Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (Vitamin B-1) (from Thiamin HCl)
50 mg
4167%
Riboflavin (Vitamin B-2)
50 mg
3846%
Niacin (Vitamin B-3) (as Niacinamide)
50 mg
313%
Vitamin B-6 (from Pyridoxine HCl)
50 mg
2941%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
2083%
Biotin
50 mcg
167%
Pantothenic Acid (from Calcium Pantothenate)
50 mg
1000%
Choline (from Choline Bitartrate)
25 mg
5%
PABA (Para-Aminobenzoic Acid)
25 mg
†
Inositol
25 mg
†
Top Medical Research Studies
9
In our review and meta-analysis, we sought to understand how Vitamin B2 supplementation influences migraines. By examining nine studies with over 670 participants, we found that taking 400 mg of Vitamin B2 daily for three months significantly reduced the frequency, duration, and pain intensity of migraine attacks.
Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.
Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.
Read More
9
We conducted a retrospective observational study involving 42 children and adolescents, aged six to 18, to assess the effectiveness of riboflavin in managing migraines.
Participants saw significant improvements, with fewer headache days per month and reduced headache intensity and duration after starting riboflavin.
Additionally, we found a decrease in reliance on acute medications and missed school days related to migraines, suggesting riboflavin is a safe and beneficial option for young migraine sufferers.
Participants saw significant improvements, with fewer headache days per month and reduced headache intensity and duration after starting riboflavin.
Additionally, we found a decrease in reliance on acute medications and missed school days related to migraines, suggesting riboflavin is a safe and beneficial option for young migraine sufferers.
Read More
8
We analyzed the role of vitamin B2, or riboflavin, in preventing migraines for adults. Our findings indicate that riboflavin is recommended for migraine prevention, though pediatric use lacks evidence.
While the adverse events associated with riboflavin are minimal, we noted that other nutraceuticals show varying levels of support for migraine treatment. Most notably, magnesium is also recommended for prevention and treatment, while coenzyme Q10 has limited evidence.
However, we observed that some supplements, like feverfew, require caution due to safety uncertainties. Overall, riboflavin stands out as a viable option for adults seeking relief from migraines.
While the adverse events associated with riboflavin are minimal, we noted that other nutraceuticals show varying levels of support for migraine treatment. Most notably, magnesium is also recommended for prevention and treatment, while coenzyme Q10 has limited evidence.
However, we observed that some supplements, like feverfew, require caution due to safety uncertainties. Overall, riboflavin stands out as a viable option for adults seeking relief from migraines.
Read More
Most Useful Reviews
9
Effective migraine remedy
3 people found this helpful
STOP THE MIGRAINES. Four of my family members use this vitamin to ward off migraines or stop them at the first sign. Caffeine, cow's milk products, and real chocolate trigger my migraines. Extreme stress exacerbates them. This yeast-based B-50 vitamin builds resistance to symptoms (bright lights, vertigo, head pain, nausea) and taken at the onset will halt a migraine immediately. The prescribed dosage for my family is 2 capsules with each of the 3 meals, adjusting by reducing the evening dose to 1 and the lunch dose as needed while keeping breakfast at 2. Each of us has a slightly different response, but we take 5-6 capsules when a migraine sneaks in. It reduces the prolonged fatigue that can ruin a day.
Read More
7.5
Severity reduction
1 people found this helpful
My family member experiences migraines occasionally, and this brand appears to be the most beneficial. After trying various brands, we found NOW brand B-50s effectively reduce the severity and intensity of migraines, so we will continue purchasing this brand.
Read More
7.5
Preventive benefits
6 people found this helpful
Please like to get iHerb rewards, God bless you! The vitamin B complex significantly reduces stress, improves mood, and helps prevent migraine headaches. It assists in forming healthy hormones in the body while increasing energy levels and alleviating muscle spasms, especially vitamin B2 (riboflavin).
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
- All Researches
9
In our review and meta-analysis, we sought to understand how Vitamin B2 supplementation influences migraines. By examining nine studies with over 670 participants, we found that taking 400 mg of Vitamin B2 daily for three months significantly reduced the frequency, duration, and pain intensity of migraine attacks.
Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.
Our analysis revealed that Vitamin B2 wasn't just a minor help; it truly made a difference in managing migraine symptoms. This suggests a potential alternative to traditional pharmaceuticals, offering hope for migraine sufferers looking for effective prevention options.
Read More
9
We conducted a retrospective observational study involving 42 children and adolescents, aged six to 18, to assess the effectiveness of riboflavin in managing migraines.
Participants saw significant improvements, with fewer headache days per month and reduced headache intensity and duration after starting riboflavin.
Additionally, we found a decrease in reliance on acute medications and missed school days related to migraines, suggesting riboflavin is a safe and beneficial option for young migraine sufferers.
Participants saw significant improvements, with fewer headache days per month and reduced headache intensity and duration after starting riboflavin.
Additionally, we found a decrease in reliance on acute medications and missed school days related to migraines, suggesting riboflavin is a safe and beneficial option for young migraine sufferers.
Read More
8
We analyzed the role of vitamin B2, or riboflavin, in preventing migraines for adults. Our findings indicate that riboflavin is recommended for migraine prevention, though pediatric use lacks evidence.
While the adverse events associated with riboflavin are minimal, we noted that other nutraceuticals show varying levels of support for migraine treatment. Most notably, magnesium is also recommended for prevention and treatment, while coenzyme Q10 has limited evidence.
However, we observed that some supplements, like feverfew, require caution due to safety uncertainties. Overall, riboflavin stands out as a viable option for adults seeking relief from migraines.
While the adverse events associated with riboflavin are minimal, we noted that other nutraceuticals show varying levels of support for migraine treatment. Most notably, magnesium is also recommended for prevention and treatment, while coenzyme Q10 has limited evidence.
However, we observed that some supplements, like feverfew, require caution due to safety uncertainties. Overall, riboflavin stands out as a viable option for adults seeking relief from migraines.
Read More
8
Vitamin B12 and magnesium effective
We set out to investigate whether combining vitamin B12, magnesium, and high-intensity interval training (HIIT) could help reduce migraine symptoms. In a randomized, placebo-controlled trial with 60 participants, we split them into four groups to assess various interventions over two months. Our findings showed that the combination of B12, magnesium, and regular exercise had significant benefits in reducing migraine pain and inflammation. This suggests that a synergistic approach could effectively improve migraine management.
Read More
8
We examined the potential benefits of vitamin B6, folate, and B12 for treating migraines, particularly migraine with aura (MA). Our systematic literature search gathered 12 studies, revealing that while these vitamins didn't significantly help with acute migraines, B6 showed promise when used preventively alongside folate and B12 in adults with MA. However, folate alone didn’t perform better than a placebo. Unfortunately, data on migraine without aura (MO) in both adults and children were limited, emphasizing the need for more rigorous studies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 8 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective migraine remedy
3 people found this helpful
STOP THE MIGRAINES. Four of my family members use this vitamin to ward off migraines or stop them at the first sign. Caffeine, cow's milk products, and real chocolate trigger my migraines. Extreme stress exacerbates them. This yeast-based B-50 vitamin builds resistance to symptoms (bright lights, vertigo, head pain, nausea) and taken at the onset will halt a migraine immediately. The prescribed dosage for my family is 2 capsules with each of the 3 meals, adjusting by reducing the evening dose to 1 and the lunch dose as needed while keeping breakfast at 2. Each of us has a slightly different response, but we take 5-6 capsules when a migraine sneaks in. It reduces the prolonged fatigue that can ruin a day.
Read More
7.5
Severity reduction
1 people found this helpful
My family member experiences migraines occasionally, and this brand appears to be the most beneficial. After trying various brands, we found NOW brand B-50s effectively reduce the severity and intensity of migraines, so we will continue purchasing this brand.
Read More
7.5
Preventive benefits
6 people found this helpful
Please like to get iHerb rewards, God bless you! The vitamin B complex significantly reduces stress, improves mood, and helps prevent migraine headaches. It assists in forming healthy hormones in the body while increasing energy levels and alleviating muscle spasms, especially vitamin B2 (riboflavin).
Read More
7.5
Rapid effect noted
4 people found this helpful
I found it effective for scintillating scotomas resulting from migraines. I took one tablet at the onset of symptoms, and it disappeared quickly. While my experience may differ from others, I hope this helps.
Read More
7.5
Recovery support
1 people found this helpful
This complex has significantly aided my recovery from a nerve injury, as it contains all the B vitamins needed for nerve tissue regeneration. After a week of use, my skin healed faster, and my migraines have markedly decreased. I plan to continue with the second pack for support post-operation.
Read More
Frequently Asked Questions
2
Frequency increase
As a migraine sufferer, I take one capsule each morning and evening. About a month later, I noticed positive effects. However, stopping the pills caused my migraines to recur with worse pain, indicating the effectiveness of the B vitamins. The capsules are large, and the taste of the powder inside is potent, but I persist in taking them.
7.5
Recovery support
1 people found this helpful
This complex has significantly aided my recovery from a nerve injury, as it contains all the B vitamins needed for nerve tissue regeneration. After a week of use, my skin healed faster, and my migraines have markedly decreased. I plan to continue with the second pack for support post-operation.
7.5
Decreased occurrence
I take this as a remedy for my migraines. I've noticed they are less frequent, and when they do occur, the pain is noticeably less intense.
7.5
Severity reduction
1 people found this helpful
My family member experiences migraines occasionally, and this brand appears to be the most beneficial. After trying various brands, we found NOW brand B-50s effectively reduce the severity and intensity of migraines, so we will continue purchasing this brand.
7.5
Preventive benefits
6 people found this helpful
Please like to get iHerb rewards, God bless you! The vitamin B complex significantly reduces stress, improves mood, and helps prevent migraine headaches. It assists in forming healthy hormones in the body while increasing energy levels and alleviating muscle spasms, especially vitamin B2 (riboflavin).
7.5
Rapid effect noted
4 people found this helpful
I found it effective for scintillating scotomas resulting from migraines. I took one tablet at the onset of symptoms, and it disappeared quickly. While my experience may differ from others, I hope this helps.
References
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Li H, Krall JR, Frankenfeld C, Slavin M. Nutritional intake of riboflavin (vitamin B2) and migraine: a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) 2001-2004. Nutr Neurosci. 2023;26:1068. 10.1080/1028415X.2022.2126760
- Li D, Guo Y, Xia M, Zhang J, Zang W. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. Headache. 2022;62:1133. 10.1111/head.14384
- Liu H, Wang L, Chen C, Dong Z, Yu S. Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey. Nutrients. 2022;14. 10.3390/nu14153052
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. 10.1007/s10072-021-05843-6
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. 10.1080/1028415X.2021.1904542
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. 10.1016/j.pediatrneurol.2020.09.009
- Yamanaka G, Suzuki S, Takeshita M, Go S, Morishita N, et al. Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine. Brain Dev. 2020;42:523. 10.1016/j.braindev.2020.04.002
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. 10.1111/head.13618
- Askari G, Nasiri M, Mozaffari-Khosravi H, Rezaie M, Bagheri-Bidakhavidi M, et al. The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial. Nutrition. 2017;38:74. 10.1016/j.nut.2017.01.007
- Thompson DF, Saluja HS. Prophylaxis of migraine headaches with riboflavin: A systematic review. J Clin Pharm Ther. 2017;42:394. 10.1111/jcpt.12548
- Prakash S, Kumar Singh A, Rathore C. Chronic Migraine Responding to Intravenous Thiamine: A Report of Two Cases. Headache. 2016;56:1204. 10.1111/head.12838
- Namazi N, Heshmati J, Tarighat-Esfanjani A. Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review. Int J Vitam Nutr Res. 2015;85:79. 10.1024/0300-9831/a000225
- Gaul C, Diener HC, Danesch U. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. J Headache Pain. 2015;16:516. 10.1186/s10194-015-0516-6
