' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 13 Researches
7.3
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
9
Vitamin D3 improves migraine symptoms
Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.
High relevance to migraine treatment
We explored the potential benefits of vitamin D3 supplementation for people suffering from migraines. In a carefully designed study, 80 individuals with episodic migraines participated in a 12-week trial where they were randomly assigned to receive either 2000 IU (50 μg) of vitamin D3 daily or a placebo.
Throughout the study, we closely monitored headache characteristics using diaries and measured various serum inflammatory markers before and after the trial. Our findings showed that those taking vitamin D3 experienced significant improvements. They reported fewer headache days each month, shorter headache durations, and less severe pain overall when compared to the placebo group.
Interestingly, while the levels of some inflammatory markers didn't change much, we did notice a striking reduction in a certain enzyme linked to inflammation in the vitamin D3 group. Additionally, there was a trend toward lower levels of another inflammation marker, suggesting that vitamin D3 might offer a protective effect against neuro-inflammation in migraine sufferers.
In essence, our study indicates that vitamin D3 could be a promising supplemental treatment to help improve the quality of life for those battling episodic migraines.
Throughout the study, we closely monitored headache characteristics using diaries and measured various serum inflammatory markers before and after the trial. Our findings showed that those taking vitamin D3 experienced significant improvements. They reported fewer headache days each month, shorter headache durations, and less severe pain overall when compared to the placebo group.
Interestingly, while the levels of some inflammatory markers didn't change much, we did notice a striking reduction in a certain enzyme linked to inflammation in the vitamin D3 group. Additionally, there was a trend toward lower levels of another inflammation marker, suggesting that vitamin D3 might offer a protective effect against neuro-inflammation in migraine sufferers.
In essence, our study indicates that vitamin D3 could be a promising supplemental treatment to help improve the quality of life for those battling episodic migraines.
Read More
8
Vitamin D3 may improve migraine
The effects of vitamin D3 supplementation on TGF-β and IL-17 serum levels in migraineurs: post hoc analysis of a randomized clinical trial.
Direct examination of vitamin D3
In a well-structured study, we examined the impact of daily vitamin D3 supplementation on migraine patients, focusing on key immune markers. Eighty episodic migraineurs participated in the trial, which was designed as a double-blind, placebo-controlled study lasting 12 weeks. Half of the participants received 2000 IU of vitamin D3 each day, while the other half were given a placebo.
Our findings revealed that those who took vitamin D3 showed a significant increase in serum levels of transforming growth factor-beta (TGF-β), a cytokine associated with immune regulation. Specifically, the vitamin D3 group had an average TGF-β level of 1665.50 ng/L, compared to 1361.90 ng/L in the placebo group. Additionally, vitamin D3 helped prevent increases in interleukin-17 (IL-17) levels, with the vitamin group registering 37.84 ng/L against 70.09 ng/L in the controls.
These observations suggest that vitamin D3 supplementation may play a role in promoting a healthier balance of cytokines related to the immune response in migraine sufferers. Although the findings are exciting, we recognize the need for further research to solidify these results and better understand the implications for migraine treatment.
Our findings revealed that those who took vitamin D3 showed a significant increase in serum levels of transforming growth factor-beta (TGF-β), a cytokine associated with immune regulation. Specifically, the vitamin D3 group had an average TGF-β level of 1665.50 ng/L, compared to 1361.90 ng/L in the placebo group. Additionally, vitamin D3 helped prevent increases in interleukin-17 (IL-17) levels, with the vitamin group registering 37.84 ng/L against 70.09 ng/L in the controls.
These observations suggest that vitamin D3 supplementation may play a role in promoting a healthier balance of cytokines related to the immune response in migraine sufferers. Although the findings are exciting, we recognize the need for further research to solidify these results and better understand the implications for migraine treatment.
Read More
8
Vitamin D3 reduces migraine frequency
A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D supplementation in adult patients with migraine.
Highly relevant to migraine treatment
We conducted a rigorous study to explore the effects of vitamin D3 supplementation on migraine in adults. This trial involved 48 participants, consisting of 36 women and 12 men, who were aged between 18 and 65 years. Participants were divided into two groups: one received a daily dose of 100 µg of D3-Vitamin, while the other group was given a placebo for a span of 24 weeks.
Throughout the study, we monitored the frequency and severity of migraine attacks through self-reported diaries. Notably, we found that those taking vitamin D3 experienced a significant reduction in the number of migraine days compared to the placebo group. This suggests that vitamin D3 may offer a valuable option for those seeking to manage their migraines more effectively.
While our study indicates promising results, we also acknowledge that further research is necessary to fully understand the role of vitamin D3 as a preventive treatment for migraines. However, these findings certainly highlight the potential benefits of considering vitamin D3 in migraine management strategies.
Throughout the study, we monitored the frequency and severity of migraine attacks through self-reported diaries. Notably, we found that those taking vitamin D3 experienced a significant reduction in the number of migraine days compared to the placebo group. This suggests that vitamin D3 may offer a valuable option for those seeking to manage their migraines more effectively.
While our study indicates promising results, we also acknowledge that further research is necessary to fully understand the role of vitamin D3 as a preventive treatment for migraines. However, these findings certainly highlight the potential benefits of considering vitamin D3 in migraine management strategies.
Read More
Most Useful Reviews
9.5
Migraine relief
Taking two capsules regularly has greatly improved my sleep and migraine condition. The intensity and frequency of my migraines have decreased, allowing me to manage them more effectively. Adding magnesium has helped immensely; I no longer experience severe PMS or menstrual pains. Chronic nasopharyngeal pain has also lessened, though I consume other supplements too. The quality is fantastic, with natural ingredients, a pleasant smell, and easy usage. I truly experienced the benefits of collagen alongside magnesium, which surprised me.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 13 Researches
7.3
9.5
Effective migraine prevention strategy
Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial.
Combines vitamin D with treatment
We conducted a thorough investigation into the effectiveness of simvastatin paired with vitamin D3 for preventing migraines in adults with episodic migraine. Our study was a well-structured randomized, double-blind, placebo-controlled trial involving 57 participants over a span of 24 weeks.
Participants were divided into two groups: one receiving simvastatin and vitamin D3, while the other received placebos. Throughout the trial, we observed that those taking the combination of simvastatin and vitamin D3 experienced a significant reduction in the number of migraine days when compared to those on placebos. Specifically, during the first 12 weeks, participants on the active regimen reported a decrease of 8.0 migraine days, whereas those on placebos noted an increase of 1.0 migraine days.
By the end of the 24-week period, an impressive 29% of participants taking the medication reported a 50% or more reduction in their migraine days. In contrast, only 3% of those taking the placebo experienced similar relief. Interestingly, we found that the occurrence of adverse events was similar in both groups, indicating that the combination therapy was generally well-tolerated.
Our findings showcase the potential benefits of using simvastatin alongside vitamin D3 as an effective strategy for managing migraines, while also addressing some underlying health risks associated with migraines, such as vascular issues.
Participants were divided into two groups: one receiving simvastatin and vitamin D3, while the other received placebos. Throughout the trial, we observed that those taking the combination of simvastatin and vitamin D3 experienced a significant reduction in the number of migraine days when compared to those on placebos. Specifically, during the first 12 weeks, participants on the active regimen reported a decrease of 8.0 migraine days, whereas those on placebos noted an increase of 1.0 migraine days.
By the end of the 24-week period, an impressive 29% of participants taking the medication reported a 50% or more reduction in their migraine days. In contrast, only 3% of those taking the placebo experienced similar relief. Interestingly, we found that the occurrence of adverse events was similar in both groups, indicating that the combination therapy was generally well-tolerated.
Our findings showcase the potential benefits of using simvastatin alongside vitamin D3 as an effective strategy for managing migraines, while also addressing some underlying health risks associated with migraines, such as vascular issues.
Read More
9
Pediatric migraine relief with vitamin D
The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis.
Combination therapy raises questions
We conducted a study to evaluate how vitamin D supplementation affects migraine relief in children aged 5 to 14 who are also taking topiramate, a common migraine medication. Our trial involved a double-blind design, where participants were randomly assigned to either receive vitamin D or a placebo alongside their topiramate treatment for four months.
The results were promising. Children who took vitamin D showed a significant decrease in the monthly frequency of their headaches and a lowered disability score related to migraines compared to those who received the placebo. Notably, about 76% of the kids in the vitamin D group reported a good response to the treatment, while only 53.5% in the placebo group did.
We also found that the side effects of both treatments were minimal and similar, indicating that vitamin D supplementation is generally well-tolerated. These findings suggest that adding vitamin D to topiramate can be an effective and safe strategy for managing migraines in young patients.
The results were promising. Children who took vitamin D showed a significant decrease in the monthly frequency of their headaches and a lowered disability score related to migraines compared to those who received the placebo. Notably, about 76% of the kids in the vitamin D group reported a good response to the treatment, while only 53.5% in the placebo group did.
We also found that the side effects of both treatments were minimal and similar, indicating that vitamin D supplementation is generally well-tolerated. These findings suggest that adding vitamin D to topiramate can be an effective and safe strategy for managing migraines in young patients.
Read More
9
Vitamin D3 enhances migraine treatment
Efficacy of Topiramate Alone and Topiramate Plus Vitamin D3 in the Prophylaxis of Pediatric Migraine: A Randomized Clinical Trial.
Combined therapy benefits evident
In our exploration of pediatric migraine prevention, we conducted a clinical trial comparing the effects of topiramate alone and in combination with vitamin D3. We targeted children aged 5 to 15 years, randomly assigning them to one of the two treatment groups over two months.
Our findings indicated that both topiramate and the combination therapy were effective in reducing the frequency, severity, and duration of migraine episodes. However, we discovered that adding vitamin D3 significantly improved results. Children receiving both treatments experienced fewer migraines and a lower disability score compared to the topiramate-only group.
We also noted that 75.9% of the children taking the combination reported a good response to treatment, compared to 60.7% in the topiramate group. Side effects were mild and similar for both treatments, suggesting that the addition of vitamin D3 is a safe option worth considering for migraine prevention in children.
Our findings indicated that both topiramate and the combination therapy were effective in reducing the frequency, severity, and duration of migraine episodes. However, we discovered that adding vitamin D3 significantly improved results. Children receiving both treatments experienced fewer migraines and a lower disability score compared to the topiramate-only group.
We also noted that 75.9% of the children taking the combination reported a good response to treatment, compared to 60.7% in the topiramate group. Side effects were mild and similar for both treatments, suggesting that the addition of vitamin D3 is a safe option worth considering for migraine prevention in children.
Read More
9
Vitamin D3 improves migraine symptoms
Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.
High relevance to migraine treatment
We explored the potential benefits of vitamin D3 supplementation for people suffering from migraines. In a carefully designed study, 80 individuals with episodic migraines participated in a 12-week trial where they were randomly assigned to receive either 2000 IU (50 μg) of vitamin D3 daily or a placebo.
Throughout the study, we closely monitored headache characteristics using diaries and measured various serum inflammatory markers before and after the trial. Our findings showed that those taking vitamin D3 experienced significant improvements. They reported fewer headache days each month, shorter headache durations, and less severe pain overall when compared to the placebo group.
Interestingly, while the levels of some inflammatory markers didn't change much, we did notice a striking reduction in a certain enzyme linked to inflammation in the vitamin D3 group. Additionally, there was a trend toward lower levels of another inflammation marker, suggesting that vitamin D3 might offer a protective effect against neuro-inflammation in migraine sufferers.
In essence, our study indicates that vitamin D3 could be a promising supplemental treatment to help improve the quality of life for those battling episodic migraines.
Throughout the study, we closely monitored headache characteristics using diaries and measured various serum inflammatory markers before and after the trial. Our findings showed that those taking vitamin D3 experienced significant improvements. They reported fewer headache days each month, shorter headache durations, and less severe pain overall when compared to the placebo group.
Interestingly, while the levels of some inflammatory markers didn't change much, we did notice a striking reduction in a certain enzyme linked to inflammation in the vitamin D3 group. Additionally, there was a trend toward lower levels of another inflammation marker, suggesting that vitamin D3 might offer a protective effect against neuro-inflammation in migraine sufferers.
In essence, our study indicates that vitamin D3 could be a promising supplemental treatment to help improve the quality of life for those battling episodic migraines.
Read More
8
Vitamin D3 may improve migraine
The effects of vitamin D3 supplementation on TGF-β and IL-17 serum levels in migraineurs: post hoc analysis of a randomized clinical trial.
Direct examination of vitamin D3
In a well-structured study, we examined the impact of daily vitamin D3 supplementation on migraine patients, focusing on key immune markers. Eighty episodic migraineurs participated in the trial, which was designed as a double-blind, placebo-controlled study lasting 12 weeks. Half of the participants received 2000 IU of vitamin D3 each day, while the other half were given a placebo.
Our findings revealed that those who took vitamin D3 showed a significant increase in serum levels of transforming growth factor-beta (TGF-β), a cytokine associated with immune regulation. Specifically, the vitamin D3 group had an average TGF-β level of 1665.50 ng/L, compared to 1361.90 ng/L in the placebo group. Additionally, vitamin D3 helped prevent increases in interleukin-17 (IL-17) levels, with the vitamin group registering 37.84 ng/L against 70.09 ng/L in the controls.
These observations suggest that vitamin D3 supplementation may play a role in promoting a healthier balance of cytokines related to the immune response in migraine sufferers. Although the findings are exciting, we recognize the need for further research to solidify these results and better understand the implications for migraine treatment.
Our findings revealed that those who took vitamin D3 showed a significant increase in serum levels of transforming growth factor-beta (TGF-β), a cytokine associated with immune regulation. Specifically, the vitamin D3 group had an average TGF-β level of 1665.50 ng/L, compared to 1361.90 ng/L in the placebo group. Additionally, vitamin D3 helped prevent increases in interleukin-17 (IL-17) levels, with the vitamin group registering 37.84 ng/L against 70.09 ng/L in the controls.
These observations suggest that vitamin D3 supplementation may play a role in promoting a healthier balance of cytokines related to the immune response in migraine sufferers. Although the findings are exciting, we recognize the need for further research to solidify these results and better understand the implications for migraine treatment.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
9.5
Migraine relief
Taking two capsules regularly has greatly improved my sleep and migraine condition. The intensity and frequency of my migraines have decreased, allowing me to manage them more effectively. Adding magnesium has helped immensely; I no longer experience severe PMS or menstrual pains. Chronic nasopharyngeal pain has also lessened, though I consume other supplements too. The quality is fantastic, with natural ingredients, a pleasant smell, and easy usage. I truly experienced the benefits of collagen alongside magnesium, which surprised me.
Read More
