Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (Vitamin B-1) (from Thiamin HCl)
50 mg
4167%
Riboflavin (Vitamin B-2)
50 mg
3846%
Niacin (Vitamin B-3) (as Niacinamide)
50 mg
313%
Vitamin B-6 (from Pyridoxine HCl)
50 mg
2941%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
2083%
Biotin
50 mcg
167%
Pantothenic Acid (from Calcium Pantothenate)
50 mg
1000%
Choline (from Choline Bitartrate)
25 mg
5%
PABA (Para-Aminobenzoic Acid)
25 mg
†
Inositol
25 mg
†
Top Medical Research Studies
7
We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Read More
9
We examined a unique case of a 58-year-old woman with recurrent endometrial cancer who showed signs of severe depression and attempted suicide. Initially, her symptoms were believed to be linked to major depressive disorder.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
Read More
8
Vitamin B12 aids specific sleep disorders
We looked into the effects of Vitamin B12 on two patients with long-standing sleep-wake rhythm disorders.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
Read More
Most Useful Reviews
9
Improvements noted
4 people found this helpful
B vitamins are vital for the body. Their deficiency can lead to insomnia and other issues. Since taking this supplement, I've noticed improvements in my nervous system's functioning, helping reduce my insomnia. The quality and dosage are good, though high doses should be monitored.
Read More
9
Immediate effect noticed
2 people found this helpful
This supplement is crucial for my vitamin B12 intake as a vegetarian. When I run out, insomnia creeps in, along with numbness and discomfort. It's a reliable supplement, providing immediate benefits from day one.
Read More
9
Insomnia disappeared
2 people found this helpful
This is the best B vitamin complex! I feel much better; my insomnia has vanished, and my husband and I can finally fall asleep. The anxiety keeping me awake has dissipated. I highly recommend it, especially for those on a keto diet.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
- All Researches
9
We examined a unique case of a 58-year-old woman with recurrent endometrial cancer who showed signs of severe depression and attempted suicide. Initially, her symptoms were believed to be linked to major depressive disorder.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
Read More
8
In a 4-week open-label study involving 40 individuals with mild-to-moderate insomnia, we explored the effects of a combination formula containing melatonin and vitamin B6.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Read More
8
Vitamin B12 aids specific sleep disorders
We looked into the effects of Vitamin B12 on two patients with long-standing sleep-wake rhythm disorders.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
Read More
7
We evaluated the effectiveness of a nutritional supplement, SPINOFF, on sleep quality and mental health in a pilot study involving 41 participants. Initially, participants reported significant sleep issues and psychological distress.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
Read More
7
We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improvements noted
4 people found this helpful
B vitamins are vital for the body. Their deficiency can lead to insomnia and other issues. Since taking this supplement, I've noticed improvements in my nervous system's functioning, helping reduce my insomnia. The quality and dosage are good, though high doses should be monitored.
Read More
9
Immediate effect noticed
2 people found this helpful
This supplement is crucial for my vitamin B12 intake as a vegetarian. When I run out, insomnia creeps in, along with numbness and discomfort. It's a reliable supplement, providing immediate benefits from day one.
Read More
9
Insomnia disappeared
2 people found this helpful
This is the best B vitamin complex! I feel much better; my insomnia has vanished, and my husband and I can finally fall asleep. The anxiety keeping me awake has dissipated. I highly recommend it, especially for those on a keto diet.
Read More
7.5
Improved sleep quality
2 people found this helpful
As stress increased, I experienced insomnia and chronic fatigue. After taking this complex alongside magnesium for a month, my sleep improved, along with my overall well-being and calmness.
Read More
7.5
Sleep improved
1 people found this helpful
Excellent for high mental stress! After two weeks, my niece's insomnia improved, and she has become calmer. This supplement is great for teenagers facing exam stress. I recommend it wholeheartedly.
Read More
Frequently Asked Questions
9
Immediate effect noticed
2 people found this helpful
This supplement is crucial for my vitamin B12 intake as a vegetarian. When I run out, insomnia creeps in, along with numbness and discomfort. It's a reliable supplement, providing immediate benefits from day one.
7.5
Improved sleep quality
2 people found this helpful
As stress increased, I experienced insomnia and chronic fatigue. After taking this complex alongside magnesium for a month, my sleep improved, along with my overall well-being and calmness.
9
No more pills
I take these in combination with magnesium every six months, which helps with my insomnia and reduces my nerves. I've completely stopped using sleeping pills and antidepressants. I highly recommend them!
7.5
Sleep improved
1 people found this helpful
Excellent for high mental stress! After two weeks, my niece's insomnia improved, and she has become calmer. This supplement is great for teenagers facing exam stress. I recommend it wholeheartedly.
7.5
Sleep improved
5 people found this helpful
I recommend Now vitamins to everyone! This excellent B vitamin complex, combined with Magnesium citrate, has stabilised my nervous system. After three months, my mood swings have reduced and my sleep has normalised, alleviating insomnia due to stress.
9
Insomnia disappeared
2 people found this helpful
This is the best B vitamin complex! I feel much better; my insomnia has vanished, and my husband and I can finally fall asleep. The anxiety keeping me awake has dissipated. I highly recommend it, especially for those on a keto diet.
7.5
Energy booster
I began taking B vitamins as they’re vital for ATP energy production. Since they’re water-soluble, I take them three times a day. However, to combat insomnia, I avoid taking them late at night and prefer an early evening dose.
7.5
Causes drowsiness
1 people found this helpful
ALL HEALTH! Now Foods, B-50 is a remarkable product. The balanced composition offers great value. A deficiency in B vitamins leads to fatigue and insomnia, among other issues. I found it best to take it an hour before bedtime, as it can cause drowsiness.
6
Mental state improvement
It effectively enhances my mental state. I recommend taking it in the morning to sustain productivity throughout the day, as taking it in the evening may cause insomnia.
9
Eczema relief
After being bitten by a tick and developing eczema, I researched and found B vitamins effective against it. Taking two tablets significantly improved my symptoms by the next day. Although the eczema cleared, I experienced some insomnia for two days, so I now take only one tablet in the morning.
7
We evaluated the effectiveness of a nutritional supplement, SPINOFF, on sleep quality and mental health in a pilot study involving 41 participants. Initially, participants reported significant sleep issues and psychological distress.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
8
In a 4-week open-label study involving 40 individuals with mild-to-moderate insomnia, we explored the effects of a combination formula containing melatonin and vitamin B6.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
7
We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
8
Vitamin B12 aids specific sleep disorders
We looked into the effects of Vitamin B12 on two patients with long-standing sleep-wake rhythm disorders.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
References
- De Simone M, De Feo R, Choucha A, Ciaglia E, Fezeu F. Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin. Med Sci (Basel). 2023;12. doi:10.3390/medsci12010002
- Ishida M, Sato S, Sato I, Yoshioka A, Uchida N, et al. What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder. Palliat Support Care. 2024;22:205. doi:10.1017/S1478951523001128
- Lemoine P, Bablon JC, Da Silva C. A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Complement Ther Med. 2019;45:104. doi:10.1016/j.ctim.2019.05.024
- Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.
- Okawa M, Mishima K, Nanami T, Shimizu T, Iijima S, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13:15.
