Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
USERS' SCORE
Good
Based on 32 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (Vitamin B-1) (from Thiamin HCl)
50 mg
4167%
Riboflavin (Vitamin B-2)
50 mg
3846%
Niacin (Vitamin B-3) (as Niacinamide)
50 mg
313%
Vitamin B-6 (from Pyridoxine HCl)
50 mg
2941%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
2083%
Biotin
50 mcg
167%
Pantothenic Acid (from Calcium Pantothenate)
50 mg
1000%
Choline (from Choline Bitartrate)
25 mg
5%
PABA (Para-Aminobenzoic Acid)
25 mg
†
Inositol
25 mg
†
Top Medical Research Studies
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
Read More
8
This study examined how dietary vitamin B6 and plasma levels of pyridoxal 5’-phosphate relate to depression in US adults. We analyzed data from nearly 25,000 people over five years, revealing that those with the highest vitamin B6 intake and plasma levels experienced a lower risk of depression.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Read More
8
Niacin shows promise for depression
We investigated how niacin (vitamin B3) impacts depression, particularly through a mouse model using lipopolysaccharide to induce depressive behaviors.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
Read More
Most Useful Reviews
9
Mood improvement
447 people found this helpful
The whole B-complex is contained in one capsule. I have noticed real results: Despite dreary, rainy weather, I feel cheerful. This year, the usual autumn depression has not affected me. I respond calmly to work stress, viewing it as part of life. My skin is managing well through the autumn-winter transition, free from dryness and tightness. My joints are also not causing issues.
Read More
9
Stomatitis cure
5 people found this helpful
I suffered from mouth ulcers for years, but surprisingly, after starting this vitamin B, my large stomatitis healed quickly. Although I didn’t take it primarily for depression, it has contributed to my overall mental stability.
Read More
9
Emotional uplift
4 people found this helpful
The quality is excellent, particularly for women. I've noticed a significant improvement in my mood; a strange depression has lifted, and I now feel energetic and active.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
- All Researches
9.5
We explored a remarkable case of a 58-year-old cancer patient who exhibited depressive symptoms potentially linked to thiamine deficiency (TD). Initially suspected of having major depressive disorder, her condition transformed dramatically after receiving intravenous thiamine.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
Read More
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
Read More
8
We explored the effects of a newly developed zinc-acetyl-l-carnitine complex on depression and neuroprotection. This innovative compound showed a remarkable 54% increase in antidepressant activity compared to standard acetyl-l-carnitine.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
Additionally, it demonstrated the ability to alleviate pain and protect nerve cells against damage. While the results are promising, further studies are needed to fully understand its long-term effectiveness and safety for depression and related conditions.
Read More
8
We explored whether combining antidepressants with low-dose methylfolate could improve outcomes for patients with depressive disorder. In this open-label trial, 44 participants received standard antidepressant treatment along with 800 µg of methylfolate daily for four weeks.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
Read More
8
This study examined how dietary vitamin B6 and plasma levels of pyridoxal 5’-phosphate relate to depression in US adults. We analyzed data from nearly 25,000 people over five years, revealing that those with the highest vitamin B6 intake and plasma levels experienced a lower risk of depression.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Read More
User Reviews
USERS' SCORE
Good
Based on 32 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Mood improvement
447 people found this helpful
The whole B-complex is contained in one capsule. I have noticed real results: Despite dreary, rainy weather, I feel cheerful. This year, the usual autumn depression has not affected me. I respond calmly to work stress, viewing it as part of life. My skin is managing well through the autumn-winter transition, free from dryness and tightness. My joints are also not causing issues.
Read More
9
Stomatitis cure
5 people found this helpful
I suffered from mouth ulcers for years, but surprisingly, after starting this vitamin B, my large stomatitis healed quickly. Although I didn’t take it primarily for depression, it has contributed to my overall mental stability.
Read More
9
Emotional uplift
4 people found this helpful
The quality is excellent, particularly for women. I've noticed a significant improvement in my mood; a strange depression has lifted, and I now feel energetic and active.
Read More
7.5
Depression relief
3 people found this helpful
After my total hysterectomy, I experienced a sharp decline in estrogen and early menopause, leading to severe depression. I found relief through B50 and other supplements, making daily life much more bearable. I hope this review helps others.
Read More
7.5
Nerves improved significantly
2 people found this helpful
I cannot imagine my life without these B vitamins. They are great for nervous individuals and address lingering depression. I take one capsule each morning. This brand has an excellent formulation, providing all B vitamins and inositol, essential for women. If you struggle with nerves or depression, I recommend this product; you’ll notice a difference in a month.
Read More
Frequently Asked Questions
7.5
Nerves improved significantly
2 people found this helpful
I cannot imagine my life without these B vitamins. They are great for nervous individuals and address lingering depression. I take one capsule each morning. This brand has an excellent formulation, providing all B vitamins and inositol, essential for women. If you struggle with nerves or depression, I recommend this product; you’ll notice a difference in a month.
9
Emotional uplift
4 people found this helpful
The quality is excellent, particularly for women. I've noticed a significant improvement in my mood; a strange depression has lifted, and I now feel energetic and active.
8
Stable mindset
1 people found this helpful
I felt the effects of the B vitamins as a physical sensation. They positively impact the brain and nerves, helping me achieve mental stability. Following the Fujikawa theory, I improved my depression and insomnia in about six months. I'm now using the 250-grain option for cost-effectiveness.
9
Mother's calmness
I gave this to my mother to help with her depression, and I've noticed she has become calmer and her mood has significantly improved. She seems much happier now.
9
Mood improvement
447 people found this helpful
The whole B-complex is contained in one capsule. I have noticed real results: Despite dreary, rainy weather, I feel cheerful. This year, the usual autumn depression has not affected me. I respond calmly to work stress, viewing it as part of life. My skin is managing well through the autumn-winter transition, free from dryness and tightness. My joints are also not causing issues.
9
Panic attack relief
The B-50 vitamin complex helped with my panic attacks and anxiety. After about a month of taking it, the panic attacks that used to occur unexpectedly disappeared, significantly improving my mental state.
7.5
Depression relief
3 people found this helpful
After my total hysterectomy, I experienced a sharp decline in estrogen and early menopause, leading to severe depression. I found relief through B50 and other supplements, making daily life much more bearable. I hope this review helps others.
9
Postpartum support
1 people found this helpful
After giving birth, I started taking vitamin B to prevent postpartum depression. It has been very helpful, and I feel great!
9
Autumn depression relief
Excellent! I took the Now Foods B-50 complex for a month to support my joints as autumn approached. Initially, I combined them with collagen powder, and later with alpha-lipoic acid. This combination not only benefited my skin and joints but also kept the autumn blues at bay. I'm feeling cheerful despite the dreary weather.
7.5
Postpartum support
2 people found this helpful
Compared to other B supplements, this one is cheaper, making it easier to maintain. I've used it alongside other treatments, and my postpartum depression has improved greatly under my doctor's guidance.
7.5
Preventative measure
2 people found this helpful
I purchased this as an ATP boost after reading Mr. Fujikawa's book. I take one tablet of vitamin B50, vitamin C, and iron in the morning, along with magnesium and vitamin E in the afternoon. The large ingredient variety means fewer tablets to take, and they are easy to swallow. Given my history of depression, I plan to continue using it to help prevent issues.
6
Peace of mind
27 people found this helpful
Since Fall 2020, I've used NOW B50, inspired by Fujikawa's theory. Initially, I took two tablets each morning and evening, totalling six. While I started with the aim of addressing depression, I now use it for a sense of peace and stability.
9
Mental health improvement
1 people found this helpful
Since I stopped drinking alcohol, my mental health has vastly improved, leading to reduced feelings of depression, anxiety, and helplessness.
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
8
We explored whether combining antidepressants with low-dose methylfolate could improve outcomes for patients with depressive disorder. In this open-label trial, 44 participants received standard antidepressant treatment along with 800 µg of methylfolate daily for four weeks.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
We used questionnaires to gauge depression levels throughout the study. The results suggested that this combination therapy might enhance treatment effectiveness compared to antidepressant monotherapy. Overall, it signals a promising avenue for those battling depression, pointing toward an approachable and potentially beneficial treatment strategy.
8
We investigated how niacin affects behavior and memory in older rats. Our study included six groups of rats receiving different treatments, including those with D-galactose-induced deficits.
After 14 days of treatment, we found that niacin significantly reduced signs of anxiety and depression, as well as improved memory. It also helped restore balance in various brain chemicals affected by aging.
Overall, niacin shows promise as a treatment for depression and cognitive decline associated with aging.
After 14 days of treatment, we found that niacin significantly reduced signs of anxiety and depression, as well as improved memory. It also helped restore balance in various brain chemicals affected by aging.
Overall, niacin shows promise as a treatment for depression and cognitive decline associated with aging.
8
Niacin shows promise for depression
We investigated how niacin (vitamin B3) impacts depression, particularly through a mouse model using lipopolysaccharide to induce depressive behaviors.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
The study revealed that niacin significantly reduced signs of despair in mice, leading to more mobility in forced swimming tests.
It not only boosted important brain chemicals but also activated protective pathways that lessen neuroinflammation associated with depression.
Overall, the findings suggest that niacin could be a promising option for managing depression by addressing key neuroprotective mechanisms.
8
This study examined how dietary vitamin B6 and plasma levels of pyridoxal 5’-phosphate relate to depression in US adults. We analyzed data from nearly 25,000 people over five years, revealing that those with the highest vitamin B6 intake and plasma levels experienced a lower risk of depression.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
9.5
We explored a remarkable case of a 58-year-old cancer patient who exhibited depressive symptoms potentially linked to thiamine deficiency (TD). Initially suspected of having major depressive disorder, her condition transformed dramatically after receiving intravenous thiamine.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. 10.12182/20250160608
- Caro-Ramírez JY, Bazán LO, Piro OE, Echeverría GA, Jori K, et al. Exploring Zn(II)-Acetyl l-carnitine complex for simultaneous management of depression, chronic pain, and neuroprotection. J Inorg Biochem. 2025;267:112857. 10.1016/j.jinorgbio.2025.112857
- Siddique A, Khokhar MM, Waheed A, Naeem U, Aziz SA. Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder. BMC Pharmacol Toxicol. 2025;26:14. 10.1186/s40360-025-00846-x
- Lu J, Mao H, Tan Y, Luo G. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010. Brain Behav. 2024;14:e70128. 10.1002/brb3.70128
- Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. 10.1016/j.exger.2024.112624
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. 10.1016/j.biopsych.2024.07.009
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. 10.1016/j.bcp.2023.115832
- Abdel Rasheed NO, Shiha NA, Mohamed SS, Ibrahim WW. SIRT1/PARP-1/NLRP3 cascade as a potential target for niacin neuroprotective effect in lipopolysaccharide-induced depressive-like behavior in mice. Int Immunopharmacol. 2023;123:110720. 10.1016/j.intimp.2023.110720
- Ishida M, Sato S, Sato I, Yoshioka A, Uchida N, et al. What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder. Palliat Support Care. 2024;22:205. 10.1017/S1478951523001128
- Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. 10.1177/00912174231179320
- Tuo LJ, Song XY, Zhu YY, He HN, Song YP, et al. Gestational folic acid supplement prevents vitamin D deficiency-induced depression-like behavior by reversing cortical DNA hypomethylation in adult offspring. J Steroid Biochem Mol Biol. 2023;231:106313. 10.1016/j.jsbmb.2023.106313
- Pan LA, Segreti AM, Wrobleski J, Shaw A, Hyland K, et al. Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior. Psychol Med. 2023;53:6046. 10.1017/S0033291722003233
