Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase.
We explored the impact of thiamine (Vitamin B1) on memory and learning in rats with hypothyroidism. In a study involving 50 young rats, we treated them with a hypothyroid-inducing agent and varying doses of thiamine over seven weeks.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
Read More
8
Vitamin B benefits hypothyroidism treatment
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
We aimed to explore how B vitamins, including pyridoxine, betaine, folic acid, and cyanocobalamin, can correct homocysteine metabolism disrupted by hypothyroidism. By studying experimental rats treated for prolonged periods, we found that hypothyroidism severely reduced the activity of key enzymes involved in methylation, which in turn raised homocysteine levels—linked to heart disease risk.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
Read More
7
Vitamin B12 deficiency linked to hypothyroidism
A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.
We explored the connection between vitamin B12 levels and hypothyroidism in a study involving 100 patients. A significant 68% of these patients were found to be vitamin B12 deficient, with a notable correlation to the presence of anti TPO and anti Thyroglobulin antibodies.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
Read More
Most Useful Reviews
9
Increased energy levels
114 people found this helpful
I liked the B-complex! After my lunch, I took one capsule. Having hypothyroidism, I often felt fatigued, weak, and irritable. Following tests, I addressed my deficiencies in vitamin B and iron, as B vitamins aid iron absorption. NOW B-50 complex is well-balanced with B-1, B-2, B-3, B-6, B-12, Biotin, Choline, Inositol, and Pantothenic Acid. After the course, I experienced a surge of energy that lasted throughout the day!
Read More
7.5
Recommended for B deficiency
2 people found this helpful
Vitamin B50 is excellent! In the hospital, I dealt with fatigue and instability due to menopausal disorders and hypothyroidism. I was advised to take vitamin B50. Although I occasionally had B supplements, this B50 offers great value by combining multiple B vitamins. Many appear to lack vitamin B, hence, I strongly recommend it!
Read More
9
Energy boost
I enjoyed the B-complex! After dinner, I took a capsule. With hypothyroidism, I faced persistent fatigue, weakness, and irritability. After tests, I began addressing my group B and iron deficiencies since B vitamins assist with iron absorption. NOW's B-50 Complex is balanced and includes various B vitamins. I'll definitely be ordering more for my family!
Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase.
We explored the impact of thiamine (Vitamin B1) on memory and learning in rats with hypothyroidism. In a study involving 50 young rats, we treated them with a hypothyroid-inducing agent and varying doses of thiamine over seven weeks.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
Read More
8
Vitamin B benefits hypothyroidism treatment
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
We aimed to explore how B vitamins, including pyridoxine, betaine, folic acid, and cyanocobalamin, can correct homocysteine metabolism disrupted by hypothyroidism. By studying experimental rats treated for prolonged periods, we found that hypothyroidism severely reduced the activity of key enzymes involved in methylation, which in turn raised homocysteine levels—linked to heart disease risk.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
Read More
7
Vitamin B12 deficiency linked to hypothyroidism
A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.
We explored the connection between vitamin B12 levels and hypothyroidism in a study involving 100 patients. A significant 68% of these patients were found to be vitamin B12 deficient, with a notable correlation to the presence of anti TPO and anti Thyroglobulin antibodies.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
Read More
7
Myo-inositol shows potential benefit
Myo-inositol in autoimmune thyroiditis, and hypothyroidism.
We examined the effects of Myo-inositol on autoimmune thyroiditis and hypothyroidism. Clinical studies indicated that combining Myo-inositol with seleniomethionine significantly reduced TSH levels in patients with subclinical hypothyroidism.
This treatment not only lowered TSH but also reduced antithyroid autoantibodies, suggesting a positive immune-modulatory effect. However, further research with larger populations is needed to better understand how this treatment impacts overall quality of life and to investigate the underlying mechanisms involved.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
All Reviews
Positive Reviews
Negative Reviews
9
Increased energy levels
114 people found this helpful
I liked the B-complex! After my lunch, I took one capsule. Having hypothyroidism, I often felt fatigued, weak, and irritable. Following tests, I addressed my deficiencies in vitamin B and iron, as B vitamins aid iron absorption. NOW B-50 complex is well-balanced with B-1, B-2, B-3, B-6, B-12, Biotin, Choline, Inositol, and Pantothenic Acid. After the course, I experienced a surge of energy that lasted throughout the day!
Read More
7.5
Recommended for B deficiency
2 people found this helpful
Vitamin B50 is excellent! In the hospital, I dealt with fatigue and instability due to menopausal disorders and hypothyroidism. I was advised to take vitamin B50. Although I occasionally had B supplements, this B50 offers great value by combining multiple B vitamins. Many appear to lack vitamin B, hence, I strongly recommend it!
Read More
9
Energy boost
I enjoyed the B-complex! After dinner, I took a capsule. With hypothyroidism, I faced persistent fatigue, weakness, and irritability. After tests, I began addressing my group B and iron deficiencies since B vitamins assist with iron absorption. NOW's B-50 Complex is balanced and includes various B vitamins. I'll definitely be ordering more for my family!
Read More
9
Improved strength
I found the B-complex excellent! Taking one capsule after dinner helped with my hypothyroidism, fatigue, and irritability. After tests, I focused on correcting my B and iron deficiencies, as B vitamins aid in iron absorption. NOW's B-50 Complex contains essential B vitamins. Following a course, I felt a surge in vitality!
Read More
7.5
Stress management
The B-complex is immensely beneficial for my hypothyroidism. I take a capsule after breakfast, avoiding other supplements to prevent incompatibility. I feel I'm coping better with stress and staying healthy!
Read More
Frequently Asked Questions
Hypothyroidism is a medical condition that occurs when the thyroid gland, a small butterfly-shaped gland located at the base of the neck, does not produce enough thyroid hormones. These hormones, mainly thyroxine (T4) and triiodothyronine (T3), play a critical role in regulating various bodily functions, including metabolism, energy production, and overall growth and development. When hormone levels drop, it can lead to a slow metabolism, weight gain, fatigue, depression, and a host of other symptoms that can significantly affect quality of life.
The condition can be caused by a variety of factors, including autoimmune diseases like Hashimoto's thyroiditis, certain medications, radiation treatment, or iodine deficiency. Diagnosis typically involves blood tests to check levels of thyroid-stimulating hormone (TSH) and thyroid hormones. Treatment primarily includes hormone replacement therapy, with synthetic thyroid hormones such as levothyroxine being the most common form of treatment. With proper management, individuals with hypothyroidism can lead normal, healthy lives by ensuring they receive the necessary hormones their bodies need to function optimally.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Based on user reviews, individuals taking B-complex supplements for hypothyroidism report varied timelines for seeing results. Many users experienced noticeable improvements in their energy levels and overall well-being after completing a course of the supplement, often referring to surges in vitality and a reduction in fatigue and irritability. For instance, one review mentions a surge of energy that lasted throughout the day after the course Read Review. Another user noted significant improvements in coping with stress and maintaining health after starting the B-complex Read Review.
While specific timelines can vary, many users suggest that it may take several weeks of consistent use to fully experience the benefits. Users emphasize the importance of addressing B vitamin and iron deficiencies for those with hypothyroidism to see optimal results. Overall, if you are considering a B-complex supplement, you might expect to start noticing positive effects within a few weeks but could find even greater benefits by maintaining consistent supplementation over a longer period.
The evidence supporting the use of supplements for managing hypothyroidism is mixed but promising. Research suggests that certain B vitamins, particularly B12, may alleviate symptoms related to hypothyroidism. A study involving 100 patients found a significant correlation between vitamin B12 deficiency and hypothyroid symptoms, indicating that B12 supplementation could potentially improve the condition, although more studies are needed to confirm its routine use in treatment [2]. Additionally, other B vitamins may play a key role in correcting metabolic disruptions caused by hypothyroidism, hinting at their potential in minimizing complications like heart disease [3].
Another supplement, Myo-inositol, has shown promise in reducing TSH levels and autoantibodies in those with subclinical hypothyroidism when combined with seleniomethionine. This suggests it may offer a beneficial effect on thyroid function and immune response [4]. However, while these findings are encouraging, they underscore the importance of further research with larger groups to validate the effectiveness and safety of these supplements in the treatment of hypothyroidism.
Based on user reviews, many individuals with hypothyroidism report experiencing significant improvements in their symptoms after incorporating B-complex supplements into their routine. Users frequently mention enhanced energy levels, with one user noting a lasting surge of energy throughout the day after completing a course of the supplement Read Review. Others echo similar sentiments, stating that the B-50 complex has helped alleviate issues with fatigue, irritability, and overall vitality after addressing their specific B vitamin and iron deficiencies Read Review.
Moreover, anecdotal experiences indicate that users are finding it easier to cope with stress and maintain better health overall, which is an encouraging sign for those dealing with the multifaceted challenges of hypothyroidism Read Review. While individual results may vary, the general consensus is that a well-balanced B-complex supplement may contribute to improved well-being and energy, particularly when combined with proper dietary adjustments.
Based on user reviews, there seems to be a mixed approach when it comes to combining the B-complex supplement with other supplements for managing hypothyroidism. Some users express concerns about compatibility, with one individual mentioning they avoid taking other supplements simultaneously to prevent any possible incompatibility issues Read Review. This caution suggests that while the B-complex may work well on its own, there is uncertainty about how it might interact with other supplements that others might be taking.
On the other hand, many users emphasize the benefits of addressing multiple deficiencies simultaneously. They report that the B-complex, which contains a variety of essential B vitamins, has significantly improved their energy levels and overall health after correcting deficiencies in both B vitamins and iron Read Review. This indicates that while some users may prefer a singular approach, others find that the B-complex can complement their regimen effectively as part of a broader strategy to manage hypothyroidism symptoms.
Based on user reviews, it seems that a common practice among those with hypothyroidism is to take one capsule of Vitamin B Complex, specifically the NOW B-50 Complex. Users report taking their dose after meals, whether it be after lunch or dinner, to combat symptoms such as fatigue, weakness, and irritability. For instance, one user mentioned taking it after lunch and feeling a surge of energy throughout the day, while another emphasized a positive experience after taking it post-dinner, noting improvements in vitality and overall well-being Read ReviewRead Review.
Users also highlighted the importance of addressing B vitamin and iron deficiencies, with specific acknowledgement that B vitamins support iron absorption, further recommending the NOW B-50 Complex due to its balanced formulation of essential B vitamins. While some users did not specify exact doses, the anecdotal evidence suggests that one capsule—taken consistently after meals—is an effective approach for managing symptoms associated with hypothyroidism Read ReviewRead Review.
9
Increased energy levels
114 people found this helpful
I liked the B-complex! After my lunch, I took one capsule. Having hypothyroidism, I often felt fatigued, weak, and irritable. Following tests, I addressed my deficiencies in vitamin B and iron, as B vitamins aid iron absorption. NOW B-50 complex is well-balanced with B-1, B-2, B-3, B-6, B-12, Biotin, Choline, Inositol, and Pantothenic Acid. After the course, I experienced a surge of energy that lasted throughout the day!
7.5
Stress management
The B-complex is immensely beneficial for my hypothyroidism. I take a capsule after breakfast, avoiding other supplements to prevent incompatibility. I feel I'm coping better with stress and staying healthy!
9
Improved strength
I found the B-complex excellent! Taking one capsule after dinner helped with my hypothyroidism, fatigue, and irritability. After tests, I focused on correcting my B and iron deficiencies, as B vitamins aid in iron absorption. NOW's B-50 Complex contains essential B vitamins. Following a course, I felt a surge in vitality!
9
Energy boost
I enjoyed the B-complex! After dinner, I took a capsule. With hypothyroidism, I faced persistent fatigue, weakness, and irritability. After tests, I began addressing my group B and iron deficiencies since B vitamins assist with iron absorption. NOW's B-50 Complex is balanced and includes various B vitamins. I'll definitely be ordering more for my family!
7.5
Recommended for B deficiency
2 people found this helpful
Vitamin B50 is excellent! In the hospital, I dealt with fatigue and instability due to menopausal disorders and hypothyroidism. I was advised to take vitamin B50. Although I occasionally had B supplements, this B50 offers great value by combining multiple B vitamins. Many appear to lack vitamin B, hence, I strongly recommend it!
7
Vitamin B12 deficiency linked to hypothyroidism
A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital.
We explored the connection between vitamin B12 levels and hypothyroidism in a study involving 100 patients. A significant 68% of these patients were found to be vitamin B12 deficient, with a notable correlation to the presence of anti TPO and anti Thyroglobulin antibodies.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
8
Vitamin B benefits hypothyroidism treatment
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
We aimed to explore how B vitamins, including pyridoxine, betaine, folic acid, and cyanocobalamin, can correct homocysteine metabolism disrupted by hypothyroidism. By studying experimental rats treated for prolonged periods, we found that hypothyroidism severely reduced the activity of key enzymes involved in methylation, which in turn raised homocysteine levels—linked to heart disease risk.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
7
Myo-inositol shows potential benefit
Myo-inositol in autoimmune thyroiditis, and hypothyroidism.
We examined the effects of Myo-inositol on autoimmune thyroiditis and hypothyroidism. Clinical studies indicated that combining Myo-inositol with seleniomethionine significantly reduced TSH levels in patients with subclinical hypothyroidism.
This treatment not only lowered TSH but also reduced antithyroid autoantibodies, suggesting a positive immune-modulatory effect. However, further research with larger populations is needed to better understand how this treatment impacts overall quality of life and to investigate the underlying mechanisms involved.
References
Saberi R, Mirazi N, Amirahmadi S, Darbandi ZK, Vafaee F, et al. Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase. Metab Brain Dis. 2023;38:2603. doi:10.1007/s11011-023-01317-0
Chatterjee T, Gupta R, Choudhary S. A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital. J Assoc Physicians India. 2023;71:1.
Nechyporuk V, Korda M, Pentiuk L, Dmytrenko I, Bulko I. The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats. Pol Merkur Lekarski. 2020;48:55.
Fallahi P, Ferrari SM, Elia G, Ragusa F, Paparo SR, et al. Myo-inositol in autoimmune thyroiditis, and hypothyroidism. Rev Endocr Metab Disord. 2018;19:349. doi:10.1007/s11154-018-9477-9