Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
10 mcg (400 IU)
50%
Top Medical Research Studies
8
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
Read More
7
We explored the effects of vitamin D supplementation on osteoporosis, especially among individuals at risk for this condition. The Osteoporosis Research and Information Group (GRIO) highlighted the critical difference between daily and intermittent vitamin D dosing.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
Read More
9
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Read More
Most Useful Reviews
9
Improves bone density
1 people found this helpful
After being diagnosed with osteoporosis following a lumbar compression fracture, I noticed a 4% improvement in bone density after taking supplements for six months, alongside calcium. Although I initially questioned the supplement's effectiveness, the osteoporosis test results confirmed its benefits. I stopped taking the hospital-prescribed vitamin D3 after two weeks (laughs).
Read More
9
Boosts immunity
As I don’t often bask in the sun, I regularly supplement vitamin D to compensate for the deficiency in my body, thereby enhancing immunity and reducing osteoporosis!
Read More
7.5
Essential for everyone
Most people today are deficient in D3 due to living in air-conditioned spaces with limited sunlight exposure. Therefore, supplementing D3 is essential. It can enhance bone health and prevent osteoporosis while also alleviating depression.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
- All Researches
9.5
We looked into the effects of vitamin D3 on osteoporosis management, particularly in relation to glucocorticoid-induced complications. In a recent case involving an 85-year-old patient with IgG4-related disease, vitamin D3 was used alongside prednisone and azathioprine. The goal was to prevent bone density loss often seen with steroid treatments.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Read More
9
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Read More
9
Vitamin D derivatives enhance bone health
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
Read More
9
We explored how Nano Vitamin D3 influences osteoporosis, particularly in the context of treatments involving anastrozole, a medication often used in cancer therapy. In our study, we observed the effects of Nano Vitamin D3 compared to selenium nanoparticles in female albino rats.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
The research involved categorizing 28 rats into four groups, with one group receiving just anastrozole, while the other groups were treated with either selenium nanoparticles or Nano Vitamin D3 alongside anastrozole. After four weeks of treatment, we looked closely at the rats' mandibular bones to see how these treatments affected bone health.
Our findings indicated that both Selenium nanoparticles and Nano Vitamin D3 showed improvements in bone structure and cell health compared to the animals taking only anastrozole. The rats in the treatment groups demonstrated more newly formed collagen and healthier osteoblasts—cells that play a crucial role in bone formation. While we focused heavily on comparing these two approaches to therapy, the results confirmed that using Nano Vitamin D3 can be beneficial for combating osteoporosis exacerbated by anastrozole.
Read More
9
We investigated the effects of vitamin D3 supplementation during pregnancy on offspring's bone mineral density (BMD) as they grow. In the MAVIDOS study, pregnant women with low levels of vitamin D were given either a daily dose of 1000 IU of cholecalciferol (vitamin D3) or a placebo from their second trimester until delivery.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
After the children reached ages 6 to 7, we assessed their bone health using advanced scanning techniques. The results revealed that those children whose mothers had received vitamin D3 supplementation exhibited higher BMD compared to those whose mothers received the placebo. This suggests that supplementing pregnant women with vitamin D3 could be a valuable public health strategy for improving bone health in children.
Even though this study focused on childhood, it reflects broader implications for how vitamin D3 might help in preventing conditions like osteoporosis later in life.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves bone density
1 people found this helpful
After being diagnosed with osteoporosis following a lumbar compression fracture, I noticed a 4% improvement in bone density after taking supplements for six months, alongside calcium. Although I initially questioned the supplement's effectiveness, the osteoporosis test results confirmed its benefits. I stopped taking the hospital-prescribed vitamin D3 after two weeks (laughs).
Read More
9
Boosts immunity
As I don’t often bask in the sun, I regularly supplement vitamin D to compensate for the deficiency in my body, thereby enhancing immunity and reducing osteoporosis!
Read More
7.5
Essential for everyone
Most people today are deficient in D3 due to living in air-conditioned spaces with limited sunlight exposure. Therefore, supplementing D3 is essential. It can enhance bone health and prevent osteoporosis while also alleviating depression.
Read More
7.5
Very useful product
This Vitamin D is incredibly beneficial for osteoporosis. I find this product very useful.
Read More
7.5
Highly recommended
Physicians recommend supplementing D3 to improve calcium and phosphorus absorption, prevent osteoporosis, boost immunity, and reduce the risk of new infections including COVID-19. This product offers excellent quality and value, and I highly recommend it to friends in need.
Read More
Frequently Asked Questions
9
Improves bone density
1 people found this helpful
After being diagnosed with osteoporosis following a lumbar compression fracture, I noticed a 4% improvement in bone density after taking supplements for six months, alongside calcium. Although I initially questioned the supplement's effectiveness, the osteoporosis test results confirmed its benefits. I stopped taking the hospital-prescribed vitamin D3 after two weeks (laughs).
7.5
Highly recommended
Physicians recommend supplementing D3 to improve calcium and phosphorus absorption, prevent osteoporosis, boost immunity, and reduce the risk of new infections including COVID-19. This product offers excellent quality and value, and I highly recommend it to friends in need.
9
Boosts immunity
As I don’t often bask in the sun, I regularly supplement vitamin D to compensate for the deficiency in my body, thereby enhancing immunity and reducing osteoporosis!
7.5
Suitable for osteoporosis
This product is suitable for osteoporosis and is beneficial for those who experience lethargy and muscle weakness, like those with rheumatism. The size and dosage are appropriate.
7.5
Bone health support
Although this bottle of D3 contains only 10mcg, it can be combined with calcium, magnesium tablets, and K2 to aid in calcium absorption, prevent osteoporosis, and safeguard cardiovascular health!
7
We explored the effects of vitamin D supplementation on osteoporosis, especially among individuals at risk for this condition. The Osteoporosis Research and Information Group (GRIO) highlighted the critical difference between daily and intermittent vitamin D dosing.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
8
We explored the role of vitamin D (VD) supplementation in supporting cancer patients undergoing chemotherapy and radiotherapy, particularly regarding its effects on osteoporosis. The aim was to sift through scientific evidence to understand how vitamin D influences not just bone health but also alleviates the side effects of demanding cancer treatments.
Our findings indicated that adequate levels of VD are important for maintaining bone density in patients, especially those receiving preoperative chemoradiotherapy. Some studies showed that vitamin D supplementation could lessen certain severe side effects, like fatigue and nausea, often experienced during cancer treatments.
However, the evidence regarding the isolated effects of vitamin D on osteoporosis, specifically, was limited due to the varied designs of the included studies. Despite these challenges, it seems clear that vitamin D plays a valuable role in managing bone health and reducing treatment-related complications.
Our findings indicated that adequate levels of VD are important for maintaining bone density in patients, especially those receiving preoperative chemoradiotherapy. Some studies showed that vitamin D supplementation could lessen certain severe side effects, like fatigue and nausea, often experienced during cancer treatments.
However, the evidence regarding the isolated effects of vitamin D on osteoporosis, specifically, was limited due to the varied designs of the included studies. Despite these challenges, it seems clear that vitamin D plays a valuable role in managing bone health and reducing treatment-related complications.
8
We examined the relationship between vitamin D levels and the risk of new vertebral fractures after patients underwent a specific spine procedure called percutaneous vertebral augmentation. Our focus was on postmenopausal women aged 50 and above, who often face an increased risk of fractures due to osteoporosis.
In this retrospective study, we categorized patients into groups based on whether they experienced new osteoporotic vertebral fractures or not. Our analysis revealed that low levels of serum 25-hydroxyvitamin D are an independent risk factor for these new fractures.
This suggests that maintaining adequate vitamin D levels could be crucial for individuals recovering from this type of spinal surgery. By ensuring active vitamin D supplementation after the procedure, patients may significantly lower their chances of future osteoporotic vertebral fractures, promoting better recovery and overall health.
In this retrospective study, we categorized patients into groups based on whether they experienced new osteoporotic vertebral fractures or not. Our analysis revealed that low levels of serum 25-hydroxyvitamin D are an independent risk factor for these new fractures.
This suggests that maintaining adequate vitamin D levels could be crucial for individuals recovering from this type of spinal surgery. By ensuring active vitamin D supplementation after the procedure, patients may significantly lower their chances of future osteoporotic vertebral fractures, promoting better recovery and overall health.
9.5
We looked into the effects of vitamin D3 on osteoporosis management, particularly in relation to glucocorticoid-induced complications. In a recent case involving an 85-year-old patient with IgG4-related disease, vitamin D3 was used alongside prednisone and azathioprine. The goal was to prevent bone density loss often seen with steroid treatments.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
Our focus on this case revealed that vitamin D3 played an essential role in supporting the patient’s bone health. This addition helped mitigate some side effects of long-term steroid use, specifically protecting against osteoporosis, while the patient experienced significant improvements in their orbital symptoms.
Over the course of treatment, the patient showed remarkable recovery in just 24 hours, along with a complete resolution of issues related to their eye condition over the following year. While direct data on vitamin D3's standalone effectiveness isn't highlighted, its use in this context underscores a possible beneficial role in osteoporosis prevention when combined with corticosteroids.
References
- Afonso ML, Capelas ML, Pimenta NM, Santos T, Mäkitie A, et al. A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?. Nutrients. 2025;17. 10.3390/nu17040634
- Wang H, Tian G, Pei Z, Yu X, Wang Y, et al. increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice. mSphere. 2025. 10.1128/msphere.01039-24
- Skubica P, Hoffmanova I, Dankova P. Chronically increased osteoclastogenesis in adult celiac disease patients does not hinder improvement in bone health induced by gluten-free diet: Role of vitamin D, OPG and IL-6. J Nutr Biochem. 2025. 10.1016/j.jnutbio.2025.109871
- Pickering ME, Souberbielle JC, Boutten A, Breuil V, Briot K, et al. Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO. Joint Bone Spine. 2025;92:105858. 10.1016/j.jbspin.2025.105858
- Shi L, Bao Y, Deng X, Xu X, Hu J. Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study. BMJ Open. 2025;15:e092901. 10.1136/bmjopen-2024-092901
- Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
- Yang C, Chen L, Guo X, Sun H, Miao D. The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. J Orthop Translat. 2025;50:211. 10.1016/j.jot.2024.10.011
- Kuwabara N, Kanda J, Sato S, Nakagawa S. Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D Biosynthesis Pathways. Biol Pharm Bull. 2025;48:39. 10.1248/bpb.b24-00536
- McCarrison S, Abdelrahman S, Quinlivan R, Keen R, Wong SC. Pharmacological and non-pharmacological therapies for prevention and treatment of osteoporosis in Duchenne Muscular Dystrophy: A systematic review. Bone. 2025;193:117410. 10.1016/j.bone.2025.117410
- Ma M, Zhang Y, Liu J, Tian C, Duan Z, et al. Associations of the serum 25-hydroxyvitamin D with mortality among patients in osteopenia or osteoporosis. Bone. 2025. 10.1016/j.bone.2025.117408
- Mendoza-Vargas LÁ, Sevilla-Fuentes S, Bautista-Becerril B, Berthaúd-González B, Falfán-Valencia R, et al. IgG4-RD-Associated Mikulicz Syndrome Without Classic Systemic Involvement-A Case Report. J Clin Med. 2025;14. 10.3390/jcm14030958
- Paul T, Garg B, Kapoor N, Patil V, Kachnerkar N, et al. A Prospective, Active-controlled, Randomized, Double-blind, Multicenter, Phase III Study to Compare the Safety and Efficacy of Biosimilar Denosumab vs Reference Denosumab in the Treatment of Postmenopausal Osteoporosis. J Assoc Physicians India. 2025;73:e8. 10.59556/japi.73.0772
- Sawant D, Kamble N. Overcoming Recurrent Isolated Sleep Paralysis: A Case Report of Integrative Management With Yoga, Meditation, and Vitamin D3 Supplementation. Cureus. 2024;16:e76626. 10.7759/cureus.76626
- Kittaka A. Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. Chem Pharm Bull (Tokyo). 2025;73:1. 10.1248/cpb.c24-00598
- Elmalah SG, Mohsen ROM, Hassan R. Selenium nano particles versus nano vitamin D3 in modulating anastrozole-induced osteoporosis on the mandibular alveolar bone of albino rats. J Stomatol Oral Maxillofac Surg. 2024. 10.1016/j.jormas.2024.102181
- Chang CH, Yang SJ, Young TH, Yao WC. Effect of co-loaded vitamin D3 on intravenous injectable raloxifene delivery system. Colloids Surf B Biointerfaces. 2025;246:114379. 10.1016/j.colsurfb.2024.114379
- Kluijver LG, Wagenmakers MAEM, Wilson JHP, Langendonk JG. The impact of minimal sunlight exposure on bone health: insights from a cohort study in erythropoietic protoporphyria. J Clin Endocrinol Metab. 2024. 10.1210/clinem/dgae729
- Chen Y, Qiu H, Xuan L, Jin Y, Chen R, et al. Acupuncture in Treating Osteopenia: A Multicenter, Randomized, Controlled Clinical Trial. Complement Med Res. 2024;31:516. 10.1159/000541440
- Moon RJ, D' Angelo S, Curtis EM, Ward KA, Crozier SR, et al. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial. Am J Clin Nutr. 2024;120:1134. 10.1016/j.ajcnut.2024.09.014
- Pinto-Bonilla R, Baeza-Noci J, Blanco CC, Gumbau GJV, Fernández RJ, et al. Real-world effectiveness and safety of combined calcium 600 mg and cholecalciferol 2000 IU for treating vitamin d deficiency: Results from a nationwide study with focus in osteoporosis. Bone Rep. 2024;22:101796. 10.1016/j.bonr.2024.101796
- Xu D, Liu J, Zhang D, Zhang X, Huang C, et al. [Effects of thunder-fire moxibustion on balance function and musculoskeletal metabolism in female patients of primary osteoporosis with low muscle mass]. Zhongguo Zhen Jiu. 2024;44:859. 10.13703/j.0255-2930.20231229-0002
- Shin S, Hong N, Rhee Y. A randomized controlled trial of the effect of raloxifene plus cholecalciferol versus cholecalciferol alone on bone mineral density in postmenopausal women with osteopenia. JBMR Plus. 2024;8:ziae073. 10.1093/jbmrpl/ziae073
- Wu T, Lin Z, Wang C, Liu X. Correlation between vitamin D levels and blood pressure in elderly hypertensive patients with osteoporosis. Front Med (Lausanne). 2024;11:1396254. 10.3389/fmed.2024.1396254
