We investigated if small extracellular vesicles (sEVs) derived from tonsil stem cells could improve myo-inositol production, which is often disrupted by inflammation in menopausal women.
Over two weeks, mice received treatments mimicking this condition. Our results indicated that those receiving sEVs showed a restoration of myo-inositol levels and healthier muscle profiles compared to those that did not.
This research suggests that sEVs could be a promising option to improve metabolic health during menopause.
Read More
7
Folate impacts bone health in menopause
Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation.
We sought to understand how vitamin B levels influence bone health in postmenopausal women. Our analysis of 117 women over five years showed that higher folate levels positively correlate with vertebral bone mineral density changes.
However, we found no significant link between changes in bone density and either homocysteine or vitamin B12 levels. This suggests that folate deficiency may play a significant role in bone health during menopause, indicating its importance for maintaining vertebral strength.
Read More
9
Effective nutritional menopause treatment
Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9.
We explored the effects of Exelvit Menopause®, a nutritional product incorporating various ingredients including vitamins and herbal extracts, on menopausal symptoms. Over 12 weeks, 156 menopausal women took this supplement daily, and we measured symptom relief using a standardized score.
Our findings revealed a noteworthy decrease in symptoms such as hot flashes, sleep disturbances, and irritability, with reductions ranging from 27.8% to 48.15%. This suggests that Exelvit Menopause® could offer a promising, non-hormonal approach to easing menopause-related discomfort.
Read More
Most Useful Reviews
9
Weight management
1 people found this helpful
I've been taking this for six months, with one tablet in the morning and one in the afternoon. I believe my weight is stabilising, and my cholesterol levels have normalised at my latest health check. This product may help with menopause symptoms, and it complements other supplements well.
Read More
9
Pain reduction
1 people found this helpful
As a post-menopausal woman, I've experienced significant finger and foot pain. Since taking this B50 supplement daily, the pain has remarkably lessened. It’s a delightful experience.
Read More
9
Fatigue reduction
This contains all the B vitamins I need in one daily tablet. Since starting it, I no longer feel easily fatigued. It’s also reassuring as it’s in a vegetable capsule, ideal for my menopause management.
Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9.
We explored the effects of Exelvit Menopause®, a nutritional product incorporating various ingredients including vitamins and herbal extracts, on menopausal symptoms. Over 12 weeks, 156 menopausal women took this supplement daily, and we measured symptom relief using a standardized score.
Our findings revealed a noteworthy decrease in symptoms such as hot flashes, sleep disturbances, and irritability, with reductions ranging from 27.8% to 48.15%. This suggests that Exelvit Menopause® could offer a promising, non-hormonal approach to easing menopause-related discomfort.
Read More
9
Vitamin B12 improves menopausal dry eyes
Efficacy of hyaluronic acid 0.3%, cyanocobalamin, electrolytes, and P-Plus in menopause patients with moderate dry eye disease.
We examined whether a combination of hyaluronic acid 0.3% and vitamin B12 could improve dry eye symptoms in menopausal women. In a study involving thirty women, we measured the effectiveness of a specially formulated eye drop containing these ingredients over a 30-day period.
After treatment, patients reported decreased symptoms and increased tear stability. Their scores on established dry eye assessment tools showed significant improvements, indicating that vitamin B12, alongside other ingredients, may play a beneficial role in alleviating dry eye issues during menopause.
Read More
8
Vitamin B may ease perimenopause
Clinical Evaluation of Effectiveness and Safety of Combined Use of Dietary Supplements Amberen and Smart B in Women with Climacteric Syndrome in Perimenopause.
This randomized, double-blind, placebo-controlled study explored how a combination of the Amberen supplement and a vitamin B complex affects women in perimenopause suffering from climacteric symptoms.
We found that this dietary supplement is not only safe but also helps alleviate various symptoms like hot flashes and mood swings. Participants experienced improved sleep, cognitive function, and overall well-being.
Overall, this suggests that vitamin B complex can be a valuable part of managing perimenopausal symptoms.
Read More
8
Vitamin-enriched oil beneficial for menopause
Effect of 1-y oral supplementation with vitaminized olive oil on platelets from healthy postmenopausal women.
We investigated the impact of vitamin-enriched extra virgin olive oil on postmenopausal women's health. In a year-long study involving 60 participants, half received the enriched oil while the other half got a placebo.
We found that those taking the vitamin-enriched olive oil showed improved platelet function and reduced levels of harmful nitrosative stress markers in their blood. This suggests that incorporating this healthy fat into our diets could help manage health issues related to menopause, particularly those affecting bone health.
Read More
7
Investigating T-MSCs for menopause
Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle.
We investigated if small extracellular vesicles (sEVs) derived from tonsil stem cells could improve myo-inositol production, which is often disrupted by inflammation in menopausal women.
Over two weeks, mice received treatments mimicking this condition. Our results indicated that those receiving sEVs showed a restoration of myo-inositol levels and healthier muscle profiles compared to those that did not.
This research suggests that sEVs could be a promising option to improve metabolic health during menopause.
I've been taking this for six months, with one tablet in the morning and one in the afternoon. I believe my weight is stabilising, and my cholesterol levels have normalised at my latest health check. This product may help with menopause symptoms, and it complements other supplements well.
Read More
9
Pain reduction
1 people found this helpful
As a post-menopausal woman, I've experienced significant finger and foot pain. Since taking this B50 supplement daily, the pain has remarkably lessened. It’s a delightful experience.
Read More
9
Fatigue reduction
This contains all the B vitamins I need in one daily tablet. Since starting it, I no longer feel easily fatigued. It’s also reassuring as it’s in a vegetable capsule, ideal for my menopause management.
Read More
7.5
Depression relief
3 people found this helpful
After my total hysterectomy, my estrogen plummeted, leading to an early menopause and a series of depressive symptoms. Life was challenging until I incorporated B50, vitamin C, B6, and magnesium into my routine, which alleviated my depression. I hope my review assists others.
Read More
7.5
Energy boost
1 people found this helpful
Post-menopause, I realised the need to supplement with B vitamins. Since doing so, my numbness has disappeared. B vitamins act as fuel for energy metabolism, and I've felt revitalised after ensuring adequate intake.
Menopause is a natural biological process that marks the end of a woman's reproductive years, characterized by the cessation of menstruation and a decline in hormonal levels, particularly estrogen and progesterone. Typically occurring between the ages of 45 and 55, menopause can bring a variety of physical and emotional changes. Common symptoms may include hot flashes, night sweats, mood swings, and changes in sleep patterns. It is important to note that menopause is a gradual process and often begins with perimenopause, where women may experience irregular periods and increased symptoms for several years before periods stop completely.
While menopause is a natural phase of life, it can have significant impacts on a woman's health and well-being. This transition can increase the risk of certain health issues, such as osteoporosis and cardiovascular disease, due in part to lowered hormone levels. Therefore, it is advisable for women to consult with healthcare providers to discuss potential management strategies and lifestyle adjustments during this time. These may include hormone replacement therapy, dietary changes, regular physical activity, and alternative therapies, all aimed at alleviating symptoms and promoting overall health during and after menopause.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Research suggests that Vitamin B Complex may offer some benefits for women experiencing menopause. The B vitamins, particularly B6 and B12, play a crucial role in hormone regulation and may help alleviate certain symptoms associated with menopause, such as mood swings, fatigue, and irritability. Additionally, Vitamin B6 is known for its potential to reduce anxiety and improve overall emotional well-being, which can be particularly beneficial during this transitional phase of life. Some evidence also indicates that B vitamins may help in reducing hot flashes, although further studies are needed to confirm this effect.
However, it's important to approach supplementation with caution. While B vitamins are essential for overall health, excessive intake can lead to adverse effects. It's best to consult with a healthcare provider before starting any new supplement regimen, especially for those experiencing menopause, to ensure it aligns with individual health needs and conditions. Combining a balanced diet rich in whole foods, which naturally provide B vitamins, along with appropriate lifestyle changes may be the most effective way to manage menopause symptoms.
Based on user reviews, results from taking a B50 supplement for menopause typically start to manifest within a few weeks to several months. Users have reported noticeable improvements in their symptoms after consistently using the supplement for about two weeks, especially regarding issues like dizziness and numbness (review-id: c06ea43d-0d64-4339-8cb1-e28e5512128c Read Review; review-id: 702db207-4a3b-4f8c-8e9e-953f1c8ae480 Read Review). Other users have noted that it took about six months for a full assessment of benefits like stabilized weight and cholesterol levels, which also aligns with positive feedback regarding menopausal symptoms (review-id: 134aef96-a3ed-40e0-92ec-821b3789305d Read Review).
Research supports the use of certain supplements for alleviating menopausal symptoms. One notable study on Exelvit Menopause®, a nutritional blend that includes vitamins and herbal extracts, reported significant reductions in symptoms such as hot flashes and sleep disturbances among menopausal women. Participants observed a symptom relief of 27.8% to 48.15% over a 12-week period, highlighting its potential as a non-hormonal approach to managing menopause-related discomfort [3]. Additionally, vitamin B complex has been found to be safe and effective in decreasing various perimenopausal symptoms, including hot flashes and mood swings, thereby improving overall well-being [2].
Moreover, findings suggest that vitamin B6 may help alleviate depression and anxiety in middle-aged women, including those experiencing menopause, enhancing mood during this transitional phase [5]. Other studies have demonstrated the role of specific vitamins, such as folate, in maintaining bone health in postmenopausal women, which could further underscore the importance of a well-rounded nutritional approach during menopause [8]. Overall, while there are promising findings regarding certain supplements, it is essential for individuals to consult with healthcare professionals to tailor their supplements to their specific needs.
Based on user reviews, many individuals have reported significant improvements in a variety of menopause-related symptoms after incorporating a B50 supplement into their routines. Users have indicated reductions in pain, such as one post-menopausal woman noting a remarkable decrease in finger and foot pain after starting the supplement (review-id: 40a5c670-521e-462f-b1a0-23ed701aa93c). Others have experienced relief from dizziness associated with menopause, with regular intake reportedly reducing the frequency of these episodes (review-id: 23d57c33-ea67-4521-9443-c7f8057a3a98; review-id: bf37fb38-7e90-4d4d-8b1a-65e0cc7f2b29).
Moreover, users have shared anecdotal experiences regarding enhancements in their overall emotional well-being, with one user stating that their depressive symptoms improved significantly after introducing the B50 into their regimen alongside other supplements (review-id: 71de13b3-3e77-4f8c-b84f-ae92baa6d75d). Others noted a revitalizing effect, attributing increased energy and decreased feelings of fatigue to the inclusion of this supplement in their diets (review-id: 93f8645f-7c38-4f00-989f-4a30faca705c). While individual outcomes can vary, the overall sentiment among users seems to lean positively towards the efficacy of B50 in alleviating menopause-related symptoms.
Based on user reviews, many individuals have reported positive experiences when combining B50 supplements with other supplements for managing menopause symptoms. For example, one user noted that their depressive symptoms improved significantly after incorporating B50 along with vitamin C, B6, and magnesium into their routine post-hysterectomy (review-id: 71de13b3-3e77-4f8c-b84f-ae92baa6d75d). Another user highlighted the beneficial effects of combining the B50 supplement with zinc to address menopause-related dry eye issues (review-id: 6adc6a4c-dfec-4c2c-b796-b2177d949f03). These anecdotes suggest that users often find a synergistic effect when integrating B50 with other nutritional supplements.
Users have also remarked that B50 effectively complements their existing supplement regimens, enhancing the overall management of menopause symptoms. One reviewer indicated that B50 aids in stabilizing weight and normalizing cholesterol levels while being a good addition alongside other supplements (review-id: 134aef96-a3ed-40e0-92ec-821b3789305d). Such testimonials underscore the potential of combining B50 with other dietary supplements to create a tailored approach to alleviating menopause-related challenges.
Users report varying experiences regarding the right dosage of Vitamin B Complex for managing menopause symptoms, with many finding success with one capsule daily. For instance, one user mentions taking one tablet in the morning and one in the afternoon for six months, suggesting this dosage may help stabilize weight and normalize cholesterol levels, which could positively influence menopause symptoms as well Read Review. Others highlight the benefits of daily intake, stating that it alleviated finger and foot pain and reduced feelings of dizziness associated with menopause Read Review, Read Review.
Additionally, some users advocate for a B50 complex specifically, citing that it contains all the necessary B vitamins in one tablet. Feedback indicates that adequate intake has led to improved energy levels and a reduction in depressive symptoms after major hormonal changes like hysterectomy Read Review, Read Review. The consensus seems to lean towards a daily regimen of one B50 capsule to effectively support various menopause-related symptoms.
6
Nerve protection
I took this to protect my nerves during menopause, as I've been suffering from paresthesia. After about two weeks, my symptoms have become less severe.
7.5
Mobility improvement
Since my late 40s, I’ve faced neck stiffness and hand numbness. I turned to B vitamins for relief and found Now Foods' B50 a cost-effective choice. After two weeks, my symptoms improved significantly, and I can now move more freely.
9
Weight management
1 people found this helpful
I've been taking this for six months, with one tablet in the morning and one in the afternoon. I believe my weight is stabilising, and my cholesterol levels have normalised at my latest health check. This product may help with menopause symptoms, and it complements other supplements well.
9
Pain reduction
1 people found this helpful
As a post-menopausal woman, I've experienced significant finger and foot pain. Since taking this B50 supplement daily, the pain has remarkably lessened. It’s a delightful experience.
6
Dizziness relief
1 people found this helpful
I've experienced dizziness due to menopause, but regular B-50 intake has significantly reduced its occurrence. I stopped taking it at one point but noticed the positive effects when I resumed.
7.5
Depression relief
3 people found this helpful
After my total hysterectomy, my estrogen plummeted, leading to an early menopause and a series of depressive symptoms. Life was challenging until I incorporated B50, vitamin C, B6, and magnesium into my routine, which alleviated my depression. I hope my review assists others.
7.5
Energy boost
1 people found this helpful
Post-menopause, I realised the need to supplement with B vitamins. Since doing so, my numbness has disappeared. B vitamins act as fuel for energy metabolism, and I've felt revitalised after ensuring adequate intake.
9
Effective nutritional menopause treatment
Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9.
We explored the effects of Exelvit Menopause®, a nutritional product incorporating various ingredients including vitamins and herbal extracts, on menopausal symptoms. Over 12 weeks, 156 menopausal women took this supplement daily, and we measured symptom relief using a standardized score.
Our findings revealed a noteworthy decrease in symptoms such as hot flashes, sleep disturbances, and irritability, with reductions ranging from 27.8% to 48.15%. This suggests that Exelvit Menopause® could offer a promising, non-hormonal approach to easing menopause-related discomfort.
8
Vitamin B may ease perimenopause
Clinical Evaluation of Effectiveness and Safety of Combined Use of Dietary Supplements Amberen and Smart B in Women with Climacteric Syndrome in Perimenopause.
This randomized, double-blind, placebo-controlled study explored how a combination of the Amberen supplement and a vitamin B complex affects women in perimenopause suffering from climacteric symptoms.
We found that this dietary supplement is not only safe but also helps alleviate various symptoms like hot flashes and mood swings. Participants experienced improved sleep, cognitive function, and overall well-being.
Overall, this suggests that vitamin B complex can be a valuable part of managing perimenopausal symptoms.
7
Vitamin B6 linked to mood improvement
Depressive Symptoms in Middle-Aged and Elderly Women Are Associated with a Low Intake of Vitamin B6: A Cross-Sectional Study.
We explored how dietary vitamin B6 intake affects depression and anxiety in middle-aged and elderly Japanese women. In our cross-sectional study with 289 participants, we found that higher consumption of vitamin B6 was linked to reduced moderate to severe depressive symptoms.
Interestingly, this connection remained even after considering age and menopausal status, making it clear that boosting our vitamin B6 intake might be beneficial for improving mood during menopause.
7
Folate impacts bone health in menopause
Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation.
We sought to understand how vitamin B levels influence bone health in postmenopausal women. Our analysis of 117 women over five years showed that higher folate levels positively correlate with vertebral bone mineral density changes.
However, we found no significant link between changes in bone density and either homocysteine or vitamin B12 levels. This suggests that folate deficiency may play a significant role in bone health during menopause, indicating its importance for maintaining vertebral strength.
References
Cho KA, Kim YH, Woo SY, Ryu KH. Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle. Tissue Eng Regen Med. 2025. 10.1007/s13770-025-00709-w
Kachko VA, Shulman LP, Kuznetsova IV, Uspenskaya YB, Burchakov DI. Clinical Evaluation of Effectiveness and Safety of Combined Use of Dietary Supplements Amberen and Smart B in Women with Climacteric Syndrome in Perimenopause. Adv Ther. 2024;41:3183. 10.1007/s12325-024-02910-0
Palacios S, Mustata C, Rizo JM, Regidor PA. Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9. Eur Rev Med Pharmacol Sci. 2023;27:8180. 10.26355/eurrev_202309_33578
De-Hita-Cantalejo C, Sánchez-González MC, Silva-Viguera C, García-Romera MC, Feria-Mantero R, et al. Efficacy of hyaluronic acid 0.3%, cyanocobalamin, electrolytes, and P-Plus in menopause patients with moderate dry eye disease. Graefes Arch Clin Exp Ophthalmol. 2022;260:529. 10.1007/s00417-021-05415-6
Odai T, Terauchi M, Suzuki R, Kato K, Hirose A, et al. Depressive Symptoms in Middle-Aged and Elderly Women Are Associated with a Low Intake of Vitamin B6: A Cross-Sectional Study. Nutrients. 2020;12. 10.3390/nu12113437
Vignini A, Nanetti L, Raffaelli F, Sabbatinelli J, Salvolini E, et al. Effect of 1-y oral supplementation with vitaminized olive oil on platelets from healthy postmenopausal women. Nutrition. 2017;42:92. 10.1016/j.nut.2017.06.013
McCabe D, Lisy K, Lockwood C, Colbeck M. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. JBI Database System Rev Implement Rep. 2017;15:402. 10.11124/JBISRIR-2016-002965
Cagnacci A, Bagni B, Zini A, Cannoletta M, Generali M, et al. Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone. 2008;42:314. 10.1016/j.bone.2007.10.022