Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (Vitamin B-1) (from Thiamin HCl)
50 mg
4167%
Riboflavin (Vitamin B-2)
50 mg
3846%
Niacin (Vitamin B-3) (as Niacinamide)
50 mg
313%
Vitamin B-6 (from Pyridoxine HCl)
50 mg
2941%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
2083%
Biotin
50 mcg
167%
Pantothenic Acid (from Calcium Pantothenate)
50 mg
1000%
Choline (from Choline Bitartrate)
25 mg
5%
PABA (Para-Aminobenzoic Acid)
25 mg
†
Inositol
25 mg
†
Top Medical Research Studies
9
We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Read More
7
Annona muricata aids diabetes treatment
We explored the antidiabetic properties of Annona muricata leaf extract using a metabolomics approach on diabetes-induced rats. The study involved administering two doses of the extract to evaluate its impacts on metabolic profiles over four weeks.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
Read More
8
We explored how nicotinamide riboside (NR), a vitamin precursor to NAD, influences bone loss in type 2 diabetic mice. By administering NR to mice with diabetes induced by a high-fat diet and streptozotocin, we observed impressive results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
Read More
Most Useful Reviews
9
Recommended for diabetics
8 people found this helpful
B vitamins need to be replenished daily, which can be challenging with meal regulation. Dietary supplements help, especially taken alongside Alpha lipoic acid, necessary for diabetics. Following my endocrinologist's advice, I take B-50 regularly four times a year. I noticed no side effects. After 2 years of low-carb eating, my sugar levels are stable, hypertension has lessened, and diabetic neuropathy has gradually improved. Highly recommend!
Read More
8
Improves well-being
2 people found this helpful
I ordered these pills for my mother, who has type 2 diabetes and requires these vitamins. The B-50 tablets provide a complete range of B vitamins alongside choline and inositol, contributing to energy production and a healthy nervous system. My mother has observed an improvement in her well-being and energy levels. I highly recommend this medication and will continue ordering it for ourselves.
Read More
7.5
Essential for vitamin absorption
14 people found this helpful
Good evening from Ukraine! People with impaired metabolism, like myself, experience poor assimilation of B vitamins due to diabetes. To support my health, I take this medication twice a year. Please pray for our peace and health!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
- All Researches
9
Thiamine treatment aids diabetes management
We examined a rare condition known as thiamine-responsive megaloblastic anaemia (TRMA) in a young man with type 1 diabetes and unexplained pancytopenia. After thorough testing revealed genetic factors, we found that daily thiamine supplementation effectively resolved his anemia.
More importantly, this treatment not only improved his blood counts but also lowered his insulin needs. This highlights the significance of identifying genetic causes in young patients presenting with such symptoms.
More importantly, this treatment not only improved his blood counts but also lowered his insulin needs. This highlights the significance of identifying genetic causes in young patients presenting with such symptoms.
Read More
9
We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Read More
8
We explored how nicotinamide riboside (NR), a vitamin precursor to NAD, influences bone loss in type 2 diabetic mice. By administering NR to mice with diabetes induced by a high-fat diet and streptozotocin, we observed impressive results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
Read More
8
We examined how ice plant extract and its active component, D-pinitol, influence insulin secretion and glucose levels in diabetic rats. The study found that both IPE and D-pinitol significantly boosted insulin secretion in rat insulin-secreting cells.
Additionally, these substances improved glucose tolerance and displayed positive effects on liver function and lipid profiles. Overall, the findings suggest that IPE and D-pinitol show promise as functional foods that could help manage diabetes.
Additionally, these substances improved glucose tolerance and displayed positive effects on liver function and lipid profiles. Overall, the findings suggest that IPE and D-pinitol show promise as functional foods that could help manage diabetes.
Read More
8
Thiamine disulfide shows promise for diabetes
We investigated whether thiamine disulfide (TD) can lower blood sugar and improve insulin resistance in rats with type 1 diabetes. By assigning rats to different treatment groups, we used various tests to measure blood sugar, insulin sensitivity, and gene expression related to diabetes.
Results showed that TD effectively reduced blood glucose levels and improved several metabolic markers. However, it didn't affect the expression of the Glut4 gene, which plays a role in glucose uptake. Overall, TD demonstrated potential as a diabetes treatment, particularly in reducing insulin resistance.
Results showed that TD effectively reduced blood glucose levels and improved several metabolic markers. However, it didn't affect the expression of the Glut4 gene, which plays a role in glucose uptake. Overall, TD demonstrated potential as a diabetes treatment, particularly in reducing insulin resistance.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Recommended for diabetics
8 people found this helpful
B vitamins need to be replenished daily, which can be challenging with meal regulation. Dietary supplements help, especially taken alongside Alpha lipoic acid, necessary for diabetics. Following my endocrinologist's advice, I take B-50 regularly four times a year. I noticed no side effects. After 2 years of low-carb eating, my sugar levels are stable, hypertension has lessened, and diabetic neuropathy has gradually improved. Highly recommend!
Read More
8
Improves well-being
2 people found this helpful
I ordered these pills for my mother, who has type 2 diabetes and requires these vitamins. The B-50 tablets provide a complete range of B vitamins alongside choline and inositol, contributing to energy production and a healthy nervous system. My mother has observed an improvement in her well-being and energy levels. I highly recommend this medication and will continue ordering it for ourselves.
Read More
7.5
Essential for vitamin absorption
14 people found this helpful
Good evening from Ukraine! People with impaired metabolism, like myself, experience poor assimilation of B vitamins due to diabetes. To support my health, I take this medication twice a year. Please pray for our peace and health!
Read More
9
Relieves diabetes symptoms
5 people found this helpful
It is very effective for a diabetic patient. My mother has diabetes, and since taking it, her nerves have calmed down, alleviating the numbness she experienced in her leg and mouth.
Read More
7.5
Supports diabetes treatment
3 people found this helpful
I bought this complex for a relative following an endocrinologist’s recommendation. They take it as a supportive therapy to address deficiencies in diabetes treatment. The price is very affordable, and the quality is excellent. If you face a similar health issue, consult your doctor about this complex. The effect of its application is very positive.
Read More
Frequently Asked Questions
9
Recommended for diabetics
8 people found this helpful
B vitamins need to be replenished daily, which can be challenging with meal regulation. Dietary supplements help, especially taken alongside Alpha lipoic acid, necessary for diabetics. Following my endocrinologist's advice, I take B-50 regularly four times a year. I noticed no side effects. After 2 years of low-carb eating, my sugar levels are stable, hypertension has lessened, and diabetic neuropathy has gradually improved. Highly recommend!
8
Improves well-being
2 people found this helpful
I ordered these pills for my mother, who has type 2 diabetes and requires these vitamins. The B-50 tablets provide a complete range of B vitamins alongside choline and inositol, contributing to energy production and a healthy nervous system. My mother has observed an improvement in her well-being and energy levels. I highly recommend this medication and will continue ordering it for ourselves.
9
Relieves diabetes symptoms
5 people found this helpful
It is very effective for a diabetic patient. My mother has diabetes, and since taking it, her nerves have calmed down, alleviating the numbness she experienced in her leg and mouth.
7.5
Enhances mental clarity
I take one pill with breakfast and another with dinner for my type 1 diabetes. This has led to better blood sugar management and improved mental clarity. I found that vitamin B6 may protect teeth from decay, which is an added benefit. Overall, I am delighted with this wonderful product.
7.5
Supports diabetes treatment
3 people found this helpful
I bought this complex for a relative following an endocrinologist’s recommendation. They take it as a supportive therapy to address deficiencies in diabetes treatment. The price is very affordable, and the quality is excellent. If you face a similar health issue, consult your doctor about this complex. The effect of its application is very positive.
7
Annona muricata aids diabetes treatment
We explored the antidiabetic properties of Annona muricata leaf extract using a metabolomics approach on diabetes-induced rats. The study involved administering two doses of the extract to evaluate its impacts on metabolic profiles over four weeks.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
8
We explored how nicotinamide riboside (NR), a vitamin precursor to NAD, influences bone loss in type 2 diabetic mice. By administering NR to mice with diabetes induced by a high-fat diet and streptozotocin, we observed impressive results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
8
We examined how ice plant extract and its active component, D-pinitol, influence insulin secretion and glucose levels in diabetic rats. The study found that both IPE and D-pinitol significantly boosted insulin secretion in rat insulin-secreting cells.
Additionally, these substances improved glucose tolerance and displayed positive effects on liver function and lipid profiles. Overall, the findings suggest that IPE and D-pinitol show promise as functional foods that could help manage diabetes.
Additionally, these substances improved glucose tolerance and displayed positive effects on liver function and lipid profiles. Overall, the findings suggest that IPE and D-pinitol show promise as functional foods that could help manage diabetes.
7
We reviewed data from a 2009-2010 survey to understand how vitamin B6 influences the link between type 2 diabetes and periodontitis, a serious gum disease.
Our findings revealed that individuals with diabetes have an increased risk of periodontitis. Importantly, higher levels of vitamin B6 appeared to reduce this risk.
This suggests that maintaining adequate vitamin B6 intake may benefit those with diabetes by potentially lowering their chances of developing gum disease.
Our findings revealed that individuals with diabetes have an increased risk of periodontitis. Importantly, higher levels of vitamin B6 appeared to reduce this risk.
This suggests that maintaining adequate vitamin B6 intake may benefit those with diabetes by potentially lowering their chances of developing gum disease.
7
We conducted a double-blind randomized trial focusing on the effects of pyridoxamine, a vitamin B6 metabolite, on bone health in older women with type 2 diabetes.
After a year of treatment with 200 mg of pyridoxamine twice daily, we saw a promising 23% increase in a bone formation marker compared to only 4% with a placebo.
Additionally, participants taking pyridoxamine experienced an improvement in bone density and a reduction in HbA1c levels, indicating better blood sugar control.
However, further research is necessary to fully understand pyridoxamine’s potential in protecting against fractures in this population.
After a year of treatment with 200 mg of pyridoxamine twice daily, we saw a promising 23% increase in a bone formation marker compared to only 4% with a placebo.
Additionally, participants taking pyridoxamine experienced an improvement in bone density and a reduction in HbA1c levels, indicating better blood sugar control.
However, further research is necessary to fully understand pyridoxamine’s potential in protecting against fractures in this population.
References
- Zubaidi SN, Wong PL, Qadi WSM, Dawoud EAD, Hamezah HS, et al. Deciphering the mechanism of Annona muricata leaf extract in alloxan-nicotinamide-induced diabetic rat model with H-NMR-based metabolomics approach. J Pharm Biomed Anal. 2025;260:116806. doi:10.1016/j.jpba.2025.116806
- Zhu J, Xu W, Wu S, Song D. Vitamin B6 status, type 2 diabetes mellitus, and periodontitis: evidence from the NHANES database 2009-2010. BMC Oral Health. 2025;25:299. doi:10.1186/s12903-025-05597-z
- Gao J, Meng X, Yang X, Xie C, Tian C, et al. The protection of nicotinamide riboside against diabetes mellitus-induced bone loss via OXPHOS. Bone. 2025;193:117411. doi:10.1016/j.bone.2025.117411
- Lee D, Kim SJ, Choi YJ, Rho YH, Kang TS, et al. The Glucose-Lowering Effect of and D-Pinitol: Studies on Insulin Secretion in INS-1 Cells and the Reduction of Blood Glucose in Diabetic Rats. Nutrients. 2025;17. doi:10.3390/nu17010193
- Brossfield AV, McMahon DJ, Fernando J, Omeragic B, Majeed R, et al. The Effects of the AGE Inhibitor Pyridoxamine on Bone in Older Women With Type 2 Diabetes: A Randomized Clinical Trial. J Clin Endocrinol Metab. 2025;110:961. doi:10.1210/clinem/dgae700
- Pascoe MA, Hall AM, Gray A. Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia. BMJ Case Rep. 2024;17. doi:10.1136/bcr-2024-261435
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- D'Haese S, Claes L, Jaeken E, Deluyker D, Evens L, et al. Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats. Int J Mol Sci. 2024;25. doi:10.3390/ijms25158508
- Rad MG, Sharifi M, Meamar R, Soltani N. Long term administration of thiamine disulfide improves FOXO1/PEPCK pathway in liver to reduce insulin resistance in type 1 diabetes rat model. Biomed Pharmacother. 2024;177:117053. doi:10.1016/j.biopha.2024.117053
- Zhu Y, Ying T, Xu M, Chen Q, Wu M, et al. Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort. Nutrients. 2024;16. doi:10.3390/nu16121901
- Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. doi:10.32725/jab.2024.009
