We focused on the challenges of wound healing in diabetic patients and explored a novel treatment using lecithin-chitosan nanoparticles loaded with melatonin, known as MEL-NP. These nanoparticles were tested in diabetic rats to see if they could enhance the healing process.
The results were promising, showing that MEL-NP led to faster wound closure compared to other treatments. This improvement was associated with increased fibroblast activity, angiogenesis, and collagen deposition. Our findings suggest that MEL-NP could be a worthwhile strategy for addressing diabetic wound healing.
Read More
8
Nanoparticles enhance diabetic wound healing
Lecithin-based deferoxamine nanoparticles accelerated cutaneous wound healing in diabetic rats.
We explored the effectiveness of lecithin-based deferoxamine nanoparticles in promoting wound healing for diabetic rats. The study divided the rats into different treatment groups, some receiving the nanoparticles while others received conventional forms.
Notably, the group treated with the highest concentration of nanoparticles demonstrated significantly faster wound closure. Our findings suggest that the nanoparticles enhance healing by improving factors like collagen deposition and blood vessel formation.
While these results are promising, further research is needed to fully understand their applicability in human diabetes treatment.
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8
Recombinant strains reduce diabetes symptoms
Rhodotorula glutinis as a living cell liposome to deliver polypeptide drugs in vivo.
We investigated the use of recombinant Rhodotorula glutinis strains as living cell liposomes to deliver insulin and other polypeptide drugs. Our study revealed that these modified microbes could effectively reduce blood glucose levels in type II diabetes mice. By incorporating a key enzyme for lecithin synthesis, we ensured the strains could safely carry insulin into the bloodstream. Overall, the results showed that utilizing these living microbes presents a promising and controllable method of delivering diabetes treatments.
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Most Useful Reviews
9
Indispensable daily use
113 people found this helpful
The drug is excellent and essential for daily use! Although the capsules are large and somewhat uncomfortable to swallow, I have no other complaints. Lecithin is a crucial fuel for the body and a component of cell membranes. It strengthens the nervous system, liver, and brain while regulating blood cholesterol and sugar levels, thus reducing external insulin needs in diabetes.
Read More
9
Health benefits
26 people found this helpful
This is a fantastic product! It enhances sleep, stabilises mood, restores liver function, assists with type 2 diabetes, and improves skin health. The dosage and quantity are great, making it an ideal choice for various health improvements.
Read More
9
Economic choice
1 people found this helpful
This product is excellent, especially for diabetes patients, as it helps control blood sugar effectively. I highly recommend it due to its affordability and the benefits it provides.
We explored a novel approach to wound care for a 65-year-old woman struggling with a persistent diabetic foot ulcer. After a year of unsuccessful healing with standard treatments, we compounded two gel formulations: one with phenytoin and misoprostol, and another with nifedipine in a Pluronic lecithin organogel.
The treatment showed promising results with significant healing within 8 weeks, leading to complete closure in 17 weeks. This case suggests that specialized wound gels could be beneficial for patients with hard-to-treat diabetic foot ulcers.
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9
Melatonin nanoparticles improve diabetes
Therapeutic effect of melatonin-loaded chitosan/lecithin nanoparticles on hyperglycemia and pancreatic beta cells regeneration in streptozotocin-induced diabetic rats.
We explored the potential of melatonin-loaded chitosan/lecithin nanoparticles in treating diabetes in rat models. This study aimed to create an innovative delivery system to enhance the effectiveness of melatonin while minimizing its side effects.
Over eight weeks, these nanoparticles were shown to successfully lower blood sugar levels, boost insulin production, and promote the regeneration of pancreatic beta cells. Additionally, we noted improvements in liver and kidney functions.
These findings suggest that using lecithin with melatonin could offer a promising therapeutic option for diabetes management, addressing both glucose control and tissue regeneration.
Read More
9
Lecithin improves diabetes gene therapy
Lecithin nano-liposomal particle as a CRISPR/Cas9 complex delivery system for treating type 2 diabetes.
We explored how lecithin, used as a nanocarrier, aids in delivering CRISPR/Cas9 gene editing tools for treating type 2 diabetes. By targeting the DPP-4 gene, we enhanced glucagon-like peptide 1 function in diabetic mice.
Remarkably, this approach significantly reduced DPP-4 activity, leading to improved blood glucose levels and reduced organ damage, outperforming traditional medication options like sitagliptin. Overall, this innovative use of lecithin shows promise for advancing diabetes treatment through gene editing.
Read More
8
Lecithin nanoparticles reduce hyperglycemia
The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice.
We explored how EGCG and tyrosol-loaded lecithin nanoparticles might help manage type 2 diabetes in mice. The study employed characterizations of the nanoparticles and examined their effects on blood sugar levels, liver function, and oxidative stress.
Our findings indicated that the nanoparticles effectively lowered fasting blood sugar and inflammation and improved liver health. We observed that these treatments could downregulate inflammatory and gluconeogenesis-related genes.
Overall, our results suggest that lecithin nanoparticles show promise as a therapeutic option for type 2 diabetes management.
Read More
8
Lecithin nanoparticles aid wound healing
Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats.
We focused on the challenges of wound healing in diabetic patients and explored a novel treatment using lecithin-chitosan nanoparticles loaded with melatonin, known as MEL-NP. These nanoparticles were tested in diabetic rats to see if they could enhance the healing process.
The results were promising, showing that MEL-NP led to faster wound closure compared to other treatments. This improvement was associated with increased fibroblast activity, angiogenesis, and collagen deposition. Our findings suggest that MEL-NP could be a worthwhile strategy for addressing diabetic wound healing.
The drug is excellent and essential for daily use! Although the capsules are large and somewhat uncomfortable to swallow, I have no other complaints. Lecithin is a crucial fuel for the body and a component of cell membranes. It strengthens the nervous system, liver, and brain while regulating blood cholesterol and sugar levels, thus reducing external insulin needs in diabetes.
Read More
9
Health benefits
26 people found this helpful
This is a fantastic product! It enhances sleep, stabilises mood, restores liver function, assists with type 2 diabetes, and improves skin health. The dosage and quantity are great, making it an ideal choice for various health improvements.
Read More
9
Economic choice
1 people found this helpful
This product is excellent, especially for diabetes patients, as it helps control blood sugar effectively. I highly recommend it due to its affordability and the benefits it provides.
Read More
7.5
Supports insulin production
1 people found this helpful
Lecithin activates the synthesis of insulin and enhances receptor sensitivity, thus lowering the risk of developing diabetes and improving pancreatic function. It also aids in the absorption of essential vitamins and minerals, particularly the fat-soluble vitamins D3, A, K, and E. Lecithin plays a crucial role in lipid metabolism and energy processes of body cells.
Read More
7.5
Beneficial for all
1 people found this helpful
Lecithin offers extensive benefits, serving as a preventive measure for diabetes. It activates pancreatic function and insulin production, while enhancing heart and vascular health, reducing harmful cholesterol, and promoting skin and hair health. It also supports nervous system function and aids in the treatment of gynecological conditions.
Diabetes is a chronic medical condition that occurs when the body either does not produce enough insulin or cannot effectively use the insulin it produces. Insulin is a hormone made by the pancreas that helps glucose from food enter the cells, providing them with energy. When diabetes is present, it leads to elevated levels of glucose in the blood, which can cause serious health complications if left unmanaged. There are primarily two types: Type 1 diabetes, which is an autoimmune condition where the body attacks insulin-producing cells, and Type 2 diabetes, which is often associated with lifestyle factors such as obesity and lack of physical activity, leading to insulin resistance.
Managing diabetes typically involves a combination of lifestyle changes, such as a balanced diet and regular exercise, along with monitoring blood sugar levels and, in many cases, medication or insulin therapy. Education is crucial for those with diabetes to understand how their condition works and how to manage it effectively. The goal of diabetes management is to keep blood sugar levels within a target range, helping to prevent complications such as heart disease, nerve damage, and kidney failure. Regular check-ups and consultations with healthcare professionals are essential to ensure optimal care.
Lecithin is a natural substance that is found in various plant and animal tissues, primarily derived from soybeans, eggs, or sunflower seeds. It is a phospholipid, which means it contains both a hydrophilic (water-attracting) and hydrophobic (water-repellent) component. This unique structure makes lecithin an excellent emulsifier, which allows it to blend ingredients that typically don't mix well together, such as oil and water. As a result, it is commonly used in food products, cosmetics, and nutritional supplements to improve texture, stability, and shelf life.
In food products, lecithin can be found in a wide range of items, from chocolates to baked goods, providing a smoother mouthfeel and enhancing flavor distribution. Additionally, lecithin plays a role in promoting better absorption of certain nutrients in the body, which has led to its popularity as a dietary supplement. While lecithin is generally considered safe for consumption, those with soy allergies should opt for alternatives like sunflower lecithin. Whether you're a home cook looking to improve your dishes or someone interested in the potential health benefits, understanding lecithin's versatile uses can enhance your culinary and nutritional knowledge.
Lecithin, a fatty substance found in various foods such as soybeans and egg yolks, is often marketed for its potential health benefits, including its ability to support heart and brain health. However, when it comes to diabetes management, the evidence is quite limited. Some studies suggest that the choline in lecithin may help in regulating insulin sensitivity and glucose metabolism, but the findings are not robust enough to recommend lecithin as a treatment for diabetes.
Furthermore, while lecithin is generally considered safe for most people and can be beneficial as part of a balanced diet, it should not be viewed as a cure or primary treatment for diabetes. Those looking to manage their blood sugar levels should focus on proven strategies such as maintaining a healthy diet, staying active, and following their healthcare provider's recommendations. Always consult a healthcare professional before adding any supplements like lecithin to your regimen, especially if you have a condition such as diabetes.
Based on user reviews, the timeframe for seeing results after taking lecithin for diabetes can vary, but many users have reported improvements in their symptoms within a month. For instance, one user noted that after a month and a half of use, their child experienced more stable blood sugar levels and improved overall health Read Review. Similarly, another user mentioned that significant benefits for their liver and well-being became apparent after starting to use the supplement Read Review.
A number of users indicated that improvements in blood sugar regulation can be felt relatively quickly, sometimes within just a few days to weeks of consistent use. For example, one person reported experiencing a noticeable energy surge and mood improvement within the first days of taking lecithin Read Review. However, responses can differ, as noted by another user who found that the product did not work for them Read Review. Overall, while many users reported positive outcomes, individual results may vary.
Recent studies point to the potential of lecithin as a supportive supplement for managing diabetes. Research involving lecithin nanoparticles demonstrated their effectiveness in lowering blood sugar levels and improving liver function in type 2 diabetes models, suggesting that lecithin could play a role in diabetes treatment protocols [2]. Additionally, lecithin has been investigated in combination with melatonin, showing promise in boosting insulin production and promoting pancreatic beta-cell regeneration in diabetic subjects [4]. These findings indicate a positive trend towards utilizing lecithin in various diabetes management strategies.
Moreover, lecithin's applications extend to enhancing insulin delivery. Studies have shown that lecithin liposomes can improve the oral bioavailability of insulin and boost its effectiveness when compared to traditional delivery methods [10]. This is in line with findings that highlight lecithin's potential in facilitating gene editing techniques for diabetes treatment, leading to improved glucose levels in diabetic subjects [8]. While current research shows promise, further studies are necessary to fully validate the efficacy of lecithin in human diabetes management.
Users have reported a variety of improvements in symptoms after taking lecithin, especially regarding its impact on diabetes management and overall health. Many noted significant benefits, such as improved blood sugar levels and enhanced insulin sensitivity. For example, one user shared that their family experienced more stable blood sugar levels and better overall health after a month and a half of usage, particularly benefiting a child with type 1 diabetes Read Review. Other users corroborated these findings, with one individual mentioning that lecithin aids in insulin production and lowers the risk of developing diabetes Read Review.
Additionally, several users highlighted improvements in cognitive function and overall vitality, with one reporting enhanced mood and energy shortly after starting the supplement Read Review. Users have also noted benefits related to liver health and cholesterol levels, positioning lecithin as an all-around wellness supplement Read Review. While the testimonials are generally optimistic, individual results can vary, as seen with a user who did not experience the desired effects for their diabetes management Read Review.
Users have shared mixed experiences regarding the combination of lecithin with other supplements for managing diabetes. Many reported significant benefits, particularly with insulin synthesis and blood sugar regulation. For instance, one user mentioned that lecithin helped reduce their need for insulin injections by enhancing insulin production and regulating blood glucose levels Read Review. Others noted that lecithin can reduce the risk of diabetes and support overall metabolic processes, which might suggest a complementary effect when combined with other diabetes management supplements Read Review.
However, some users did not experience the desired outcomes, indicating that results can vary significantly from person to person. One individual reported that lecithin did not work effectively for their type 2 diabetes, highlighting the importance of personal response when combining it with other diabetes-related supplements Read Review. Overall, while many users recommend lecithin for its potential supportive role in diabetes management, others suggest consulting healthcare professionals when considering it alongside other supplements to achieve the best results.
Users report various insights regarding the effective dosage of lecithin for diabetes management, emphasizing its ability to regulate blood sugar levels and enhance insulin sensitivity. For example, one user noted that after using lecithin, they observed a significant improvement in their stable blood sugar levels and overall health, making it an integral part of their family's routineRead Review. Another user highlighted the natural ingredients and excellent dosage of lecithin as particularly beneficial for managing diabetes through its role in blood sugar regulation and overall metabolic supportRead Review.
While there isn't a definitive consensus on the ideal dosage, many users indicated that consistent use, particularly of sunflower lecithin, has led to noticeable health improvements. Lecithin's function in lipid metabolism and insulin synthesis was frequently cited, suggesting that it can be a supportive factor in both preventive and active management strategies for diabetesRead Review. However, it's worth noting that not all experiences were positive, as one user mentioned it did not provide the expected benefits for their type 2 diabetesRead Review. Overall, these user reviews suggest that while lecithin can be beneficial for diabetes management, individual responses may vary and should ideally be discussed with a healthcare professional.
7.5
Stabilised blood sugar
2 people found this helpful
Lecithin has worked well for my family over the past month and a half. We all feel better, with my older child, who has type 1 diabetes, now enjoying more stable blood sugar levels and improved overall health.
8
Liver protection
5 people found this helpful
Lecithin is vital from conception to old age, containing multiple beneficial substances. It lowers the risk of cirrhosis, encourages insulin synthesis, and mitigates diabetes risk. Personally, I’ve noticed significant benefits for my liver and overall well-being after its use.
7.5
Energy boost
1 people found this helpful
We take lecithin as a family. It is essential for our lungs, liver, and brain. It supports recovery after illness and helps manage diabetes among many other conditions. I experienced a noticeable energy surge and mood improvement from the first days of taking it.
2
Ineffective for me
Used it for type 2 diabetes, but unfortunately, it did not work for me.
7.5
Supports insulin production
1 people found this helpful
Lecithin activates the synthesis of insulin and enhances receptor sensitivity, thus lowering the risk of developing diabetes and improving pancreatic function. It also aids in the absorption of essential vitamins and minerals, particularly the fat-soluble vitamins D3, A, K, and E. Lecithin plays a crucial role in lipid metabolism and energy processes of body cells.
7.5
Helps diabetes management
Lecithin is a key component of cell membranes, constituting 50% of the liver and 30% of brain tissues. It aids in lowering blood cholesterol, safeguarding the nervous system and liver, and bolstering the immune system. Furthermore, it maintains the integrity of blood vessels, enhances metabolism, and prevents cholesterol deposits, providing protection against damage in diabetes and atherosclerosis.
7.5
Blood glucose regulation
Lecithin greatly aids my ailments. It accelerates tissue regeneration with gastritis and is preventive for pancreatitis and cholestasis. With diabetes, it regulates blood glucose levels and enhances insulin production, which reduces my need for insulin injections.
7.5
Blood sugar support
1 people found this helpful
I continuously take sunflower lecithin on my doctor's advice for managing diabetes mellitus. It aids in regulating blood sugar levels. The benefits and dosage are excellent, and it contains all-natural ingredients.
5
Cholesterol reduction
1 people found this helpful
Lecithin is a fatty substance that helps break down cholesterol and lowers low-density lipoproteins. It normalises blood lipid composition, aids pancreas function, and decreases the risk of diabetes. I find that it supports maintaining healthy cholesterol levels, keeping my blood vessels clear.
8
Lecithin nanoparticles reduce hyperglycemia
The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice.
We explored how EGCG and tyrosol-loaded lecithin nanoparticles might help manage type 2 diabetes in mice. The study employed characterizations of the nanoparticles and examined their effects on blood sugar levels, liver function, and oxidative stress.
Our findings indicated that the nanoparticles effectively lowered fasting blood sugar and inflammation and improved liver health. We observed that these treatments could downregulate inflammatory and gluconeogenesis-related genes.
Overall, our results suggest that lecithin nanoparticles show promise as a therapeutic option for type 2 diabetes management.
9
Melatonin nanoparticles improve diabetes
Therapeutic effect of melatonin-loaded chitosan/lecithin nanoparticles on hyperglycemia and pancreatic beta cells regeneration in streptozotocin-induced diabetic rats.
We explored the potential of melatonin-loaded chitosan/lecithin nanoparticles in treating diabetes in rat models. This study aimed to create an innovative delivery system to enhance the effectiveness of melatonin while minimizing its side effects.
Over eight weeks, these nanoparticles were shown to successfully lower blood sugar levels, boost insulin production, and promote the regeneration of pancreatic beta cells. Additionally, we noted improvements in liver and kidney functions.
These findings suggest that using lecithin with melatonin could offer a promising therapeutic option for diabetes management, addressing both glucose control and tissue regeneration.
8
Positive effects on diabetes management
Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system.
We explored the effectiveness of lecithin liposomes combined with insulin-chitosan polyelectrolyte complexes for oral insulin delivery. This innovative approach showed a noteworthy reduction in blood glucose levels in diabetic rats, outperforming traditional subcutaneous insulin in duration of hypoglycemic effect.
This suggests that lecithin might enhance the stability and delivery of insulin, representing a potential advancement in diabetes treatment. However, further research is necessary to confirm its efficacy in humans.
9
Lecithin improves diabetes gene therapy
Lecithin nano-liposomal particle as a CRISPR/Cas9 complex delivery system for treating type 2 diabetes.
We explored how lecithin, used as a nanocarrier, aids in delivering CRISPR/Cas9 gene editing tools for treating type 2 diabetes. By targeting the DPP-4 gene, we enhanced glucagon-like peptide 1 function in diabetic mice.
Remarkably, this approach significantly reduced DPP-4 activity, leading to improved blood glucose levels and reduced organ damage, outperforming traditional medication options like sitagliptin. Overall, this innovative use of lecithin shows promise for advancing diabetes treatment through gene editing.
References
Wynn T, Thompson C. Case Report: Wound Care of a Diabetic Foot Ulcer. Int J Pharm Compd. 2024;28:455.
Es-Haghi A, Soltani M, Tabrizi MH, Noghondar MK, Khatamian N, et al. The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice. Int J Biol Macromol. 2024;267:131496. doi:10.1016/j.ijbiomac.2024.131496
Gu H, Pu L, Yu S. Efficacy and safety of iodized lecithin tablets versus spironolactone in alleviating central serous retinopathy among Chinese patients with uncontrolled diabetes. Pak J Pharm Sci. 2023;36:595.
Alaa H, Abdelaziz M, Mustafa M, Mansour M, Magdy S, et al. Therapeutic effect of melatonin-loaded chitosan/lecithin nanoparticles on hyperglycemia and pancreatic beta cells regeneration in streptozotocin-induced diabetic rats. Sci Rep. 2023;13:10617. doi:10.1038/s41598-023-36929-0
Lopes Rocha Correa V, Assis Martins J, Ribeiro de Souza T, de Castro Nunes Rincon G, Pacheco Miguel M, et al. Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats. Int J Biol Macromol. 2020;162:1465. doi:10.1016/j.ijbiomac.2020.08.027
Qayoom A, Aneesha VA, Anagha S, Dar JA, Kumar P, et al. Lecithin-based deferoxamine nanoparticles accelerated cutaneous wound healing in diabetic rats. Eur J Pharmacol. 2019;858:172478. doi:10.1016/j.ejphar.2019.172478
Fei Z, Li S, Wang J, Wang Y, Jiang Z, et al. Rhodotorula glutinis as a living cell liposome to deliver polypeptide drugs in vivo. Drug Deliv. 2019;26:51. doi:10.1080/10717544.2018.1551439
Cho EY, Ryu JY, Lee HAR, Hong SH, Park HS, et al. Lecithin nano-liposomal particle as a CRISPR/Cas9 complex delivery system for treating type 2 diabetes. J Nanobiotechnology. 2019;17:19. doi:10.1186/s12951-019-0452-8
Mazzolani F, Togni S, Giacomelli L, Eggenhoffner R, Franceschi F. Oral administration of a curcumin-phospholipid formulation (Meriva®) for treatment of chronic diabetic macular edema: a pilot study. Eur Rev Med Pharmacol Sci. 2018;22:3617. doi:10.26355/eurrev_201806_15189
Al-Remawi M, Elsayed A, Maghrabi I, Hamaidi M, Jaber N. Chitosan/lecithin liposomal nanovesicles as an oral insulin delivery system. Pharm Dev Technol. 2017;22:390. doi:10.1080/10837450.2016.1213745
Liu L, Zhou C, Xia X, Liu Y. Self-assembled lecithin/chitosan nanoparticles for oral insulin delivery: preparation and functional evaluation. Int J Nanomedicine. 2016;11:761. doi:10.2147/IJN.S96146
Gonçalves LM, Maestrelli F, Di Cesare Mannelli L, Ghelardini C, Almeida AJ, et al. Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide. Eur J Pharm Biopharm. 2016;102:41. doi:10.1016/j.ejpb.2016.02.012