' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 14 Researches
8.4
USERS' SCORE
Very Good
Based on 13 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
9
Vitamin D derivatives enhance bone health
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Significant benefits for osteoporosis.
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
Read More
9
Vitamin D3 improves bone health
Selenium nano particles versus nano vitamin D3 in modulating anastrozole-induced osteoporosis on the mandibular alveolar bone of albino rats.
Important but partially isolated effect.
We explored how Nano Vitamin D3 influences osteoporosis, particularly in the context of treatments involving anastrozole, a medication often used in cancer therapy. In our study, we observed the effects of Nano Vitamin D3 compared to selenium nanoparticles in female albino rats.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
Read More
9
Vitamin D3 boosts childhood bone health
Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
Relevant study on bone health
We investigated the effects of vitamin D3 supplementation during pregnancy on offspring's bone mineral density (BMD) as they grow. In the MAVIDOS study, pregnant women with low levels of vitamin D were given either a daily dose of 1000 IU of cholecalciferol (vitamin D3) or a placebo from their second trimester until delivery.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
Read More
Most Useful Reviews
9.5
Increases calcium absorption
It's important to take one capsule weekly with a fatty meal. Vitamin D aids in calcium absorption, promoting bone strength and preventing osteoporosis. The quality is superb, and it boosts immunity. There’s no taste.
Read More
9.5
Facilitates calcium metabolism
Vitamin D3 is essential for bone development and calcium absorption. Its deficiency leads to osteoporosis and other health issues. Maintaining proper levels is crucial for overall health, including skin and bone integrity.
Read More
8.3
Supports bone health
I appreciate the quality ingredients. This product protects against osteoporosis and aids in fracture healing. It also boosts resistance to viral diseases and supports strong bones and the immune system. For those with a severe D3 deficiency, this is exactly what you need for immediate results.
Read More
Most Recommended Products for Osteoporosis
NOW Foods Zinc Picolinate
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 8 Reviews
9.4
ChildLife Essentials Essentials
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
NOW Foods Potassium Citrate
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 4 Reviews
9
Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 14 Researches
8.4
9.5
Vitamin D3 aids osteoporosis prevention
IgG4-RD-Associated Mikulicz Syndrome Without Classic Systemic Involvement-A Case Report.
Highlights role in osteoporosis management
We looked into the effects of vitamin D3 on osteoporosis management, particularly in relation to glucocorticoid-induced complications. In a recent case involving an 85-year-old patient with IgG4-related disease, vitamin D3 was used alongside prednisone and azathioprine. The goal was to prevent bone density loss often seen with steroid treatments.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Read More
9
Vitamin D derivatives enhance bone health
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Significant benefits for osteoporosis.
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
Read More
9
Vitamin D3 improves bone health
Selenium nano particles versus nano vitamin D3 in modulating anastrozole-induced osteoporosis on the mandibular alveolar bone of albino rats.
Important but partially isolated effect.
We explored how Nano Vitamin D3 influences osteoporosis, particularly in the context of treatments involving anastrozole, a medication often used in cancer therapy. In our study, we observed the effects of Nano Vitamin D3 compared to selenium nanoparticles in female albino rats.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
Read More
9
Vitamin D3 boosts childhood bone health
Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
Relevant study on bone health
We investigated the effects of vitamin D3 supplementation during pregnancy on offspring's bone mineral density (BMD) as they grow. In the MAVIDOS study, pregnant women with low levels of vitamin D were given either a daily dose of 1000 IU of cholecalciferol (vitamin D3) or a placebo from their second trimester until delivery.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
Read More
9
Calcium and Vitamin D3 boost bone health
Real-world effectiveness and safety of combined calcium 600 mg and cholecalciferol 2000 IU for treating vitamin d deficiency: Results from a nationwide study with focus in osteoporosis.
Study relevant to osteoporosis management
We conducted a comprehensive study to assess the effectiveness and safety of a daily regimen of calcium 600 mg combined with cholecalciferol (vitamin D3) 2000 IU in treating vitamin D deficiency, particularly in the context of osteoporosis. Our research included 302 adults who took these orodispersible tablets for at least 24 weeks.
The results showed that this combination therapy successfully increased serum levels of 25-hydroxivitamin D, an essential marker of vitamin D status. Notably, patients suffering from vitamin D deficiency experienced significant improvement in their vitamin D levels, reaching an optimal range conducive to better bone health.
We also observed that while the treatment led to improved vitamin D status, there were no significant adverse events reported, making it a safe option for long-term management of vitamin D deficiency and osteoporosis. Additionally, we found that reducing secondary hyperparathyroidism, a condition often associated with low vitamin D, was another positive outcome of this treatment.
Overall, the magnitude of increase in vitamin D levels directly correlated with the severity of the deficiency, indicating that those most in need benefited the most. Our study emphasizes the importance of addressing vitamin D deficiency, especially for individuals at risk of osteoporosis, without any notable burden of side effects.
The results showed that this combination therapy successfully increased serum levels of 25-hydroxivitamin D, an essential marker of vitamin D status. Notably, patients suffering from vitamin D deficiency experienced significant improvement in their vitamin D levels, reaching an optimal range conducive to better bone health.
We also observed that while the treatment led to improved vitamin D status, there were no significant adverse events reported, making it a safe option for long-term management of vitamin D deficiency and osteoporosis. Additionally, we found that reducing secondary hyperparathyroidism, a condition often associated with low vitamin D, was another positive outcome of this treatment.
Overall, the magnitude of increase in vitamin D levels directly correlated with the severity of the deficiency, indicating that those most in need benefited the most. Our study emphasizes the importance of addressing vitamin D deficiency, especially for individuals at risk of osteoporosis, without any notable burden of side effects.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 13 Reviews
8.5
9.5
Increases calcium absorption
It's important to take one capsule weekly with a fatty meal. Vitamin D aids in calcium absorption, promoting bone strength and preventing osteoporosis. The quality is superb, and it boosts immunity. There’s no taste.
9.5
Boosts immunity
This product effectively compensates for vitamin D deficiency, enhancing immunity to help prevent osteoporosis. It is a high-quality supplement.
9.5
Facilitates calcium metabolism
Vitamin D3 is essential for bone development and calcium absorption. Its deficiency leads to osteoporosis and other health issues. Maintaining proper levels is crucial for overall health, including skin and bone integrity.
8.8
Enhances bone strength
Vitamin D is crucial for my health and livelihood. It plays a vital role in absorbing magnesium and phosphate, regulating calcium and phosphorus levels in the blood, and supports bone strength, fighting osteoporosis. The quality, ingredients, and dosage—one pill a week—are excellent. It even boosts immunity. There is no taste.
Read More
8.8
Prevents hair loss
Excellent! Vitamin D is vital for bones. Deficiency can lead to osteoporosis and other issues. I take 50,000 units weekly. It’s easy to swallow and doesn’t cause nausea or weight gain. The price is fair for the number of pills.
