Reviewed By
Infographics 
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
2
Vitamin D3 shows no diabetes benefit
We conducted a thorough investigation to understand how vitamin D3 supplementation influences the risk of developing type 2 diabetes in healthy older adults. Over the course of five years, we carried out a randomized, placebo-controlled trial involving 2,271 participants aged 60 and over. This diverse group of adults was free from cardiovascular disease and cancer, ensuring a focus on individuals not at high risk for diabetes.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
Our study involved three groups: one receiving a placebo, another taking 1600 IU of vitamin D3 daily, and a third consuming 3200 IU daily. Remarkably, neither dosage of vitamin D3 showed a significant reduction in the risk of developing diabetes during our observations. Throughout the trial, we utilized national health registries to track the occurrence of diabetes, while a subgroup of participants underwent more detailed health assessments at various points.
Overall, despite the promising discussions around vitamin D and its health benefits, our findings indicate that vitamin D3 supplementation doesn't significantly lower diabetes risk in older adults who already have adequate vitamin D levels for maintaining bone health. This intriguing outcome adds valuable insight into the ongoing conversation about vitamin D's role in diabetes prevention.
Read More
8
We conducted a well-structured double-blind, randomized, placebo-controlled trial to explore the effects of cholecalciferol, a form of vitamin D3, on depressive symptoms among individuals with type 2 diabetes mellitus (T2DM). Our primary goal was to determine how this supplementation could influence both mood and specific markers related to diabetes, such as C-peptide, serotonin, and neurotrophin-3 levels.
Over the course of 12 weeks, 70 patients with T2DM and existing depression were split into two groups: one received 4000 IU of cholecalciferol daily, while the other received a placebo. At the end of the trial, we noticed a significant increase in C-peptide levels among those taking vitamin D3 compared to the placebo group. However, when it came to serotonin and neurotrophin-3, there were no notable differences.
Importantly, the patients who received cholecalciferol saw a marked reduction in their depression scores, suggesting that this vitamin may alleviate mild to moderate depressive symptoms in those living with diabetes. While our findings accentuate the benefits of vitamin D3 concerning mood improvement, its relationship with certain biochemical markers remains less clear.
Over the course of 12 weeks, 70 patients with T2DM and existing depression were split into two groups: one received 4000 IU of cholecalciferol daily, while the other received a placebo. At the end of the trial, we noticed a significant increase in C-peptide levels among those taking vitamin D3 compared to the placebo group. However, when it came to serotonin and neurotrophin-3, there were no notable differences.
Importantly, the patients who received cholecalciferol saw a marked reduction in their depression scores, suggesting that this vitamin may alleviate mild to moderate depressive symptoms in those living with diabetes. While our findings accentuate the benefits of vitamin D3 concerning mood improvement, its relationship with certain biochemical markers remains less clear.
Read More
8
We aimed to understand how high doses of vitamin D3 could affect individuals with type 2 diabetes (T2DM). Our analysis included data from 20 studies, comprising 612 patients receiving vitamin D3 and 592 in the control group. This research focused on vitamin D3 doses exceeding 4000 IU and their potential impact on various metabolic parameters like blood glucose levels, hemoglobin A1c, and blood pressure.
Our findings indicated that supplementing with vitamin D3 significantly enhanced serum levels of 25(OH)D, a marker of vitamin D status, with an increase of about 177% after treatment. Moreover, it appears that vitamin D3 supplementation could benefit several aspects of health in T2DM patients, including improved glycemic control and management of blood pressure.
However, we noted that not all studies showed consistent results regarding these benefits, suggesting that more research is needed to fully understand the role of vitamin D3 in diabetes management. While the potential for vitamin D3 supplementation is promising, the variability in study outcomes calls for further exploration to confirm its effectiveness in clinical settings.
Our findings indicated that supplementing with vitamin D3 significantly enhanced serum levels of 25(OH)D, a marker of vitamin D status, with an increase of about 177% after treatment. Moreover, it appears that vitamin D3 supplementation could benefit several aspects of health in T2DM patients, including improved glycemic control and management of blood pressure.
However, we noted that not all studies showed consistent results regarding these benefits, suggesting that more research is needed to fully understand the role of vitamin D3 in diabetes management. While the potential for vitamin D3 supplementation is promising, the variability in study outcomes calls for further exploration to confirm its effectiveness in clinical settings.
Read More
Most Useful Reviews
7.5
Increases immunity
10 people found this helpful
Excellent dosage of Vitamin D! Those wishing to maintain their vitamin D levels can take 1 capsule weekly. For those with an acute deficiency like mine, it’s better to take every other day. I’m ordering again for my whole family! Correct consumption of vitamin D strengthens bones, improves blood composition, alleviates dry hair and skin, reduces the risk of oncology and diabetes, enhances immunity, and boosts concentration. Highly recommend it for good health!
Read More
9
Suitable for diabetes
The quality is superb. The ingredients are pure, and the dosage is ideal for those with diabetes. The packaging is commendable. Vitamin D deficiency is addressed effectively, leading to good bone absorption. The taste is neutral.
Read More
9
One of the best
Excellent product! Vitamin D3 acts as a general tonic for immunity and strengthens bones. It regulates heart disease and vascular issues and assists in controlling blood sugar levels. It activates and regulates cell growth while counteracting diseases like diabetes and high blood pressure.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
- All Researches
9
Vitamin D3 combined benefits in diabetes
We examined how vitamin D3 works alongside empagliflozin, a medication often used for diabetes, to tackle a condition called metabolic dysfunction-associated steatohepatitis (MASH) in diabetic mice. In this study, we grouped the mice into several categories, including control groups and those receiving treatments, all while feeding them a high-fructose and high-fat diet.
The results showed that while empagliflozin alone helped improve conditions like high blood sugar and fatty liver, when combined with vitamin D3, the benefits were even more pronounced. We observed significant reductions in symptoms such as hyperglycemia and fat buildup in the liver.
Interestingly, this dual therapy demonstrated enhanced control over metabolic processes, oxidative stress, and inflammation markers in the liver. These findings suggest that vitamin D3, when paired with empagliflozin, has potential benefits in managing diabetes-related liver issues. However, as the study primarily focused on the combination effect, isolating the specific impact of vitamin D alone would require further investigation.
The results showed that while empagliflozin alone helped improve conditions like high blood sugar and fatty liver, when combined with vitamin D3, the benefits were even more pronounced. We observed significant reductions in symptoms such as hyperglycemia and fat buildup in the liver.
Interestingly, this dual therapy demonstrated enhanced control over metabolic processes, oxidative stress, and inflammation markers in the liver. These findings suggest that vitamin D3, when paired with empagliflozin, has potential benefits in managing diabetes-related liver issues. However, as the study primarily focused on the combination effect, isolating the specific impact of vitamin D alone would require further investigation.
Read More
9
Vitamin D3 aids diabetes management
We investigated the impact of vitamin D3, in combination with high-intensity interval training (HIIT), on specific markers related to diabetes, namely Chemokine Ligand 5 (CCL-5) and Chemokine Receptor 5 (CCR5). Our study focused on male rats with type 2 diabetes, examining how these interventions could influence conditions exacerbated by a high-fat diet.
Over eight weeks, we divided our 40 rats into five groups: a healthy control group, a diabetic control group, a group undergoing HIIT, one receiving vitamin D3, and a group combining both HIIT and vitamin D3. The findings were quite revealing. While both vitamin D3 and HIIT showed some benefits, the combination of the two had the most significant impact in lowering CCL-5 and CCR5 levels in white adipose tissue.
Notably, vitamin D3 alone reduced the CCR5 levels effectively, demonstrating its potential role in diabetes management. We also noticed that the combined treatment had a notably stronger effect than either intervention alone, highlighting the importance of a multi-faceted approach to manage diabetes. Our study suggests that incorporating both vitamin D3 and exercise may help in lowering certain inflammatory markers in diabetic conditions.
Over eight weeks, we divided our 40 rats into five groups: a healthy control group, a diabetic control group, a group undergoing HIIT, one receiving vitamin D3, and a group combining both HIIT and vitamin D3. The findings were quite revealing. While both vitamin D3 and HIIT showed some benefits, the combination of the two had the most significant impact in lowering CCL-5 and CCR5 levels in white adipose tissue.
Notably, vitamin D3 alone reduced the CCR5 levels effectively, demonstrating its potential role in diabetes management. We also noticed that the combined treatment had a notably stronger effect than either intervention alone, highlighting the importance of a multi-faceted approach to manage diabetes. Our study suggests that incorporating both vitamin D3 and exercise may help in lowering certain inflammatory markers in diabetic conditions.
Read More
8
We sought to explore the effects of vitamin D on diabetes by fortifying jamun juice with this essential nutrient. Our approach involved creating a nanoemulsion of vitamin D using a low-temperature sonication method, which allowed us to enhance its presence in the juice.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
Read More
8
We explored the possibility of using vitamin D3, or cholecalciferol, as part of a combination therapy to enhance diabetes treatment, particularly for type 2 diabetes mellitus (T2DM). Recent research by Attia investigated this approach using a rat model, where they combined metformin, vitamin D3, and taurine.
The findings from this study suggest that this treatment combination can lead to better blood sugar control and also reduce oxidative stress, inflammation, and lipid issues, which are common in diabetes patients. However, it’s essential to note that the study does not provide a detailed safety profile or explore the underlying biological mechanisms that explain these benefits.
While the idea of incorporating vitamin D3 in diabetes therapy is promising, the lack of comprehensive safety data means we should approach this combination with caution. There’s a clear need for further research to fully understand how vitamin D3 works in this context and to ensure that it is safe for broader use among diabetes patients.
The findings from this study suggest that this treatment combination can lead to better blood sugar control and also reduce oxidative stress, inflammation, and lipid issues, which are common in diabetes patients. However, it’s essential to note that the study does not provide a detailed safety profile or explore the underlying biological mechanisms that explain these benefits.
While the idea of incorporating vitamin D3 in diabetes therapy is promising, the lack of comprehensive safety data means we should approach this combination with caution. There’s a clear need for further research to fully understand how vitamin D3 works in this context and to ensure that it is safe for broader use among diabetes patients.
Read More
8
We conducted a well-structured double-blind, randomized, placebo-controlled trial to explore the effects of cholecalciferol, a form of vitamin D3, on depressive symptoms among individuals with type 2 diabetes mellitus (T2DM). Our primary goal was to determine how this supplementation could influence both mood and specific markers related to diabetes, such as C-peptide, serotonin, and neurotrophin-3 levels.
Over the course of 12 weeks, 70 patients with T2DM and existing depression were split into two groups: one received 4000 IU of cholecalciferol daily, while the other received a placebo. At the end of the trial, we noticed a significant increase in C-peptide levels among those taking vitamin D3 compared to the placebo group. However, when it came to serotonin and neurotrophin-3, there were no notable differences.
Importantly, the patients who received cholecalciferol saw a marked reduction in their depression scores, suggesting that this vitamin may alleviate mild to moderate depressive symptoms in those living with diabetes. While our findings accentuate the benefits of vitamin D3 concerning mood improvement, its relationship with certain biochemical markers remains less clear.
Over the course of 12 weeks, 70 patients with T2DM and existing depression were split into two groups: one received 4000 IU of cholecalciferol daily, while the other received a placebo. At the end of the trial, we noticed a significant increase in C-peptide levels among those taking vitamin D3 compared to the placebo group. However, when it came to serotonin and neurotrophin-3, there were no notable differences.
Importantly, the patients who received cholecalciferol saw a marked reduction in their depression scores, suggesting that this vitamin may alleviate mild to moderate depressive symptoms in those living with diabetes. While our findings accentuate the benefits of vitamin D3 concerning mood improvement, its relationship with certain biochemical markers remains less clear.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Increases immunity
10 people found this helpful
Excellent dosage of Vitamin D! Those wishing to maintain their vitamin D levels can take 1 capsule weekly. For those with an acute deficiency like mine, it’s better to take every other day. I’m ordering again for my whole family! Correct consumption of vitamin D strengthens bones, improves blood composition, alleviates dry hair and skin, reduces the risk of oncology and diabetes, enhances immunity, and boosts concentration. Highly recommend it for good health!
Read More
9
Suitable for diabetes
The quality is superb. The ingredients are pure, and the dosage is ideal for those with diabetes. The packaging is commendable. Vitamin D deficiency is addressed effectively, leading to good bone absorption. The taste is neutral.
Read More
9
One of the best
Excellent product! Vitamin D3 acts as a general tonic for immunity and strengthens bones. It regulates heart disease and vascular issues and assists in controlling blood sugar levels. It activates and regulates cell growth while counteracting diseases like diabetes and high blood pressure.
Read More
9
Normalises functions
I consistently give these vitamins to my son, who has type 1 diabetes mellitus, based on his endocrinologist's recommendation. With these vitamins, his bodily functions normalise, blood sugar levels decrease, limb sensitivity improves, and he appears more alert in general.
Read More
6
Strengthens immunity
20 people found this helpful
Good quality vitamin in high dosage. Proper consumption of vitamin D strengthens bones and muscles, improves blood composition, alleviates dry hair and skin, reduces the risk of oncology and diabetes, enhances immunity, and regulates blood pressure. Take 1 capsule with a fat-containing meal once a week or as directed by your doctor.
Read More
Frequently Asked Questions
9
Normalises functions
I consistently give these vitamins to my son, who has type 1 diabetes mellitus, based on his endocrinologist's recommendation. With these vitamins, his bodily functions normalise, blood sugar levels decrease, limb sensitivity improves, and he appears more alert in general.
7.5
Improves eye health
This is a great quality product, providing a sufficient dose weekly of 50,000 IU. My husband has diabetes, and we've noticed improved eye health. My vitamin D deficiency has significantly improved. I take it with a fatty meal for better absorption.
6
Strengthens immunity
20 people found this helpful
Good quality vitamin in high dosage. Proper consumption of vitamin D strengthens bones and muscles, improves blood composition, alleviates dry hair and skin, reduces the risk of oncology and diabetes, enhances immunity, and regulates blood pressure. Take 1 capsule with a fat-containing meal once a week or as directed by your doctor.
7.5
High-quality ingredients
Amazing! The product and packaging are excellent. The quality of the ingredients is high, and there's plenty for those with limited sunlight exposure. One capsule daily is quickly absorbed and helps combat low vitamin D levels. It strengthens bones and reduces the risk of chronic diseases like diabetes and heart disease while enhancing the immune system.
7.5
Increases immunity
10 people found this helpful
Excellent dosage of Vitamin D! Those wishing to maintain their vitamin D levels can take 1 capsule weekly. For those with an acute deficiency like mine, it’s better to take every other day. I’m ordering again for my whole family! Correct consumption of vitamin D strengthens bones, improves blood composition, alleviates dry hair and skin, reduces the risk of oncology and diabetes, enhances immunity, and boosts concentration. Highly recommend it for good health!
8
We sought to explore the effects of vitamin D on diabetes by fortifying jamun juice with this essential nutrient. Our approach involved creating a nanoemulsion of vitamin D using a low-temperature sonication method, which allowed us to enhance its presence in the juice.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
The resulting drink, known as vitamin D fortified jamun juice (VDFJJ), showcased impressive nutritional attributes. It contained notable levels of total polyphenols and flavonoids, along with a high antioxidant activity of 94.2%.
When we examined its anti-diabetic potential, VDFJJ demonstrated significant inhibition of key enzymes related to carbohydrate digestion. Specifically, it showed effective inhibition of α-amylase and α-glucosidase, which play crucial roles in sugar absorption in the body.
Additionally, in our animal models that were deficient in vitamin D, we noted considerable improvements in various serum levels after four weeks of consuming the fortified juice. Results indicated increased levels of 25-OHD and calcium, among others, showcasing vitamin D's positive impact.
Overall, our nanoemulsion method appeared to boost vitamin D's solubility and bioavailability in a delicious beverage, paving the way for innovative solutions to tackle vitamin D deficiency while possibly aiding in diabetes management.
4
We explored the relationship between vitamin D3 and type 2 diabetes mellitus (T2DM), particularly focusing on how this vitamin might influence outcomes for those affected by the condition. Previous research has shown that patients with T2DM often experience low levels of glutathione, a vital antioxidant that helps combat oxidative stress and inflammation. Vitamin D3 not only possesses anti-inflammatory properties but may also play a role in boosting glutathione synthesis.
Our investigation highlighted the potential dual benefits of vitamin D3 supplementation for T2DM patients. By addressing both oxidative stress and inflammation, vitamin D3 could help improve insulin signaling and reduce related complications like nephropathy and retinopathy. However, ongoing studies are necessary to determine the extent of its effectiveness in managing these challenges over time.
As we continue to investigate the interactions between vitamin D3 and metabolic health, keeping an eye on lifestyle modifications and other antioxidant treatments suggests a comprehensive approach may yield the best results for controlling T2DM.
Our investigation highlighted the potential dual benefits of vitamin D3 supplementation for T2DM patients. By addressing both oxidative stress and inflammation, vitamin D3 could help improve insulin signaling and reduce related complications like nephropathy and retinopathy. However, ongoing studies are necessary to determine the extent of its effectiveness in managing these challenges over time.
As we continue to investigate the interactions between vitamin D3 and metabolic health, keeping an eye on lifestyle modifications and other antioxidant treatments suggests a comprehensive approach may yield the best results for controlling T2DM.
8
We aimed to understand how high doses of vitamin D3 could affect individuals with type 2 diabetes (T2DM). Our analysis included data from 20 studies, comprising 612 patients receiving vitamin D3 and 592 in the control group. This research focused on vitamin D3 doses exceeding 4000 IU and their potential impact on various metabolic parameters like blood glucose levels, hemoglobin A1c, and blood pressure.
Our findings indicated that supplementing with vitamin D3 significantly enhanced serum levels of 25(OH)D, a marker of vitamin D status, with an increase of about 177% after treatment. Moreover, it appears that vitamin D3 supplementation could benefit several aspects of health in T2DM patients, including improved glycemic control and management of blood pressure.
However, we noted that not all studies showed consistent results regarding these benefits, suggesting that more research is needed to fully understand the role of vitamin D3 in diabetes management. While the potential for vitamin D3 supplementation is promising, the variability in study outcomes calls for further exploration to confirm its effectiveness in clinical settings.
Our findings indicated that supplementing with vitamin D3 significantly enhanced serum levels of 25(OH)D, a marker of vitamin D status, with an increase of about 177% after treatment. Moreover, it appears that vitamin D3 supplementation could benefit several aspects of health in T2DM patients, including improved glycemic control and management of blood pressure.
However, we noted that not all studies showed consistent results regarding these benefits, suggesting that more research is needed to fully understand the role of vitamin D3 in diabetes management. While the potential for vitamin D3 supplementation is promising, the variability in study outcomes calls for further exploration to confirm its effectiveness in clinical settings.
8
We explored the possibility of using vitamin D3, or cholecalciferol, as part of a combination therapy to enhance diabetes treatment, particularly for type 2 diabetes mellitus (T2DM). Recent research by Attia investigated this approach using a rat model, where they combined metformin, vitamin D3, and taurine.
The findings from this study suggest that this treatment combination can lead to better blood sugar control and also reduce oxidative stress, inflammation, and lipid issues, which are common in diabetes patients. However, it’s essential to note that the study does not provide a detailed safety profile or explore the underlying biological mechanisms that explain these benefits.
While the idea of incorporating vitamin D3 in diabetes therapy is promising, the lack of comprehensive safety data means we should approach this combination with caution. There’s a clear need for further research to fully understand how vitamin D3 works in this context and to ensure that it is safe for broader use among diabetes patients.
The findings from this study suggest that this treatment combination can lead to better blood sugar control and also reduce oxidative stress, inflammation, and lipid issues, which are common in diabetes patients. However, it’s essential to note that the study does not provide a detailed safety profile or explore the underlying biological mechanisms that explain these benefits.
While the idea of incorporating vitamin D3 in diabetes therapy is promising, the lack of comprehensive safety data means we should approach this combination with caution. There’s a clear need for further research to fully understand how vitamin D3 works in this context and to ensure that it is safe for broader use among diabetes patients.
8
We set out to investigate how vitamin D3, specifically in the form of 1,25(OH)2D3, influences diabetes and its associated complications like inflammation and pancreatic damage. Our study utilized both laboratory models and real-life scenarios where we introduced this treatment to those with diabetes.
We found that 1,25(OH)2D3 seems to have an intriguing impact on insulin secretion levels and could play a role in reducing inflammation in pancreatic β-cells. This suggests that vitamin D3 not only aids in insulin production but also helps protect these cells from damage caused by diabetes.
Through our experiments, we observed that this form of vitamin D3 appears to lower the expression of certain proteins linked to a type of cell death called pyroptosis, which is particularly damaging in diabetes. By inhibiting these processes, 1,25(OH)2D3 might help preserve the function of pancreatic cells and alleviate some symptoms of diabetes.
While further research is needed, our findings hint at the potential benefits of 1,25(OH)2D3 for those dealing with diabetes, creating a strong case for considering vitamin D3 as an adjuvant treatment in managing this chronic condition.
We found that 1,25(OH)2D3 seems to have an intriguing impact on insulin secretion levels and could play a role in reducing inflammation in pancreatic β-cells. This suggests that vitamin D3 not only aids in insulin production but also helps protect these cells from damage caused by diabetes.
Through our experiments, we observed that this form of vitamin D3 appears to lower the expression of certain proteins linked to a type of cell death called pyroptosis, which is particularly damaging in diabetes. By inhibiting these processes, 1,25(OH)2D3 might help preserve the function of pancreatic cells and alleviate some symptoms of diabetes.
While further research is needed, our findings hint at the potential benefits of 1,25(OH)2D3 for those dealing with diabetes, creating a strong case for considering vitamin D3 as an adjuvant treatment in managing this chronic condition.
References
- Jan Y, Binsuwaidan R, Malik M, Yaseen M, Ahmad S, et al. Characterization of jamun () juice fortified with nanoemulsified vitamin D: and assessment of its nutraceutical value and anti-diabetic potential. Food Chem X. 2025;25:102133. 10.1016/j.fochx.2024.102133
- Dawi J, Misakyan Y, Affa S, Kades S, Narasimhan A, et al. Oxidative Stress, Glutathione Insufficiency, and Inflammatory Pathways in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions. Biomedicines. 2024;13. 10.3390/biomedicines13010018
- El-Akabawy G, Eid N. Enhancing metformin efficacy with cholecalciferol and taurine in diabetes therapy: Potential and limitations. World J Diabetes. 2025;16:100066. 10.4239/wjd.v16.i1.100066
- Putranto R, Setiati S, Nasrun MW, Witjaksono F, Immanuel S, et al. Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. Narra J. 2024;4:e1342. 10.52225/narra.v4i3.1342
- Atteia HH, Ahmed SF, Askar ME, Sakr AT. Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04476-y
- Zheng Y, Wu Z, Wei X, Zhang L, Hu Y, et al. 1,25(OH)2D3 promotes insulin secretion through the classical pyroptosis pathway in vitro and vivo. Biochem Biophys Res Commun. 2025;742:151058. 10.1016/j.bbrc.2024.151058
- Virtanen JK, Hantunen S, Kallio N, Lamberg-Allardt C, Manson JE, et al. The effect of vitamin D supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial. Diabetologia. 2024. 10.1007/s00125-024-06336-9
- Max F, Gažová A, Smaha J, Jankovský M, Tesař T, et al. High Doses of Vitamin D and Specific Metabolic Parameters in Type 2 Diabetes Patients: Systematic Review. Nutrients. 2024;16. 10.3390/nu16223903
- Shokri B, Mohebbi H, Mehrabani J. Amelioration of fructose-induced hepatic lipid accumulation by vitamin D supplementation and high-intensity interval training in male Sprague‒Dawley rats. Lipids Health Dis. 2024;23:362. 10.1186/s12944-024-02347-y
- Farrash WF, Idris S, Elzubier ME, Khidir EBA, Aslam A, et al. Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction-associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways. Int J Exp Pathol. 2024;105:219. 10.1111/iep.12519
- Fallahi F, Tahmasebi W, Rahimi MR, Azizi M. High-Intensity Interval Training and Vitamin D3 Supplementation Decrease CCL-5 and CCR5 Expression In White Adipose Tissue of Diabetic Rats Fed with A High-Fat Diet and Streptozotocin. Cell J. 2024;26:465. 10.22074/cellj.2024.2027582.1560
