenues for treating menopausal symptoms like dry mouth.
Read More
8
Impact of periodontal therapy on ferritin
We investigated the impact of non-surgical periodontal therapy on serum ferritin levels in postmenopausal women dealing with chronic periodontitis.
In our cross-sectional study with 38 women, we measured ferritin levels and periodontal health before and three months after treatment.
Interestingly, we found that serum ferritin decreased significantly from 108.55 mcg/L to 98.28 mcg/L after therapy.
Alongside this, improvements in gum health were also noteworthy, showcasing that periodontal care can play an essential role in managing ferritin levels post-menopause.
In our cross-sectional study with 38 women, we measured ferritin levels and periodontal health before and three months after treatment.
Interestingly, we found that serum ferritin decreased significantly from 108.55 mcg/L to 98.28 mcg/L after therapy.
Alongside this, improvements in gum health were also noteworthy, showcasing that periodontal care can play an essential role in managing ferritin levels post-menopause.
Read More
User Reviews
USERS' SCORE
Good
Based on 24 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Ferritin level increase
16 people found this helpful
I started taking iron supplements when my ferritin was in the thirties. After three months, my level rose to the sixties, which I consider effective. I plan to continue taking it since my meals have not been sufficient, especially during menopause.
Read More
9
Regained vitality
12 people found this helpful
I had been taking female hormones for menopause, but they stopped working, leaving me feeling depressed. After reading Dr. Ishihara's book and trying this iron supplement, I quickly regained my energy and motivation. My hair and nails have improved, and I am very thankful.
Read More
9
Essential for wellbeing
3 people found this helpful
Suffering from postpartum depression after my first child, I began taking iron on my doctor’s advice. After a long struggle, my ferritin rose, and my health improved significantly. I was unable to take it during my second pregnancy, but I realised it is essential for me, especially during menopause. Please, don't stop carrying this product, iHerb!
Read More
7.5
Normalised health
3 people found this helpful
Since feeling fatigued during menopause, I started taking iron. Initially, I had black stools, but that’s gone now, indicating my body absorbs it. A recent blood test showed my white blood cells normalised, and my iron levels are fine as well. This supplement is high quality and affordable, making it easy to continue taking.
Read More
9
Effective treatment
1 people found this helpful
My chaotic menstrual cycles during early menopause led to low haemoglobin, and the iron prescribed upset my stomach. This product has helped my levels increase without discomfort—highly recommended.
Read More
Frequently Asked Questions
6
No more dizziness
1 people found this helpful
I experienced dizziness due to anaemia during menopause, but after using this supplement for a few days, I feel much better without any dizziness.
9
Ferritin level increase
16 people found this helpful
I started taking iron supplements when my ferritin was in the thirties. After three months, my level rose to the sixties, which I consider effective. I plan to continue taking it since my meals have not been sufficient, especially during menopause.
7
No more constipation
I've dealt with low haemoglobin since youth, especially during menopause. I've been taking iron for 10 days now with no constipation, and I'm feeling better.
9
Daily energy boost
I've experienced dizziness daily during menopause, worsened during my period. I've taken menopause supplements and this chelated iron, which has energised me every day, regardless of my cycle.
8.5
Skin improvement
My gynaecologist recommended iron before menopause. I noticed even my skin improved.
7
Improved nails
1 people found this helpful
I've had brittle nails due to long-term iron deficiency. Once I replenished my iron, my nails looked better during menopause.
7.5
Improved quality of life
28 people found this helpful
I began reading Fujikawa Sensei's book and started taking protein. Initially, iron tablets caused stomach issues, but after switching to protein, I felt better and my daughter's dizziness improved. Past treatments for headaches were ineffective, but both of us relieved our painful symptoms, improving our quality of life during menopause. I'm hopeful for recovery after experiencing qualitative malnutrition.
9
Energised daily activities
15 people found this helpful
My ferritin was so low it couldn't be measured, leaving me fatigued. Since taking this iron supplement with vitamin C, I haven't experienced constipation and feel more energetic. Cooking and cleaning are enjoyable again, and I've increased my ferritin levels considerably. I intend to continue this supplement until menopause to help with my anxiety.
7.5
Reduced fatigue
1 people found this helpful
Is it finally working? I’ve been feeling dizzy frequently, likely due to menopause. I tried an iron supplement after reading good reviews. Initially, it felt too strong, so I reduced it to one and a half capsules daily. Now I take it every night and notice I'm less fatigued in the mornings. The capsules are large, so sometimes I struggle to swallow them. If you don’t mind that, you might want to give it a go.
7.5
No more panic attacks
9 people found this helpful
Recommended by my chiropractor, I take 1 to 3 iron bottles a day. Despite postpartum depression and panic attacks, since supplementing with iron and protein, I have seen no further issues. Iron is essential, especially for breastfeeding mothers. I will keep using it!
7.5
Increased energy
2 people found this helpful
Initially, I thought I didn’t need iron after menopause, but I realised its importance after feeling fatigued. I've had improved productivity after taking iron again.
7
We examined the connection between iron levels and cognitive performance in women going through menopause. Non-anemic participants, with varying iron levels, provided blood samples and completed cognitive tests while brain scans measured iron content.
Our findings revealed that higher iron levels were linked to improved cognitive abilities. However, we did not observe a direct relationship between systemic iron and brain iron levels.
This suggests that increasing iron might be a viable strategy to help combat the "brain fog" that often accompanies menopause.
Our findings revealed that higher iron levels were linked to improved cognitive abilities. However, we did not observe a direct relationship between systemic iron and brain iron levels.
This suggests that increasing iron might be a viable strategy to help combat the "brain fog" that often accompanies menopause.
7
We explored the relationship between iron accumulation and the effectiveness of hormone replacement therapy (HRT) in postmenopausal women facing atherosclerosis.
Our findings indicated that excess iron can hinder estrogen receptor activity, reducing the effectiveness of HRT.
In a mouse model, we noted that combining estradiol treatment with iron further diminished estrogen receptor expression and worsened atherosclerosis.
Interestingly, iron chelation showed promise in alleviating the issues caused by HRT ineffectiveness in late postmenopausal stages. Thus, managing iron levels may enhance HRT benefits for some women.
Our findings indicated that excess iron can hinder estrogen receptor activity, reducing the effectiveness of HRT.
In a mouse model, we noted that combining estradiol treatment with iron further diminished estrogen receptor expression and worsened atherosclerosis.
Interestingly, iron chelation showed promise in alleviating the issues caused by HRT ineffectiveness in late postmenopausal stages. Thus, managing iron levels may enhance HRT benefits for some women.
References
- Barnett AL, Wenger MJ, Miles P, Wu D, Isingizwe ZR, et al. Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause. medRxiv. 2025. doi:10.1101/2025.01.28.25321122
- Honari N, Sayadi M, Sajjadi SM, Solhjoo S, Sarab GA. Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation. Sci Rep. 2025;15:2449. doi:10.1038/s41598-025-86333-z
- Barnett AL, Wenger MJ, Miles P, Wu D, Isingizwe ZR, et al. Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause. Nutrients. 2025;17. doi:10.3390/nu17050745
- Kastrati L, Groothof D, Quezada-Pinedo HG, Raeisi-Dehkordi H, Bally L, et al. Utility of iron biomarkers in differentiating menopausal status: Findings from CoLaus and PREVEND. Maturitas. 2024;179:107872. doi:10.1016/j.maturitas.2023.107872
- Xu T, Cai J, Wang L, Xu L, Zhao H, et al. Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition. Elife. 2023;12. doi:10.7554/eLife.80494
- Cheon YI, Kim JM, Shin SC, Kim HS, Lee JC, et al. Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats. Aging (Albany NY). 2023;15:2418. doi:10.18632/aging.204641
- Kim JM, Shin SC, Cheon YI, Kim HS, Park GC, et al. Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats. Mar Drugs. 2022;20. doi:10.3390/md20120729
- Faramarzi M, Shirmohammadi A, Khorramdel A, Sadighi M, Bargahi E. Effect of non-surgical periodontal therapy on serum ferritin levels in postmenopausal women with chronic periodontitis. J Dent Res Dent Clin Dent Prospects. 2021;15:178. doi:10.34172/joddd.2021.030
- Liu LL, Liu GW, Liu H, Zhao K, Xu YJ. Iron accumulation deteriorated bone loss in estrogen-deficient rats. J Orthop Surg Res. 2021;16:525. doi:10.1186/s13018-021-02663-4
