We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Read More
8
Vitamin D3 reduces flu incidence
Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren.
We carried out a study to investigate whether vitamin D3 supplements could help prevent seasonal influenza A in schoolchildren. Our approach involved a randomized, double-blind, placebo-controlled trial conducted from December 2008 to March 2009.
This ensured that neither the participants nor the researchers knew who was receiving the vitamin D3 or the placebo, making our findings more reliable. During the trial, we provided 1200 IU of vitamin D3 daily to one group while the other received a placebo.
The results were promising; we found that only 10.8% of the children taking vitamin D3 contracted influenza A, compared to 18.6% in the placebo group. This reduced incidence led us to a relative risk of 0.58, suggesting that vitamin D3 supplementation may lower the chances of getting the flu.
Interestingly, we noticed the most significant benefits among children who hadn’t been taking any other vitamin D supplements and those who began nursery school after age three. Additionally, in children with a past asthma diagnosis, vitamin D3 seemed to dramatically reduce asthma attacks.
Overall, our findings indicate that taking vitamin D3 in the winter could be beneficial for schoolchildren, especially for certain groups. We believe this study adds valuable insights into preventive health measures against influenza A.
Read More
8
Vitamin D3 reduces flu-like illnesses
Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial.
We conducted a practical study to investigate how daily vitamin D3 supplementation at 5000 IU might help reduce flu-like illnesses in healthcare workers. This was especially important during the COVID-19 pandemic, where preventing viral infections is crucial for those on the front lines.
Our study involved 255 healthcare workers who received the vitamin D3 supplement for at least two months and compared them to a control group of 2827 workers who did not receive the supplement. We asked participants to monitor themselves for any flu-like symptoms and report for COVID-19 testing accordingly.
The results were promising; those supplementing with vitamin D experienced a significant reduction in the incidence of flu-like illnesses. The numbers showed a noteworthy drop in non-COVID-19 flu-like illness rates among those taking the supplement. However, when it came to COVID-19 related flu-like illnesses, the difference was not statistically significant.
Overall, our exploration of vitamin D3's effects suggests that it may be a beneficial addition to the health routines of healthcare workers to stave off flu-like illnesses, although its influence on COVID-19 specifically requires further investigation.
Read More
Most Useful Reviews
9
Vitamin D improvement
11 people found this helpful
Love it! I need sublinguals due to severe digestive issues. Most vitamins cause extreme flushing for me, but these are gentler. After three months of use, my Vitamin D level improved from a 7 to 30, crucial for my recovery, alongside a better diet.
Read More
9
Effective immunity booster
1 people found this helpful
Help for immunity! If I had known earlier that this miraculous vitamin could eliminate cold and flu in a short time, I might have avoided numerous sicknesses. Vitamin D3 is a potent prohormone that not only aids calcium absorption and strengthens bone structure but also serves as a robust protector against viruses, bacteria, and fungi. The effects are astounding; as soon as a cold hits, taking a high dosage leaves no trace of it. I wholeheartedly recommend this product as highly effective. It's essential for everyone's medicine cabinet. For a family of three, two cans should suffice for a season. Please like my review if you find it helpful; you won't regret it, trust me.
Read More
8
Fighting off illness
1 people found this helpful
A good company with a great product at a good price. I use it daily, especially when fighting off an illness. It truly works! Seldom do I get sick. When illness strikes, we grab this among other remedies to manage flu and colds effectively. Also, Vitamin D3 is essential for various reasons.
We recently examined how vitamin D impacts our body's response to influenza H1N1, an important viral infection. Utilizing 142 clinical cases from the Department of Otolaryngology at Sun Yat-sen University, we dug into the effects of vitamin D deficiency on chronic rhinosinusitis (CRS), a condition that frequently involves damage to the airway's lining. By studying airway organoids treated with vitamin D, we were able to simulate how this treatment might bolster our defenses against flu viruses and bacteria like Staphylococcus aureus.
Our observations showed that many patients with CRS suffered from vitamin D deficiency. Notably, those who received vitamin D treatment exhibited faster cell growth in the nasal epithelium. When exposed to the H1N1 virus, these treated organoids demonstrated a remarkable ability to fend off the infection better than those without vitamin D. This protection stemmed from enhancements in host defenses, including improved production of antimicrobial proteins, reduced inflammation, and better epithelial integrity—crucial factors in fighting off infections.
We also uncovered some fascinating insights about the biological mechanisms at work. Vitamin D seemed to actively influence how epithelial cells develop and repair themselves while managing immune responses against infections. These findings underscore the significance of addressing vitamin D deficiency, especially for those vulnerable to respiratory illnesses.
Read More
9
Oxarol enhances flu vaccine response
Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine.
We explored the potential of Oxarol, a medication usually prescribed for psoriasis, as a new adjuvant for influenza vaccines. In our research, we found that applying Oxarol ointment on the skin significantly enhanced the immune response of mice when they were vaccinated against the flu. This treatment helped boost humoral responses—essentially the production of antibodies—and improved germinal center reactions, which are critical for effective immunity.
Our findings highlighted that the vitamin D3 receptor in skin cells played a vital role in this process. By stimulating the production of a molecule called thymic stromal lymphopoietin (TSLP), Oxarol effectively facilitated better immune responses against the virus. Experiments showed that giving mice TSLP directly or blocking it produced noticeable changes in their immune responses, indicating its importance.
Importantly, we identified specific immune cells responsible for the effective response, confirming that targeted treatments like Oxarol could pave the way for safer and more efficient vaccine strategies in the future. This study suggests that vitamin D3’s role in skin treatments can be harnessed to improve flu vaccines.
Read More
8
Vitamin D may reduce flu risk
The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review.
We explored how vitamin D supplementation might help reduce the risk of respiratory infections, particularly the flu, in care homes. Our systematic review of several randomized controlled trials focused on interventions to reduce the transmission of acute respiratory infections, looking beyond just vaccines.
Our findings highlighted that high-dose vitamin D supplementation led to a significant decrease in the incidence of acute respiratory infections, reducing the likelihood of getting sick. Specifically, one trial indicated a 40% reduction in these infections among participants receiving vitamin D compared to those who did not.
However, not all studies we reviewed showed compelling results for related supplements like vitamins, minerals, probiotics, and herbal aids, which did not significantly impact infection rates. This means that while vitamin D supplementation shows promise, more research is needed to fully understand its effects and confirm its benefits in combating flu and other respiratory illnesses.
Read More
8
Vitamin D3 reduces flu-like illnesses
Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial.
We conducted a practical study to investigate how daily vitamin D3 supplementation at 5000 IU might help reduce flu-like illnesses in healthcare workers. This was especially important during the COVID-19 pandemic, where preventing viral infections is crucial for those on the front lines.
Our study involved 255 healthcare workers who received the vitamin D3 supplement for at least two months and compared them to a control group of 2827 workers who did not receive the supplement. We asked participants to monitor themselves for any flu-like symptoms and report for COVID-19 testing accordingly.
The results were promising; those supplementing with vitamin D experienced a significant reduction in the incidence of flu-like illnesses. The numbers showed a noteworthy drop in non-COVID-19 flu-like illness rates among those taking the supplement. However, when it came to COVID-19 related flu-like illnesses, the difference was not statistically significant.
Overall, our exploration of vitamin D3's effects suggests that it may be a beneficial addition to the health routines of healthcare workers to stave off flu-like illnesses, although its influence on COVID-19 specifically requires further investigation.
Read More
8
Vitamin D reduces flu risk
Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Love it! I need sublinguals due to severe digestive issues. Most vitamins cause extreme flushing for me, but these are gentler. After three months of use, my Vitamin D level improved from a 7 to 30, crucial for my recovery, alongside a better diet.
Read More
9
Effective immunity booster
1 people found this helpful
Help for immunity! If I had known earlier that this miraculous vitamin could eliminate cold and flu in a short time, I might have avoided numerous sicknesses. Vitamin D3 is a potent prohormone that not only aids calcium absorption and strengthens bone structure but also serves as a robust protector against viruses, bacteria, and fungi. The effects are astounding; as soon as a cold hits, taking a high dosage leaves no trace of it. I wholeheartedly recommend this product as highly effective. It's essential for everyone's medicine cabinet. For a family of three, two cans should suffice for a season. Please like my review if you find it helpful; you won't regret it, trust me.
Read More
8
Fighting off illness
1 people found this helpful
A good company with a great product at a good price. I use it daily, especially when fighting off an illness. It truly works! Seldom do I get sick. When illness strikes, we grab this among other remedies to manage flu and colds effectively. Also, Vitamin D3 is essential for various reasons.
Read More
9
Highly recommended vitamin
I was prone to colds and illness, but since taking this vitamin D3 and Zinc, I rarely catch a cold or flu. During the Covid era, it was instrumental in my survival. I urge my family to take it during winter; I personally take it daily.
Read More
6
Keeps kids healthy
1 people found this helpful
Excellent! If you want your children to remain healthy and reduce their flu incidence, give them this daily.
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
Vitamin D has been shown to play a crucial role in immune function, and there is some evidence suggesting that it may help reduce the risk of respiratory infections, including the flu. Some studies indicate that individuals with adequate levels of Vitamin D might experience fewer infections and potentially milder symptoms if they do contract the flu. This correlation is thought to be due to Vitamin D's ability to modulate the immune system and promote the production of antimicrobial proteins in the respiratory tract.
However, while a deficiency in Vitamin D is linked to an increased susceptibility to infections, it's important to note that taking Vitamin D supplements should not be seen as a substitute for traditional flu prevention measures, such as vaccination and good hygiene practices. Overall, maintaining appropriate Vitamin D levels through a combination of sun exposure, diet, and supplements may contribute to better overall health and potentially help fend off illnesses like the flu, but more research is needed to establish a definitive causal relationship.
Based on user reviews, many individuals report that they experience benefits from taking Vitamin D3 for flu relief relatively quickly. For instance, one user states that taking a high dosage of Vitamin D3 as soon as a cold hits can "leave no trace of it," suggesting that some users may notice improvements soon after starting the supplement Read Review. Another reviewer mentions using the supplement daily, claiming it has helped them keep flu and colds at bay consistently throughout seasons Read Review.
Overall, while specific timelines can vary from person to person, reports imply that many users feel a positive impact in their immune response and health within a short period of regular use. Some testimonials indicated noticeable improvements in overall well-being and a reduced incidence of illness as users continued their daily regimen of Vitamin D3, especially during the peak seasons for colds and flu Read Review.
Vitamin D supplementation has garnered attention for its potential role in reducing the risk of influenza infections, supported by a variety of scientific studies. A systematic review analyzing multiple randomized controlled trials indicated that high-dose vitamin D supplementation could significantly decrease the incidence of acute respiratory infections, including influenza, with one trial reporting a 40% reduction in cases among participants taking vitamin D compared to those who did not [1]. Furthermore, research has shown that vitamin D may enhance the body's defenses against the flu virus by improving immune responses and reducing inflammation in the lungs [3].
While some studies suggest beneficial effects, such as a significant reduction in flu-like illnesses among healthcare workers taking vitamin D3 [3], the results are not universally conclusive. For example, a study involving young children showed an 84% relative risk reduction for flu infection, but this did not achieve statistical significance, suggesting the findings need to be interpreted with caution [5]. Additionally, a review of 10 trials concluded that while vitamin D supplementation could provide some degree of protection against flu, the evidence is mixed and calls for further research to better understand its effectiveness and identify optimal usage [6]. Overall, while vitamin D may offer some promise as part of broader preventive measures against flu, more rigorous studies are needed to confirm its role definitively.
Users report a variety of improvements in their symptoms after incorporating Vitamin D3 into their daily routine. Many individuals have noted significant reductions in the frequency of colds and flu, stating that the supplement has made them feel less susceptible to illness, particularly during the colder months. One user emphasized that taking a high dosage of Vitamin D3 as soon as a cold hits can completely eliminate its effects, highlighting its rapid action in reducing symptoms Read Review. Another reviewer, who had been prone to frequent colds, noted that they rarely catch illness since beginning their Vitamin D3 regimen, urging others to take it, especially during winter Read Review.
Additionally, parents using Vitamin D3 for their children have reported positive effects, including a decrease in flu instances Read Review. Several users also mentioned an overall boost in both physical and mental well-being linked to the supplement, stating that it plays a vital role in their immune system and bone health Read Review. Overall, while individual results can vary, it appears that many users feel a marked improvement in their health and immunity when consistently taking Vitamin D3.
Users report favorable experiences when combining Vitamin D3 with other supplements, particularly Zinc, for managing flu symptoms. One reviewer mentioned that since they began taking both Vitamin D3 and Zinc, they have rarely caught a cold or the flu, urging their family to adopt this regimen during winter for enhanced immunity Read Review. This suggests that users believe that the synergistic effect of these two supplements can significantly bolster the body's defenses against seasonal illnesses.
Additionally, parents have indicated that giving Vitamin D3 to their children on a daily basis helps reduce flu instances, emphasizing its importance in maintaining their health Read Review. Another user mentions a large study supporting vitamin D's role in preventing acute respiratory infections, further reinforcing the notion that a combination of Vitamin D3 with other immunity-supporting supplements is perceived as a proactive strategy for flu prevention Read Review. Overall, reviews indicate that many users advocate for integrating Vitamin D3 with other supplements to enhance their immune response during the flu season.
According to recent research, the optimal dose of Vitamin D for treating and preventing the flu appears to be around 5000 IU per day. A study conducted among healthcare workers found that this dosage significantly reduced the incidence of flu-like illnesses, highlighting its potential benefits during flu season [3]. Additionally, another trial among children indicated that a daily intake of 2000 IU resulted in a notable reduction of influenza A infections, although the findings did not achieve statistical significance, suggesting that higher doses may be more effective [5].
While some studies support Vitamin D's protective role against respiratory infections, there is variability in the results across different populations and trial designs. For example, a systematic review indicated that Vitamin D supplementation led to improvements in immune responses and reduced risks of acute respiratory infections overall, although the exact mechanism and effectiveness against the flu specifically require further research [6]. Therefore, while 5000 IU may emerge as a practical daily dose for adults, individuals should consult healthcare professionals for personalized recommendations, especially if they are considering supplementation during flu season.
9
Effective immunity booster
1 people found this helpful
Help for immunity! If I had known earlier that this miraculous vitamin could eliminate cold and flu in a short time, I might have avoided numerous sicknesses. Vitamin D3 is a potent prohormone that not only aids calcium absorption and strengthens bone structure but also serves as a robust protector against viruses, bacteria, and fungi. The effects are astounding; as soon as a cold hits, taking a high dosage leaves no trace of it. I wholeheartedly recommend this product as highly effective. It's essential for everyone's medicine cabinet. For a family of three, two cans should suffice for a season. Please like my review if you find it helpful; you won't regret it, trust me.
7.5
Prevents colds effectively
Used 2-3 per day, helped to keep the colds and flu at bay.
7.5
Boosts immune system
Since starting this Vitamin D-3 supplement, I've noticed improvements in my physical and mental well-being. Vitamin D plays a crucial role in calcium absorption and bone health, and I feel more secure about maintaining strong bones as I age. Additionally, it bolsters my immune system, making me less susceptible to illness during cold and flu season.
9
Highly recommended vitamin
I was prone to colds and illness, but since taking this vitamin D3 and Zinc, I rarely catch a cold or flu. During the Covid era, it was instrumental in my survival. I urge my family to take it during winter; I personally take it daily.
6
Keeps kids healthy
1 people found this helpful
Excellent! If you want your children to remain healthy and reduce their flu incidence, give them this daily.
7.5
Prevents respiratory infections
A large multinational study indicated that vitamin D supplements can prevent acute respiratory infections, including colds and flu. Thus, taking vitamin D3 is a key measure to protect oneself from new coronary pneumonia.
8
Vitamin D may reduce flu risk
The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review.
We explored how vitamin D supplementation might help reduce the risk of respiratory infections, particularly the flu, in care homes. Our systematic review of several randomized controlled trials focused on interventions to reduce the transmission of acute respiratory infections, looking beyond just vaccines.
Our findings highlighted that high-dose vitamin D supplementation led to a significant decrease in the incidence of acute respiratory infections, reducing the likelihood of getting sick. Specifically, one trial indicated a 40% reduction in these infections among participants receiving vitamin D compared to those who did not.
However, not all studies we reviewed showed compelling results for related supplements like vitamins, minerals, probiotics, and herbal aids, which did not significantly impact infection rates. This means that while vitamin D supplementation shows promise, more research is needed to fully understand its effects and confirm its benefits in combating flu and other respiratory illnesses.
8
Vitamin D3 reduces flu-like illnesses
Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial.
We conducted a practical study to investigate how daily vitamin D3 supplementation at 5000 IU might help reduce flu-like illnesses in healthcare workers. This was especially important during the COVID-19 pandemic, where preventing viral infections is crucial for those on the front lines.
Our study involved 255 healthcare workers who received the vitamin D3 supplement for at least two months and compared them to a control group of 2827 workers who did not receive the supplement. We asked participants to monitor themselves for any flu-like symptoms and report for COVID-19 testing accordingly.
The results were promising; those supplementing with vitamin D experienced a significant reduction in the incidence of flu-like illnesses. The numbers showed a noteworthy drop in non-COVID-19 flu-like illness rates among those taking the supplement. However, when it came to COVID-19 related flu-like illnesses, the difference was not statistically significant.
Overall, our exploration of vitamin D3's effects suggests that it may be a beneficial addition to the health routines of healthcare workers to stave off flu-like illnesses, although its influence on COVID-19 specifically requires further investigation.
5
Vitamin D's limited flu benefits
A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children.
We conducted a randomized, double-blind, controlled trial to explore whether vitamin D supplementation could lower the risk of flu among young children. The study involved 248 participants aged two to five years from daycare centers in Taiwan, who were divided into two groups: one received 2000 IU of vitamin D daily, while the other group received a placebo for one month.
The results were intriguing. We found an 84% relative risk reduction for flu infection in the vitamin D group compared to the placebo group. However, this finding did not achieve statistical significance, which means we can't be certain of its importance. The data suggested that the placebo group might have a higher chance of getting the flu, but again, the results were not definitive.
Additionally, no significant differences were observed in terms of enterovirus infections between the two groups, and the same trend was seen among household members of the children. Everyone who received the vitamin D treatment managed to raise their vitamin D levels above 30 ng/ml, indicating that the supplementation was effective in boosting their vitamin D status.
Overall, while vitamin D supplementation might offer some protective effect against flu in preschoolers, the evidence does not strongly support this. We recommend further research to fully understand the impact.
8
Vitamin D reduces flu risk
Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
References
Willcox ML, Lavu D, Yousaf U, Dalton S, Roberts N, et al. The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review. J Public Health (Oxf). 2024;46:551. 10.1093/pubmed/fdae178
Liao S, Huang Y, Zhang J, Xiong Q, Chi M, et al. Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections. Respir Res. 2023;24:175. 10.1186/s12931-023-02477-4
van Helmond N, Brobyn TL, LaRiccia PJ, Cafaro T, Hunter K, et al. Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial. Nutrients. 2022;15. 10.3390/nu15010180
Arora J, Patel DR, Nicol MJ, Field CJ, Restori KH, et al. Vitamin D and the Ability to Produce 1,25(OH)D Are Critical for Protection from Viral Infection of the Lungs. Nutrients. 2022;14. 10.3390/nu14153061
Huang YN, Chi H, Chiu NC, Huang CY, Li ST, et al. A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children. J Microbiol Immunol Infect. 2022;55:803. 10.1016/j.jmii.2022.01.003
Zhu Z, Zhu X, Gu L, Zhan Y, Chen L, et al. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials. Front Nutr. 2021;8:799709. 10.3389/fnut.2021.799709
Godan Hauptman A, Lukić-Grlić A, Vraneš J, Milošević M, Gagro A. The effect of standard-dose wintertime vitamin D supplementation on influenza infection in immunized nursing home elderly residents. Croat Med J. 2021;62:495.
Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. 10.1136/bmjgh-2020-003176
Slusky DJG, Zeckhauser RJ. Sunlight and Protection Against Influenza. Econ Hum Biol. 2021;40:100942. 10.1016/j.ehb.2020.100942
Godbole NM, Sinha RA, Tiwari S, Pawar SD, Dhole TN. Analysis of influenza virus-induced perturbation in autophagic flux and its modulation during Vitamin D3 mediated anti-apoptotic signaling. Virus Res. 2020;282:197936. 10.1016/j.virusres.2020.197936
Sato R, Makino-Okamura C, Lin Q, Wang M, Shoemaker JE, et al. Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine. Int Immunol. 2020;32:499. 10.1093/intimm/dxaa012
Urashima M, Mezawa H, Noya M, Camargo CA. Effects of vitamin D supplements on influenza A illness during the 2009 H1N1 pandemic: a randomized controlled trial. Food Funct. 2014;5:2365. 10.1039/c4fo00371c
Khare D, Godbole NM, Pawar SD, Mohan V, Pandey G, et al. Calcitriol [1, 25[OH]2 D3] pre- and post-treatment suppresses inflammatory response to influenza A (H1N1) infection in human lung A549 epithelial cells. Eur J Nutr. 2013;52:1405. 10.1007/s00394-012-0449-7
Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91:1255. 10.3945/ajcn.2009.29094
Kriesel JD, Spruance J. Calcitriol (1,25-dihydroxy-vitamin D3) coadministered with influenza vaccine does not enhance humoral immunity in human volunteers. Vaccine. 1999;17:1883.